{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:50:23Z","timestamp":1791996623015,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.envres.2021.111865","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T13:43:16Z","timestamp":1628689396000},"page":"111865","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Mortality in the cohort of talc miners and millers from Val Chisone, Northern Italy: 74 years of follow-up"],"prefix":"10.1016","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2740-5767","authenticated-orcid":false,"given":"Catalina","family":"Ciocan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Pira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Coggiola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Godono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"La Vecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Negri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-2791","authenticated-orcid":false,"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2021.111865_bib1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1470-2045(06)70577-0","article-title":"Alcohol and cancer","volume":"7","author":"Boffetta","year":"2006","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.envres.2021.111865_bib2","series-title":"Statistical Methods in Cancer Research. Volume II\u2014The Design and Analysis of Cohort Studies","author":"Breslow","year":"1987"},{"key":"10.1016\/j.envres.2021.111865_bib3","first-page":"1270608","article-title":"Occupational exposure to talc increases the risk of lung cancer: a meta-analysis of occupational cohort studies","author":"Chang","year":"2017","journal-title":"Canc. Res. J."},{"issue":"4","key":"10.1016\/j.envres.2021.111865_bib4","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jfma.2018.07.015","article-title":"Talc exposure and risk of stomach cancer: systematic review and meta-analysis of occupational cohort studies","volume":"119","author":"Chang","year":"2020","journal-title":"J. Formos. Med. Assoc."},{"key":"10.1016\/j.envres.2021.111865_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/ajim.10240","article-title":"An update of a mortality study of talc miners and millers in Italy","volume":"44","author":"Coggiola","year":"2003","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.envres.2021.111865_bib6","first-page":"20","article-title":"Decreto Ministeriale del 06\/09\/1994. Normative e metodologie tecniche di applicazione dell'art. 6, comma 3, e dell'art. 12, comma 2, della legge 27 marzo 1992, n. 257, relativa alla cessazione dell'impiego dell'amianto","volume":"220","year":"1994","journal-title":"Gazz. Uff. Suppl. Ordin. n."},{"key":"10.1016\/j.envres.2021.111865_bib7","first-page":"321","article-title":"Meta-analyses of published epidemiological studies, 1979-2006, point to open causal questions in silica-silicosis-lung cancer research","volume":"102","author":"Erren","year":"2011","journal-title":"Med. Lav."},{"key":"10.1016\/j.envres.2021.111865_bib8","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1097\/JOM.0000000000001139","article-title":"Re: mortality of talc miners and millers from val Chisone, northern Italy","volume":"59","author":"Finkelstein","year":"2017","journal-title":"J. Occup. Environ. Med."},{"issue":"6","key":"10.1016\/j.envres.2021.111865_bib9","doi-asserted-by":"crossref","first-page":"659","DOI":"10.5858\/arpa.2018-0145-LE","article-title":"Malignant mesothelioma and its nonasbestos causes","volume":"143","author":"Finkelstein","year":"2019","journal-title":"Arch. Pathol. Lab Med."},{"key":"10.1016\/j.envres.2021.111865_bib10","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.5858\/arpa.2019-0388-LE","article-title":"Malignant mesothelioma and its nonasbestos causes: talcum powder does not create occult asbestos exposure","volume":"143","author":"Geyer","year":"2019","journal-title":"Arch. Pathol. Lab Med."},{"key":"10.1016\/j.envres.2021.111865_bib11","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1179\/2049396714Y.0000000081","article-title":"Asbestos in commercial cosmetic talcum powder as a cause of mesothelioma in women","volume":"20","author":"Gordon","year":"2014","journal-title":"Int. J. Occup. Environ. Health"},{"key":"10.1016\/j.envres.2021.111865_bib12","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/ajim.4700240408","article-title":"Correlation between radiological and pathological diagnosis of silicosis: an autopsy population based study","volume":"24","author":"Hnizdo","year":"1993","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.envres.2021.111865_bib13","series-title":"Silica, Some Silicates, Coal, Dust and Para Aramid Fibrils. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","first-page":"42","article-title":"Silica","volume":"vol. 68","year":"1997"},{"key":"10.1016\/j.envres.2021.111865_bib14","series-title":"Carbon Black, Titanium Dioxide and Talc. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","first-page":"277","article-title":"Talc","volume":"vol. 93","year":"2010"},{"key":"10.1016\/j.envres.2021.111865_bib15","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2486\/indhealth.42.303","article-title":"Silicosis and smoking strongly increase lung cancer risk in silica-exposed workers","volume":"42","author":"Kurihara","year":"2004","journal-title":"Ind. Health"},{"key":"10.1016\/j.envres.2021.111865_bib16","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/S0140-6736(12)60235-9","volume":"379","author":"Leung","year":"2012","journal-title":"Silicosis. Lancet"},{"key":"10.1016\/j.envres.2021.111865_bib17","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1097\/JOM.0b013e318297327a","article-title":"Threshold value estimation for respirable quartz dust exposure and silicosis incidence among workers in the German porcelain industry","volume":"55","author":"Morfeld","year":"2013","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.envres.2021.111865_bib18","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/030089169608200403","article-title":"Smoking in Italy, 1994","volume":"82","author":"Pagano","year":"1996","journal-title":"Tumori"},{"key":"10.1016\/j.envres.2021.111865_bib19","series-title":"Occupational Lung Disorders","author":"Parkes","year":"1994"},{"key":"10.1016\/j.envres.2021.111865_bib20","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/annonc\/mdj125","article-title":"Occupational silica exposure and lung cancer risk: a review of epidemiological studies 1996-2005","volume":"17","author":"Pelucchi","year":"2006","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.envres.2021.111865_bib21","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/JOM.0000000000000992","article-title":"Mortality of talc miners and millers from val Chisone, northern Italy: an updated cohort study","volume":"59","author":"Pira","year":"2017","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.envres.2021.111865_bib22","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.1097\/JOM.0000000000001138","article-title":"Response to letter to the editor on the mortality of talc miners and millers from val Chisone, northern Italy","volume":"59","author":"Pira","year":"2017","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.envres.2021.111865_bib23","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1186\/s12889-016-3791-5","article-title":"Occupational exposure to silica dust and risk of lung cancer: an updated meta-analysis of epidemiological studies","volume":"16","author":"Poinen-Rughooputh","year":"2016","journal-title":"BMC Publ. Health"},{"key":"10.1016\/j.envres.2021.111865_bib24","first-page":"390","article-title":"Asbestos fibre in the lung and mesothelioma. A re-examination of the Malm\u00f6 material","volume":"81","author":"Pooley","year":"1973","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"10.1016\/j.envres.2021.111865_bib25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00043764-197603000-00013","article-title":"Mortality study of talc miners and millers","volume":"18","author":"Rubino","year":"1976","journal-title":"J. Occup. Med."},{"key":"10.1016\/j.envres.2021.111865_bib26","series-title":"Dust and Disease: Proceedings of the Conference on Occupational Exposures to Fibrous and Particulate Dust and Their Extension into the Environment. 1977","first-page":"357","article-title":"Mortality and morbidity among talc miners and millers in Italy","author":"Rubino","year":"1979"},{"key":"10.1016\/j.envres.2021.111865_bib27","series-title":"Recommendation from the Scientific Committee on Occupational Exposure Limits for Silica, Crystalline (Respirable Dust)","year":"2003"},{"key":"10.1016\/j.envres.2021.111865_bib28","series-title":"Dust and Disease: Proceedings of the Conference on Occupational Exposures to Fibrous and Particulate Dust and Their Extension into the Environment. 1977","first-page":"378","article-title":"Mortality patterns among miners and millers of non-asbestiform talc: preliminary report","author":"Selevan","year":"1979"},{"key":"10.1016\/j.envres.2021.111865_bib29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/oxfordjournals.aje.a114510","article-title":"Mortality from lung cancer and respiratory disease among pottery workers exposed to silica and talc","volume":"125","author":"Thomas","year":"1987","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envres.2021.111865_bib30","first-page":"725","article-title":"[Talc varieties in the main Mediterranean deposits (France, Italy and Spain), and contaminating minerals]","volume":"6","author":"Verdel","year":"1983","journal-title":"Riv Inf Mal Prof"},{"key":"10.1016\/j.envres.2021.111865_bib31","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/ajim.4700170408","article-title":"Morbidity and mortality in talc-exposed workers","volume":"17","author":"Wergeland","year":"1990","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.envres.2021.111865_bib32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1136\/oem.2005.020750","article-title":"Lung cancer risk and talc not containing asbestiform fibres: a review of the epidemiological evidence","volume":"63","author":"Wild","year":"2006","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.envres.2021.111865_bib33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1136\/oem.59.2.98","article-title":"A cohort mortality and nested case-control study of French and Austrian talc workers","volume":"59","author":"Wild","year":"2002","journal-title":"Occup. Environ. Med."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935121011592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935121011592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:22:47Z","timestamp":1791994967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935121011592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":33,"alternative-id":["S0013935121011592"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2021.111865","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mortality in the cohort of talc miners and millers from Val Chisone, Northern Italy: 74 years of follow-up","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2021.111865","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111865"}}