{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:04:55Z","timestamp":1787731495440,"version":"build-2784847793"},"reference-count":178,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.envres.2023.115771","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T12:07:57Z","timestamp":1679659677000},"page":"115771","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Therapeutic potential of marine peptides in malignant melanoma"],"prefix":"10.1016","volume":"227","author":[{"given":"Salman","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqas","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalaf F.","family":"Alsharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Aschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-5214","authenticated-orcid":false,"given":"Fuad M.","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-8706","authenticated-orcid":false,"given":"Luciano","family":"Saso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1736-4404","authenticated-orcid":false,"given":"Haroon","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2023.115771_bib1","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s11172-019-2616-y","article-title":"Metallatranes and hydrometallatranes: their immunotropic and antitumor properties","volume":"68","author":"Adamovich","year":"2019","journal-title":"Russ. Chem. Bull."},{"issue":"6","key":"10.1016\/j.envres.2023.115771_bib2","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.3390\/ijms21061939","article-title":"Cold atmospheric plasma and silymarin nanoemulsion activate autophagy in human melanoma cells","volume":"21","author":"Adhikari","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.envres.2023.115771_bib3","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3390\/biom9110735","article-title":"Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements","volume":"9","author":"Aggarwal","year":"2019","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib4","article-title":"Exploring marine as a rich source of bioactive peptides: challenges and opportunities from marine pharmacology","volume":"20","author":"Ahmed","year":"2022","journal-title":"Marine Drugs [Internet]"},{"issue":"8","key":"10.1016\/j.envres.2023.115771_bib5","article-title":"Therapeutic potential of marine peptides in prostate cancer: mechanistic insights","volume":"20","author":"Ahmed","year":"2022","journal-title":"Marine Drugs [Internet]"},{"issue":"Suppl. 1","key":"10.1016\/j.envres.2023.115771_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4161\/cbt.201","article-title":"Cyclin E and its low molecular weight forms in human cancer and as targets for cancer therapy","volume":"2","author":"Akli","year":"2003","journal-title":"Cancer Biol. Ther."},{"issue":"1","key":"10.1016\/j.envres.2023.115771_bib7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1476-4598-6-24","article-title":"The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention","volume":"6","author":"Alao","year":"2007","journal-title":"Mol. Cancer"},{"issue":"6","key":"10.1016\/j.envres.2023.115771_bib8","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.3390\/ijms19061690","article-title":"Pharmacological targeting of cell cycle, apoptotic and cell adhesion signaling pathways implicated in chemoresistance of cancer cells","volume":"19","author":"Alimbetov","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.envres.2023.115771_bib9","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1039\/C4NP00130C","article-title":"Natural products with therapeutic potential in melanoma metastasis","volume":"32","author":"AlQathama","year":"2015","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.envres.2023.115771_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108301","article-title":"Targeting the epigenome in malignant melanoma: facts, challenges and therapeutic promises","volume":"240","author":"Anestopoulos","year":"2022","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.envres.2023.115771_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2011.00034","article-title":"Born to be alive: a role for the BCL-2 family in melanoma tumor cell survival, apoptosis, and treatment","volume":"1","author":"Anvekar","year":"2011","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib12","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/eji.201142011","article-title":"Enhanced structural stability of Concholepas hemocyanin increases its immunogenicity and maintains its non-specific immunostimulatory effects","volume":"42","author":"Arancibia","year":"2012","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.envres.2023.115771_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087240","article-title":"A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata promotes potent anti-tumor activity in melanoma","volume":"9","author":"Arancibia","year":"2014","journal-title":"PLoS One"},{"issue":"35","key":"10.1016\/j.envres.2023.115771_bib14","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.1200\/JCO.2008.17.5448","volume":"26","author":"Atkins","year":"2008","journal-title":"J. Clin. Oncol."},{"issue":"28","key":"10.1016\/j.envres.2023.115771_bib15","doi-asserted-by":"crossref","first-page":"17141","DOI":"10.1016\/S0021-9258(17)44880-0","article-title":"Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites","volume":"265","author":"Bai","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.envres.2023.115771_bib16","doi-asserted-by":"crossref","first-page":"348","DOI":"10.20892\/j.issn.2095-3941.2017.0033","article-title":"Cell cycle regulation and anticancer drug discovery","volume":"14","author":"Bai","year":"2017","journal-title":"Cancer biology & medicine"},{"issue":"12","key":"10.1016\/j.envres.2023.115771_bib17","article-title":"Marine anticancer agents: an overview with a particular focus on their chemical classes","volume":"18","author":"Barreca","year":"2020","journal-title":"Marine Drugs [Internet]"},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/bcp.13126","article-title":"Microtubule destabilising agents: far more than just antimitotic anticancer drugs","volume":"83","author":"Bates","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"15","key":"10.1016\/j.envres.2023.115771_bib19","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1016\/S0040-4039(99)00393-7","article-title":"Sansalvamide: a new cytotoxic cyclic depsipeptide produced by a marine fungus of the genus Fusarium","volume":"40","author":"Belofsky","year":"1999","journal-title":"Tetrahedron Lett."},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib20","doi-asserted-by":"crossref","first-page":"E378","DOI":"10.1208\/aapsj0903045","article-title":"Pharmacokinetics in mice implanted with xenografted tumors after intravenous administration of tasidotin (ILX651) or its carboxylate metabolite","volume":"9","author":"Bonate","year":"2007","journal-title":"AAPS J."},{"issue":"6","key":"10.1016\/j.envres.2023.115771_bib21","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1021\/jm061307x","article-title":"Total structure and inhibition of tumor cell proliferation of laxaphycins","volume":"50","author":"Bonnard","year":"2007","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.envres.2023.115771_bib22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3390\/pharmaceutics11040151","article-title":"Synthesis and biological evaluation of RGD\u2013cryptophycin conjugates for targeted drug delivery","volume":"11","author":"Borb\u00e9ly","year":"2019","journal-title":"Pharmaceutics"},{"issue":"33","key":"10.1016\/j.envres.2023.115771_bib23","doi-asserted-by":"crossref","first-page":"11219","DOI":"10.1021\/ja8033763","article-title":"Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor","volume":"130","author":"Bowers","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.envres.2023.115771_bib24","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.ejmech.2017.11.062","article-title":"Recent advances in microtubule-stabilizing agents","volume":"143","author":"Cao","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"10.1016\/j.envres.2023.115771_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2020.151075","article-title":"Microtubule-targeting agents and their impact on cancer treatment","volume":"99","author":"\u010cerm\u00e1k","year":"2020","journal-title":"Eur. J. Cell Biol."},{"issue":"12","key":"10.1016\/j.envres.2023.115771_bib26","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1021\/jf073399k","article-title":"In vitro antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enriched spirulina platensis","volume":"56","author":"Chen","year":"2008","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"10.1016\/j.envres.2023.115771_bib27","first-page":"2434","article-title":"RGD-tachyplesin inhibits tumor Growth 1","volume":"61","author":"Chen","year":"2001","journal-title":"Cancer Res."},{"issue":"20","key":"10.1016\/j.envres.2023.115771_bib28","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1021\/ol035476c","article-title":"A new cytotoxic and tubulin-interactive milnamide derivative from a marine sponge cymbastela sp","volume":"5","author":"Chevallier","year":"2003","journal-title":"Org. Lett."},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib29","doi-asserted-by":"crossref","first-page":"678","DOI":"10.3892\/ijo.2020.5099","article-title":"Anticancer peptide: physicochemical property, functional aspect and trend in clinical application","volume":"57","author":"Chiangjong","year":"2020","journal-title":"Int. J. Oncol."},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib30","doi-asserted-by":"crossref","first-page":"678","DOI":"10.3892\/ijo.2020.5099","article-title":"Anticancer peptide: physicochemical property, functional aspect and trend in clinical application (Review)","volume":"57","author":"Chiangjong","year":"2020","journal-title":"Int. J. Oncol."},{"issue":"8","key":"10.1016\/j.envres.2023.115771_bib31","doi-asserted-by":"crossref","first-page":"11679","DOI":"10.3390\/molecules190811679","article-title":"Review of natural compounds for potential skin cancer treatment","volume":"19","author":"Chinembiri","year":"2014","journal-title":"Molecules [Internet]"},{"key":"10.1016\/j.envres.2023.115771_bib32","series-title":"Cell Division Machinery and Disease","first-page":"93","article-title":"The elephant in the room: the role of microtubules in cancer","author":"Cirillo","year":"2017"},{"issue":"Suppl. 1","key":"10.1016\/j.envres.2023.115771_bib33","article-title":"Epidemiology and risk factors of melanoma: a review","volume":"11","author":"Conforti","year":"2021","journal-title":"Dermatol. Pract. Concept."},{"key":"10.1016\/j.envres.2023.115771_bib34","first-page":"1","article-title":"How can we improve peptide drug discovery? Learning from the past","author":"Craik","year":"2021","journal-title":"Expet Opin. Drug Discov."},{"issue":"5","key":"10.1016\/j.envres.2023.115771_bib35","first-page":"1796","article-title":"Biochemical and cellular effects of didemnins A and B","volume":"44","author":"Crampton","year":"1984","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.envres.2023.115771_bib36","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1021\/jo00090a008","article-title":"Milnamide A, an unusual cytotoxic tripeptide from the marine sponge Auletta cf. constricta","volume":"59","author":"Crews","year":"1994","journal-title":"J. Org. Chem."},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib37","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0031-9422(00)00280-6","article-title":"A cytotoxic cyclic depsipeptide from a marine fungus of the genus Fusarium","volume":"55","author":"Cueto","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.envres.2023.115771_bib38","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.tifs.2021.08.017","article-title":"Bioactive peptides derived from marine sources: biological and functional properties","volume":"119","author":"Cunha","year":"2022","journal-title":"Trends Food Sci. Technol."},{"issue":"28","key":"10.1016\/j.envres.2023.115771_bib39","doi-asserted-by":"crossref","first-page":"9589","DOI":"10.1016\/0040-4020(96)00496-6","article-title":"Callipeltins B and C; bioactive peptides from a marine Lithistida sponge Callipelta sp","volume":"52","author":"D'Auria","year":"1996","journal-title":"Tetrahedron"},{"key":"10.1016\/j.envres.2023.115771_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2020.614766","article-title":"Exploring the diversity of the marine environment for new anti-cancer compounds","volume":"7","author":"Dayanidhi","year":"2021","journal-title":"Front. Mar. Sci."},{"issue":"6","key":"10.1016\/j.envres.2023.115771_bib41","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/bjc.1998.570","article-title":"In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells","volume":"78","author":"Depenbrock","year":"1998","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.envres.2023.115771_bib42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2147\/ITT.S134842","article-title":"Melanoma treatment in review","volume":"7","author":"Domingues","year":"2018","journal-title":"ImmunoTargets Ther."},{"issue":"8","key":"10.1016\/j.envres.2023.115771_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27082585","article-title":"Recent advances in the antiproliferative and proapoptotic activity of various plant extracts and constituents against murine malignant melanoma","volume":"27","author":"Dumitra\u0219","year":"2022","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.envres.2023.115771_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/md18010020","article-title":"Marine compounds and cancer: the first two decades of XXI century","volume":"18","author":"Dyshlovoy","year":"2020","journal-title":"Mar. Drugs"},{"issue":"14_Suppl. l","key":"10.1016\/j.envres.2023.115771_bib45","doi-asserted-by":"crossref","first-page":"7530","DOI":"10.1200\/jco.2004.22.90140.7530","article-title":"Phase II study of synthadotin (SYN-D; ILX651) administered daily for 5 consecutive days once every 3 weeks (qdx5q3w) in patients (Pts) with inoperable locally advanced or metastatic melanoma","volume":"22","author":"Ebbinghaus","year":"2004","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.envres.2023.115771_bib46","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0006-2952(01)00898-X","article-title":"Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10","volume":"63","author":"Edler","year":"2002","journal-title":"Biochem. Pharmacol."},{"issue":"30","key":"10.1016\/j.envres.2023.115771_bib47","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1200\/JCO.2012.47.9303","article-title":"Adjuvant ganglioside GM2-KLH\/QS-21 vaccination versus observation after resection of primary tumor> 1.5 mm in patients with stage II melanoma: results of the EORTC 18961 randomized phase III trial","volume":"31","author":"Eggermont","year":"2013","journal-title":"J. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib48","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/CMR.0b013e32832bbde6","article-title":"Phase II study of biweekly plitidepsin as second-line therapy in patients with advanced malignant melanoma","volume":"19","author":"Eisen","year":"2009","journal-title":"Melanoma Res."},{"issue":"10","key":"10.1016\/j.envres.2023.115771_bib49","article-title":"Marine compounds, mitochondria, and malignancy: a therapeutic nexus","volume":"20","author":"Fakhri","year":"2022","journal-title":"Marine Drugs [Internet]"},{"key":"10.1016\/j.envres.2023.115771_bib50","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/690916","article-title":"Stabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option?","volume":"2015","author":"Fanale","year":"2015","journal-title":"Anal. Cell Pathol."},{"issue":"8","key":"10.1016\/j.envres.2023.115771_bib51","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/S0968-0896(99)00089-9","article-title":"Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges","volume":"7","author":"Gamble","year":"1999","journal-title":"Bioorg. Med. Chem."},{"issue":"9","key":"10.1016\/j.envres.2023.115771_bib52","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/sj.cdd.4401950","article-title":"Mechanisms of cytochrome c release from mitochondria","volume":"13","author":"Garrido","year":"2006","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib53","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF01954842","article-title":"Novel cytotoxic peptides from the tropical marine cyanobacteriumHormothamnion enteromorphoides 1. Discovery, isolation and initial chemical and biological characterization of the hormothamnins from wild and cultured material","volume":"45","author":"Gerwick","year":"1989","journal-title":"Experientia"},{"issue":"1","key":"10.1016\/j.envres.2023.115771_bib54","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/md18010051","article-title":"Isolation and characterization of antimicrobial peptides with unusual disulfide connectivity from the colonial ascidian synoicum turgens","volume":"18","author":"Hansen","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.envres.2023.115771_bib55","doi-asserted-by":"crossref","unstructured":"Helmbach H, Sinha P, Schadendorf D, editors. Human Melanoma: Drug Resistance 2003; Berlin, Heidelberg: Springer Berlin Heidelberg.","DOI":"10.1007\/978-3-642-19022-3_9"},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib56","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1023\/A:1006110431250","article-title":"A phase II study of Didemnin B (NSC 325319) in advanced malignant melanoma: an Eastern Cooperative Oncology Group study (PB687)","volume":"16","author":"Hochster","year":"1998","journal-title":"Invest. N. Drugs"},{"issue":"4","key":"10.1016\/j.envres.2023.115771_bib57","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1021\/np010560r","article-title":"Malevamide D: isolation and structure determination of an isodolastatin H analogue from the marine cyanobacterium symploca hydnoides","volume":"65","author":"Horgen","year":"2002","journal-title":"J. Nat. Prod."},{"issue":"6","key":"10.1016\/j.envres.2023.115771_bib58","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/s42255-022-00585-x","article-title":"The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages","volume":"4","author":"Hu","year":"2022","journal-title":"Nature Metabolism"},{"issue":"11","key":"10.1016\/j.envres.2023.115771_bib59","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1021\/acs.molpharmaceut.6b00564","article-title":"Structure determinants of lagunamide A for anticancer activity and its molecular mechanism of mitochondrial apoptosis","volume":"13","author":"Huang","year":"2016","journal-title":"Mol. Pharm."},{"issue":"5","key":"10.1016\/j.envres.2023.115771_bib60","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s12223-010-0087-5","article-title":"Antitumor activity of N-acetyl-d-glucosamine-substituted glycoconjugates and combined therapy with keyhole limpet hemocyanin in B16F10 mouse melanoma model","volume":"55","author":"Hul\u00edkov\u00e1","year":"2010","journal-title":"Folia Microbiol."},{"key":"10.1016\/j.envres.2023.115771_bib61","series-title":"Human Skin Cancers","first-page":"87","article-title":"The modern approach to targeting melanoma","author":"Jane","year":"2018"},{"issue":"6","key":"10.1016\/j.envres.2023.115771_bib62","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1007\/s11033-020-05435-1","article-title":"Role of PI3K\/AKT pathway in cancer: the framework of malignant behavior","volume":"47","author":"Jiang","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.envres.2023.115771_bib63","article-title":"The significant role of the microfilament system in tumors","volume":"11","author":"Jiang","year":"2021","journal-title":"Front. Oncol."},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib64","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1021\/np000462q","article-title":"New lipopeptides from the caribbean cyanobacterium lyngbya majuscula","volume":"64","author":"Jim\u00e9nez","year":"2001","journal-title":"J. Nat. Prod."},{"issue":"1","key":"10.1016\/j.envres.2023.115771_bib65","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41597-022-01564-3","article-title":"Fives: a fundus image dataset for artificial Intelligence based vessel segmentation","volume":"9","author":"Jin","year":"2022","journal-title":"Sci. Data"},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib66","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1021\/jm00106a002","article-title":"Antineoplastic activity of didemnin congeners: nordidemnin and modified chain analogs","volume":"34","author":"Jouin","year":"1991","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.envres.2023.115771_bib67","first-page":"326","article-title":"Chemotherapy resistance mechanisms in advanced skin cancer","volume":"11","author":"Kalal","year":"2017","journal-title":"Oncology reviews"},{"key":"10.1016\/j.envres.2023.115771_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113252","article-title":"A critical review on the use of potentiometric based biosensors for biomarkers detection","volume":"184","author":"Karimi-Maleh","year":"2021","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib69","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1021\/acs.iecr.0c04698","article-title":"Guanine-based DNA biosensor amplified with Pt\/SWCNTs nanocomposite as analytical tool for nanomolar determination of daunorubicin as an anticancer drug: a docking\/experimental investigation","volume":"60","author":"Karimi-Maleh","year":"2021","journal-title":"Ind. Eng. Chem. Res."},{"key":"10.1016\/j.envres.2023.115771_bib70","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.dnarep.2016.04.008","article-title":"Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage","volume":"42","author":"Karimian","year":"2016","journal-title":"DNA Repair"},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib71","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1349-7006.1997.tb00383.x","article-title":"Antitumor activity of TZT-1027, a novel doiastatin 10 derivative","volume":"88","author":"Kobayashi","year":"1997","journal-title":"Jpn. J. Cancer Res."},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib72","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nrc2998","article-title":"DNA polymerases and cancer","volume":"11","author":"Lange","year":"2011","journal-title":"Nat. Rev. Cancer"},{"issue":"42","key":"10.1016\/j.envres.2023.115771_bib73","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1200\/EDBK_351153","article-title":"Current state of adjuvant therapy for melanoma: less is more, or more is better?","author":"Lao","year":"2022","journal-title":"American Society of Clinical Oncology Educational Book"},{"issue":"13","key":"10.1016\/j.envres.2023.115771_bib74","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.2094","article-title":"ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells","volume":"5","author":"Lee","year":"2014","journal-title":"Oncotarget"},{"issue":"7","key":"10.1016\/j.envres.2023.115771_bib75","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.3390\/ijms18071508","article-title":"Cudraflavone C induces apoptosis of A375.S2 melanoma cells through mitochondrial ROS production and MAPK activation","volume":"18","author":"Lee","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.envres.2023.115771_bib76","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.3390\/ijms20102383","article-title":"A comprehensive review on current advances in peptide drug development and design","volume":"20","author":"Lee","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2023.115771_bib77","article-title":"The roles of histone deacetylases and their inhibitors in cancer therapy","volume":"8","author":"Li","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib78","first-page":"291","article-title":"Natural bioactive cyclopeptides from microbes as promising anticancer drug leads: a mini-review","volume":"32","author":"Linda","year":"2021","journal-title":"Indones. J. Pharm."},{"issue":"16","key":"10.1016\/j.envres.2023.115771_bib79","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1158\/1078-0432.CCR-10-1948","article-title":"PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the akt\/mTOR signaling pathway, and activation of death-associated protein KinasePM02734-induced dell death is associated with autophagy","volume":"17","author":"Ling","year":"2011","journal-title":"Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.envres.2023.115771_bib80","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1021\/jm048952t","article-title":"N-methylsansalvamide A peptide analogues. Potent new antitumor agents","volume":"48","author":"Liu","year":"2005","journal-title":"J. Med. Chem."},{"issue":"6","key":"10.1016\/j.envres.2023.115771_bib81","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s13238-010-0072-4","article-title":"Effect of themicrobial lipopeptide on tumor cell lines: apoptosis induced by disturbing the fatty acid composition of cell membrane","volume":"1","author":"Liu","year":"2010","journal-title":"Protein & Cell"},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib82","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.3892\/ol.2015.4025","article-title":"Novel cyclic pentapeptide H-15 induces differentiation and inhibits proliferation in murine melanoma B16 cells","volume":"11","author":"Liu","year":"2016","journal-title":"Oncol. Lett."},{"issue":"8","key":"10.1016\/j.envres.2023.115771_bib83","first-page":"1838","article-title":"HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo","volume":"63","author":"Loganzo","year":"2003","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.envres.2023.115771_bib84","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/s41467-022-28741-7","article-title":"Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer","volume":"13","author":"Lopez","year":"2022","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.envres.2023.115771_bib85","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s00018-019-03351-7","article-title":"Tumor angiogenesis: causes, consequences, challenges and opportunities","volume":"77","author":"Lugano","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib86","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1021\/np049725x","article-title":"Lajollamycin, a nitro-tetraene spiro-\u03b2-lactone-\u03b3-lactam antibiotic from the marine actinomycete streptomyces nodosus","volume":"68","author":"Manam","year":"2005","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.envres.2023.115771_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175330","article-title":"Potential role of Marine Bioactive Compounds in cancer signaling pathways: a review","volume":"936","author":"Manoharan","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.envres.2023.115771_bib88","series-title":"Immune Response Activation","article-title":"Mollusk hemocyanins as natural immunostimulants in biomedical applications","author":"Mar\u00eda In\u00e9s","year":"2014"},{"issue":"6","key":"10.1016\/j.envres.2023.115771_bib89","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1021\/np0106283","article-title":"Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly","volume":"65","author":"Marquez","year":"2002","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.envres.2023.115771_bib90","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.ejca.2008.12.005","article-title":"Phase II study of weekly Kahalalide F in patients with advanced malignant melanoma","volume":"45","author":"Mart\u00edn-Algarra","year":"2009","journal-title":"Eur. J. Cancer"},{"issue":"49","key":"10.1016\/j.envres.2023.115771_bib91","doi-asserted-by":"crossref","first-page":"6384","DOI":"10.1016\/j.tetlet.2010.06.105","article-title":"Lyngbyacyclamides A and B, novel cytotoxic peptides from marine cyanobacteria Lyngbya sp","volume":"51","author":"Maru","year":"2010","journal-title":"Tetrahedron Lett."},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib92","doi-asserted-by":"crossref","first-page":"553","DOI":"10.13005\/bpj\/2396","article-title":"The DNA-topoisomerase inhibitors in cancer therapy","volume":"15","author":"Mastrangelo","year":"2022","journal-title":"Biomedical and Pharmacology Journal"},{"issue":"4","key":"10.1016\/j.envres.2023.115771_bib93","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/ja.2007.30","article-title":"Urukthapelstatin A, a novel cytotoxic substance from marine-derived mechercharimyces asporophorigenens YM11-542","volume":"60","author":"Matsuo","year":"2007","journal-title":"J. Antibiot."},{"issue":"1","key":"10.1016\/j.envres.2023.115771_bib94","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/1568009043481669","article-title":"A dual role of cyclin E in cell proliferation and apotosis may provide a target for cancer therapy","volume":"4","author":"Mazumder","year":"2004","journal-title":"Curr. Cancer Drug Targets"},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib95","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.amjsurg.2006.09.009","article-title":"Keyhole limpet hemocyanin potentiates standard immunotherapy for melanoma","volume":"193","author":"McFadden","year":"2007","journal-title":"Am. J. Surg."},{"issue":"20","key":"10.1016\/j.envres.2023.115771_bib96","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1021\/ja801383f","article-title":"Coibamide A, a potent antiproliferative cyclic depsipeptide from the Panamanian marine cyanobacterium leptolyngbya sp","volume":"130","author":"Medina","year":"2008","journal-title":"J. Am. Chem. Soc."},{"issue":"8_Suppl. ment","key":"10.1016\/j.envres.2023.115771_bib97","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1158\/1538-7445.AM2012-481","article-title":"Abstract 481: the role of jaspamide in the actin cytoskeleton of melanoma cells: the relation between migration and invasion","volume":"72","author":"Menezes","year":"2012","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.envres.2023.115771_bib98","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144241","article-title":"Investigation of FOXM1 as a potential new target for melanoma","volume":"10","author":"Miyashita","year":"2015","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.envres.2023.115771_bib99","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810284","article-title":"Marine compounds for melanoma treatment and prevention","volume":"23","author":"Montuori","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib100","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/(SICI)1097-0215(19971104)73:3<440::AID-IJC20>3.0.CO;2-F","article-title":"Induction of apoptosis by cryptophycin 1, a new antimicrotubule agent","volume":"73","author":"Mooberry","year":"1997","journal-title":"Int. J. Cancer"},{"issue":"4","key":"10.1016\/j.envres.2023.115771_bib101","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/ijc.10982","article-title":"The molecular pharmacology of symplostatin 1: a new antimitotic dolastatin 10 analog","volume":"104","author":"Mooberry","year":"2003","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib102","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1124\/jpet.107.132662","article-title":"Plitidepsin has a dual effect inhibiting cell cycle and inducing apoptosis via rac1\/c-jun NH2-terminal kinase activation in human melanoma cells","volume":"324","author":"Mu\u00f1oz-Alonso","year":"2008","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"4","key":"10.1016\/j.envres.2023.115771_bib103","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41573-020-00135-8","article-title":"Trends in peptide drug discovery","volume":"20","author":"Muttenthaler","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"8","key":"10.1016\/j.envres.2023.115771_bib104","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1021\/np049949f","article-title":"Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk philinopsis speciosa","volume":"67","author":"Nakao","year":"2004","journal-title":"J. Nat. Prod."},{"issue":"14","key":"10.1016\/j.envres.2023.115771_bib105","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1021\/jm070381s","article-title":"Antitumor activity, X-ray crystal structure, and DNA binding properties of thiocoraline A, a natural bisintercalating thiodepsipeptide","volume":"50","author":"Negri","year":"2007","journal-title":"J. Med. Chem."},{"issue":"8","key":"10.1016\/j.envres.2023.115771_bib106","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1021\/np040031y","article-title":"Marine natural products and related compounds in clinical and advanced preclinical trials","volume":"67","author":"Newman","year":"2004","journal-title":"J. Nat. Prod."},{"issue":"5","key":"10.1016\/j.envres.2023.115771_bib107","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2217\/imt.11.45","article-title":"Immunomodulatory cytokines as therapeutic agents for melanoma","volume":"3","author":"Nicholas","year":"2011","journal-title":"Immunotherapy"},{"issue":"48","key":"10.1016\/j.envres.2023.115771_bib108","doi-asserted-by":"crossref","first-page":"8625","DOI":"10.1016\/j.tetlet.2006.08.113","article-title":"Zygosporamide, a cytotoxic cyclic depsipeptide from the marine-derived fungus Zygosporium masonii","volume":"47","author":"Oh","year":"2006","journal-title":"Tetrahedron Lett."},{"issue":"8","key":"10.1016\/j.envres.2023.115771_bib109","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.procbio.2015.05.007","article-title":"A novel peptide purified from the fermented microalga Pavlova lutheri attenuates oxidative stress and melanogenesis in B16F10 melanoma cells","volume":"50","author":"Oh","year":"2015","journal-title":"Process Biochem."},{"issue":"16","key":"10.1016\/j.envres.2023.115771_bib110","doi-asserted-by":"crossref","first-page":"9313","DOI":"10.1073\/pnas.95.16.9313","article-title":"Antiproliferative mechanism of action of cryptophycin-52: kinetic stabilization of microtubule dynamics by high-affinity binding to microtubule ends","volume":"95","author":"Panda","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.envres.2023.115771_bib111","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1158\/1078-0432.CCR-07-4366","article-title":"Phase I clinical and pharmacokinetic study of kahalalide F administered weekly as a 1-hour infusion to patients with advanced solid tumors","volume":"14","author":"Pardo","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.envres.2023.115771_bib112","first-page":"25","article-title":"Antioxidant potential of C-phycocyanin isolated from cyanobacterial species Lyngbya, Phormidium and Spirulina spp","volume":"43","author":"Patel","year":"2006","journal-title":"Indian J. Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.envres.2023.115771_bib113","article-title":"Resistance to molecularly targeted therapies in melanoma","volume":"13","author":"Patel","year":"2021","journal-title":"Cancers [Internet]"},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib114","first-page":"373","article-title":"Dolastatin-10 induces polyploidy, telomeric associations and apoptosis in a murine melanoma cell line","volume":"5","author":"Pathak","year":"1998","journal-title":"Oncol. Rep."},{"issue":"22","key":"10.1016\/j.envres.2023.115771_bib115","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1021\/ja00256a070","article-title":"The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10","volume":"109","author":"Pettit","year":"1987","journal-title":"J. Am. Chem. Soc."},{"issue":"41","key":"10.1016\/j.envres.2023.115771_bib116","doi-asserted-by":"crossref","first-page":"9151","DOI":"10.1016\/0040-4020(93)80003-C","article-title":"Isolation of dolastatins 10\u201315 from the marine mollusc dolabella auricularia","volume":"49","author":"Pettit","year":"1993","journal-title":"Tetrahedron"},{"issue":"12","key":"10.1016\/j.envres.2023.115771_bib117","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1016\/S0960-894X(01)80781-2","article-title":"Isolation and structure of phakellistatin 2 from the eastern indian ocean marine sponge phakellia carteri","volume":"3","author":"Pettit","year":"1993","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"22","key":"10.1016\/j.envres.2023.115771_bib118","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1016\/S0960-894X(01)80695-8","article-title":"Antineoplastic agents 323. Isolation and structure of phakellistatin 6 from a Chuuk archipelago marine sponge","volume":"4","author":"Pettit","year":"1994","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"17","key":"10.1016\/j.envres.2023.115771_bib119","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/S0960-894X(01)80108-6","article-title":"Antineoplastic agents 315. Isolation and structure of the marine sponge cancer cell growth inhibitor phakellistatin 5","volume":"4","author":"Pettit","year":"1994","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib120","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3987\/COM-94-S45","article-title":"Isolation and structure of the human cancer cell growth inhibitory phakellistatin 4 from the western Pacific sponge Phakellia costata","volume":"40","author":"Pettit","year":"1995","journal-title":"Heterocycles"},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib121","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1021\/np700738k","article-title":"Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms","volume":"71","author":"Pettit","year":"2008","journal-title":"J. Nat. Prod."},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib122","article-title":"Apoptosis: a target for anticancer therapy","volume":"19","author":"Pfeffer","year":"2018","journal-title":"International Journal of Molecular Sciences [Internet]"},{"key":"10.1016\/j.envres.2023.115771_bib123","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.csbj.2019.12.013","article-title":"The genomics of oxidative DNA damage, repair, and resulting mutagenesis","volume":"18","author":"Poetsch","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.envres.2023.115771_bib124","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.571237","article-title":"New insights into targeting membrane lipids for cancer therapy","volume":"8","author":"Preta","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib125","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.3390\/md13031432","article-title":"A new cyclic hexapeptide and a new isocoumarin derivative from the marine sponge-associated fungus Aspergillus similanensis KUFA 0013","volume":"13","author":"Prompanya","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.envres.2023.115771_bib126","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.3389\/fonc.2019.01370","article-title":"Role of matrix metalloproteinases in angiogenesis and cancer","volume":"9","author":"Quintero-Fabi\u00e1n","year":"2019","journal-title":"Front. Oncol."},{"issue":"5","key":"10.1016\/j.envres.2023.115771_bib127","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/(SICI)1097-0215(20000301)85:5<659::AID-IJC11>3.0.CO;2-5","article-title":"Induction of antibodies against GD3 ganglioside in melanoma patients by vaccination with GD3-lactone-KLH conjugate plus immunological adjuvant QS-21","volume":"85","author":"Ragupathi","year":"2000","journal-title":"Int. J. Cancer"},{"issue":"14","key":"10.1016\/j.envres.2023.115771_bib128","first-page":"5214","article-title":"Consistent antibody response against ganglioside GD2 induced in patients with melanoma by a GD2 lactone-keyhole limpet hemocyanin conjugate vaccine plus immunological adjuvant QS-21","volume":"9","author":"Ragupathi","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.envres.2023.115771_bib129","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9235638","article-title":"Immunotherapy in the treatment of metastatic melanoma: current knowledge and future directions","volume":"2020","author":"Ralli","year":"2020","journal-title":"Journal of Immunology Research"},{"issue":"14","key":"10.1016\/j.envres.2023.115771_bib130","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.3390\/molecules27144428","article-title":"Cyclic peptides for the treatment of cancers: a review","volume":"27","author":"Ramadhani","year":"2022","journal-title":"Molecules [Internet]"},{"issue":"4","key":"10.1016\/j.envres.2023.115771_bib131","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1021\/np50118a020","article-title":"Patellamide F, a new cytotoxic cyclic peptide from the colonial ascidian lissoclinum patella","volume":"58","author":"Rashid","year":"1995","journal-title":"J. Nat. Prod."},{"issue":"12","key":"10.1016\/j.envres.2023.115771_bib132","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"1863","author":"Redza-Dutordoir","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"5","key":"10.1016\/j.envres.2023.115771_bib133","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.amjsurg.2007.08.005","article-title":"Keyhole limpet hemocyanin: an effective adjunct against melanoma in vivo","volume":"194","author":"Rizvi","year":"2007","journal-title":"Am. J. Surg."},{"issue":"24","key":"10.1016\/j.envres.2023.115771_bib134","article-title":"Apoptosis pathways triggered by a potent antiproliferative hybrid chalcone on human melanoma cells","volume":"22","author":"Rodr\u00edguez","year":"2021","journal-title":"International Journal of Molecular Sciences [Internet]"},{"issue":"9","key":"10.1016\/j.envres.2023.115771_bib135","doi-asserted-by":"crossref","first-page":"734","DOI":"10.7164\/antibiotics.50.734","article-title":"Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora I. Taxonomy, fermentation, isolation, and biological activities","volume":"50","author":"Romero","year":"1997","journal-title":"J. Antibiot."},{"issue":"1","key":"10.1016\/j.envres.2023.115771_bib136","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/19336918.2021.1934958","article-title":"Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells","volume":"15","author":"Roncato","year":"2021","journal-title":"Cell Adhes. Migrat."},{"issue":"43","key":"10.1016\/j.envres.2023.115771_bib137","doi-asserted-by":"crossref","first-page":"13203","DOI":"10.1016\/S0040-4020(98)00801-1","article-title":"Four new cytotoxic cyclic hexa- and heptapeptides from the marine ascidian Didemnum molle","volume":"54","author":"Rudi","year":"1998","journal-title":"Tetrahedron"},{"issue":"4","key":"10.1016\/j.envres.2023.115771_bib138","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1021\/np020531w","article-title":"Didmolamide A and B, two new cyclic hexapeptides from the marine ascidian didemnum molle","volume":"66","author":"Rudi","year":"2003","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.envres.2023.115771_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111091","article-title":"Marine-derived drugs: recent advances in cancer therapy and immune signaling","volume":"134","author":"Saeed","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.envres.2023.115771_bib140","article-title":"Epidemiology of melanoma","volume":"9","author":"Saginala","year":"2021","journal-title":"Med. Sci."},{"issue":"6","key":"10.1016\/j.envres.2023.115771_bib141","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3892\/or.2022.8432","article-title":"Melanoma metastasis: what role does melanin play? (Review)","volume":"48","author":"Saud","year":"2022","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.envres.2023.115771_bib142","doi-asserted-by":"crossref","first-page":"vi41","DOI":"10.1093\/annonc\/mdp253","article-title":"Immunotherapy of distant metastatic disease","volume":"20","author":"Schadendorf","year":"2009","journal-title":"Ann. Oncol."},{"issue":"24","key":"10.1016\/j.envres.2023.115771_bib143","doi-asserted-by":"crossref","first-page":"8924","DOI":"10.1158\/0008-5472.CAN-04-0324","article-title":"Microtubule-Dependent matrix metalloproteinase-2\/matrix metalloproteinase-9 exocytosis: prerequisite in human melanoma cell invasion","volume":"64","author":"Schnaeker","year":"2004","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib144","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3390\/md11030944","article-title":"Predictive factors of sensitivity to elisidepsin, a novel kahalalide F-derived marine compound","volume":"11","author":"Serova","year":"2013","journal-title":"Mar. Drugs"},{"issue":"1","key":"10.1016\/j.envres.2023.115771_bib145","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s10637-015-0303-x","article-title":"Coibamide A, a natural lariat depsipeptide, inhibits VEGFA\/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts","volume":"34","author":"Serrill","year":"2016","journal-title":"Invest. N. Drugs"},{"issue":"8","key":"10.1016\/j.envres.2023.115771_bib146","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.3390\/cancers11081178","article-title":"p21 in cancer research","volume":"11","author":"Shamloo","year":"2019","journal-title":"Cancers"},{"issue":"6","key":"10.1016\/j.envres.2023.115771_bib147","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/ijc.24005","article-title":"Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells","volume":"124","author":"Slominski","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.envres.2023.115771_bib148","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.842496","article-title":"Melanoma, melanin, and melanogenesis: the yin and yang relationship","volume":"12","author":"Slominski","year":"2022","journal-title":"Front. Oncol."},{"issue":"4","key":"10.1016\/j.envres.2023.115771_bib149","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1023\/A:1011194910571","article-title":"Activity of the dolastatin analogue, LU103793, in malignant melanoma","volume":"12","author":"Smyth","year":"2001","journal-title":"Ann. Oncol."},{"issue":"5","key":"10.1016\/j.envres.2023.115771_bib150","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.amjsurg.2005.07.008","article-title":"Inhibition of melanoma growth by hemocyanin occurs via early apoptotic pathways","volume":"190","author":"Somasundar","year":"2005","journal-title":"Am. J. Surg."},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib151","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00001813-199404000-00004","article-title":"Didemnin B in metastatic malignant melanoma: a phase II trial of the Southwest Oncology Group","volume":"5","author":"Sondak","year":"1994","journal-title":"Anti Cancer Drugs"},{"issue":"4","key":"10.1016\/j.envres.2023.115771_bib152","first-page":"271","article-title":"Apoptosis induced by topoisomerase inhibitors","volume":"3","author":"Sordet","year":"2003","journal-title":"Curr. Med. Chem.: Anti-Cancer Agents"},{"issue":"44","key":"10.1016\/j.envres.2023.115771_bib153","doi-asserted-by":"crossref","first-page":"6929","DOI":"10.1016\/j.tet.2016.09.016","article-title":"New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp","volume":"72","author":"Stierhof","year":"2016","journal-title":"Tetrahedron"},{"issue":"10","key":"10.1016\/j.envres.2023.115771_bib154","doi-asserted-by":"crossref","DOI":"10.3390\/cells10102509","article-title":"ERK: a double-edged sword in cancer. ERK-Dependent apoptosis as a potential therapeutic strategy for cancer","volume":"10","author":"Sugiura","year":"2021","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.envres.2023.115771_bib155","first-page":"809","article-title":"A new cyclotetrapeptide from marine fungus Trichoderma reesei","volume":"61","author":"Sun","year":"2006","journal-title":"Pharmazie"},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib156","first-page":"3052","article-title":"Mechanism of apoptosis induction associated with ERK1\/2 upregulation via goniothalamin in melanoma cells","volume":"15","author":"Tangchirakhaphan","year":"2018","journal-title":"Exp. Ther. Med."},{"issue":"12","key":"10.1016\/j.envres.2023.115771_bib157","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1038\/sj.bjc.6601864","article-title":"Antiangiogenic activity of aplidine, a new agent of marine origin","volume":"90","author":"Taraboletti","year":"2004","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib158","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/15384101.2019.1706903","article-title":"The double dealing of cyclin D1","volume":"19","author":"Tchakarska","year":"2020","journal-title":"Cell Cycle"},{"issue":"21","key":"10.1016\/j.envres.2023.115771_bib159","doi-asserted-by":"crossref","first-page":"5062","DOI":"10.1021\/ol9020546","article-title":"Bisebromoamide, a potent cytotoxic peptide from the marine cyanobacterium lyngbya sp.: isolation, stereostructure, and biological activity","volume":"11","author":"Teruya","year":"2009","journal-title":"Org. Lett."},{"issue":"3","key":"10.1016\/j.envres.2023.115771_bib160","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.3892\/mmr.2016.4856","article-title":"Suppression of c-FLIPL promotes JNK activation in malignant melanoma cells","volume":"13","author":"Tian","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.envres.2023.115771_bib161","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.immuni.2019.05.020","article-title":"Caspases in cell death, inflammation, and disease","volume":"50","author":"Van Opdenbosch","year":"2019","journal-title":"Immunity"},{"issue":"17","key":"10.1016\/j.envres.2023.115771_bib162","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.3390\/ijms20174184","article-title":"Characterization of tachyplesin peptides and their cyclized analogues to improve antimicrobial and anticancer properties","volume":"20","author":"Vernen","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.envres.2023.115771_bib163","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.chembiol.2020.07.003","article-title":"Introduction to thiopeptides: biological activity, biosynthesis, and strategies for functional reprogramming","volume":"27","author":"Vinogradov","year":"2020","journal-title":"Cell Chemical Biology"},{"issue":"1","key":"10.1016\/j.envres.2023.115771_bib164","article-title":"Structural diversity and biological activities of cyclic depsipeptides from fungi","volume":"23","author":"Wang","year":"2018","journal-title":"Molecules [Internet]"},{"key":"10.1016\/j.envres.2023.115771_bib165","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110484","article-title":"Marine compounds targeting the PI3K\/Akt signaling pathway in cancer therapy","volume":"129","author":"Wei","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.envres.2023.115771_bib166","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/np960153t","article-title":"Keenamide A, a bioactive cyclic peptide from the marine mollusk pleurobranchus forskalii","volume":"59","author":"Wesson","year":"1996","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.envres.2023.115771_bib167","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111221","article-title":"Sanggenol L promotes apoptotic cell death in melanoma skin cancer cells through activation of caspase cascades and apoptosis-inducing factor","volume":"138","author":"Won","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"7","key":"10.1016\/j.envres.2023.115771_bib168","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1073\/pnas.0712198105","article-title":"The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8","volume":"105","author":"Wrasidlo","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.envres.2023.115771_bib169","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s40364-022-00415-y","article-title":"Direct and indirect effects of IFN-\u03b12b in malignancy treatment: not only an archer but also an arrow","volume":"10","author":"Xiong","year":"2022","journal-title":"Biomarker Research"},{"issue":"10","key":"10.1016\/j.envres.2023.115771_bib170","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/ptr.5895","article-title":"Apoptotic effect of astragalin in melanoma skin cancers via activation of caspases and inhibition of sry-related HMg-box gene 10","volume":"31","author":"You","year":"2017","journal-title":"Phytother Res."},{"issue":"7","key":"10.1016\/j.envres.2023.115771_bib171","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.3390\/ijms21072346","article-title":"Understanding MAPK signaling pathways in apoptosis","volume":"21","author":"Yue","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2023.115771_bib172","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ctrv.2016.10.008","article-title":"Cell membrane modulation as adjuvant in cancer therapy","volume":"52","author":"Zalba","year":"2017","journal-title":"Cancer Treat Rev."},{"issue":"1","key":"10.1016\/j.envres.2023.115771_bib173","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3892\/ol.2014.2121","article-title":"A novel cyclic pentapeptide, H-10, inhibits B16 cancer cell growth and induces cell apoptosis","volume":"8","author":"Zhang","year":"2014","journal-title":"Oncol. Lett."},{"issue":"2","key":"10.1016\/j.envres.2023.115771_bib174","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109821","article-title":"Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation","volume":"37","author":"Zhang","year":"2021","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.envres.2023.115771_bib175","article-title":"Natural cyclopeptides as anticancer agents in the last 20 years","volume":"22","author":"Zhang","year":"2021","journal-title":"International Journal of Molecular Sciences [Internet]"},{"issue":"11","key":"10.1016\/j.envres.2023.115771_bib176","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.4049\/jimmunol.1501156","article-title":"Hemocyanins stimulate innate immunity by inducing different temporal patterns of proinflammatory cytokine expression in macrophages","volume":"196","author":"Zhong","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.envres.2023.115771_bib177","doi-asserted-by":"crossref","DOI":"10.1016\/j.seares.2022.102300","article-title":"Integrated ecosystem management and regulation strategies in the South China Sea","volume":"190","author":"Zhou","year":"2022","journal-title":"J. Sea Res."},{"issue":"12","key":"10.1016\/j.envres.2023.115771_bib178","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1007\/s12272-016-0828-3","article-title":"Penicilazaphilone C, a new antineoplastic and antibacterial azaphilone from the Marine Fungus Penicillium sclerotiorum","volume":"39","author":"Zhou","year":"2016","journal-title":"Arch Pharm. Res. (Seoul)"}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935123005637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935123005637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:35:29Z","timestamp":1782927329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935123005637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":178,"alternative-id":["S0013935123005637"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2023.115771","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic potential of marine peptides in malignant melanoma","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2023.115771","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115771"}}