{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:58:00Z","timestamp":1785391080304,"version":"3.55.0"},"reference-count":103,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010769","name":"Axencia Galega de Innovaci\u00f3n","doi-asserted-by":"publisher","award":["IN607B 2020\/08"],"award-info":[{"award-number":["IN607B 2020\/08"]}],"id":[{"id":"10.13039\/501100010769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001129","name":"Australasian Centre for Italian Studies","doi-asserted-by":"publisher","award":["PRIS-3"],"award-info":[{"award-number":["PRIS-3"]}],"id":[{"id":"10.13039\/501100001129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.envres.2022.112890","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T03:24:27Z","timestamp":1645500267000},"page":"112890","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["A multi-tissue study of immune gene expression profiling highlights the key role of the nasal epithelium in COVID-19 severity"],"prefix":"10.1016","volume":"210","author":[{"given":"Alberto","family":"G\u00f3mez-Carballa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Rivero-Calle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobo","family":"Pardo-Seco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"G\u00f3mez-Rial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Rivero-Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Rodr\u00edguez-N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Barbeito-Casti\u00f1eiras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"P\u00e9rez-Freixo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Cebey-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Barral-Arca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Rodriguez-Tenreiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Dacosta-Urbieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xabier","family":"Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Pischedda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Curr\u00e1s-Tuala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Viz-Lasheras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Martin\u00f3n-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2336-702X","authenticated-orcid":false,"given":"Antonio","family":"Salas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aguilera Guirao","family":"Antonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvarez","family":"Escudero Juli\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antela L\u00f3pez","family":"Antonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbeito Casti\u00f1eiras","family":"Gema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bello Paderne","family":"Xabier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben Garc\u00eda","family":"Miriam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carral Garc\u00eda","family":"Mar\u00eda Victoria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cebey L\u00f3pez","family":"Miriam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coira Nieto","family":"Amparo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conde P\u00e1jaro","family":"M\u00f3nica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costa Alcalde","family":"Jos\u00e9 Javier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curr\u00e1s Tuala","family":"Mar\u00eda Jos\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dacosta Urbieta","family":"Ana Isabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00edaz Esteban","family":"Blanca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dom\u00ednguez Santalla","family":"Mar\u00eda Jes\u00fas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fern\u00e1ndez P\u00e9rez","family":"Cristina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fern\u00e1ndez Villaverde","family":"Juan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galb\u00e1n Rodr\u00edguez","family":"Crist\u00f3bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garc\u00eda Allut","family":"Jos\u00e9 Luis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garc\u00eda Vicente","family":"Luisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gir\u00e1ldez V\u00e1zquez","family":"Elena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f3mez Carballa","family":"Alberto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f3mez Rial","family":"Jos\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonz\u00e1lez Barcala","family":"Francisco Javier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guerra Li\u00f1ares","family":"Beatriz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lebor\u00e1ns Iglesias","family":"Pilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lence Massa","family":"Beatriz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00f3pez Franco","family":"Montserrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00f3pez Lago","family":"Ana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin\u00f3n-Torres","family":"Federico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Salas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navarro","family":"De la Cruz Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00fa\u00f1ez Masid","family":"Elo\u00edna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ortol\u00e1 Devesa","family":"Juan Bautista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardo Seco","family":"Jacobo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pazo N\u00fa\u00f1ez","family":"Mar\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9rez del Molino Bernal","family":"Marisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9rez Freixo","family":"Hugo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi\u00f1eiro Rodr\u00edguez","family":"Lidia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pischedda","family":"Sara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Portela Romero","family":"Manuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pose Reino","family":"Antonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prada Hervella","family":"Gloria Mar\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Queiro Verdes","family":"Teresa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Redondo Collazo","family":"Lorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regueiro Casuso","family":"Patricia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rey Garc\u00eda","family":"Susana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rey V\u00e1zquez","family":"Sara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riveiro Blanco","family":"Vanessa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rivero Calle","family":"Irene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rivero Velasco","family":"Carmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodr\u00edguez N\u00fa\u00f1ez","family":"Nuria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodr\u00edguez-Tenreiro","family":"S\u00e1nchez Carmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saborido Paz","family":"Eva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadiki Orayyou","family":"Jos\u00e9 Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saito Villanueva","family":"Carla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ser\u00e9n Fern\u00e1ndez","family":"Sonia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souto Sanmart\u00edn","family":"Pablo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taboada Mu\u00f1iz","family":"Manuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trastoy Pena","family":"Roc\u00edo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevi\u00f1o Castellano","family":"Mercedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vald\u00e9s Cuadrado","family":"Luis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varela Garc\u00eda","family":"Pablo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilas Iglesias","family":"Mar\u00eda Soledad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viz Lasheras","family":"Sandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferreiro-Iglesias","family":"Rocio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Bast\u00f3n-Rey iria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvi\u00f1o-Su\u00e1rez","family":"Cristina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2022.112890_bib1","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00130-21","article-title":"Human nasal and lung tissues infected ex vivo with SARS-CoV-2 provide insights into differential tissue-specific and virus-specific innate immune responses in the upper and lower respiratory tract","author":"Alfi","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.envres.2022.112890_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000897","article-title":"Superspreading events in the transmission dynamics of SARS-CoV-2: opportunities for interventions and control","volume":"18","author":"Althouse","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.envres.2022.112890_bib3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13073-020-00823-5","article-title":"Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients","volume":"13","author":"Aschenbrenner","year":"2021","journal-title":"Genome Med."},{"key":"10.1016\/j.envres.2022.112890_bib4","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1261\/rna.070052.118","article-title":"Ancestry patterns inferred from massive RNA-seq data","volume":"25","author":"Barral-Arca","year":"2019","journal-title":"RNA"},{"key":"10.1016\/j.envres.2022.112890_bib5","doi-asserted-by":"crossref","first-page":"8043","DOI":"10.1038\/s41598-018-26239-1","article-title":"A 2-transcript host cell signature distinguishes viral from bacterial diarrhea and it is influenced by the severity of symptoms","volume":"8","author":"Barral-Arca","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2022.112890_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003229","article-title":"Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis","volume":"9","author":"Berri","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.envres.2022.112890_bib7","article-title":"An approach for normalization and quality control for NanoString RNA expression data","author":"Bhattacharya","year":"2020","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.envres.2022.112890_bib8","series-title":"EnhancedVolcano: publication-ready volcano plots with enhanced colouring and labeling","author":"Blighe","year":"2020"},{"key":"10.1016\/j.envres.2022.112890_bib9","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106267","article-title":"Syncytia formation by SARS-CoV-2-infected cells","volume":"39","author":"Buchrieser","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.envres.2022.112890_bib10","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.12688\/f1000research.25979.2","article-title":"Immunopathology of galectin-3: an increasingly promising target in COVID-19","volume":"9","author":"Caniglia","year":"2020","journal-title":"F1000Res"},{"key":"10.1016\/j.envres.2022.112890_bib11","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1093\/bioinformatics\/btq431","article-title":"A framework for oligonucleotide microarray preprocessing","volume":"26","author":"Carvalho","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envres.2022.112890_bib13","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.ajpath.2017.12.014","article-title":"Galectin-3 enhances avian H5N1 influenza A virus-induced pulmonary inflammation by promoting NLRP3 inflammasome activation","volume":"188","author":"Chen","year":"2018","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.envres.2022.112890_bib14","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/s41587-020-0602-4","article-title":"COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis","volume":"38","author":"Chua","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.envres.2022.112890_bib15","doi-asserted-by":"crossref","first-page":"648004","DOI":"10.3389\/fimmu.2021.648004","article-title":"Blood interferon-\u03b1 levels and severity, outcomes, and inflammatory profiles in hospitalized COVID-19 patients","volume":"12","author":"Contoli","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envres.2022.112890_bib16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nri3806","article-title":"Regulation of antiviral T cell responses by type I interferons","volume":"15","author":"Crouse","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.envres.2022.112890_bib17","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.drudis.2020.06.013","article-title":"COVID-19 and pneumonia: a role for the uPA\/uPAR system","volume":"25","author":"D'Alonzo","year":"2020","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.envres.2022.112890_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/science.abg3055","article-title":"Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England","volume":"372","author":"Davies","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.envres.2022.112890_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192082","article-title":"Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling","volume":"13","author":"DeBerg","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2022.112890_bib20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jmii.2020.04.015","article-title":"ACE2 receptor polymorphism: susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome","volume":"53","author":"Devaux","year":"2020","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.envres.2022.112890_bib21","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/bioinformatics\/btn224","article-title":"lumi: a pipeline for processing Illumina microarray","volume":"24","author":"Du","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envres.2022.112890_bib22","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1128\/iai.40.1.351-358.1983","article-title":"Enhancement of respiratory syncytial virus-induced cytopathology by trypsin, thrombin, and plasmin","volume":"40","author":"Dubovi","year":"1983","journal-title":"Infect. Immun."},{"key":"10.1016\/j.envres.2022.112890_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006546","article-title":"The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases","volume":"13","author":"Earnest","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.envres.2022.112890_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009130","article-title":"Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles","volume":"16","author":"Gamage","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.envres.2022.112890_bib25","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.3389\/fimmu.2020.02069","article-title":"Hyperinflammation and fibrosis in severe COVID-19 patients: galectin-3, a target molecule to consider","volume":"11","author":"Garcia-Revilla","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envres.2022.112890_bib26","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.2147\/IDR.S258639","article-title":"Role of monocytes\/macrophages in covid-19 pathogenesis: implications for therapy","volume":"13","author":"Gomez-Rial","year":"2020","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.envres.2022.112890_bib27","doi-asserted-by":"crossref","first-page":"9297","DOI":"10.1128\/JVI.75.19.9297-9301.2001","article-title":"Plasminogen-binding activity of neuraminidase determines the pathogenicity of influenza A virus","volume":"75","author":"Goto","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.envres.2022.112890_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00271-13","article-title":"Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury","volume":"4","author":"Gralinski","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.envres.2022.112890_bib29","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envres.2022.112890_bib30","doi-asserted-by":"crossref","first-page":"605","DOI":"10.24272\/j.issn.2095-8137.2020.217","article-title":"Phylogeography of SARS-CoV-2 pandemic in Spain: a story of multiple introductions, micro-geographic stratification, founder effects, and super-spreaders","volume":"41","author":"G\u00f3mez-Carballa","year":"2020","journal-title":"Zool. Res."},{"key":"10.1016\/j.envres.2022.112890_bib31","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1101\/gr.266221.120","article-title":"Mapping genome variation of SARS-CoV-2 worldwide highlights the impact of COVID-19 super-spreaders","volume":"30","author":"G\u00f3mez-Carballa","year":"2020","journal-title":"Genome Res."},{"key":"10.1016\/j.envres.2022.112890_bib32","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.tig.2021.09.003","article-title":"Superspreading in the emergence of COVID-19 variants","volume":"37","author":"G\u00f3mez-Carballa","year":"2021","journal-title":"Trends Genet."},{"key":"10.1016\/j.envres.2022.112890_bib33","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.3389\/fimmu.2020.560381","article-title":"Increased serum levels of sCD14 and sCD163 indicate a preponderant role for monocytes in COVID-19 immunopathology","volume":"11","author":"G\u00f3mez-Rial","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envres.2022.112890_bib34","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.abc6027","article-title":"Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients","volume":"369","author":"Hadjadj","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.envres.2022.112890_bib35","doi-asserted-by":"crossref","first-page":"104422","DOI":"10.1016\/j.meegid.2020.104422","article-title":"The role of extracellular vesicles in COVID-19 virus infection","volume":"85","author":"Hassanpour","year":"2020","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.envres.2022.112890_bib37","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1093\/infdis\/jit348","article-title":"Transcriptomic profiling in childhood H1N1\/09 influenza reveals reduced expression of protein synthesis genes","volume":"208","author":"Herberg","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.envres.2022.112890_bib38","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1001\/jama.2016.11236","article-title":"Diagnostic test accuracy of a 2-transcript host RNA signature for discriminating bacterial vs viral infection in febrile children","volume":"316","author":"Herberg","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.envres.2022.112890_bib39","series-title":"Fibrinolysis Influences SARS-CoV-2 Infection in Ciliated Cells","author":"Hou","year":"2021"},{"key":"10.1016\/j.envres.2022.112890_bib40","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.envres.2022.112890_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-021-01296-8","article-title":"SARS-CoV-2 infection of the oral cavity and saliva","author":"Huang","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.envres.2022.112890_bib42","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.3389\/fimmu.2020.01426","article-title":"Profiling the course of resolving vs. Persistent inflammation in human monocytes: the role of IL-1 family molecules","volume":"11","author":"Italiani","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envres.2022.112890_bib43","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.csbj.2020.12.016","article-title":"Host transcriptomic profiling of COVID-19 patients with mild, moderate, and severe clinical outcomes","volume":"19","author":"Jain","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.envres.2022.112890_bib44","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1152\/physrev.00013.2020","article-title":"Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility","volume":"100","author":"Ji","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.envres.2022.112890_bib45","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1136\/gutjnl-2020-320926","article-title":"Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms","volume":"69","author":"Jin","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.envres.2022.112890_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007870","article-title":"Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro","volume":"4","author":"Kam","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2022.112890_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031283","article-title":"The central role of fibrinolytic response in COVID-19-A hematologist's perspective","volume":"22","author":"Kwaan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2022.112890_bib48","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.abc1669","article-title":"SARS-CoV-2 productively infects human gut enterocytes","volume":"369","author":"Lamers","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.envres.2022.112890_bib49","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/infdis\/jix648","article-title":"Antiviral response in the nasopharynx identifies patients with respiratory virus infection","volume":"217","author":"Landry","year":"2018","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.envres.2022.112890_bib50","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.envres.2022.112890_bib51","article-title":"Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events","volume":"371","author":"Lemieux","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.envres.2022.112890_bib52","doi-asserted-by":"crossref","first-page":"102925","DOI":"10.1016\/j.ebiom.2020.102925","article-title":"Vascular occlusion by neutrophil extracellular traps in COVID-19","volume":"58","author":"Leppkes","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.envres.2022.112890_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/v10050219","article-title":"Relative contribution of cellular complement inhibitors CD59, CD46, and CD55 to parainfluenza virus 5 inhibition of complement-mediated neutralization","volume":"10","author":"Li","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.envres.2022.112890_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000849","article-title":"In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age","volume":"18","author":"Lieberman","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.envres.2022.112890_bib55","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1358\/dnp.2007.20.7.1183933","article-title":"The role of galectin-3 in promotion of the inflammatory response","volume":"20","author":"Liu","year":"2007","journal-title":"Drug News Perspect."},{"key":"10.1016\/j.envres.2022.112890_bib56","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01410-20","article-title":"Type I interferon susceptibility distinguishes SARS-CoV-2 from SARS-CoV","volume":"94","author":"Lokugamage","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.envres.2022.112890_bib57","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.envres.2022.112890_bib58","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1001\/jama.2016.9207","article-title":"Association of RNA biosignatures with bacterial infections in febrile infants aged 60 Days or younger","volume":"316","author":"Mahajan","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.envres.2022.112890_bib59","doi-asserted-by":"crossref","first-page":"108351","DOI":"10.1016\/j.clim.2020.108351","article-title":"Interactions of viruses and the humoral innate immune response","volume":"212","author":"Maloney","year":"2020","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.envres.2022.112890_bib60","doi-asserted-by":"crossref","first-page":"104811","DOI":"10.1016\/j.antiviral.2020.104811","article-title":"Antiviral activities of type I interferons to SARS-CoV-2 infection","volume":"179","author":"Mantlo","year":"2020","journal-title":"Antivir. Res."},{"key":"10.1016\/j.envres.2022.112890_bib61","doi-asserted-by":"crossref","first-page":"10839","DOI":"10.1128\/JVI.79.17.10839-10851.2005","article-title":"Tetraspanins in viral infections: a fundamental role in viral biology?","volume":"79","author":"Martin","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.envres.2022.112890_bib62","doi-asserted-by":"crossref","first-page":"102537","DOI":"10.1016\/j.autrev.2020.102537","article-title":"The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease","volume":"19","author":"McGonagle","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.envres.2022.112890_bib63","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.envres.2022.112890_bib64","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s00018-015-2119-4","article-title":"Exploring NAD+ metabolism in host-pathogen interactions","volume":"73","author":"Mesquita","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.envres.2022.112890_bib65","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.virusres.2014.11.021","article-title":"Host cell proteases: critical determinants of coronavirus tropism and pathogenesis","volume":"202","author":"Millet","year":"2015","journal-title":"Virus Res."},{"key":"10.1016\/j.envres.2022.112890_bib66","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01930-20","article-title":"SARS-CoV-2 is restricted by zinc finger antiviral protein despite preadaptation to the low-CpG environment in humans","volume":"11","author":"Nchioua","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.envres.2022.112890_bib67","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.envres.2022.112890_bib68","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","article-title":"Determining cell type abundance and expression from bulk tissues with digital cytometry","volume":"37","author":"Newman","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.envres.2022.112890_bib70","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5501\/wjv.v2.i2.71","article-title":"Viral proteins and Src family kinases: mechanisms of pathogenicity from a \"liaison dangereuse","volume":"2","author":"Pagano","year":"2013","journal-title":"World J. Virol."},{"key":"10.1016\/j.envres.2022.112890_bib71","doi-asserted-by":"crossref","first-page":"R157","DOI":"10.1186\/cc11477","article-title":"A distinct influenza infection signature in the blood transcriptome of patients with severe community-acquired pneumonia","volume":"16","author":"Parnell","year":"2012","journal-title":"Crit. Care"},{"key":"10.1016\/j.envres.2022.112890_bib72","article-title":"Saliva sample as a non-invasive specimen for the diagnosis of coronavirus disease 2019: a cross-sectional study","author":"Pasomsub","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.envres.2022.112890_bib73","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.148694","article-title":"Natural mucosal barriers and COVID-19 in children","volume":"6","author":"Pierce","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.envres.2022.112890_bib74","article-title":"Kinases as potential therapeutic targets for anti-coronaviral therapy","author":"Pillaiyar","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.envres.2022.112890_bib75","article-title":"Assessing uncertainty in the rooting of the SARS-CoV-2 phylogeny","author":"Pipes","year":"2020","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.envres.2022.112890_bib76","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/cid\/ciaa248","article-title":"Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in wuhan, China","volume":"71","author":"Qin","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.envres.2022.112890_bib77","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/nbt.2931","article-title":"Normalization of RNA-seq data using factor analysis of control genes or samples","volume":"32","author":"Risso","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.envres.2022.112890_bib78","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envres.2022.112890_bib79","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1038\/s41467-020-18781-2","article-title":"Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium","volume":"11","author":"Sajuthi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2022.112890_bib80","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/genes9050240","article-title":"Whole exome sequencing identifies new host genomic susceptibility factors in empyema caused by streptococcus pneumoniae in children: a pilot study","volume":"9","author":"Salas","year":"2018","journal-title":"Genes"},{"key":"10.1016\/j.envres.2022.112890_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-15752-4","article-title":"Whole exome sequencing reveals new candidate genes in host genomic susceptibility to respiratory syncytial virus disease","volume":"7","author":"Salas","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2022.112890_bib82","doi-asserted-by":"crossref","DOI":"10.3390\/v10060283","article-title":"Saracatinib inhibits Middle East respiratory syndrome-coronavirus replication in vitro","volume":"10","author":"Shin","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.envres.2022.112890_bib83","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/infdis\/jiv047","article-title":"Superiority of transcriptional profiling over procalcitonin for distinguishing bacterial from viral lower respiratory tract infections in hospitalized adults","volume":"212","author":"Suarez","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.envres.2022.112890_bib84","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envres.2022.112890_bib85","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41591-020-0868-6","article-title":"SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes","volume":"26","author":"Sungnak","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.envres.2022.112890_bib86","doi-asserted-by":"crossref","first-page":"346ra391","DOI":"10.1126\/scitranslmed.aaf7165","article-title":"Robust classification of bacterial and viral infections via integrated host gene expression diagnostics","volume":"8","author":"Sweeney","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.envres.2022.112890_bib88","doi-asserted-by":"crossref","first-page":"101947","DOI":"10.1016\/j.isci.2020.101947","article-title":"Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections","volume":"24","author":"Thair","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.envres.2022.112890_bib89","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/cid\/ciaa149","article-title":"Consistent detection of 2019 novel coronavirus in saliva","volume":"71","author":"To","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.envres.2022.112890_bib90","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.chest.2019.06.012","article-title":"The emerging role of neutrophil extracellular traps in respiratory disease","volume":"156","author":"Twaddell","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.envres.2022.112890_bib91","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.envres.2022.112890_bib92","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201129","article-title":"SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology","volume":"217","author":"Veras","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.envres.2022.112890_bib93","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.jmii.2019.09.005","article-title":"The role of galectins in virus infection - a systemic literature review","volume":"53","author":"Wang","year":"2020","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.envres.2022.112890_bib94","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1099\/jgv.0.000962","article-title":"CD59 association with infectious bronchitis virus particles protects against antibody-dependent complement-mediated lysis","volume":"98","author":"Wei","year":"2017","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.envres.2022.112890_bib95","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11095-020-02851-7","article-title":"Repurposing of kinase inhibitors for treatment of COVID-19","volume":"37","author":"Weisberg","year":"2020","journal-title":"Pharm. Res. (N. Y.)"},{"key":"10.1016\/j.envres.2022.112890_bib96","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.envres.2022.112890_bib97","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1056\/NEJMc2016359","article-title":"Saliva or nasopharyngeal swab specimens for detection of SARS-CoV-2","volume":"383","author":"Wyllie","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envres.2022.112890_bib98","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41421-020-00225-2","article-title":"The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing","volume":"6","author":"Xu","year":"2020","journal-title":"Cell Discov."},{"key":"10.1016\/j.envres.2022.112890_bib99","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.4049\/jimmunol.2001325","article-title":"Longitudinal peripheral blood transcriptional analysis reveals molecular signatures of disease progression in COVID-19 patients","volume":"206","author":"Yan","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.envres.2022.112890_bib100","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S2213-2600(20)30079-5","article-title":"Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study","volume":"8","author":"Yang","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.envres.2022.112890_bib101","series-title":"Enrichplot: visualization of functional enrichment result","author":"Yu","year":"2021"},{"key":"10.1016\/j.envres.2022.112890_bib102","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS A J. Integr. Biol."},{"key":"10.1016\/j.envres.2022.112890_bib103","doi-asserted-by":"crossref","first-page":"105954","DOI":"10.1016\/j.ijantimicag.2020.105954","article-title":"Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality","volume":"55","author":"Zhang","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.envres.2022.112890_bib104","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s41392-020-00457-4","article-title":"Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19","volume":"5","author":"Zheng","year":"2020","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.envres.2022.112890_bib105","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41423-020-0401-3","article-title":"Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients","volume":"17","author":"Zheng","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.envres.2022.112890_bib106","series-title":"ctrlGene: Assess the Stability of Candidate Housekeeping Genes. Version 101, R Package","author":"Zhong","year":"2019"},{"key":"10.1016\/j.envres.2022.112890_bib107","doi-asserted-by":"crossref","first-page":"102596","DOI":"10.1016\/j.jaut.2021.102596","article-title":"Profiling of the immune repertoire in COVID-19 patients with mild, severe, convalescent, or retesting-positive status","volume":"118","author":"Zhou","year":"2021","journal-title":"J. Autoimmun."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935122002171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935122002171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T02:45:25Z","timestamp":1762137925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935122002171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":103,"alternative-id":["S0013935122002171"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2022.112890","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.10.27.466206","asserted-by":"object"}]},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A multi-tissue study of immune gene expression profiling highlights the key role of the nasal epithelium in COVID-19 severity","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2022.112890","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112890"}}