{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:01:24Z","timestamp":1790787684080,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015693","name":"Research Institute for Gastroenterology and Liver Diseases","doi-asserted-by":"publisher","award":["987"],"award-info":[{"award-number":["987"]}],"id":[{"id":"10.13039\/501100015693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.envres.2023.117117","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:04:31Z","timestamp":1696471471000},"page":"117117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"P1","title":["Identification of antisense and sense RNAs of intracrine fibroblast growth factor components as novel biomarkers in colorectal cancer and in silico studies for drug and nanodrug repurposing"],"prefix":"10.1016","volume":"239","author":[{"given":"Leili","family":"Rejali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Nazemalhosseini-Mojarad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazaher","family":"Maghsoudloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Asadzadeh Aghdaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadis","family":"Mohammadpoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Zali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binazir","family":"Khanabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maliheh","family":"Entezari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiavash","family":"Hushmandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshin","family":"Taheriazam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2023.117117_bib1","series-title":"Basic Immunology: Functions and Disorders of the Immune System","author":"Abbas","year":"2014"},{"issue":"4","key":"10.1016\/j.envres.2023.117117_bib2","doi-asserted-by":"crossref","first-page":"580","DOI":"10.4161\/cc.8.4.7657","article-title":"Paths of FGFR-driven tumorigenesis","volume":"8","author":"Acevedo","year":"2009","journal-title":"Cell Cycle"},{"issue":"4","key":"10.1016\/j.envres.2023.117117_bib3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"Arnold","year":"2017","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.envres.2023.117117_bib4","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1101\/gr.180596.114","article-title":"The landscape of antisense gene expression in human cancers","volume":"25","author":"Balbin","year":"2015","journal-title":"Genome Res."},{"issue":"5","key":"10.1016\/j.envres.2023.117117_bib5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regen."},{"issue":"6","key":"10.1016\/j.envres.2023.117117_bib6","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.cell.2013.02.012","article-title":"Long noncoding RNAs: cellular address codes in development and disease","volume":"152","author":"Batista","year":"2013","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.envres.2023.117117_bib7","doi-asserted-by":"crossref","first-page":"E496","DOI":"10.1073\/pnas.1614876114","article-title":"Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival","volume":"114","author":"Bublik","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.envres.2023.117117_bib8","series-title":"Establishment and Characterization of a Paired Human Non-small Cell Lung Cancer Cell Lines from Primary Cancer and Metastasis Lymph Node","author":"Chen","year":"2014"},{"issue":"8","key":"10.1016\/j.envres.2023.117117_bib9","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv1507","article-title":"TCGAbiolinks: an R\/Bioconductor package for integrative analysis of TCGA data","volume":"44","author":"Colaprico","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envres.2023.117117_bib10","series-title":"Seminars in Cancer Biology","article-title":"The role of reactive oxygen species and metabolism on cancer cells and their microenvironment","author":"Costa","year":"2014"},{"key":"10.1016\/j.envres.2023.117117_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114224","article-title":"Dual inhibitors of histone deacetylases and other cancer-related targets: a pharmacological perspective","volume":"182","author":"Gao","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.envres.2023.117117_bib12","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/cancers13030399","article-title":"Tumor cells and cancer-associated fibroblasts: an updated metabolic perspective","volume":"13","author":"Gentric","year":"2021","journal-title":"Cancers"},{"issue":"26","key":"10.1016\/j.envres.2023.117117_bib13","doi-asserted-by":"crossref","first-page":"17883","DOI":"10.1074\/jbc.M109.001842","article-title":"Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels","volume":"284","author":"Goetz","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.envres.2023.117117_bib14","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1053\/j.gastro.2017.07.034","article-title":"Association between concentrations of hemoglobin determined by fecal immunochemical tests and long-term development of advanced colorectal neoplasia","volume":"153","author":"Grobbee","year":"2017","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.envres.2023.117117_bib15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cytogfr.2005.01.003","article-title":"Fibroblast growth factor signaling in tumorigenesis","volume":"16","author":"Grose","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"issue":"12","key":"10.1016\/j.envres.2023.117117_bib16","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1056\/NEJMp1607591","article-title":"Toward a shared vision for cancer genomic data","volume":"375","author":"Grossman","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.envres.2023.117117_bib17","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nm.3967","article-title":"The consensus molecular subtypes of colorectal cancer","volume":"21","author":"Guinney","year":"2015","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.envres.2023.117117_bib18","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/ijc.32489","article-title":"Clinicopathologic features and prognostic value of KRAS, NRAS and BRAF mutations and DNA mismatch repair status: a single\u2010center retrospective study of 1,834 Chinese patients with Stage I\u2013IV colorectal cancer","volume":"145","author":"Guo","year":"2019","journal-title":"Int. J. Cancer"},{"issue":"12","key":"10.1016\/j.envres.2023.117117_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082241","article-title":"Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer","volume":"8","author":"Gy\u0151rffy","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.envres.2023.117117_bib20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.molonc.2014.07.013","article-title":"Infiltrating T cells promote prostate cancer metastasis via modulation of FGF11\u2192 miRNA-541\u2192 androgen receptor (AR)\u2192 MMP9 signaling","volume":"9","author":"Hu","year":"2015","journal-title":"Mol. Oncol."},{"issue":"5","key":"10.1016\/j.envres.2023.117117_bib21","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/13543776.2021.1866540","article-title":"Small molecule DNA-PK inhibitors as potential cancer therapy: a patent review (2010\u2013present)","volume":"31","author":"Hu","year":"2021","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.envres.2023.117117_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2021.213949","article-title":"Application of smart nanoparticles as a potential platform for effective colorectal cancer therapy","volume":"442","author":"Iranpour","year":"2021","journal-title":"Coord. Chem. Rev."},{"issue":"1","key":"10.1016\/j.envres.2023.117117_bib23","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/ijc.32874","article-title":"FGF13 promotes metastasis of triple\u2010negative breast cancer","volume":"147","author":"Johnstone","year":"2020","journal-title":"Int. J. Cancer"},{"issue":"9","key":"10.1016\/j.envres.2023.117117_bib24","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri","year":"2016","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.envres.2023.117117_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrclinonc.2013.213","article-title":"Screening\u2014one small step for mankind, one giant leap for man","volume":"11","author":"Kuipers","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.envres.2023.117117_bib26","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.envres.2023.117117_bib27","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.2147\/OTT.S163883","article-title":"Increased expression of antisense lncRNA SPINT1-AS1 predicts a poor prognosis in colorectal cancer and is negatively correlated with its sense transcript","volume":"11","author":"Li","year":"2018","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.envres.2023.117117_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105920","article-title":"Long noncoding RNA p21 enhances autophagy to alleviate endothelial progenitor cells damage and promote endothelial repair in hypertension through SESN2\/AMPK\/TSC2 pathway","volume":"173","author":"Li","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"17","key":"10.1016\/j.envres.2023.117117_bib29","doi-asserted-by":"crossref","first-page":"7017","DOI":"10.1007\/s00253-019-09973-y","article-title":"Purification of recombinant human fibroblast growth factor 13 in E. coli and its molecular mechanism of mitogenesis","volume":"103","author":"Lin","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"13","key":"10.1016\/j.envres.2023.117117_bib30","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.3748\/wjg.14.2110","article-title":"Expression of connective tissue growth factor in tumor tissues is an independent predictor of poor prognosis in patients with gastric cancer","volume":"14","author":"Liu","year":"2008","journal-title":"World J. Gastroenterol.: WJG"},{"key":"10.1016\/j.envres.2023.117117_bib31","article-title":"New insights into natural products that target the gut microbiota: effects on the prevention and treatment of colorectal cancer","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.envres.2023.117117_bib32","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3390\/ijms22010130","article-title":"Molecular mechanisms of colon cancer progression and metastasis: recent insights and advancements","volume":"22","author":"Malki","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2023.117117_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.imu.2016.06.002","article-title":"World Competitive Contests (WCC) algorithm: a novel intelligent optimization algorithm for biological and non-biological problems","volume":"3","author":"Masoudi-Sobhanzadeh","year":"2016","journal-title":"Inform. Med. Unlocked"},{"key":"10.1016\/j.envres.2023.117117_bib34","series-title":"Seminars in Immunology","article-title":"Fibroblast heterogeneity in tumor micro-environment: role in immunosuppression and new therapies","author":"Mhaidly","year":"2020"},{"issue":"4","key":"10.1016\/j.envres.2023.117117_bib35","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1074\/jbc.275.4.2589","article-title":"Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing","volume":"275","author":"Munoz-Sanjuan","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.envres.2023.117117_bib36","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1269\/jrr.08021","article-title":"Involvement of intracellular expression of FGF12 in radiation-induced apoptosis in mast cells","volume":"49","author":"Nakayama","year":"2008","journal-title":"J. Radiat. Res."},{"issue":"1","key":"10.1016\/j.envres.2023.117117_bib37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12029-019-00201-4","article-title":"Prognostic value of BRAF and KRAS mutation in relation to colorectal cancer survival in Iranian patients: correlated to microsatellite instability","volume":"51","author":"Nazemalhosseini-Mojarad","year":"2020","journal-title":"J. Gastrointest. Cancer"},{"issue":"7407","key":"10.1016\/j.envres.2023.117117_bib38","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","author":"Network","year":"2012","journal-title":"Nature"},{"issue":"36","key":"10.1016\/j.envres.2023.117117_bib39","doi-asserted-by":"crossref","first-page":"34226","DOI":"10.1074\/jbc.M303183200","article-title":"Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs","volume":"278","author":"Olsen","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.envres.2023.117117_bib40","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/wdev.176","article-title":"The fibroblast growth factor signaling pathway","volume":"4","author":"Ornitz","year":"2015","journal-title":"Wiley Interdiscip. Rev.: Dev. Biol."},{"issue":"15","key":"10.1016\/j.envres.2023.117117_bib41","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1002\/pmic.201400515","article-title":"FunRich: an open access standalone functional enrichment and interaction network analysis tool","volume":"15","author":"Pathan","year":"2015","journal-title":"Proteomics"},{"issue":"12","key":"10.1016\/j.envres.2023.117117_bib42","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nrg3594","article-title":"Gene regulation by antisense transcription","volume":"14","author":"Pelechano","year":"2013","journal-title":"Nat. Rev. Genet."},{"issue":"D1","key":"10.1016\/j.envres.2023.117117_bib43","doi-asserted-by":"crossref","first-page":"D130","DOI":"10.1093\/nar\/gkr1079","article-title":"NCBI Reference Sequences (RefSeq): current status, new features and genome annotation policy","volume":"40","author":"Pruitt","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.envres.2023.117117_bib44","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.envres.2023.117117_bib45","article-title":"A novel long non coding RNA FGF10AS and sense transcript are correlated with poor prognosis in colorectal cancer","volume":"vol. 4","author":"Rejali","year":"2020"},{"issue":"3","key":"10.1016\/j.envres.2023.117117_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.envres.2023.117117_bib47","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.envres.2023.117117_bib48","first-page":"665","article-title":"Biological functions of natural antisense transcripts","volume":"63","author":"Rosikiewicz","year":"2016","journal-title":"Acta Biochim. Pol."},{"issue":"5","key":"10.1016\/j.envres.2023.117117_bib49","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3390\/brainsci13050741","article-title":"Mood stabilizers of first and second generation","volume":"13","author":"Rybakowski","year":"2023","journal-title":"Brain Sci."},{"key":"10.1016\/j.envres.2023.117117_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.628144","article-title":"Drug repurposing strategy (DRS): emerging approach to identify potential therapeutics for treatment of novel coronavirus infection","volume":"8","author":"Sahoo","year":"2021","journal-title":"Front. Mol. Biosci."},{"issue":"9","key":"10.1016\/j.envres.2023.117117_bib51","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1080\/10837450.2019.1569678","article-title":"Pegylated magnetic mesoporous silica nanoparticles decorated with AS1411 Aptamer as a targeting delivery system for cytotoxic agents","volume":"24","author":"Sakhtianchi","year":"2019","journal-title":"Pharmaceut. Dev. Technol."},{"issue":"10","key":"10.1016\/j.envres.2023.117117_bib52","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0960-9822(01)00232-9","article-title":"Fibroblast growth factor homologous factors are intracellular signaling proteins","volume":"11","author":"Schoorlemmer","year":"2001","journal-title":"Curr. Biol."},{"issue":"11","key":"10.1016\/j.envres.2023.117117_bib53","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"1","key":"10.1016\/j.envres.2023.117117_bib54","first-page":"7","article-title":"Cancer statistics","volume":"69","author":"Siegel","year":"2019","journal-title":"CA A Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.envres.2023.117117_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-020-00573-2","article-title":"FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner","volume":"18","author":"Sochacka","year":"2020","journal-title":"Cell Commun. Signal."},{"issue":"4","key":"10.1016\/j.envres.2023.117117_bib56","doi-asserted-by":"crossref","first-page":"819","DOI":"10.7150\/jca.36316","article-title":"FGF14 functions as a tumor suppressor through inhibiting PI3K\/AKT\/mTOR pathway in colorectal cancer","volume":"11","author":"Su","year":"2020","journal-title":"J. Cancer"},{"key":"10.1016\/j.envres.2023.117117_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154792","article-title":"Berberine is a suppressor of Hedgehog signaling cascade in colorectal cancer","volume":"114","author":"Sun","year":"2023","journal-title":"Phytomedicine"},{"issue":"D1","key":"10.1016\/j.envres.2023.117117_bib58","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.envres.2023.117117_bib59","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nrc2780","article-title":"Fibroblast growth factor signalling: from development to cancer","volume":"10","author":"Turner","year":"2010","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.envres.2023.117117_bib60","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.18632\/oncotarget.6446","article-title":"Long non-coding RNAs in colorectal cancer","volume":"7","author":"Xie","year":"2016","journal-title":"Oncotarget"},{"issue":"7","key":"10.1016\/j.envres.2023.117117_bib61","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.13573","article-title":"LncRNAs: the bridge linking RNA and colorectal cancer","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.envres.2023.117117_bib62","series-title":"Seminars in Cancer Biology","article-title":"Nanoparticles: attractive tools to treat colorectal cancer","author":"Younis","year":"2022"},{"issue":"1","key":"10.1016\/j.envres.2023.117117_bib63","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/ijc.30048","article-title":"Increased expression of fibroblast growth factor 13 in prostate cancer is associated with shortened time to biochemical recurrence after radical prostatectomy","volume":"139","author":"Yu","year":"2016","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.envres.2023.117117_bib64","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/mp\/sst051","article-title":"Mechanisms of small RNA generation from cis-NATs in response to environmental and developmental cues","volume":"6","author":"Zhang","year":"2013","journal-title":"Mol. Plant"},{"issue":"12","key":"10.1016\/j.envres.2023.117117_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-018-1224-3","article-title":"m 6 A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression","volume":"9","author":"Zhang","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.envres.2023.117117_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-020-01700-0","article-title":"Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark","volume":"39","author":"Zhao","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.envres.2023.117117_bib67","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12943-022-01616-7","article-title":"Wnt signaling in colorectal cancer: pathogenic role and therapeutic target","volume":"21","author":"Zhao","year":"2022","journal-title":"Mol. Cancer"},{"issue":"9","key":"10.1016\/j.envres.2023.117117_bib68","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1021\/acs.jafc.2c06775","article-title":"Ursolic acid suppresses colorectal cancer by down-regulation of Wnt\/\u03b2-catenin signaling pathway activity","volume":"71","author":"Zhao","year":"2023","journal-title":"J. Agric. Food Chem."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935123019217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935123019217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:22:56Z","timestamp":1790785376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935123019217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":68,"alternative-id":["S0013935123019217"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2023.117117","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of antisense and sense RNAs of intracrine fibroblast growth factor components as novel biomarkers in colorectal cancer and in silico studies for drug and nanodrug repurposing","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2023.117117","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117117"}}