{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T07:02:18Z","timestamp":1794294138400,"version":"4.9.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014440","name":"Gobierno de Espa\u00f1a Ministerio de Ciencia Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["CAS21\/00008"],"award-info":[{"award-number":["CAS21\/00008"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Gobierno de Espa\u00f1a Ministerio de Ciencia Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["MS21-013"],"award-info":[{"award-number":["MS21-013"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["AICO 2020\/285"],"award-info":[{"award-number":["AICO 2020\/285"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["BEST\/2020\/059"],"award-info":[{"award-number":["BEST\/2020\/059"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["13\/1944"],"award-info":[{"award-number":["13\/1944"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["16\/1288"],"award-info":[{"award-number":["16\/1288"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["17\/00260"],"award-info":[{"award-number":["17\/00260"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["19\/1338"],"award-info":[{"award-number":["19\/1338"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CD21\/00186"],"award-info":[{"award-number":["CD21\/00186"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CP15\/0025"],"award-info":[{"award-number":["CP15\/0025"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CPII20\/00006"],"award-info":[{"award-number":["CPII20\/00006"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["MSII 16\/00051"],"award-info":[{"award-number":["MSII 16\/00051"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14\/00891"],"award-info":[{"award-number":["PI14\/00891"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/00663"],"award-info":[{"award-number":["PI17\/00663"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.envres.2022.113620","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T15:36:53Z","timestamp":1654875413000},"page":"113620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Pre and postnatal exposure to mercury and sexual development in 9-year-old children in Spain: The role of brain-derived neurotrophic factor"],"prefix":"10.1016","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7305-6564","authenticated-orcid":false,"given":"Blanca","family":"Sarzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6165-3465","authenticated-orcid":false,"given":"Ferran","family":"Ballester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Soler-Blasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1202-8740","authenticated-orcid":false,"given":"Maria-Jose","family":"Lopez-Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2046-5959","authenticated-orcid":false,"given":"Manuel","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorka","family":"Iriarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Beneito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Riutort-Mayol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6996-1158","authenticated-orcid":false,"given":"Mario","family":"Murcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Llop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2022.113620_bib1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.chemosphere.2007.01.003","article-title":"Mercury in hair and blood from residents of Phnom Penh (Cambodia) and possible effect on serum hormone levels","volume":"68","author":"Agusa","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2022.113620_bib2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ijheh.2019.01.007","article-title":"Maternal copper status and neuropsychological development in infants and preschool children","volume":"222","author":"Amor\u00f3s","year":"2019","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envres.2022.113620_bib3","first-page":"975","article-title":"Diurnal rhythm of testosterone secretion before and throughout puberty in healthy girls: correlation with 17beta-estradiol and dehydroepiandrosterone sulfate","volume":"84","author":"Ankarberg","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.envres.2022.113620_bib4","article-title":"Update on the genetics of differences of sex development (DSD)","volume":"33","author":"Baetens","year":"2019","journal-title":"Best Pract Res Clin Endocrinol Metab. Netherlands"},{"key":"10.1016\/j.envres.2022.113620_bib5","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1093\/humrep\/del479","article-title":"Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor","volume":"22","author":"Begliuomini","year":"2007","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.envres.2022.113620_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033850","article-title":"Sex matters during adolescence: testosterone-related cortical thickness maturation differs between boys and girls","volume":"7","author":"Bramen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2022.113620_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108958","article-title":"Association of urinary metal concentrations with blood pressure and serum hormones in Spanish male adolescents","volume":"182","author":"Castiello","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2022.113620_bib8","series-title":"Cook's Distance. International Encyclopedia of Statistical Science. Lovric M","author":"Cook","year":"2011"},{"key":"10.1016\/j.envres.2022.113620_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijheh.2013.06.004","article-title":"Health effects in the Flemish population in relation to low levels of mercury exposure: from organ to transcriptome level","volume":"217","author":"Croes","year":"2014","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envres.2022.113620_bib10","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/01.ede.0000129514.46451.ce","article-title":"Fish intake during pregnancy and early cognitive development of offspring","volume":"15","author":"Daniels","year":"2004","journal-title":"Epidemiology"},{"issue":"5","key":"10.1016\/j.envres.2022.113620_bib11","first-page":"350","article-title":"Proposal for a social class measure [in Spanish]. Working group of the Spanish society of epidemiology and the Spanish society of family and community medicine","volume":"25","author":"Domingo-Salvany","year":"2000","journal-title":"Atenci\u00f3n Primaria"},{"key":"10.1016\/j.envres.2022.113620_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13293-020-0283-1","article-title":"Neuroprotective and neurotoxic outcomes of androgens and estrogens in an oxidative stress environment","volume":"11","author":"Duong","year":"2020","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.envres.2022.113620_bib13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","article-title":"The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function","volume":"112","author":"Egan","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.envres.2022.113620_bib14","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/andr.12024","article-title":"Dietary fatty acids affect semen quality: a review","volume":"3","author":"Esmaeili","year":"2015","journal-title":"Andrology"},{"key":"10.1016\/j.envres.2022.113620_bib15","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.3390\/ijms23052542","article-title":"Diet and male fertility: the impact of nutrients and antioxidants on sperm energetic metabolism","volume":"23","author":"Ferramosca","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2022.113620_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0301-0082(00)00025-3","article-title":"Neuroprotection by estradiol","volume":"63","author":"Garcia-Segura","year":"2001","journal-title":"Prog Neurobiol. England"},{"key":"10.1016\/j.envres.2022.113620_bib17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.taap.2003.10.010","article-title":"Incorporating pharmacokinetic differences between children and adults in assessing children's risks to environmental toxicants","volume":"198","author":"Ginsberg","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envres.2022.113620_bib18","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S1474-4422(13)70278-3","article-title":"Neurobehavioural effects of developmental toxicity","volume":"13","author":"Grandjean","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.envres.2022.113620_bib19","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0892-0362(97)00097-4","article-title":"Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury","volume":"19","author":"Grandjean","year":"1997","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.envres.2022.113620_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2019.113445","article-title":"Multi-exposures to suspected endocrine disruptors in electronic waste recycling workers: associations with thyroid and reproductive hormones","volume":"225","author":"Gravel","year":"2020","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envres.2022.113620_bib21","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1093\/ije\/dyr054","article-title":"Cohort profile: the INMA--INfancia y medio ambiente--(environment and childhood) project","volume":"41","author":"Guxens","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.envres.2022.113620_bib22","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1588\/medver.2005.02.00070","article-title":"Mercury toxicity: genetic susceptibility and synergistic effects","volume":"2","author":"Haley","year":"2005","journal-title":"Medicar Veritas"},{"key":"10.1016\/j.envres.2022.113620_bib23","first-page":"365","article-title":"Organomercurials. Their formation and pathways in the environment","volume":"7","author":"Hintelmann","year":"2010","journal-title":"Met Ions Life Sci"},{"key":"10.1016\/j.envres.2022.113620_bib24","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1210\/en.2013-1242","article-title":"Oxidative stress defines the neuroprotective or neurotoxic properties of androgens in immortalized female rat dopaminergic neuronal cells","volume":"154","author":"Holmes","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.envres.2022.113620_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.110928","article-title":"Association between mercury exposure and thyroid hormones levels: a meta-analysis","volume":"196","author":"Hu","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2022.113620_bib26","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.envint.2007.06.001","article-title":"Fish consumption in pregnancy, cord blood mercury level and cognitive and psychomotor development of infants followed over the first three years of life: krakow epidemiologic study","volume":"33","author":"Jedrychowski","year":"2007","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2022.113620_bib27","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.19462","article-title":"Associations of fish oil supplement use with testicular function in young men","volume":"3","author":"Jensen","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.envres.2022.113620_bib28","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1289\/ehp.1104494","article-title":"Evidence on the human health effects of low-level methylmercury exposure","volume":"120","author":"Karagas","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2022.113620_bib29","doi-asserted-by":"crossref","first-page":"269","DOI":"10.21307\/ane-2017-061","article-title":"Developmental neurotoxicants and the vulnerable male brain: a systematic review of suspected neurotoxicants that disproportionally affect males","volume":"77","author":"Kern","year":"2017","journal-title":"Acta Neurobiol. Exp."},{"key":"10.1016\/j.envres.2022.113620_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083929","article-title":"The influence of sex steroids on structural brain maturation in adolescence","volume":"9","author":"Koolschijn","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2022.113620_bib31","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1289\/ehp.10831","article-title":"Relation between cord blood mercury levels and early child development in a World Trade Center cohort","volume":"116","author":"Lederman","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2022.113620_bib32","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/oemed-2014-102264","article-title":"Phthalates, perfluoroalkyl acids, metals and organochlorines and reproductive function: a multipollutant assessment in Greenlandic, Polish and Ukrainian men","volume":"72","author":"Lenters","year":"2015","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.envres.2022.113620_bib33","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/aje\/kwr328","article-title":"Prenatal exposure to mercury and infant neurodevelopment in a multicenter cohort in Spain: study of potential modifiers","volume":"175","author":"Llop","year":"2012","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envres.2022.113620_bib34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.envres.2014.03.023","article-title":"Exposure to mercury among Spanish preschool children: trend from birth to age four","volume":"132C","author":"Llop","year":"2014","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2022.113620_bib35","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.envres.2015.02.026","article-title":"Synergism between exposure to mercury and use of iodine supplements on thyroid hormones in pregnant women","volume":"138","author":"Llop","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2022.113620_bib36","first-page":"827","article-title":"Prenatal exposure to mercury and neuropsychological development in young children: the role of fish consumption","volume":"46","author":"Llop","year":"2016","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.envres.2022.113620_bib37","article-title":"Exposure to mercury among 9-year-old children and neurobehavioural function","volume":"146","author":"Lozano","year":"2021","journal-title":"Environ Int. Netherlands"},{"key":"10.1016\/j.envres.2022.113620_bib38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/978-3-642-45106-5_9","article-title":"BDNF and synaptic plasticity, cognitive function, and dysfunction","volume":"220","author":"Lu","year":"2014","journal-title":"Handb Exp Pharmacol. Germany"},{"key":"10.1016\/j.envres.2022.113620_bib39","series-title":"Variations in Pattern of Pubertal Changes in Girls","first-page":"291","author":"Marshall","year":"1969"},{"key":"10.1016\/j.envres.2022.113620_bib40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/adc.45.239.13","article-title":"Variations in the pattern of pubertal changes in boys","volume":"45","author":"Marshall","year":"1970","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.envres.2022.113620_bib41","first-page":"236","article-title":"Associations between brain-derived neurotrophic factor and estradiol in women's saliva","volume":"35","author":"Matsuki","year":"2014","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/j.envres.2022.113620_bib42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/aja.2012.121","article-title":"Environmental mercury exposure, semen quality and reproductive hormones in Greenlandic Inuit and European men: a cross-sectional study","volume":"15","author":"Mocevic","year":"2013","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.envres.2022.113620_bib43","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/S0140-6736(03)13371-5","article-title":"Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study","volume":"361","author":"Myers","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.envres.2022.113620_bib44","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/cercor\/bhs125","article-title":"Testosterone-related cortical maturation across childhood and adolescence","volume":"23","author":"Nguyen","year":"2013","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.envres.2022.113620_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108682","article-title":"Combined prenatal exposure to mercury and LCPUFA on newborn's brain measures and neurodevelopment at the age of 18 months","volume":"178","author":"Ni\u0161evi\u0107","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2022.113620_bib46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ntt.2016.07.001","article-title":"Maternal prenatal fish consumption and cognition in mid childhood: mercury, fatty acids, and selenium","volume":"57","author":"Oken","year":"2016","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.envres.2022.113620_bib47","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0306-4522(02)00211-7","article-title":"The effects of beta-estradiol on SHSY5Y neuroblastoma cells during heavy metal induced oxidative stress, neurotoxicity and beta-amyloid secretion","volume":"113","author":"Olivieri","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.envres.2022.113620_bib48","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1126\/science.1230667","article-title":"The genetic basis for bacterial mercury methylation","volume":"339","author":"Parks","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.envres.2022.113620_bib49","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neuroscience.2013.01.025","article-title":"Steroid hormones and BDNF","volume":"239","author":"Pluchino","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.envres.2022.113620_bib50","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1289\/ehp.1003284","article-title":"Cadmium, lead, and mercury in relation to reproductive hormones and anovulation in premenopausal women","volume":"119","author":"Pollack","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2022.113620_bib51","first-page":"94","article-title":"The role of thyroid hormones in prenatal and neonatal neurological development--current perspectives","volume":"14","author":"Porterfield","year":"1993","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.envres.2022.113620_bib52","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.envint.2010.12.004","article-title":"Prenatal mercury exposure in a multicenter cohort study in Spain","volume":"37","author":"Ramon","year":"2011","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2022.113620_bib53","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1186\/s40064-016-2898-6","article-title":"On studentized residuals in the quantile regression framework","volume":"5","author":"Ranganai","year":"2016","journal-title":"SpringerPlus"},{"key":"10.1016\/j.envres.2022.113620_bib54","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s10653-015-9758-0","article-title":"Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging","volume":"38","author":"Rotter","year":"2016","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.envres.2022.113620_bib55","doi-asserted-by":"crossref","DOI":"10.1093\/humupd\/dmac005","article-title":"Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine","author":"S\u00e1nchez-Garrido","year":"2022","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.envres.2022.113620_bib56","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.physbeh.2009.09.015","article-title":"Relationships of putative endocrine disruptors to human sexual maturation and thyroid activity in youth","volume":"99","author":"Schell","year":"2010","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.envres.2022.113620_bib57","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1210\/en.2014-1734","article-title":"Elucidating the links between endocrine disruptors and neurodevelopment","volume":"156","author":"Schug","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.envres.2022.113620_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-008-8199-3","article-title":"Thyroid hormones and methylmercury toxicity","volume":"126","author":"Soldin","year":"2008","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envres.2022.113620_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.05.029","article-title":"Exposure to mercury among 9-year-old Spanish children: associated factors and trend throughout childhood","volume":"130","author":"Soler-Blasco","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2022.113620_bib60","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/10408440802233259","article-title":"The endocrine effects of mercury in humans and wildlife","volume":"39","author":"Tan","year":"2009","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envres.2022.113620_bib61","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1126\/science.270.5236.593","article-title":"Neurotrophins and neuronal plasticity","volume":"270","author":"Thoenen","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.envres.2022.113620_bib62","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1475-2891-12-26","article-title":"Reproducibility and validity of a food frequency questionnaire among pregnant women in a Mediterranean area","volume":"12","author":"Vioque","year":"2013","journal-title":"Nutr. J."},{"key":"10.1016\/j.envres.2022.113620_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167338","article-title":"Reproducibility and validity of a food frequency questionnaire designed to assess diet in children aged 4-5 years","volume":"11","author":"Vioque","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2022.113620_bib64","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1017\/S2040174419000254","article-title":"Methods for determining pubertal status in research studies: literature review and opinions of experts and adolescents","volume":"11","author":"Walker","year":"2020","journal-title":"J Dev Orig Health Dis"},{"key":"10.1016\/j.envres.2022.113620_bib65","first-page":"pe29","article-title":"Estrogen actions in the brain","volume":"2002","author":"Wang","year":"2002","journal-title":"Sci STKE. United States"},{"key":"10.1016\/j.envres.2022.113620_bib66","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/humrep\/deaa315","article-title":"Prenatal exposure to mercury and precocious puberty: a prospective birth cohort study","volume":"36","author":"Wang","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.envres.2022.113620_bib67","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/mp.2017.72","article-title":"Brain-derived neurotrophic factor Val66Met genotype and ovarian steroids interactively modulate working memory-related hippocampal function in women: a multimodal neuroimaging study","volume":"23","author":"Wei","year":"2018","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.envres.2022.113620_bib68","series-title":"Weight-for-height and Body Mass Index-for-age: Methods and Development","article-title":"WHO child growth standards: length\/height-for-age, weight-for-age, weight-for-length","year":"2006"},{"key":"10.1016\/j.envres.2022.113620_bib69","series-title":"Exposure to Mercury: a Major Public Health Concern [Internet]","year":"2007"},{"key":"10.1016\/j.envres.2022.113620_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/52376e1c-1a2d-44af-a129-849345da78a0","article-title":"De novo synthesized estradiol protects against methylmercury-induced neurotoxicity in cultured rat hippocampal slices","volume":"8","author":"Yamazaki","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2022.113620_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224892","article-title":"Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011-2012","volume":"14","author":"Yao","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2022.113620_bib72","doi-asserted-by":"crossref","first-page":"8991","DOI":"10.21037\/apm-21-2018","article-title":"Efficacy of omega-3 polyunsaturated fatty acids on hormones, oxidative stress, and inflammatory parameters among polycystic ovary syndrome: a systematic review and meta-analysis","volume":"10","author":"Yuan","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.envres.2022.113620_bib73","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.reprotox.2013.06.062","article-title":"Associations of urinary metal concentrations and circulating testosterone in Chinese men","volume":"41","author":"Zeng","year":"2013","journal-title":"Reprod. Toxicol."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935122009471?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935122009471?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:44:06Z","timestamp":1779727446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935122009471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":73,"alternative-id":["S0013935122009471"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2022.113620","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre and postnatal exposure to mercury and sexual development in 9-year-old children in Spain: The role of brain-derived neurotrophic factor","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2022.113620","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113620"}}