{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:15:15Z","timestamp":1792059315435,"version":"4.4.0"},"reference-count":161,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773384"],"award-info":[{"award-number":["81773384"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.envres.2020.110254","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T14:12:59Z","timestamp":1601302379000},"page":"110254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":157,"special_numbering":"C","title":["The latest advances in the reproductive toxicity of microcystin-LR"],"prefix":"10.1016","volume":"192","author":[{"given":"Shiyu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingde","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Losiewic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2020.110254_bib1","first-page":"1309175","article-title":"Piperine enhances the antioxidant and anti-inflammatory activities of thymoquinone against microcystin-LR-induced hepatotoxicity and neurotoxicity in mice","volume":"2019","author":"Abdel-Daim","year":"2019","journal-title":"Oxid. Med. Cellul. Long."},{"key":"10.1016\/j.envres.2020.110254_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.etap.2018.09.001","article-title":"Microcystin-leucine arginine (MC-LR) induced inflammatory response in bovine sertoli cell via TLR4\/NF-kB signaling pathway","volume":"63","author":"Adegoke","year":"2018","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envres.2020.110254_bib3","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1007\/s11356-019-06931-z","article-title":"Fucoidan alleviates microcystin-LR-induced hepatic, renal, and cardiac oxidative stress and inflammatory injuries in mice","volume":"27","author":"AlKahtane","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envres.2020.110254_bib4","volume":"vol. 5","author":"Bell","year":"1994"},{"key":"10.1016\/j.envres.2020.110254_bib5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/etc.4305","article-title":"Cyanobacteria reduce motility of quagga mussel (Dreissena rostriformis bugensis sperm)","volume":"38","author":"Boegehold","year":"2019","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envres.2020.110254_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11090482","article-title":"Effects of microcystin-LR on the microstructure and inflammation-related factors of jejunum in mice","volume":"11","author":"Cao","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.envres.2020.110254_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11090507","article-title":"A Review of Cardiovascular Toxicity of Microcystins","volume":"11","author":"Cao","year":"2019","journal-title":"Toxins."},{"key":"10.1016\/j.envres.2020.110254_bib8","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1289\/ehp.01109663","article-title":"Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins","volume":"109","author":"Carmichael","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2020.110254_bib9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.toxlet.2018.03.003","article-title":"Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells","volume":"289","author":"Chen","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envres.2020.110254_bib15","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00018-017-2687-6","article-title":"Microcystin-leucine-arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8","volume":"75","author":"Chen","year":"2018","journal-title":"Cellul. Mol. Life CM"},{"key":"10.1016\/j.envres.2020.110254_bib16","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.envpol.2017.07.081","article-title":"Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis","volume":"229","author":"Chen","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2020.110254_bib11","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.toxicon.2005.01.003","article-title":"Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in two freshwater shrimps, Palaemon modestus and Macrobrachium nipponensis, from a large shallow, eutrophic lake of the subtropical China","volume":"45","author":"Chen","year":"2005","journal-title":"Toxicon: official journal of the International Society on Toxinology"},{"key":"10.1016\/j.envres.2020.110254_bib12","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1016\/j.scitotenv.2009.02.005","article-title":"Simultaneous determination of microcystin contaminations in various vertebrates (fish, turtle, duck and water bird) from a large eutrophic Chinese lake, Lake Taihu, with toxic Microcystis blooms","volume":"407","author":"Chen","year":"2009","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2020.110254_bib13","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jhazmat.2015.08.041","article-title":"A review of reproductive toxicity of microcystins","volume":"301","author":"Chen","year":"2016","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envres.2020.110254_bib10","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s00128-017-2051-4","article-title":"Effects of microcystis on hypothalamic-pituitary-gonadal-liver Axis in nile Tilapia (Oreochromis niloticus)","volume":"98","author":"Chen","year":"2017","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.aquatox.2018.03.018","article-title":"Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels","volume":"199","author":"Chen","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib17","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.reprotox.2011.02.006","article-title":"Decline of sperm quality and testicular function in male mice during chronic low-dose exposure to microcystin-LR","volume":"31","author":"Chen","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib18","first-page":"39238","volume":"6","author":"Chen","year":"2016","journal-title":"Microcystin-Leucine Arginine Causes Cytotoxic Effects in Sertoli Cells Resulting in Reproductive Dysfunction in Male Mice Scientific Reports"},{"key":"10.1016\/j.envres.2020.110254_bib19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.toxicon.2013.09.005","article-title":"Microcystin-LR induces autophagy and apoptosis in rat Sertoli cells in vitro","volume":"76","author":"Chen","year":"2013","journal-title":"Toxicon : official journal of the International Society on Toxinology"},{"key":"10.1016\/j.envres.2020.110254_bib20","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s00204-014-1301-z","article-title":"Bisphenol A modulates colorectal cancer protein profile and promotes the metastasis via induction of epithelial to mesenchymal transitions","volume":"89","author":"Chen","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib21","doi-asserted-by":"crossref","first-page":"A493","DOI":"10.1016\/j.autrev.2011.11.027","article-title":"The role of environmental estrogens and autoimmunity","volume":"11","author":"Chighizola","year":"2012","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.envres.2020.110254_bib22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.toxicon.2014.06.010","article-title":"First report of microcystin-producing fischerella sp. (stigonematales, cyanobacteria) in tropical Australia","volume":"88","author":"Cir\u00e9s","year":"2014","journal-title":"Toxicon : official journal of the International Society on Toxinology"},{"key":"10.1016\/j.envres.2020.110254_bib23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mce.2009.04.009","article-title":"Endocrine\/paracrine control of zebrafish ovarian development","volume":"312","author":"Clelland","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envres.2020.110254_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20246249","article-title":"Deciphering miRNAs' action through miRNA editing","volume":"20","author":"Correia de Sousa","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2020.110254_bib25","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.envpol.2018.09.055","article-title":"Transgenerational effects of cyanobacterial toxins on a tropical micro-crustacean Daphnia lumholtzi across three generations","volume":"243","author":"Dao","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2020.110254_bib26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cell.2012.06.013","article-title":"Cancer epigenetics: from mechanism to therapy","volume":"150","author":"Dawson","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.envres.2020.110254_bib27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2174\/187152011794941217","article-title":"Can we effectively degrade microcystins?--Implications on human health","volume":"11","author":"de la Cruz","year":"2011","journal-title":"Anti Canc. Agents Med. Chem."},{"key":"10.1016\/j.envres.2020.110254_bib28","doi-asserted-by":"crossref","first-page":"111391","DOI":"10.1016\/j.fct.2020.111391","article-title":"In vitro assessment of cyanotoxins bioaccessibility in raw and cooked mussels","volume":"140","author":"D\u00edez-Quijada Jim\u00e9nez","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib29","doi-asserted-by":"crossref","first-page":"109284","DOI":"10.1016\/j.envres.2020.109284","article-title":"A new method for the simultaneous determination of cyanotoxins (Microcystins and Cylindrospermopsin) in mussels using SPE-UPLC-MS\/MS","volume":"185","author":"D\u00edez-Quijada Jim\u00e9nez","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2020.110254_bib30","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.scitotenv.2018.06.123","article-title":"Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice","volume":"643","author":"Ding","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2020.110254_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11090530","article-title":"The diversity of cyanobacterial toxins on structural characterization, distribution and identification: A systematic review","volume":"11","author":"Du","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.envres.2020.110254_bib32","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000442870","article-title":"Association between PSA levels and biomarkers of subclinical systemic inflammation in middle-aged healthy men from the general population","volume":"9","author":"Elzanaty","year":"2016","journal-title":"Curr. Urol."},{"key":"10.1016\/j.envres.2020.110254_bib33","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1074\/jbc.M109049200","article-title":"Ca2+\/calmodulin-dependent protein kinase II is required for microcystin-induced apoptosis","volume":"277","author":"Fladmark","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envres.2020.110254_bib34","first-page":"11","volume":"18","author":"Francis","year":"1878","journal-title":"Poisonous Australian Lake Nature"},{"key":"10.1016\/j.envres.2020.110254_bib35","first-page":"710","article-title":"Comparative study of cyanotoxins affecting cytoskeletal and chromatin structures in CHO-K1 cells Toxicology in vitro","volume":"23","author":"G\u00e1csi","year":"2009","journal-title":"an international journal published in association with BIBRA"},{"key":"10.1016\/j.envres.2020.110254_bib36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1534\/genetics.105.047340","article-title":"spe-10 encodes a DHHC-CRD zinc-finger membrane protein required for endoplasmic reticulum\/Golgi membrane morphogenesis during Caenorhabditis elegans spermatogenesis","volume":"172","author":"Gleason","year":"2006","journal-title":"Genetics"},{"key":"10.1016\/j.envres.2020.110254_bib37","doi-asserted-by":"crossref","first-page":"101801","DOI":"10.1016\/j.hal.2020.101801","article-title":"Relationship between cyanobacterial bloom impacted drinking water sources and hepatocellular carcinoma incidence rates","volume":"95","author":"Gorham","year":"2020","journal-title":"Harmful Algae"},{"key":"10.1016\/j.envres.2020.110254_bib38","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/cr.2014.41","article-title":"Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis","volume":"24","author":"Gou","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.envres.2020.110254_bib39","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0300-483X(02)00469-9","article-title":"Xenoendocrine disrupters-tiered screening and testing: filling key data gaps","volume":"181\u2013182","author":"Gray","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2020.110254_bib40","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0300-483X(03)00112-4","article-title":"Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice","volume":"188","author":"Gupta","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2020.110254_bib41","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/pros.23786","article-title":"piRNA-DQ722010 contributes to prostate hyperplasia of the male offspring mice after the maternal exposed to microcystin-leucine arginine","volume":"79","author":"Han","year":"2019","journal-title":"Prostate"},{"key":"10.1016\/j.envres.2020.110254_bib42","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.molcel.2017.06.017","article-title":"The unfolded protein response and cell fate control","volume":"69","author":"Hetz","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.envres.2020.110254_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069518","article-title":"Sublethal microcystin exposure and biochemical outcomes among hemodialysis patients","volume":"8","author":"Hilborn","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.envres.2020.110254_bib45","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.envpol.2018.04.140","article-title":"Estrogenic potency of MC-LR is induced via stimulating steroidogenesis: in vitro and in vivo evidence","volume":"240","author":"Hou","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2020.110254_bib44","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.aquatox.2014.06.010","article-title":"Damage and recovery of the ovary in female zebrafish i.p.-injected with MC-LR","volume":"155","author":"Hou","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ecoenv.2017.01.025","article-title":"Microcystin-LR retards gonadal maturation through disrupting the growth hormone\/insulin-like growth factors system in zebrafish Ecotoxicol","volume":"139","author":"Hou","year":"2017","journal-title":"Environ Saf"},{"key":"10.1016\/j.envres.2020.110254_bib47","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3389\/fphys.2016.00397","article-title":"Microcystin-LR induced apoptosis in rat sertoli cells via the mitochondrial caspase-dependent pathway: role of reactive oxygen species","volume":"7","author":"Huang","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.envres.2020.110254_bib48","article-title":"The mitochondria-mediate apoptosis of Lepidopteran cells induced by azadirachtin","volume":"8","author":"Huang","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.envres.2020.110254_bib49","first-page":"1","article-title":"Monographs on the evaluation of carcinogenic risks to humans. Ingested nitrate and nitrite, and cyanobacterial peptide toxins","volume":"94","year":"2010","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.envres.2020.110254_bib50","first-page":"156","volume":"vol. 226","author":"Ibrahim","year":"2019"},{"key":"10.1016\/j.envres.2020.110254_bib52","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.tox.2019.03.010","article-title":"Down-regulation of GCLC is involved in microcystin-LR-induced malignant transformation of human liver cells","volume":"421","author":"Jia","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2020.110254_bib53","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.envpol.2018.01.057","article-title":"Effects of MCLR exposure on sex hormone synthesis and reproduction-related genes expression of testis in male Rana nigromaculata","volume":"236","author":"Jia","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2020.110254_bib51","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.aquatox.2014.06.002","article-title":"Endocrine-disrupting effects and reproductive toxicity of low dose MCLR on male frogs (Rana nigromaculata) in vivo","volume":"155","author":"Jia","year":"2014","journal-title":"Aquatic toxicology (Amsterdam, Netherlands"},{"key":"10.1016\/j.envres.2020.110254_bib54","first-page":"24","volume":"vol. 19","author":"Kawai","year":"2007"},{"key":"10.1016\/j.envres.2020.110254_bib56","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.watres.2019.06.005","article-title":"A Bayesian risk assessment framework for microcystin violations of drinking water and recreational standards in the Bay of Quinte, Lake Ontario, Canada","volume":"162","author":"Kelly","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2020.110254_bib57","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/dbio.1997.8673","article-title":"Introduction of cyclin B induces activation of the maturation-promoting factor and breakdown of germinal vesicle in growing zebrafish oocytes unresponsive to the maturation-inducing hormone","volume":"190","author":"Kondo","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.envres.2020.110254_bib58","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1152\/physiolgenomics.00106.2009","article-title":"C. elegans dysferlin homolog fer-1 is expressed in muscle, and fer-1 mutations initiate altered gene expression of muscle enriched genes","volume":"40","author":"Krajacic","year":"2009","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.envres.2020.110254_bib59","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1074\/jbc.RA119.011635","article-title":"Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization","volume":"295","author":"Kuwana","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envres.2020.110254_bib60","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.cell.2013.01.052","article-title":"H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation","volume":"152","author":"Lauberth","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.envres.2020.110254_bib61","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1210\/mend.16.2.0767","article-title":"cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes","volume":"16","author":"Lazar","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.envres.2020.110254_bib62","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev-food-030216-030116","article-title":"Cyanobacterial toxins in freshwater and food: important sources of exposure to humans","volume":"8","author":"Lee","year":"2017","journal-title":"Annual review of food science and technology"},{"key":"10.1016\/j.envres.2020.110254_bib63","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/ATVBAHA.112.300399","article-title":"Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation","volume":"33","author":"Leeper","year":"2013","journal-title":"Arteriosclerosis Thrombosis. Vascul. Biol."},{"key":"10.1016\/j.envres.2020.110254_bib64","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10238-019-00550-1","article-title":"Microcystin-LR in peripheral circulation worsens the prognosis partly through oxidative stress in patients with hepatocellular carcinoma","volume":"19","author":"Lei","year":"2019","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.envres.2020.110254_bib65","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1002\/pmic.201000442","article-title":"Protein expression profiling in the zebrafish (Danio rerio) embryos exposed to the microcystin-LR","volume":"11","author":"Li","year":"2011","journal-title":"Proteomics"},{"key":"10.1016\/j.envres.2020.110254_bib66","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.toxicon.2017.01.022","article-title":"Expression analysis of microRNAs and mRNAs in ovarian granulosa cells after microcystin-LR exposure","volume":"129","author":"Li","year":"2017","journal-title":"Toxicon : official journal of the International Society on Toxinology"},{"key":"10.1016\/j.envres.2020.110254_bib67","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.reprotox.2008.09.004","article-title":"The toxic effects of microcystin-LR on the reproductive system of male rats in vivo and in vitro","volume":"26","author":"Li","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib68","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.reprotox.2008.09.004","article-title":"The toxic effects of microcystin-LR on the reproductive system of male rats in vivo and in vitro","volume":"26","author":"Li","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib69","doi-asserted-by":"crossref","first-page":"22927","DOI":"10.3390\/ijms160922927","article-title":"Effects of microcystin-LR exposure on spermiogenesis in nematode Caenorhabditis elegans","volume":"16","author":"Li","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2020.110254_bib70","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1021\/acs.est.6b01062","article-title":"Determination of environmental exposure to microcystin and aflatoxin as a risk for renal function based on 5493 rural people in southwest China","volume":"50","author":"Lin","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2020.110254_bib71","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.chemosphere.2018.08.049","article-title":"Single and combined exposure of microcystin-LR and nitrite results in reproductive endocrine disruption via hypothalamic-pituitary-gonadal-liver axis","volume":"211","author":"Lin","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2020.110254_bib74","doi-asserted-by":"crossref","first-page":"22819","DOI":"10.1038\/srep22819","article-title":"Sex-dependent effects of microcystin-LR on hypothalamic-pituitary-gonad axis and gametogenesis of adult zebrafish","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2020.110254_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10060235","article-title":"Resveratrol ameliorates microcystin-LR-induced testis germ cell apoptosis in rats via SIRT1 signaling pathway activation","volume":"10","author":"Liu","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.envres.2020.110254_bib73","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.3389\/fphys.2018.01058","article-title":"Oxidative stress mediates microcystin-LR-induced endoplasmic reticulum stress and autophagy in KK-1 cells and C57bl\/6 mice ovaries","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.envres.2020.110254_bib75","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.aquatox.2014.07.011","article-title":"Microcystin-LR exposure to adult zebrafish (Danio rerio) leads to growth inhibition and immune dysfunction in F1 offspring, a parental transmission effect of toxicity","volume":"155","author":"Liu","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib77","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0041-0101(01)00173-8","article-title":"The toxic effects of microcystin-LR on embryo-larval and juvenile development of loach misguruns mizolepis gunthe","volume":"40","author":"Liu","year":"2002","journal-title":"Toxicon\u202f: official journal of the International Society on Toxinology"},{"key":"10.1016\/j.envres.2020.110254_bib76","doi-asserted-by":"crossref","first-page":"105261","DOI":"10.1016\/j.aquatox.2019.105261","article-title":"Microcystin-LR influences the in vitro oocyte maturation of zebrafish by activating the MAPK pathway","volume":"215","author":"Liu","year":"2019","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib78","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0014-5793(90)80245-E","article-title":"Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants","volume":"264","author":"MacKintosh","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/j.envres.2020.110254_bib79","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12040228","article-title":"Investigation of in vitro endocrine activities of microcystis and planktothrix cyanobacterial strains","volume":"12","author":"Mallia","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.envres.2020.110254_bib80","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.mehy.2008.11.041","article-title":"Microcystins from tap water could be a risk factor for liver and colorectal cancer: a risk intensified by global change","volume":"72","author":"Mart\u00ednez Hern\u00e1ndez","year":"2009","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.envres.2020.110254_bib81","doi-asserted-by":"crossref","first-page":"841","DOI":"10.2108\/zsj.17.841","article-title":"Toward modeling of a general mechanism of MPF formation during oocyte maturation in vertebrates","volume":"17","author":"Masakane","year":"2000","journal-title":"Zool. Sci."},{"key":"10.1016\/j.envres.2020.110254_bib82","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.tiv.2018.09.017","article-title":"Disruption of oocyte maturation by selected environmental chemicals in zebrafish","volume":"54","author":"Maskey","year":"2019","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.envres.2020.110254_bib83","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.envint.2007.09.008","article-title":"Vitellogenin as a biomarker of exposure to estrogenic compounds in aquatic invertebrates a review","volume":"34","author":"Matozzo","year":"2008","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2020.110254_bib84","series-title":"Community Needs Assessment After Microcystin Toxin Contamination of a Municipal Water Supply - Lucas County, Ohio, 2014","first-page":"925","volume":"vol. 65","author":"McCarty","year":"2016"},{"key":"10.1016\/j.envres.2020.110254_bib85","first-page":"229","volume":"vol. 34","author":"Mehta","year":"2015"},{"key":"10.1016\/j.envres.2020.110254_bib86","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.scitotenv.2019.02.393","article-title":"A transcriptomic regulatory network among miRNAs, piRNAs, circRNAs, lncRNAs and mRNAs regulates microcystin-leucine arginine (MC-LR)-induced male reproductive toxicity","volume":"667","author":"Meng","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2020.110254_bib87","doi-asserted-by":"crossref","DOI":"10.3390\/toxins8090260","article-title":"miR-541 contributes to microcystin-LR-induced reproductive toxicity through regulating the expression of p15 in mice","volume":"8","author":"Meng","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.envres.2020.110254_bib88","doi-asserted-by":"crossref","first-page":"139678","DOI":"10.1016\/j.scitotenv.2020.139678","article-title":"The mechanisms in the altered ontogenetic development and lung-related pathology in microcystin-leucine arginine (MC-LR)-paternal-exposed offspring mice","volume":"736","author":"Meng","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2020.110254_bib89","first-page":"227","volume":"vol. 8","author":"Mitchell","year":"2016"},{"key":"10.1016\/j.envres.2020.110254_bib90","first-page":"564","volume":"vol. 36","author":"Mruk","year":"2015"},{"key":"10.1016\/j.envres.2020.110254_bib91","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.semcancer.2017.08.009","article-title":"FoxM1: repurposing an oncogene as a biomarker","volume":"52","author":"Nandi","year":"2018","journal-title":"Semin. Canc. Biol."},{"key":"10.1016\/j.envres.2020.110254_bib92","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1289\/ehp.6591","article-title":"Endocrine-disrupting effects of cattle feedlot effluent on an aquatic sentinel species, the fathead minnow","volume":"112","author":"Orlando","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2020.110254_bib93","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.envpol.2018.08.024","article-title":"Chronic exposure to microcystin-leucine-arginine promoted proliferation of prostate epithelial cells resulting in benign prostatic hyperplasia","volume":"242","author":"Pan","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2020.110254_bib94","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s10646-012-0870-y","article-title":"Assessment of microcystin distribution and biomagnification in tissues of aquatic food web compartments from a shallow lake and evaluation of potential risks to public health","volume":"21","author":"Papadimitriou","year":"2012","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.envres.2020.110254_bib95","first-page":"154","article-title":"Cyanobacterial (blue-green algae) contamination in drinking water and perinatal outcomes Australian and New Zealand","volume":"23","author":"Pilotto","year":"1999","journal-title":"J. Publ. Health"},{"key":"10.1016\/j.envres.2020.110254_bib96","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.chemosphere.2016.05.038","article-title":"Microcystin-LR induced developmental toxicity and apoptosis in zebrafish (Danio rerio) larvae by activation of ER stress response","volume":"157","author":"Qi","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2020.110254_bib97","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ecoenv.2017.12.059","article-title":"Developmental neurotoxicity of Microcystis aeruginosa in the early life stages of zebrafish","volume":"151","author":"Qian","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2020.110254_bib98","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.toxicon.2018.12.006","article-title":"Subcellular localization of microcystin in the liver and the gonads of medaka fish acutely exposed to microcystin-LR","volume":"159","author":"Qiao","year":"2019","journal-title":"Toxicon : official journal of the International Society on Toxinology"},{"key":"10.1016\/j.envres.2020.110254_bib99","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.aquatox.2013.07.002","article-title":"Female zebrafish (Danio rerio) are more vulnerable than males to microcystin-LR exposure, without exhibiting estrogenic effects","volume":"142\u2013143","author":"Qiao","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib100","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.mito.2010.05.015","article-title":"Mitochondria, spermatogenesis and male infertility","volume":"10","author":"Rajender","year":"2010","journal-title":"Mitochondrion"},{"key":"10.1016\/j.envres.2020.110254_bib101","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1021\/es103538b","article-title":"Global gene expression profiling in larval zebrafish exposed to microcystin-LR and microcystis reveals endocrine disrupting effects of Cyanobacteria","volume":"45","author":"Rogers","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2020.110254_bib102","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000874","article-title":"Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: a role for MMP-8","volume":"6","author":"Schubert-Unkmeir","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.envres.2020.110254_bib103","first-page":"342","article-title":"Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis","volume":"15","author":"Simpson","year":"1994","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.envres.2020.110254_bib104","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.toxicon.2017.05.017","article-title":"Vertical transmission of microcystins to Nile crocodile (Crocodylus niloticus) eggs","volume":"134","author":"Singo","year":"2017","journal-title":"Toxicon : official journal of the International Society on Toxinology"},{"key":"10.1016\/j.envres.2020.110254_bib105","doi-asserted-by":"crossref","first-page":"109549","DOI":"10.1016\/j.envres.2020.109549","article-title":"The behaviors of Microcystis aeruginosa and microcystins during the Fe(2+)\/persulfate (PS) preoxidation-coagulation and flocs storage period","volume":"186","author":"Song","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2020.110254_bib106","series-title":"Appendix 3: Tables of Microcystins and Nodularins","author":"Spoof","year":"2017"},{"key":"10.1016\/j.envres.2020.110254_bib107","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.aquatox.2016.03.018","article-title":"Life-cycle exposure to microcystin-LR interferes with the reproductive endocrine system of male","volume":"175","author":"Su","year":"2016","journal-title":"zebrafish Aquat Toxicol"},{"key":"10.1016\/j.envres.2020.110254_bib108","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00204-016-1921-6","article-title":"Toxicology of microcystins with reference to cases of human intoxications and epidemiological investigations of exposures to cyanobacteria and cyanotoxins","volume":"91","author":"Svir\u010dev","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib109","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1007\/s00204-019-02524-4","article-title":"Global geographical and historical overview of cyanotoxin distribution and cyanobacterial poisonings","volume":"93","author":"Svir\u010dev","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib110","first-page":"47","article-title":"Vitellogenesis: a versatile model for hormonal regulation of gene expression","volume":"35","author":"Tata","year":"1979","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/j.envres.2020.110254_bib111","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/jez.1090","article-title":"Developmental expression of cytochrome P450 aromatase genes (CYP19a and CYP19b) in zebrafish fry (Danio rerio)","volume":"290","author":"Trant","year":"2001","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.envres.2020.110254_bib112","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/carcin\/17.6.1317","article-title":"Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay","volume":"17","author":"Ueno","year":"1996","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.envres.2020.110254_bib113","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20236004","article-title":"The interplay between Ca(2+) signaling pathways and neurodegeneration","volume":"20","author":"Ureshino","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2020.110254_bib115","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/tox.21958","article-title":"The role of Pten\/Akt signaling pathway involved in BPA-induced apoptosis of rat Sertoli cells","volume":"30","author":"Wang","year":"2015","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib116","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ecoenv.2018.07.094","article-title":"Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus","volume":"163","author":"Wang","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2020.110254_bib117","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s10646-013-1141-2","article-title":"Distribution of microcystin-LR to testis of male","volume":"22","author":"Wang","year":"2013","journal-title":"Sprague-Dawley rats Ecotoxicology (London, England)"},{"key":"10.1016\/j.envres.2020.110254_bib118","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.toxicon.2004.10.016","article-title":"Inhibition of embryonic development by microcystin-LR in zebrafish, Danio rerio","volume":"45","author":"Wang","year":"2005","journal-title":"Toxicon : official journal of the International Society on Toxinology"},{"key":"10.1016\/j.envres.2020.110254_bib119","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.toxicon.2016.10.011","article-title":"Microcystin-LR causes sexual hormone disturbance in male rat by targeting gonadotropin-releasing hormone neurons","volume":"123","author":"Wang","year":"2016","journal-title":"Toxicon : official journal of the International Society on Toxinology"},{"key":"10.1016\/j.envres.2020.110254_bib120","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.toxicon.2011.12.001","article-title":"Microcystin (-LR) affects hormones level of male mice by damaging hypothalamic-pituitary system","volume":"59","author":"Wang","year":"2012","journal-title":"Toxicon : official journal of the International Society on Toxinology"},{"key":"10.1016\/j.envres.2020.110254_bib114","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1242\/dev.122.3.815","article-title":"Mos is required for MAP kinase activation and is involved in microtubule organization during meiotic maturation in the mouse","volume":"122","author":"Verlhac","year":"1996","journal-title":"Development (Cambridge, England"},{"key":"10.1016\/j.envres.2020.110254_bib121","doi-asserted-by":"crossref","first-page":"125073","DOI":"10.1016\/j.chemosphere.2019.125073","article-title":"Histone acetylation plays an important role in MC-LR-induced apoptosis and cycle disorder in SD rat testicular cells","volume":"241","author":"Wang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2020.110254_bib122","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.reprotox.2020.01.009","article-title":"A closed vitrification system enables a murine ovarian follicle bank for high-throughput ovotoxicity screening, which identifies endocrine disrupting activity of microcystins","volume":"93","author":"Wang","year":"2020","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib123","first-page":"125","volume":"vol. 80","author":"Weidberg","year":"2011"},{"key":"10.1016\/j.envres.2020.110254_bib124","series-title":"Guidelines for Drinking-Water Quality","author":"World Health Organization","year":"2011"},{"key":"10.1016\/j.envres.2020.110254_bib125","first-page":"546","volume":"vol. 9","author":"Wu","year":"2018"},{"key":"10.1016\/j.envres.2020.110254_bib126","doi-asserted-by":"crossref","DOI":"10.1002\/tox.22808","article-title":"p53-Dependent pathway and the opening of mPTP mediate the apoptosis of co-cultured Sertoli-germ cells induced by microcystin-LR","author":"Wu","year":"2019","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib127","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/tox.22808","article-title":"p53-Dependent pathway and the opening of mPTP mediate the apoptosis of co-cultured Sertoli-germ cells induced by microcystin-LR","volume":"34","author":"Wu","year":"2019","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib128","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.3390\/toxins7124872","article-title":"MC-LR exposure leads to subfertility of female mice and induces oxidative stress in granulosa cells","volume":"7","author":"Wu","year":"2015","journal-title":"Toxins"},{"key":"10.1016\/j.envres.2020.110254_bib129","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.envpol.2017.08.038","article-title":"Parental transfer of microcystin-LR induced transgenerational effects of developmental neurotoxicity in zebrafish offspring","volume":"231","author":"Wu","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2020.110254_bib130","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.envpol.2016.03.048","article-title":"Microcystin-LR exposure induces developmental neurotoxicity in zebrafish embryo","volume":"213","author":"Wu","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2020.110254_bib131","first-page":"4911","article-title":"N-acetylcysteine protects Chinese Hamster ovary cells from oxidative injury and apoptosis induced by microcystin-LR","volume":"8","author":"Xue","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.envres.2020.110254_bib132","doi-asserted-by":"crossref","first-page":"115638","DOI":"10.1016\/j.watres.2020.115638","article-title":"A complete route for biodegradation of potentially carcinogenic cyanotoxin microcystin-LR in a novel indigenous bacterium","volume":"174","author":"Yang","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2020.110254_bib133","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/15287394.2017.1415580","article-title":"MicroRNA expression profiling involved in MC-LR-induced hepatotoxicity using high-throughput sequencing analysis","volume":"81","author":"Yang","year":"2018","journal-title":"J. Toxicol. Environ. Health Part A"},{"key":"10.1016\/j.envres.2020.110254_bib134","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4161\/cc.9.3.10508","article-title":"Regulation of Akt signaling activation by ubiquitination","volume":"9","author":"Yang","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.envres.2020.110254_bib135","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16245030","article-title":"Effects of chronic exposure to microcystin-LR on kidney in mice","volume":"16","author":"Yi","year":"2019","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envres.2020.110254_bib136","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbrc.2005.11.147","article-title":"Ras regulates neuronal polarity via the PI3-kinase\/Akt\/GSK-3beta\/CRMP-2 pathway","volume":"340","author":"Yoshimura","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envres.2020.110254_bib137","article-title":"Epigenetic modification of H3K4 and oxidative stress are involved in MC-LR-induced apoptosis in testicular cells of SD rats","author":"Yuan","year":"2019","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib138","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.aquatox.2014.01.021","article-title":"The role of apoptosis in MCLR-induced developmental toxicity in zebrafish embryos","volume":"149","author":"Zeng","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib139","doi-asserted-by":"crossref","first-page":"121939","DOI":"10.1016\/j.jhazmat.2019.121939","article-title":"Microcystin-LR triggers different endoplasmic reticulum stress pathways in the liver, ovary, and offspring of zebrafish (Danio rerio)","volume":"386","author":"Zhan","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envres.2020.110254_bib140","doi-asserted-by":"crossref","first-page":"113843","DOI":"10.1016\/j.envpol.2019.113843","article-title":"Microcystin-LR promotes zebrafish (Danio rerio) oocyte (in vivo) maturation by activating ERK1\/2-MPF signaling pathways, and cAMP is involved in this process","volume":"259","author":"Zhan","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2020.110254_bib141","volume":"vol. 12","author":"Zhang","year":"2020"},{"key":"10.1016\/j.envres.2020.110254_bib142","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1897\/06-222R.1","article-title":"Bioaccumulation of the hepatotoxic microcystins in various organs of a freshwater snail from a subtropical Chinese lake, Taihu Lake, with dense toxic Microcystis blooms","volume":"26","author":"Zhang","year":"2007","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envres.2020.110254_bib144","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tox.2017.02.004","article-title":"Toxic effects of microcystin-LR on the development of prostate in mice","volume":"380","author":"Zhang","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2020.110254_bib145","article-title":"MycN is critical for the maintenance of human embryonic stem cell-derived neural crest stem cells","volume":"11","author":"Zhang","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.envres.2020.110254_bib146","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/toxsci\/kfx209","article-title":"From the cover: roles of mmu_piR_003399 in microcystin-leucine arginine-induced reproductive toxicity in the spermatogonial cells and testis toxicological sciences","volume":"161","author":"Zhang","year":"2018","journal-title":"an official journal of the Society of Toxicology"},{"key":"10.1016\/j.envres.2020.110254_bib143","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.aquatox.2012.09.017","article-title":"Toxic effects of microcystin-LR on the reproductive system of male Rana nigromaculata in vitro","volume":"126","author":"Zhang","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envres.2020.110254_bib147","first-page":"527","volume":"vol. 7","author":"Zhang","year":"2016"},{"key":"10.1016\/j.envres.2020.110254_bib148","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.chemosphere.2019.01.146","article-title":"Microcystin-LR disturbs testicular development of giant freshwater prawn Macrobrachium","volume":"222","author":"Zhang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2020.110254_bib149","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.chemosphere.2019.01.146","article-title":"Microcystin-LR disturbs testicular development of giant freshwater prawn Macrobrachium rosenbergii","volume":"222","author":"Zhang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2020.110254_bib150","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.scitotenv.2019.05.144","article-title":"Epigenetic silencing of ALX4 regulates microcystin-LR induced hepatocellular carcinoma through the P53 pathway","volume":"683","author":"Zhao","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2020.110254_bib151","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.scitotenv.2019.05.144","article-title":"Epigenetic silencing of ALX4 regulates microcystin-LR induced hepatocellular carcinoma through the P53 pathway","volume":"683","author":"Zhao","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2020.110254_bib152","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.chemosphere.2018.04.020","article-title":"N-acetylcysteine protects against microcystin-LR-induced endoplasmic reticulum stress and germ cell apoptosis in zebrafish testes","volume":"204","author":"Zhao","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2020.110254_bib153","doi-asserted-by":"crossref","first-page":"113362","DOI":"10.1016\/j.envpol.2019.113362","article-title":"Microcystin-LR exposure decreased the fetal weight of mice by disturbance of placental development and ROS-mediated endoplasmic reticulum stress in the placenta","volume":"256","author":"Zhao","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2020.110254_bib154","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.chemosphere.2014.06.028","article-title":"Microcystin-LR impairs zebrafish reproduction by affecting oogenesis and endocrine system","volume":"120","author":"Zhao","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2020.110254_bib155","doi-asserted-by":"crossref","first-page":"113890","DOI":"10.1016\/j.envpol.2019.113890","article-title":"Daphnia enhances relative reproductive allocation in response to toxic microcystis: changes in the performance of parthenogenetic and sexual reproduction","volume":"259","author":"Zhou","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2020.110254_bib156","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.envpol.2019.04.114","article-title":"Icariin attenuate microcystin-LR-induced gap junction injury in Sertoli cells through suppression of Akt pathways","volume":"251","author":"Zhou","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2020.110254_bib157","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.envpol.2019.04.114","article-title":"Icariin attenuate microcystin-LR-induced gap junction injury in Sertoli cells through suppression of Akt pathways","volume":"251","author":"Zhou","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2020.110254_bib158","first-page":"290","article-title":"Essential roles of Akt\/Snail pathway in microcystin-LR-induced tight junction toxicity in Sertoli cell Food and chemical toxicology","volume":"112","author":"Zhou","year":"2018","journal-title":"an international journal published for the British Industrial Biological Research Association"},{"key":"10.1016\/j.envres.2020.110254_bib159","doi-asserted-by":"crossref","first-page":"109824","DOI":"10.1016\/j.ecoenv.2019.109824","article-title":"Responses of the proteome in testis of mice exposed chronically to environmentally relevant concentrations of Microcystin-LR","volume":"187","author":"Zhou","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2020.110254_bib160","doi-asserted-by":"crossref","first-page":"6383","DOI":"10.1021\/es500152m","article-title":"Regulation of microcystin-LR-induced toxicity in mouse spermatogonia by miR-96","volume":"48","author":"Zhou","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2020.110254_bib161","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.toxlet.2012.05.001","article-title":"The toxic effects of microcystin-LR on rat spermatogonia in vitro","volume":"212","author":"Zhou","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envres.2020.110254_bib162","first-page":"265","volume":"vol. 65","author":"Zhu","year":"2019"}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935120311518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935120311518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T16:54:09Z","timestamp":1779468849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935120311518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":161,"alternative-id":["S0013935120311518"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2020.110254","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The latest advances in the reproductive toxicity of microcystin-LR","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2020.110254","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110254"}}