{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:20:14Z","timestamp":1792516814207,"version":"4.5.0"},"reference-count":120,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006978","name":"University of California Berkeley","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.envres.2022.115188","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T02:08:45Z","timestamp":1672366125000},"page":"115188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"special_numbering":"C","title":["A systematic evidence map of chronic inflammation and immunosuppression related to per- and polyfluoroalkyl substance (PFAS) exposure"],"prefix":"10.1016","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7866-8391","authenticated-orcid":false,"given":"Luoping","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Louie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Rigutto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Dahlberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sholinbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn T.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2022.115188_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105979","article-title":"Effect of prenatal exposure to per- and polyfluoroalkyl substances on childhood allergies and common infectious diseases in children up to age 7 years: the Hokkaido study on environment and children's health","volume":"143","author":"Ait Bamai","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2022.115188_bib3","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.envpol.2019.01.064","article-title":"Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines","volume":"247","author":"Bassler","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2022.115188_bib4","series-title":"Hallmark and Key Characteristics Mapping","author":"Borrel","year":"2019"},{"key":"10.1016\/j.envres.2022.115188_bib5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.chemosphere.2014.06.093","article-title":"Complement activation is involved in the hepatic injury caused by high-dose exposure of mice to perfluorooctanoic acid","volume":"129","author":"Botelho","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2022.115188_bib6","series-title":"Guidelines and Standards for Evidence Synthesis in Environmental Management","year":"2018"},{"key":"10.1016\/j.envres.2022.115188_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110445","article-title":"Serum per- and polyfluoroalkyl substance (PFAS) concentrations and predictors of exposure among pregnant African American women in the Atlanta area, Georgia","volume":"198","author":"Chang","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2022.115188_bib8","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1158\/0008-5472.CAN-12-0509","article-title":"NLRP3 suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases","volume":"72","author":"Chow","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.envres.2022.115188_bib9","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/icb.2012.46","article-title":"NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma","volume":"90","author":"Chow","year":"2012","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.envres.2022.115188_bib10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41370-018-0099-9","article-title":"Guideline levels for PFOA and PFOS in drinking water: the role of scientific uncertainty, risk assessment decisions, and social factors","volume":"29","author":"Cordner","year":"2019","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.envres.2022.115188_bib11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.taap.2011.11.004","article-title":"In vitro characterization of the immunotoxic potential of several perfluorinated compounds (PFCs)","volume":"258","author":"Corsini","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envres.2022.115188_bib12","doi-asserted-by":"crossref","first-page":"15673","DOI":"10.3390\/ijerph121215012","article-title":"Investigation of the effects of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) on apoptosis and cell cycle in a zebrafish (Danio rerio) liver cell line","volume":"12","author":"Cui","year":"2015","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envres.2022.115188_bib13","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1084\/jem.20161707","article-title":"NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma","volume":"214","author":"Daley","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.envres.2022.115188_bib14","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.envint.2016.08.026","article-title":"Association between prenatal exposure to perfluorinated compounds and symptoms of infections at age 1-4years among 359 children in the Odense Child Cohort","volume":"96","author":"Dalsager","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2022.115188_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.canlet.2018.10.030","article-title":"NLRP3 inflammasomes in macrophages drive colorectal cancer metastasis to the liver","volume":"442","author":"Deng","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.envres.2022.115188_bib16","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1158\/0008-5472.CAN-17-1887","article-title":"Inflammasome adaptor ASC suppresses apoptosis of gastric cancer cells by an IL18-mediated inflammation-independent mechanism","volume":"78","author":"Deswaerte","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.envres.2022.115188_bib17","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/toxsci\/kfp040","article-title":"Suppression of humoral immunity by perfluorooctanoic acid is independent of elevated serum corticosterone concentration in mice","volume":"109","author":"DeWitt","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2022.115188_bib18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3109\/1547691X.2014.996682","article-title":"Suppression of antigen-specific antibody responses in mice exposed to perfluorooctanoic acid: role of PPARalpha and T- and B-cell targeting","volume":"13","author":"DeWitt","year":"2016","journal-title":"J. Immunot."},{"key":"10.1016\/j.envres.2022.115188_bib19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/BCR.0000000000000496","article-title":"Intratracheal instillation of perfluorohexane modulates the pulmonary immune microenvironment by attenuating early inflammatory factors in patients with smoke inhalation injury: a randomized controlled clinical trial","volume":"38","author":"Ding","year":"2017","journal-title":"J. Burn Care Res."},{"key":"10.1016\/j.envres.2022.115188_bib20","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s00204-011-0661-x","article-title":"Sub-chronic effect of perfluorooctanesulfonate (PFOS) on the balance of type 1 and type 2 cytokine in adult C57BL6 mice","volume":"85","author":"Dong","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envres.2022.115188_bib21","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1289\/ehp.1205351","article-title":"Serum polyfluoroalkyl concentrations, asthma outcomes, and immunological markers in a case-control study of Taiwanese children","volume":"121","author":"Dong","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2022.115188_bib22","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/tox.20642","article-title":"Subchronic effects of perfluorooctanesulfonate exposure on inflammation in adult male C57BL\/6 mice","volume":"27","author":"Dong","year":"2010","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envres.2022.115188_bib23","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/toxsci\/kfm053","article-title":"Exposure to the immunosuppressant, perfluorooctanoic acid, enhances the murine IgE and airway hyperreactivity response to ovalbumin","volume":"97","author":"Fairley","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2022.115188_bib24","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/toxsci\/kfp019","article-title":"Alterations of cytokines and MAPK signaling pathways are related to the immunotoxic effect of perfluorononanoic acid","volume":"108","author":"Fang","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2022.115188_bib25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.tox.2009.10.020","article-title":"Perfluorononanoic acid-induced apoptosis in rat spleen involves oxidative stress and the activation of caspase-independent death pathway","volume":"267","author":"Fang","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2022.115188_bib26","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.etap.2012.06.011","article-title":"In vitro and in vivo studies of the toxic effects of perfluorononanoic acid on rat hepatocytes and Kupffer cells","volume":"34","author":"Fang","year":"2012","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envres.2022.115188_bib27","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/toxsci\/kfn127","article-title":"Immunotoxic effects of perfluorononanoic acid on BALB\/c mice","volume":"105","author":"Fang","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2022.115188_bib28","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1007\/s00204-012-0877-4","article-title":"Kupffer cells suppress perfluorononanoic acid-induced hepatic peroxisome proliferator-activated receptor alpha expression by releasing cytokines","volume":"86","author":"Fang","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envres.2022.115188_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/1547691X.2018.1445145","article-title":"Immunotoxic and hepatotoxic effects of perfluoro-n-decanoic acid (PFDA) on female Harlan Sprague-Dawley rats and B6C3F1\/N mice when administered by oral gavage for 28 days","volume":"15","author":"Frawley","year":"2018","journal-title":"J. Immunot."},{"key":"10.1016\/j.envres.2022.115188_bib30","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1593\/neo.13310","article-title":"Silica-induced chronic inflammation promotes lung carcinogenesis in the context of an immunosuppressive microenvironment","volume":"15","author":"Freire","year":"2013","journal-title":"Neoplasia"},{"key":"10.1016\/j.envres.2022.115188_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/847827","article-title":"Activation of toll-like receptors and inflammasome complexes in the diabetic cardiomyopathy-associated inflammation","author":"Fuentes-Antras","year":"2014","journal-title":"Internet J. Endocrinol."},{"key":"10.1016\/j.envres.2022.115188_bib32","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/1568010054022024","article-title":"Macrophages in inflammation","volume":"4","author":"Fujiwara","year":"2005","journal-title":"Curr. Drug Targets - Inflamm. Allergy"},{"key":"10.1016\/j.envres.2022.115188_bib33","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.envres.2022.115188_bib34","doi-asserted-by":"crossref","DOI":"10.1289\/EHP10800","article-title":"Consensus on the key characteristics of immunotoxic agents as a basis for hazard identification","volume":"130","author":"Germolec","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2022.115188_bib35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1289\/EHP142","article-title":"The association of prenatal exposure to perfluorinated chemicals with glucocorticoid and androgenic hormones in cord blood samples: the hokkaido study","volume":"125","author":"Goudarzi","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2022.115188_bib36","article-title":"Severity of COVID-19 at elevated exposure to perfluorinated alkylates","author":"Grandjean","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.envres.2022.115188_bib37","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3109\/1547691X.2012.755580","article-title":"Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood","volume":"10","author":"Granum","year":"2013","journal-title":"J. Immunot."},{"key":"10.1016\/j.envres.2022.115188_bib38","article-title":"Targeting inflammasome\/IL-1 pathways for cancer immunotherapy","volume":"6","author":"Guo","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2022.115188_bib39","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/oemed-2020-106517","article-title":"Benzene-associated immunosuppression and chronic inflammation in humans: a systematic review","volume":"78","author":"Guo","year":"2020","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.envres.2022.115188_bib40","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.fsi.2019.05.018","article-title":"The PFOS disturbed immunomodulatory functions via nuclear Factor-kappaB signaling in liver of zebrafish (Danio rerio)","volume":"91","author":"Guo","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"12","key":"10.1016\/j.envres.2022.115188_bib41","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1021\/acs.chemrestox.8b00321","article-title":"Key characteristics approach to carcinogenic hazard identification","volume":"31","author":"Guyton","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envres.2022.115188_bib42","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/carcin\/bgy031","article-title":"Application of the key characteristics of carcinogens in cancer hazard identification","volume":"39","author":"Guyton","year":"2018","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.envres.2022.115188_bib43","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.chemosphere.2017.08.070","article-title":"Perfluorooctane sulphonate induces oxidative hepatic damage via mitochondria-dependent and NF-kappaB\/TNF-alpha-mediated pathway","volume":"191","author":"Han","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2022.115188_bib44","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41423-021-00832-3","article-title":"Neutrophils in chronic inflammatory diseases","volume":"19","author":"Herrero-Cervera","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.envres.2022.115188_bib45","first-page":"11","article-title":"Arsenic, metals, fibres, and dusts","volume":"100","year":"2012","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.envres.2022.115188_bib46","volume":"vol. 110","year":"2016"},{"key":"10.1016\/j.envres.2022.115188_bib47","series-title":"Benzene. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 120","year":"2018"},{"key":"10.1016\/j.envres.2022.115188_bib48","series-title":"IARC Monographs on the Identification of Carcinogenic Hazards to Humans: Preamble","year":"2019"},{"key":"10.1016\/j.envres.2022.115188_bib49","series-title":"Report of the Advisory Group to Recommend Priorities for the IARC Monographs during 2020-2024","first-page":"302","year":"2019"},{"key":"10.1016\/j.envres.2022.115188_bib50","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.envint.2018.12.041","article-title":"Maternal levels of perfluoroalkyl substances (PFASs) during pregnancy and childhood allergy and asthma related outcomes and infections in the Norwegian Mother and Child (MoBa) cohort","volume":"124","author":"Impinen","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2022.115188_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13750-016-0059-6","article-title":"A methodology for systematic mapping in environmental sciences","volume":"5","author":"James","year":"2016","journal-title":"Environ. Evid."},{"key":"10.1016\/j.envres.2022.115188_bib52","doi-asserted-by":"crossref","first-page":"36617","DOI":"10.1074\/jbc.M112.407130","article-title":"Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation","volume":"287","author":"Juliana","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envres.2022.115188_bib53","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/toxsci\/kfn015","article-title":"Gestational exposure to perfluorooctane sulfonate suppresses immune function in B6C3F1 mice","volume":"103","author":"Keil","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2022.115188_bib54","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.envres.2022.115188_bib55","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41574-019-0273-8","article-title":"Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification","volume":"16","author":"La Merrill","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.envres.2022.115188_bib56","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/jat.3389","article-title":"Association between perfluorooctanoic acid exposure and degranulation of mast cells in allergic inflammation","volume":"37","author":"Lee","year":"2016","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envres.2022.115188_bib57","article-title":"High levels of toxic PFAS chemicals pollute breast milk around the world","author":"Lerner","year":"2019","journal-title":"Intercept"},{"key":"10.1016\/j.envres.2022.115188_bib58","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.envres.2016.07.013","article-title":"Immunomodulatory effects of exposure to polychlorinated biphenyls and perfluoroalkyl acids in East Greenland ringed seals (Pusa hispida)","volume":"151","author":"Levin","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2022.115188_bib59","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.toxlet.2018.05.009","article-title":"Perfluorooctanoic acid stimulates ovarian cancer cell migration, invasion via ERK\/NF-kappaB\/MMP-2\/-9 pathway","volume":"294","author":"Li","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envres.2022.115188_bib60","doi-asserted-by":"crossref","first-page":"14182","DOI":"10.1021\/acs.est.0c03387","article-title":"Per- and polyfluoroalkyl substances in the air particles of asia: levels, seasonality, and size-dependent distribution","volume":"54","author":"Lin","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2022.115188_bib61","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1039\/c5tx00260e","article-title":"Grape seed proanthocyanidin extract protects against perfluorooctanoic acid-induced hepatotoxicity by attenuating inflammatory response, oxidative stress and apoptosis in mice","volume":"5","author":"Liu","year":"2016","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.envres.2022.115188_bib63","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/15476910490438342","article-title":"Suppression of immune function and susceptibility to infections in humans: association of immune function with clinical disease","volume":"1","author":"Luebke","year":"2004","journal-title":"J. Immunot."},{"key":"10.1016\/j.envres.2022.115188_bib64","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.intimp.2018.09.019","article-title":"Naringin protects against perfluorooctane sulfonate-induced liver injury by modulating NRF2 and NF-kappaB in mice","volume":"65","author":"Lv","year":"2018","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.envres.2022.115188_bib65","doi-asserted-by":"crossref","first-page":"36064","DOI":"10.1007\/s11356-018-3483-z","article-title":"Per- and polyfluoroalkyl substances in human breast milk and current analytical methods","volume":"25","author":"Macheka-Tendenguwo","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envres.2022.115188_bib67","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.3390\/ijerph18073332","article-title":"Investigating molecular mechanisms of immunotoxicity and the utility of ToxCast for immunotoxicity screening of chemicals added to food","volume":"18","author":"Naidenko","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envres.2022.115188_bib68","series-title":"Asbestos-Induced Chronic Inflammation and Cancer","first-page":"223","author":"Napolitano","year":"2014"},{"key":"10.1016\/j.envres.2022.115188_bib69","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fcimb.2017.00373","article-title":"Neutrophils to the ROScue: mechanisms of NADPH oxidase activation and bacterial resistance","volume":"7","author":"Nguyen","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.envres.2022.115188_bib70","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ejmhg.2015.08.006","article-title":"Natural killer cells enhance the immune surveillance of cancer","volume":"17","author":"Nouroz","year":"2016","journal-title":"Egypt. J. Med. Hum. Genet."},{"key":"10.1016\/j.envres.2022.115188_bib71","series-title":"National Toxicology Program Monograph on Immunotoxicity Associated with Exposure to Perfluorooctanoic Acid or Perfluorooctane Sulfonate. Office of Health Assessment and Translation Divisions of the National Toxicology Program","year":"2016"},{"key":"10.1016\/j.envres.2022.115188_bib72","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.envres.2011.10.003","article-title":"Prenatal exposure to perfluorinated chemicals and relationship with allergies and infectious diseases in infants","volume":"112","author":"Okada","year":"2012","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2022.115188_bib73","series-title":"Association between Per and Polyfluoroalkyl Substances and Markers of Inflammation and Oxidative Stress","author":"Omoike","year":"2020"},{"key":"10.1016\/j.envres.2022.115188_bib74","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00018-017-2686-7","article-title":"CD4 and CD8 T lymphocyte interplay in controlling tumor growth","volume":"75","author":"Ostroumov","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.envres.2022.115188_bib75","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.envres.2022.115188_bib76","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1186\/s13104-020-05255-3","article-title":"Exposure to perfluorooctanoic acid (PFOA) decreases neutrophil migration response to injury in zebrafish embryos","volume":"13","author":"Pecquet","year":"2020","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.envres.2022.115188_bib77","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/toxsci\/kfn059","article-title":"Suppression of humoral immunity in mice following exposure to perfluorooctane sulfonate","volume":"104","author":"Peden-Adams","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2022.115188_bib78","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.canlet.2014.08.015","article-title":"A novel beta-catenin signaling pathway activated by IL-1beta leads to the onset of epithelial-mesenchymal transition in breast cancer cells","volume":"354","author":"Perez-Yepez","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.envres.2022.115188_bib79","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.intimp.2010.08.009","article-title":"Dietary exposure to perfluorooctanoate or perfluorooctane sulfonate induces hypertrophy in centrilobular hepatocytes and alters the hepatic immune status in mice","volume":"10","author":"Qazi","year":"2010","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.envres.2022.115188_bib80","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.tox.2009.06.010","volume":"262","author":"Qazi","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2022.115188_bib82","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.tox.2009.03.009","volume":"260","author":"Qazi","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2022.115188_bib81","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1016\/j.fct.2012.06.023","article-title":"High-dose dietary exposure of mice to perfluorooctanoate or perfluorooctane sulfonate exerts toxic effects on myeloid and B-lymphoid cells in the bone marrow and these effects are partially dependent on reduced food consumption","volume":"50","author":"Qazi","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envres.2022.115188_bib84","doi-asserted-by":"crossref","first-page":"12938","DOI":"10.1021\/acs.est.0c01951","article-title":"Legacy and novel per-and polyfluoroalkyl substances in juvenile seabirds from the US atlantic coast","volume":"54","author":"Robuck","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"4","key":"10.1016\/j.envres.2022.115188_bib85","first-page":"S4","article-title":"Acute immunotoxic effects of perfluorononanoic acid (PFNA) in C57BL\/6 mice","author":"Rockwell","year":"2013","journal-title":"Clin. Exp. Pharmacol."},{"key":"10.1016\/j.envres.2022.115188_bib86","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.envpol.2018.11.097","article-title":"Contaminants in Atlantic walruses in Svalbard Part 2: relationships with endocrine and immune systems","volume":"246","author":"Routti","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2022.115188_bib87","series-title":"The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification","author":"Samet","year":"2019"},{"key":"10.1016\/j.envres.2022.115188_bib88","doi-asserted-by":"crossref","first-page":"111141","DOI":"10.1016\/j.fct.2020.111141","article-title":"Immunotoxicity and allergenic potential induced by topical application of perfluorooctanoic acid (PFOA) in a murine model","volume":"137","author":"Shane","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envres.2022.115188_bib89","article-title":"Early-life perfluorooctanoic acid exposure induces obesity in male offspring and the intervention role of chlorogenic acid","volume":"272","author":"Shao","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2022.115188_bib90","doi-asserted-by":"crossref","first-page":"13916","DOI":"10.1021\/acs.jafc.0c05834","article-title":"Exposure to perfluorooctanoic acid induces cognitive deficits via altering gut microbiota composition, impairing intestinal barrier integrity, and causing inflammation in gut and brain","volume":"68","author":"Shi","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.envres.2022.115188_bib91","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mrrev.2017.08.003","article-title":"Inflammation and the chemical carcinogen benzo[a]pyrene: partners in crime","volume":"774","author":"Shi","year":"2017","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envres.2022.115188_bib92","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.toxlet.2012.01.014","article-title":"Perfluorooctanoic acid induces mast cell-mediated allergic inflammation by the release of histamine and inflammatory mediators","volume":"210","author":"Singh","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envres.2022.115188_bib93","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1289\/ehp.1509912","article-title":"Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis","volume":"124","author":"Smith","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2022.115188_bib94","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/tox.20459","article-title":"Perfluorooctanoic acid alters T lymphocyte phenotypes and cytokine expression in mice","volume":"24","author":"Son","year":"2008","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envres.2022.115188_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2019.104656","article-title":"Per- and polyfluoroalkyl substances (PFASs) modify lung surfactant function and pro-inflammatory responses in human bronchial epithelial cells","volume":"62","author":"Sorli","year":"2020","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.envres.2022.115188_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110690","article-title":"PFAS and cancer, a scoping review of the epidemiologic evidence","volume":"194","author":"Steenland","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2022.115188_bib97","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/pr.2015.213","article-title":"Perfluoroalkyl and polyfluoroalkyl substances and indicators of immune function in children aged 12-19 y: National Health and Nutrition Examination Survey","volume":"79","author":"Stein","year":"2016","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.envres.2022.115188_bib98","series-title":"SysRev","year":"2018"},{"key":"10.1016\/j.envres.2022.115188_bib99","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s40572-020-00279-0","article-title":"Perfluoroalkyl substances (PFAS) and their effects on the placenta, pregnancy, and child development: a potential mechanistic role for placental peroxisome proliferator-activated receptors (PPARs)","volume":"7","author":"Szilagyi","year":"2020","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.envres.2022.115188_bib100","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17051668","article-title":"Application of the key characteristics of carcinogens to per and polyfluoroalkyl substances","volume":"17","author":"Temkin","year":"2020","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envres.2022.115188_bib101","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12929-019-0558-1","article-title":"Regulatory mechanisms of B cell responses and the implication in B cell-related diseases","volume":"26","author":"Tsai","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.envres.2022.115188_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2019.108628","article-title":"Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation","volume":"127","author":"Wang","year":"2020","journal-title":"Food Res. Int."},{"key":"10.1016\/j.envres.2022.115188_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110590","article-title":"Intestinal environmental disorders associate with the tissue damages induced by perfluorooctane sulfonate exposure","volume":"197","author":"Wang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2022.115188_bib104","doi-asserted-by":"crossref","first-page":"12850","DOI":"10.1021\/acs.est.0c01877","article-title":"Temporal trends in prenatal exposure (1998-2018) to emerging and legacy per- and polyfluoroalkyl substances (PFASs) in cord plasma from the beijing cord blood bank, China","volume":"54","author":"Wang","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2022.115188_bib105","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.toxlet.2011.04.029","article-title":"Modulation of dietary fat on the toxicological effects in thymus and spleen in BALB\/c mice exposed to perfluorooctane sulfonate","volume":"204","author":"Wang","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envres.2022.115188_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115655","article-title":"Autophagy mediates perfluorooctanoic acid-induced lipid metabolism disorder and NLRP3 inflammasome activation in hepatocytes","volume":"267","author":"Weng","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2022.115188_bib107","series-title":"Guidance for Immunotoxicity Risk Assessment for Chemicals","year":"2012"},{"key":"10.1016\/j.envres.2022.115188_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.05.065","article-title":"Systematic evidence maps as a novel tool to support evidence-based decision-making in chemicals policy and risk management","volume":"130","author":"Wolffe","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2022.115188_bib109","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3390\/toxics9050100","article-title":"Immunotoxicity of per- and polyfluoroalkyl substances: insights into short-chain PFAS exposure","volume":"9","author":"Woodlief","year":"2021","journal-title":"Toxics"},{"key":"10.1016\/j.envres.2022.115188_bib110","article-title":"Involvement of oxidative stress and inflammation in liver injury caused by perfluorooctanoic acid exposure in mice","volume":"2014","author":"Yang","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.envres.2022.115188_bib113","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0006-2952(01)00752-3","article-title":"Further evidence for the involvement of inhibition of cell proliferation and development in thymic and splenic atrophy induced by the peroxisome proliferator perfluoroctanoic acid in mice","volume":"62","author":"Yang","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.envres.2022.115188_bib111","first-page":"157","volume":"vol. 22","author":"Yang","year":"2006"},{"key":"10.1016\/j.envres.2022.115188_bib112","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.chemosphere.2010.06.028","article-title":"Perfluorooctanoic acid induces peroxisomal fatty acid oxidation and cytokine expression in the liver of male Japanese medaka (Oryzias latipes)","volume":"81","author":"Yang","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2022.115188_bib115","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jhazmat.2014.08.043","article-title":"The role of interleukin family in perfluorooctanoic acid (PFOA)-induced immunotoxicity","volume":"280","author":"Zhang","year":"2014","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envres.2022.115188_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115535","article-title":"Effects of gestational exposure to perfluorooctane sulfonate on the lung development of offspring rats","volume":"272","author":"Zhang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2022.115188_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2020.108736","article-title":"Transcriptome analysis of acute exposure of the Manila clam, Ruditapes philippinarum to perfluorooctane sulfonate (PFOS)","volume":"231","author":"Zhang","year":"2020","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.envres.2022.115188_bib114","first-page":"995","article-title":"Perfluorooctanesulfonate (PFOS) induces apoptosis signaling and proteolysis in human lymphocytes through ROS mediated mitochondrial dysfunction and lysosomal membrane labialization","volume":"17","author":"Zarei","year":"2017","journal-title":"Iran. J. Pharm. Res. (IJPR)."},{"key":"10.1016\/j.envres.2022.115188_bib118","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3109\/1547691X.2012.691123","article-title":"Mechanism of perfluorooctanesulfonate (PFOS)-induced apoptosis in the immunocyte","volume":"10","author":"Zhang","year":"2013","journal-title":"J. Immunot."},{"key":"10.1016\/j.envres.2022.115188_bib119","doi-asserted-by":"crossref","first-page":"7510","DOI":"10.1021\/acs.est.0c06978","article-title":"Per- and polyfluoroalkyl substances (PFAS) in breast milk: concerning trends for current-use PFAS","volume":"55","author":"Zheng","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2022.115188_bib120","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00204-008-0361-3","article-title":"Immunotoxic changes associated with a 7-day oral exposure to perfluorooctanesulfonate (PFOS) in adult male C57BL\/6 mice","volume":"83","author":"Zheng","year":"2009","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envres.2022.115188_bib121","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091509","article-title":"Testosterone-mediated endocrine function and TH1\/TH2 cytokine balance after prenatal exposure to perfluorooctane sulfonate: by sex status","volume":"17","author":"Zhong","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2022.115188_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126200","article-title":"Mechanism of immunosuppression in zebrafish (Danio rerio) spleen induced by environmentally relevant concentrations of perfluorooctanoic acid","volume":"249","author":"Zhong","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2022.115188_bib123","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.envres.2017.08.005","article-title":"Perfluoroalkyl substance exposure and urine CC16 levels among asthmatics: a case-control study of children","volume":"159","author":"Zhou","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2022.115188_bib124","first-page":"481","article-title":"[Effects of PFOS on inflammatory factors in human placental trophoblast cells]","volume":"38","author":"Zhu","year":"2020","journal-title":"Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi"}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935122025154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935122025154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T02:59:13Z","timestamp":1762138753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935122025154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":120,"alternative-id":["S0013935122025154"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2022.115188","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A systematic evidence map of chronic inflammation and immunosuppression related to per- and polyfluoroalkyl substance (PFAS) exposure","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2022.115188","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115188"}}