{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:28:51Z","timestamp":1790270931931,"version":"4.1.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T00:00:00Z","timestamp":1689984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2019-103888RB-I00"],"award-info":[{"award-number":["PID2019-103888RB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Gobierno de Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["FI_B00314"],"award-info":[{"award-number":["FI_B00314"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.envres.2023.116722","type":"journal-article","created":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T11:56:47Z","timestamp":1690113407000},"page":"116722","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"P1","title":["Metals linked with the most prevalent primary neurodegenerative dementias in the elderly: A narrative review"],"prefix":"10.1016","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9584-7356","authenticated-orcid":false,"given":"David","family":"Mateo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-8578","authenticated-orcid":false,"given":"Montse","family":"Marqu\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Torrente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.envres.2023.116722_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijerph17217941","article-title":"Environmental risk factors for early-onset Alzheimer's dementia and frontotemporal dementia: a case-control study in Northern Italy","volume":"17","author":"Adani","year":"2020","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"21","key":"10.1016\/j.envres.2023.116722_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25215113","article-title":"Using volatile organic compounds to investigatethe effect of oral iron supplementation onthe human intestinal metabolome","volume":"25","author":"Ahmed","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.envres.2023.116722_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2019.126423","article-title":"Assessment of copper, iron, zinc and manganese status and speciation in patients with Parkinson's disease: a pilot study","volume":"59","author":"Ajsuvakova","year":"2020","journal-title":"J. Trace Elem. Med. Biol.: Organ of the Society for Minerals and Trace Elements (GMS)"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib4","article-title":"Pattern of altered plasma elemental phosphorus, calcium, zinc, and iron in Alzheimer's disease","volume":"9","author":"Ashraf","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2023.116722_bib5","article-title":"ATSDR's substance priority list","year":"2022","journal-title":"Agency for Toxic Substances and Disease Registry"},{"issue":"3","key":"10.1016\/j.envres.2023.116722_bib6","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/mds.27581","article-title":"Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism","volume":"34","author":"Barichella","year":"2019","journal-title":"Mov. Disorders"},{"issue":"Suppl. 1","key":"10.1016\/j.envres.2023.116722_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/jnc.13425","article-title":"Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics","volume":"139","author":"Belaidi","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.envres.2023.116722_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.conb.2019.11.009","article-title":"The microbiome-gut-brain axis in acute and chronic brain diseases","volume":"61","author":"Benakis","year":"2020","journal-title":"Curr. Opin. Neurobiol."},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-88840-1","article-title":"Age-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning","volume":"11","author":"Biel","year":"2021","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.envres.2023.116722_bib94","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.3390\/nu12061661","article-title":"The role and the effect of magnesium in mental disorders: a systematic review","volume":"12","author":"Botturi","year":"2020","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/2050-6511-14-62","article-title":"Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome","volume":"14","author":"Breton","year":"2013","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.envres.2023.116722_bib11","article-title":"Source, toxicity and carcinogenic health risk assessment of heavy metals","author":"Budi","year":"2022","journal-title":"Rev. Environ. Health"},{"issue":"13","key":"10.1016\/j.envres.2023.116722_bib12","doi-asserted-by":"crossref","first-page":"993","DOI":"10.2174\/1567205018666211215152411","article-title":"Modifiable risk factors for dementia: the role of gut microbiota","volume":"18","author":"Cabrera","year":"2021","journal-title":"Curr. Alzheimer Res."},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib13","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s13311-018-0662-z","article-title":"Supranutritional sodium selenate supplementation delivers selenium to the central nervous system: results from a randomized controlled pilot trial in Alzheimer's disease","volume":"16","author":"Cardoso","year":"2019","journal-title":"Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics"},{"issue":"4","key":"10.1016\/j.envres.2023.116722_bib14","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.3233\/JAD-201047","article-title":"Iron serum markers profile in frontotemporal lobar degeneration","volume":"78","author":"De Luca","year":"2020","journal-title":"J. Alzheim. Dis.: JAD"},{"issue":"2","key":"10.1016\/j.envres.2023.116722_bib95","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.chom.2020.07.013","article-title":"The gut microbiota and unhealthy aging: disentangling cause from consequence","volume":"28","author":"DeJong","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"3","key":"10.1016\/j.envres.2023.116722_bib15","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s43440-022-00353-4","article-title":"Neurotoxic effects of aluminium exposure as a potential risk factor for Alzheimer's disease","volume":"74","author":"Dey","year":"2022","journal-title":"Pharmacol. Rep.: PR"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ajim.23060","article-title":"Manganese exposure, parkinsonian signs, and quality of life in South African mine workers","volume":"63","author":"Dlamini","year":"2020","journal-title":"Am. J. Ind. Med."},{"issue":"10","key":"10.1016\/j.envres.2023.116722_bib17","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s00702-019-02041-9","article-title":"Higher zinc concentrations in hair of Parkinson's disease are associated with psychotic complications and depression","volume":"126","author":"Dos Santos","year":"2019","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.envres.2023.116722_bib18","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jtemb.2018.02.003","article-title":"Hair in Parkinson's disease patients exhibits differences in Calcium, Iron and Zinc concentrations measured by flame atomic absorption spectrometry - faas","volume":"47","author":"Dos Santos","year":"2018","journal-title":"J. Trace Elem. Med. Biol.: Organ of the Society for Minerals and Trace Elements (GMS)"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12940-017-0349-7","article-title":"Heavy metal exposure and nasal Staphylococcus aureus colonization: analysis of the national health and nutrition examination survey (NHANES)","volume":"17","author":"Eggers","year":"2018","journal-title":"Environ. Health: A Global Access Science Source"},{"key":"10.1016\/j.envres.2023.116722_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105122","article-title":"Urinary lead concentration and composition of the adult gut microbiota in a cross-sectional population-based sample","volume":"133","author":"Eggers","year":"2019","journal-title":"Environ. Int."},{"issue":"8","key":"10.1016\/j.envres.2023.116722_bib21","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/1533317518794032","article-title":"Comparison of blood lead levels in patients with Alzheimer's disease and healthy people","volume":"33","author":"Fathabadi","year":"2018","journal-title":"Am. J. Alzheimer's Dis. Other Dementias"},{"key":"10.1016\/j.envres.2023.116722_bib22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jtemb.2019.06.001","article-title":"Acetylcholinesterase inhibitors in Alzheimer's disease influence Zinc and Copper homeostasis","volume":"55","author":"Giacconi","year":"2019","journal-title":"J. Trace Elem. Med. Biol.: Organ of the Society for Minerals and Trace Elements (GMS)"},{"issue":"12","key":"10.1016\/j.envres.2023.116722_bib23","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1007\/s10482-020-01474-7","article-title":"Human gut microbiota\/microbiome in health and diseases: a review","volume":"113","author":"Gomaa","year":"2020","journal-title":"Antonie Leeuwenhoek"},{"issue":"8","key":"10.1016\/j.envres.2023.116722_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0255595","article-title":"Association between serum iron concentrations and cognitive impairment in older adults aged 60 years and older: a dose-response analysis of National Health and Nutrition Examination Survey","volume":"16","author":"Gong","year":"2021","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.envres.2023.116722_bib26","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s40520-021-02034-3","article-title":"Blood copper excess is associated with mild cognitive impairment in elderly Chinese","volume":"34","author":"Gu","year":"2022","journal-title":"Ageing Clin. Exp. Res."},{"key":"10.1016\/j.envres.2023.116722_bib27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neurobiolaging.2018.11.013","article-title":"Iron-related nigral degeneration influences functional topology mediated by striatal dysfunction in Parkinson's disease","volume":"75","author":"Guan","year":"2019","journal-title":"Neurobiol. Ageing"},{"issue":"Pt 3","key":"10.1016\/j.envres.2023.116722_bib28","article-title":"Dynamic changes in the intestinal microbial community of two time-aged soils under combined cadmium and ciprofloxacin contaminated conditions","volume":"806","author":"Guo","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"Pt 2","key":"10.1016\/j.envres.2023.116722_bib29","article-title":"Aluminum induced intestinal dysfunction via mechanical, immune, chemical and biological barriers","volume":"288","author":"Hao","year":"2022","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.envres.2023.116722_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00632-19","article-title":"Alzheimer's disease microbiome is associated with dysregulation of the anti-inflammatory P-glycoprotein pathway","volume":"10","author":"Haran","year":"2019","journal-title":"mBio"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib31","doi-asserted-by":"crossref","DOI":"10.1186\/s12877-022-02988-7","article-title":"Interaction between \u03c9-6 fatty acids intake and blood cadmium on the risk of low cognitive performance in older adults from National Health and Nutrition Examination Survey (NHANES) 2011-2014","volume":"22","author":"Huang","year":"2022","journal-title":"BMC Geriatr."},{"issue":"9","key":"10.1016\/j.envres.2023.116722_bib32","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.jmb.2019.01.018","article-title":"Metal toxicity links to Alzheimer's disease and neuroinflammation","volume":"431","author":"Huat","year":"2019","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.envres.2023.116722_bib33","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neures.2017.11.011","article-title":"A low blood copper concentration is a co-morbidity burden factor in Parkinson's disease development","volume":"135","author":"Ilyechova","year":"2018","journal-title":"Neurosci. Res."},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib34","doi-asserted-by":"crossref","DOI":"10.4081\/vsd.2015.6061","article-title":"Impact of synbiotic diets including inulin, Bacillus coagulans and Lactobacillus plantarum on intestinal microbiota of rat exposed to cadmium and mercury","volume":"5","author":"Jafarpour","year":"2015","journal-title":"Vet. Sci. Dev."},{"issue":"3","key":"10.1016\/j.envres.2023.116722_bib35","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.3233\/JAD-215085","article-title":"B vitamins prevent iron-associated brain atrophy and domain-specific effects of iron, copper, aluminum, and silicon on cognition in mild cognitive impairment","volume":"84","author":"Jakubowski","year":"2021","journal-title":"J. Alzheim. Dis.: JAD"},{"issue":"4","key":"10.1016\/j.envres.2023.116722_bib36","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.3233\/JAD-201250","article-title":"Impacts of iron metabolism dysregulation on Alzheimer's disease","volume":"80","author":"Jouini","year":"2021","journal-title":"J. Alzheim. Dis.: JAD"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib37","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-021-01126-5","article-title":"Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients","volume":"9","author":"Kenkhuis","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"issue":"10","key":"10.1016\/j.envres.2023.116722_bib38","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/mds.26307","article-title":"Colonic bacterial composition in Parkinson's disease","volume":"30","author":"Keshavarzian","year":"2015","journal-title":"Mov. Disorders"},{"key":"10.1016\/j.envres.2023.116722_bib39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.parkreldis.2018.05.022","article-title":"Association of metals with the risk and clinical characteristics of Parkinson's disease","volume":"55","author":"Kim","year":"2018","journal-title":"Parkinsonism Relat. Disorders"},{"key":"10.1016\/j.envres.2023.116722_bib40","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neuro.2017.09.012","article-title":"Environmental exposure to manganese in air: tremor, motor and cognitive symptom profiles","volume":"64","author":"Kornblith","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envres.2023.116722_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2020.126684","article-title":"Arsenic and selenium measurements in nail and hair show important relationships to Alzheimer's disease in the elderly","volume":"64","author":"Koseoglu","year":"2021","journal-title":"J. Trace Elem. Med. Biol.: Organ of the Society for Minerals and Trace Elements (GMS)"},{"key":"10.1016\/j.envres.2023.116722_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.parkreldis.2021.05.029","article-title":"Increased prevalence of Parkinson's disease in soils with high arsenic levels","volume":"88","author":"Lee","year":"2021","journal-title":"Parkinsonism Relat. Disorders"},{"issue":"2","key":"10.1016\/j.envres.2023.116722_bib43","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3233\/JAD-210158","article-title":"The association of essential metals with APOE genotype in Alzheimer's disease","volume":"82","author":"Leko","year":"2021","journal-title":"J. Alzheim. Dis.: JAD"},{"issue":"11","key":"10.1016\/j.envres.2023.116722_bib48","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s11427-016-9001-4","article-title":"Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features","volume":"60","author":"Li","year":"2017","journal-title":"Sci. China Life Sci."},{"issue":"4","key":"10.1016\/j.envres.2023.116722_bib46","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-020533","article-title":"Associations between blood cadmium levels and cognitive function in a cross-sectional study of US adults aged 60 years or older","volume":"8","author":"Li","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.envres.2023.116722_bib45","article-title":"Alteration of the fecal microbiota in North-Eastern Han Chinese population with sporadic Parkinson\u2019s disease","volume":"vol. 707","author":"Li","year":"2019"},{"issue":"4","key":"10.1016\/j.envres.2023.116722_bib47","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.3233\/JAD-190263","article-title":"Association of zinc, iron, copper, and selenium intakes with low cognitive performance in older adults: a cross-sectional study from national health and nutrition examination survey (NHANES)","volume":"72","author":"Li","year":"2019","journal-title":"J. Alzheim. Dis.: JAD"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib44","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3233\/JAD-200843","article-title":"Quantitative study of the changes in cerebral blood flow and iron deposition during progression of Alzheimer's disease","volume":"78","author":"Li","year":"2020","journal-title":"J. Alzheim. Dis.: JAD"},{"key":"10.1016\/j.envres.2023.116722_bib49","volume":"vol. 756","author":"Liu","year":"2021"},{"key":"10.1016\/j.envres.2023.116722_bib50","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.bbi.2019.05.008","article-title":"Altered microbiomes distinguish Alzheimer's disease from amnestic mild cognitive impairment and health in a Chinese cohort","volume":"80","author":"Liu","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.envres.2023.116722_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2019.126412","article-title":"Selenium speciation analysis in the cerebrospinal fluid of patients with Parkinson's disease","volume":"57","author":"Maass","year":"2020","journal-title":"J. Trace Elem. Med. Biol.: Organ of the Society for Minerals and Trace Elements (GMS)"},{"issue":"11","key":"10.1016\/j.envres.2023.116722_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/nu13114114","article-title":"Correlation between serum zinc levels and levodopa in Parkinson's disease","volume":"13","author":"Matsuyama","year":"2021","journal-title":"Nutrients"},{"issue":"Suppl. 2","key":"10.1016\/j.envres.2023.116722_bib53","article-title":"Selenium concentrations in elderly people with Alzheimer's disease: a cross-sectional study with control group","volume":"2","author":"Nascimento","year":"2021","journal-title":"Revista Brasileira de Enfermagem, 74Suppl"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0262464","article-title":"Mercury is present in neurons and oligodendrocytes in regions of the brain affected by Parkinson's disease and co-localises with Lewy bodies","volume":"17","author":"Pamphlett","year":"2022","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.envres.2023.116722_bib99","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00234-019-02159-3","article-title":"Motor cortex hypointensity on susceptibility-weighted imaging: a potential imaging marker of iron accumulation in patients with cognitive impairment","volume":"61","author":"Park","year":"2019","journal-title":"Neuroradiology"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib55","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-021-01051-3","article-title":"DNA methylation biomarker for cumulative lead exposure is associated with Parkinson's disease","volume":"13","author":"Paul","year":"2021","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.envres.2023.116722_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126535","article-title":"Relation between cadmium body burden and cognitive function in older men: a cross-sectional study in China","volume":"250","author":"Peng","year":"2020","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.envres.2023.116722_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/cells8020096","article-title":"Impairment of motor function correlates with neurometabolite and brain iron alterations in Parkinson's disease","volume":"8","author":"Pesch","year":"2019","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.envres.2023.116722_bib58","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/joim.12190","article-title":"Mild cognitive impairment: a concept in evolution","volume":"275","author":"Petersen","year":"2014","journal-title":"J. Intern. Med."},{"issue":"10","key":"10.1016\/j.envres.2023.116722_bib59","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1212\/WNL.0b013e3181f11d85","article-title":"Prevalence of mild cognitive impairment is higher in men: the Mayo Clinic Study of Ageing","volume":"75","author":"Petersen","year":"2010","journal-title":"Neurology"},{"issue":"22","key":"10.1016\/j.envres.2023.116722_bib60","article-title":"Links between cognitive status and trace element levels in hair for an environmentally exposed population: a case study in the surroundings of the estarreja industrial area","volume":"16","author":"Pinto","year":"2019","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib61","doi-asserted-by":"crossref","DOI":"10.1186\/s12940-021-00712-3","article-title":"Severity of parkinsonism associated with environmental manganese exposure","volume":"20","author":"Racette","year":"2021","journal-title":"Environ. Health: A Global Access Science Source"},{"issue":"3","key":"10.1016\/j.envres.2023.116722_bib62","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3233\/JAD-170552","article-title":"Serum non-ceruloplasmin non-albumin copper elevation in mild cognitive impairment and dementia due to Alzheimer's disease: a case control study","volume":"61","author":"Rozzini","year":"2018","journal-title":"J. Alzheim. Dis.: JAD"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib63","article-title":"Analysis of the relationship between the gut microbiome and dementia: a cross-sectional study conducted in Japan","volume":"9","author":"Saji","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib64","doi-asserted-by":"crossref","DOI":"10.1186\/s12910-022-00819-3","article-title":"The concept of vulnerability in aged care: a systematic review of argument-based ethics literature","volume":"23","author":"Sanchini","year":"2022","journal-title":"BMC Med. Ethics"},{"key":"10.1016\/j.envres.2023.116722_bib65","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ajp.2017.11.036","article-title":"Lower levels of serum copper in patients with Alzheimer's dementia: a controlled study from India","volume":"32","author":"Shere","year":"2018","journal-title":"Asian Journal of Psychiatry"},{"issue":"2","key":"10.1016\/j.envres.2023.116722_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu13020287","article-title":"Dietary habits, selenium, copper, zinc and total antioxidant status in serum in relation to cognitive functions of patients with Alzheimer's disease","volume":"13","author":"Socha","year":"2021","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.envres.2023.116722_bib67","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/brain\/awaa089","article-title":"Relationship between cortical iron and tau aggregation in Alzheimer's disease","volume":"143","author":"Spotorno","year":"2020","journal-title":"Brain: J. Neurol."},{"issue":"4","key":"10.1016\/j.envres.2023.116722_bib68","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.3233\/JAD-171074","article-title":"Serum copper is not altered in frontotemporal lobar degeneration","volume":"63","author":"Squitti","year":"2018","journal-title":"J. Alzheim. Dis.: JAD"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib69","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/WAD.0000000000000280","article-title":"Copper in glucose intolerance, cognitive decline, and Alzheimer disease","volume":"33","author":"Squitti","year":"2019","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.envres.2023.116722_bib96","doi-asserted-by":"crossref","DOI":"10.3390\/cells10082125","article-title":"Calcium signaling regulates autophagy and apoptosis","author":"Sukumaran","year":"2021","journal-title":"Cells"},{"issue":"21","key":"10.1016\/j.envres.2023.116722_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/nu14214671","article-title":"A prospective study on the relationship between iron supplement intake, hemoglobin concentration, and risk of parkinsonism","volume":"14","author":"Takeuchi","year":"2022","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.envres.2023.116722_bib71","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/j.clnu.2018.11.034","article-title":"Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer's disease: a randomized, double-blind, controlled trial","volume":"38","author":"Tamtaji","year":"2019","journal-title":"Clinical Nutrition (Edinburgh, Scotland)"},{"issue":"4","key":"10.1016\/j.envres.2023.116722_bib72","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1136\/jnnp-2019-322042","article-title":"Brain iron deposition is linked with cognitive severity in Parkinson's disease","volume":"91","author":"Thomas","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"6","key":"10.1016\/j.envres.2023.116722_bib73","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/brain\/awab084","article-title":"Regional brain iron and gene expression provide insights into neurodegeneration in Parkinson's disease","volume":"144","author":"Thomas","year":"2021","journal-title":"Brain: J. Neurol."},{"issue":"8","key":"10.1016\/j.envres.2023.116722_bib74","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/mds.27717","article-title":"Voxel-based quantitative susceptibility mapping in Parkinson's disease with mild cognitive impairment","volume":"34","author":"Uchida","year":"2019","journal-title":"Mov. Disorders: Official Journal of the Movement Disorder Society"},{"issue":"9","key":"10.1016\/j.envres.2023.116722_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.xcrm.2021.100398","article-title":"Identification of Faecalibacterium prausnitzii strains for gut microbiome-based intervention in Alzheimer\u2019s-type dementia","volume":"2","author":"Ueda","year":"2021","journal-title":"Cell Reports. Medicine"},{"key":"10.1016\/j.envres.2023.116722_bib76","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.parkreldis.2016.08.019","article-title":"Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls","volume":"32","author":"Unger","year":"2016","journal-title":"Parkinsonism Relat. Disorders"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib97","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-73324-5","article-title":"Effects of Alzheimer\u2019s disease and formalin fixation on the different mineralised-iron forms in the human brain","volume":"10","author":"van der Weerd","year":"2020","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.envres.2023.116722_bib77","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12011-017-1042-y","article-title":"The relationship between copper, iron, and selenium levels and Alzheimer disease","volume":"181","author":"Vaz","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envres.2023.116722_bib78","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jtemb.2019.03.002","article-title":"Selenium and selenium species in the etiology of Alzheimer's dementia: the potential for bias of the case-control study design","volume":"53","author":"Vinceti","year":"2019","journal-title":"J. Trace Elem. Med. Biol.: Organ of the Society for Minerals and Trace Elements (GMS)"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13601-y","article-title":"Gut microbiome alterations in Alzheimer's disease","volume":"7","author":"Vogt","year":"2017","journal-title":"Sci. Rep."},{"issue":"10004","key":"10.1016\/j.envres.2023.116722_bib98","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0140-6736(15)00462-6","article-title":"Lewy body dementias","volume":"386","author":"Walker","year":"2015","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.envres.2023.116722_bib80","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0233872","article-title":"Alpha-, beta-, and gamma-diversity of bacteria varies across habitats","volume":"15","author":"Walters","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.envres.2023.116722_bib81","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3233\/JAD-132204","article-title":"Chronic aluminum intake causes Alzheimer's disease: applying Sir Austin Bradford Hill's causality criteria","volume":"40","author":"Walton","year":"2014","journal-title":"J. Alzheim. Dis.: JAD"},{"key":"10.1016\/j.envres.2023.116722_bib82","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jtemb.2018.01.005","article-title":"Species fractionation in a case-control study concerning Parkinson's disease: Cu-amino acids discriminate CSF of PD from controls","volume":"49","author":"Willkommen","year":"2018","journal-title":"J. Trace Elem. Med. Biol.: Organ of the Society for Minerals and Trace Elements (GMS)"},{"key":"10.1016\/j.envres.2023.116722_bib83","series-title":"World Report on Ageing and Health","author":"World Health Organization","year":"2015"},{"key":"10.1016\/j.envres.2023.116722_bib84","volume":"vol. 5","author":"World Health Organization","year":"2020"},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu13010228","article-title":"Altered gut microbial metabolites in amnestic mild cognitive impairment and Alzheimer's disease: signals in host-microbe interplay","volume":"13","author":"Wu","year":"2021","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.envres.2023.116722_bib86","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1007\/s11033-021-06386-x","article-title":"Metals toxicity and its correlation with the gene expression in Alzheimer's disease","volume":"48","author":"Yadav","year":"2021","journal-title":"Mol. Biol. Rep."},{"issue":"7\u20138","key":"10.1016\/j.envres.2023.116722_bib87","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1080\/03014460.2020.1836253","article-title":"A cross-sectional study of blood selenium concentration and cognitive function in elderly Americans: national Health and Nutrition Examination Survey 2011-2014","volume":"47","author":"Yan","year":"2020","journal-title":"Ann. Hum. Biol."},{"key":"10.1016\/j.envres.2023.116722_bib88","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.taap.2018.07.015","article-title":"Risk of Alzheimer's disease with metal concentrations in whole blood and urine: a case-control study using propensity score matching","volume":"356","author":"Yang","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.envres.2023.116722_bib89","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12011-022-03136-3","article-title":"Associations between mild cognitive impairment and whole blood zinc and selenium in the elderly cohort","volume":"201","author":"Yu","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"issue":"4","key":"10.1016\/j.envres.2023.116722_bib90","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.3233\/JAD-171108","article-title":"Colocalization of aluminum and iron in nuclei of nerve cells in brains of patients with Alzheimer's disease","volume":"65","author":"Yumoto","year":"2018","journal-title":"J. Alzheim. Dis.: JAD"},{"issue":"7","key":"10.1016\/j.envres.2023.116722_bib91","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1007\/s12011-021-02941-6","article-title":"Associations between plasma metals and cognitive function in people aged 60 and above","volume":"200","author":"Zhang","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"issue":"4","key":"10.1016\/j.envres.2023.116722_bib92","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3233\/JAD-180176","article-title":"Gut microbiota is altered in patients with Alzheimer's disease","volume":"63","author":"Zhuang","year":"2018","journal-title":"J. Alzheim. Dis."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935123015268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935123015268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T03:04:14Z","timestamp":1762139054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935123015268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":97,"alternative-id":["S0013935123015268"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2023.116722","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metals linked with the most prevalent primary neurodegenerative dementias in the elderly: A narrative review","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2023.116722","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116722"}}