{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:47:22Z","timestamp":1792691242117,"version":"4.5.0"},"reference-count":164,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES07331"],"award-info":[{"award-number":["R01ES07331"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013833","name":"I.M. Sechenov First Moscow State Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017638","name":"Ministry of Health of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017638","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.envres.2023.117134","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T21:25:14Z","timestamp":1694640314000},"page":"117134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"P1","title":["Dissecting the role of cadmium, lead, arsenic, and mercury in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis"],"prefix":"10.1016","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-6192","authenticated-orcid":false,"given":"Alexey A.","family":"Tinkov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2619-1656","authenticated-orcid":false,"given":"Michael","family":"Aschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Santamaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred R.","family":"Bogdanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Tizabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam B.","family":"Virgolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4177-614X","authenticated-orcid":false,"given":"Ji-Chang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly V.","family":"Skalny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2023.117134_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ccr.2017.12.011","article-title":"Chelator combination as therapeutic strategy in mercury and lead poisonings","volume":"358","author":"Aaseth","year":"2018","journal-title":"Coord. Chem. Rev."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/biof.1724","article-title":"Quercetin prevents cadmium chloride-induced hepatic steatosis and fibrosis by downregulating the transcription of miR-21","volume":"47","author":"Alshammari","year":"2021","journal-title":"Biofactors"},{"key":"10.1016\/j.envres.2023.117134_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147182","article-title":"Cadmium chloride induces non-alcoholic fatty liver disease in rats by stimulating miR-34a\/SIRT1\/FXR\/p53 axis","volume":"784","author":"Alshehri","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.envres.2023.117134_bib4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.taap.2007.08.020","article-title":"Subhepatotoxic exposure to arsenic enhances lipopolysaccharide-induced liver injury in mice","volume":"226","author":"Arteel","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1289\/EHP360","article-title":"Sex-dependent effects of cadmium exposure in early life on gut microbiota and fat accumulation in mice","volume":"125","author":"Ba","year":"2017","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.envres.2023.117134_bib6","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.031575","article-title":"Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish","volume":"11","author":"Bambino","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.envres.2023.117134_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.110980","article-title":"Association between cumulative childhood blood lead exposure and hepatic steatosis in young Mexican adults","volume":"196","author":"Betanzos-Robledo","year":"2021","journal-title":"Environ. Res."},{"issue":"8","key":"10.1016\/j.envres.2023.117134_bib8","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"issue":"9","key":"10.1016\/j.envres.2023.117134_bib9","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1124\/dmd.112.046177","article-title":"Altered arsenic disposition in experimental nonalcoholic fatty liver disease","volume":"40","author":"Canet","year":"2012","journal-title":"Drug Metab. Dispos."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12389","article-title":"Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome","volume":"62","author":"Cao","year":"2017","journal-title":"J. Pineal Res."},{"issue":"7","key":"10.1016\/j.envres.2023.117134_bib11","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1177\/0748233712462442","article-title":"Low concentration of mercury induces autophagic cell death in rat hepatocytes","volume":"30","author":"Chatterjee","year":"2014","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.envres.2023.117134_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114192","article-title":"MicroRNA-101 inhibits cadmium-induced angiogenesis by targeting cyclooxygenase-2 in primary human umbilical vein endothelial cells","volume":"189","author":"Che","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.envres.2023.117134_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119906","article-title":"Role of mitochondrial dysfunction and PINK1\/Parkin-mediated mitophagy in Cd-induced hepatic lipid accumulation in chicken embryos","volume":"284","author":"Chen","year":"2021","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.envres.2023.117134_bib14","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1093\/carcin\/bgh161","article-title":"Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis","volume":"25","author":"Chen","year":"2004","journal-title":"Carcinogenesis"},{"issue":"30","key":"10.1016\/j.envres.2023.117134_bib15","doi-asserted-by":"crossref","first-page":"31384","DOI":"10.1007\/s11356-019-06224-5","article-title":"Associations between mercury exposure and the risk of nonalcoholic fatty liver disease (NAFLD) in US adolescents","volume":"26","author":"Chen","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envres.2023.117134_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130459","article-title":"Integrated miRNA-mRNA analysis reveals the dysregulation of lipid metabolism in mouse liver induced by developmental arsenic exposure","volume":"445","author":"Chen","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envres.2023.117134_bib17","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.chemosphere.2018.12.129","article-title":"Blood lead and cadmium levels associated with hematological and hepatic functions in patients from an e-waste-polluted area","volume":"220","author":"Chen","year":"2019","journal-title":"Chemosphere"},{"issue":"8","key":"10.1016\/j.envres.2023.117134_bib18","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1039\/c9mt00144a","article-title":"Inorganic arsenic causes intestinal barrier disruption","volume":"11","author":"Chiocchetti","year":"2019","journal-title":"Metallomics"},{"issue":"6","key":"10.1016\/j.envres.2023.117134_bib19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3961\/jpmph.17.099","article-title":"Mercury exposure in association with decrease of liver function in adults: a longitudinal study","volume":"50","author":"Choi","year":"2017","journal-title":"J. Prev. Med. Public. Health."},{"issue":"4","key":"10.1016\/j.envres.2023.117134_bib20","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.3390\/ijerph20043290","article-title":"Association of blood mercury level with liver enzymes in Korean adults: an analysis of 2015-2017 Korean national environmental health survey","volume":"20","author":"Chung","year":"2023","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envres.2023.117134_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2020.126601","article-title":"The sex-specific effects of blood lead, mercury, and cadmium levels on hepatic steatosis and fibrosis: Korean nationwide cross-sectional study","volume":"62","author":"Chung","year":"2020","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"8","key":"10.1016\/j.envres.2023.117134_bib22","doi-asserted-by":"crossref","DOI":"10.14309\/crj.0000000000000171","article-title":"Acute colonic pseudo-obstruction as a manifestation of lead intoxication in a conservator","volume":"6","author":"Costa-Moreira","year":"2019","journal-title":"ACG. Case Rep. J."},{"issue":"11","key":"10.1016\/j.envres.2023.117134_bib23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3390\/toxics9110287","article-title":"Methylmercury-induced metabolic alterations in Caenorhabditis elegans are diet-dependent","volume":"9","author":"Crawford","year":"2021","journal-title":"Toxics"},{"key":"10.1016\/j.envres.2023.117134_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.113015","article-title":"Cadmium exposure activates the PI3K\/AKT signaling pathway through miRNA-21, induces an increase in M1 polarization of macrophages, and leads to fibrosis of pig liver tissue","volume":"228","author":"Cui","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib25","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/0013-9351(75)90003-1","article-title":"Ultrastructural changes in rat hepatocytes following acute methyl mercury intoxication","volume":"9","author":"Desnoyers","year":"1975","journal-title":"Environ. Res."},{"issue":"2","key":"10.1016\/j.envres.2023.117134_bib26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1289\/ehp.1409501","article-title":"Effects of arsenite exposure during fetal development on energy metabolism and susceptibility to diet-induced fatty liver disease in male mice","volume":"124","author":"Ditzel","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2023.117134_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.140429","article-title":"Gut microbiota: a target for heavy metal toxicity and a probiotic protective strategy","volume":"742","author":"Duan","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.envres.2023.117134_bib28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12989-017-0236-y","article-title":"Sub-chronic inhalation of lead oxide nanoparticles revealed their broad distribution and tissue-specific subcellular localization in target organs","volume":"14","author":"Dumkov\u00e1","year":"2017","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envres.2023.117134_bib29","article-title":"Alleviative effect of threonine on cadmium-induced liver injury in mice","author":"Fang","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.envres.2023.117134_bib30","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12940-017-0350-1","article-title":"Arsenic exposure and risk of nonalcoholic fatty liver disease (NAFLD) among U.S. adolescents and adults: an association modified by race\/ethnicity, NHANES 2005-2014","volume":"17","author":"Frediani","year":"2018","journal-title":"Environ. Health"},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1136\/jech.46.3.237","article-title":"An epidemiological study with risk analysis of liver diseases in the general population living in a methyl mercury polluted area","volume":"46","author":"Futatsuka","year":"1992","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.envres.2023.117134_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.113018","article-title":"Selenium alleviates mercury chloride-induced liver injury by regulating mitochondrial dynamics to inhibit the crosstalk between energy metabolism disorder and NF-\u03baB\/NLRP3 inflammasome-mediated inflammation","volume":"228","author":"Gao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2023.117134_bib33","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13098-020-00570-y","article-title":"NAFLD as a continuum: from obesity to metabolic syndrome and diabetes","volume":"12","author":"Godoy-Matos","year":"2020","journal-title":"Diabetol. Metab. Syndrome"},{"issue":"2","key":"10.1016\/j.envres.2023.117134_bib34","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/0748233717750981","article-title":"Lead inhalation and hepatic damage: morphological and functional evaluation in mice","volume":"34","author":"Gonz\u00e1lez Rend\u00f3n","year":"2018","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.envres.2023.117134_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114254","article-title":"Cadmium perturbed lipid profile and induced liver dysfunction in mice through phosphatidylcholine remodeling and promoting arachidonic acid synthesis and metabolism","volume":"247","author":"Gu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.envres.2023.117134_bib36","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s12011-019-01859-4","article-title":"Emerging roles of MicroRNAs and long noncoding RNAs in cadmium toxicity","volume":"195","author":"Gu","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"issue":"4","key":"10.1016\/j.envres.2023.117134_bib37","article-title":"Serum cadmium is associated with hepatic steatosis and fibrosis: Korean national health and nutrition examination survey data IV-VII","volume":"101","author":"Han","year":"2022","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.envres.2023.117134_bib38","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.chemosphere.2018.03.106","article-title":"Gender differences in mercury-induced hepatotoxicity: potential mechanisms","volume":"202","author":"Hazelhoff","year":"2018","journal-title":"Chemosphere"},{"issue":"23","key":"10.1016\/j.envres.2023.117134_bib39","doi-asserted-by":"crossref","first-page":"13992","DOI":"10.1021\/acs.est.9b05131","article-title":"Inhibition of mitochondrial fatty acid oxidation contributes to development of nonalcoholic fatty liver disease induced by environmental cadmium exposure","volume":"53","author":"He","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2023.117134_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114123","article-title":"Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis","volume":"245","author":"He","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.envres.2023.117134_bib41","first-page":"783","article-title":"Lead exposure exacerbates adverse effects of HFD on metabolic function via disruption of gut microbiome, leading to compromised barrier function and inflammation","volume":"62","author":"Hu","year":"2023","journal-title":"Eur. J. Nutr."},{"issue":"7","key":"10.1016\/j.envres.2023.117134_bib42","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s11605-013-2210-9","article-title":"Cadmium exposure and liver disease among US adults","volume":"17","author":"Hyder","year":"2013","journal-title":"J. Gastrointest. Surg."},{"issue":"4","key":"10.1016\/j.envres.2023.117134_bib43","doi-asserted-by":"crossref","DOI":"10.1177\/15593258211060941","article-title":"Biochemical investigation of therapeutic potential of resveratrol against arsenic intoxication","volume":"19","author":"Irshad","year":"2021","journal-title":"Dose Response"},{"key":"10.1016\/j.envres.2023.117134_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.163069","article-title":"Alpha-ketoglutarate alleviates cadmium-induced inflammation by inhibiting the HIF1A-TNFAIP3 pathway in hepatocytes","volume":"878","author":"Jia","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2023.117134_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153133","article-title":"Identification of miRNAs involved in liver injury induced by chronic exposure to cadmium","volume":"469","author":"Jiang","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2023.117134_bib46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jtemb.2018.11.006","article-title":"The relationship between mercury exposure and epigenetic alterations regarding human health, risk assessment and diagnostic strategies","volume":"52","author":"Khan","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib47","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1007\/s11356-013-2057-3","article-title":"Effects of sodium arsenate exposure on liver fatty acid profiles and oxidative stress in rats","volume":"21","author":"Kharroubi","year":"2014","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"13","key":"10.1016\/j.envres.2023.117134_bib48","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.3390\/ijerph18136783","article-title":"Association between Pb, Cd, and Hg exposure and liver injury among Korean adults","volume":"18","author":"Kim","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envres.2023.117134_bib49","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jtemb.2019.05.003","article-title":"Heavy metal toxicity: an update of chelating therapeutic strategies","volume":"54","author":"Kim","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.envres.2023.117134_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109649","article-title":"Cadmium induces triglyceride levels via microsomal triglyceride transfer protein (MTTP) accumulation caused by lysosomal deacidification regulated by endoplasmic reticulum (ER) Ca2+ homeostasis","volume":"348","author":"Kong","year":"2021","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib51","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3350\/cmh.2013.19.3.210","article-title":"Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis","volume":"19","author":"Koo","year":"2013","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.envres.2023.117134_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110055","article-title":"The effects of chronic lead exposure on the liver of female Japanese quail (Coturnix japonica): histopathological damages, oxidative stress and AMP-activated protein kinase based lipid metabolism disorder","volume":"190","author":"Kou","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.envres.2023.117134_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038249","article-title":"Effects of low-dose drinking water arsenic on mouse fetal and postnatal growth and development","volume":"7","author":"Kozul-Horvath","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2023.117134_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111036","article-title":"Pollutants and nutrition: are methylmercury effects on blood pressure and lipoprotein profile comparable to high-fat diet in mice?","volume":"204","author":"Lacerda Leoc\u00e1dio","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.envres.2023.117134_bib55","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.fct.2008.01.018","article-title":"Lipid metabolism in liver of rat exposed to cadmium","volume":"46","author":"Larregle","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envres.2023.117134_bib56","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.envres.2014.01.005","article-title":"Associations between blood mercury levels and subclinical changes in liver enzymes among South Korean general adults: analysis of 2008-2012 Korean national health and nutrition examination survey data","volume":"130","author":"Lee","year":"2014","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.envres.2023.117134_bib57","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12940-017-0228-2","article-title":"Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study","volume":"16","author":"Lee","year":"2017","journal-title":"Environ. Health."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib58","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/toxics8030047","article-title":"Mercury exposure and associations with hyperlipidemia and elevated liver enzymes: a nationwide cross-sectional survey","volume":"8","author":"Lee","year":"2020","journal-title":"Toxics"},{"issue":"2","key":"10.1016\/j.envres.2023.117134_bib59","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/liv.15416","article-title":"Long-term exposure to air pollution and incident non-alcoholic fatty liver disease and cirrhosis: a cohort study","volume":"43","author":"Li","year":"2023","journal-title":"Liver Int."},{"key":"10.1016\/j.envres.2023.117134_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164746","article-title":"As3MT via consuming SAM is involved in arsenic-induced nonalcoholic fatty liver disease by blocking m6A-mediated miR-142-5p maturation","volume":"892","author":"Li","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"16","key":"10.1016\/j.envres.2023.117134_bib61","doi-asserted-by":"crossref","first-page":"48260","DOI":"10.1007\/s11356-023-25540-5","article-title":"Associations of arsenic exposure with liver injury in US adults: NHANES 2003-2018","volume":"30","author":"Li","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envres.2023.117134_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.137854","article-title":"Associations of blood metals with liver function: analysis of NHANES from 2011 to 2018","volume":"317","author":"Li","year":"2023","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.envres.2023.117134_bib63","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s10620-021-06869-8","article-title":"Cadmium exposure in young adulthood is associated with risk of nonalcoholic fatty liver disease in midlife","volume":"67","author":"Li","year":"2022","journal-title":"Dig. Dis. Sci."},{"issue":"1","key":"10.1016\/j.envres.2023.117134_bib64","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-014215","article-title":"Association between soil heavy metals and fatty liver disease in men in Taiwan: a cross sectional study","volume":"7","author":"Lin","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.envres.2023.117134_bib65","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.envint.2014.05.010","article-title":"Association of body burden of mercury with liver function test status in the U.S. population","volume":"70","author":"Lin","year":"2014","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.envres.2023.117134_bib66","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3390\/ijerph17010138","article-title":"Cadmium induces acute liver injury by inhibiting Nrf2 and the role of NF-\u03baB, NLRP3, and MAPKs signaling pathway","volume":"17","author":"Liu","year":"2019","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"14","key":"10.1016\/j.envres.2023.117134_bib67","doi-asserted-by":"crossref","first-page":"14189","DOI":"10.18632\/aging.103430","article-title":"Co-exposure to multi-walled carbon nanotube and lead ions aggravates hepatotoxicity of nonalcoholic fatty liver via inhibiting AMPK\/PPAR\u03b3 pathway","volume":"12","author":"Liu","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.envres.2023.117134_bib68","doi-asserted-by":"crossref","DOI":"10.1007\/s12024-023-00654-x","article-title":"Four cases of fatal acute arsenic poisoning: histopathology, toxicology, and new trends","author":"Liu","year":"2023","journal-title":"Forensic Sci. Med. Pathol."},{"issue":"11","key":"10.1016\/j.envres.2023.117134_bib69","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nrgastro.2013.171","article-title":"The global NAFLD epidemic","volume":"10","author":"Loomba","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.envres.2023.117134_bib70","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3390\/toxics11060503","article-title":"Inhibition of histone H3K18 acetylation-dependent antioxidant pathways involved in arsenic-induced liver injury in rats and the protective effect of rosa roxburghii tratt juice","volume":"11","author":"Ma","year":"2023","journal-title":"Toxics"},{"issue":"2","key":"10.1016\/j.envres.2023.117134_bib71","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s12011-018-1263-8","article-title":"Toxicological effects of mercury chloride on laying performance, egg quality, serum biochemistry, and histopathology of liver and kidney in laying hens","volume":"185","author":"Ma","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.envres.2023.117134_bib72","first-page":"205","article-title":"Flavonoids fractions of Adansonia digitata L. fruits protects adult Wistar rats from mercury chloride-induced hepatorenal toxicity: histopathological and biochemical studies. Egypt","volume":"9","author":"Makena","year":"2022","journal-title":"J. Basic Appl. Sci."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib73","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.taap.2015.02.022","article-title":"Oligofructose protects against arsenic-induced liver injury in a model of environment\/obesity interaction","volume":"284","author":"Massey","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.envres.2023.117134_bib74","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2131\/jts.43.291","article-title":"Hepatic histopathological changes and dysfunction in primates following exposure to organic arsenic diphenylarsinic acid","volume":"43","author":"Masuda","year":"2018","journal-title":"J. Toxicol. Sci."},{"issue":"7","key":"10.1016\/j.envres.2023.117134_bib75","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/occmed\/kqg091","article-title":"Chronic lead poisoning in an adult battery worker","volume":"53","author":"Menezes","year":"2003","journal-title":"Occup. Med."},{"key":"10.1016\/j.envres.2023.117134_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120730","article-title":"Melatonin alleviates lead-induced fatty liver in the common carps (Cyprinus carpio) via gut-liver axis","volume":"317","author":"Miao","year":"2023","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib77","first-page":"513","article-title":"Phytochemical: a treatment option for heavy metal induced neurotoxicity","volume":"19","author":"Mishra","year":"2022","journal-title":"J. Compl. Integr. Med."},{"issue":"Pt A","key":"10.1016\/j.envres.2023.117134_bib78","article-title":"Lead, mercury, and cadmium exposures are associated with obesity but not with diabetes mellitus: Korean National Environmental Health Survey (KoNEHS) 2015-2017","volume":"204","author":"Moon","year":"2022","journal-title":"Environ. Res."},{"issue":"6","key":"10.1016\/j.envres.2023.117134_bib79","first-page":"518","article-title":"Lead hepatotoxicity potential health effects","volume":"126","author":"Mudipalli","year":"2007","journal-title":"Indian J. Med. Res."},{"issue":"14","key":"10.1016\/j.envres.2023.117134_bib80","doi-asserted-by":"crossref","first-page":"14087","DOI":"10.1007\/s11356-019-04620-5","article-title":"The protective role of ascorbic acid in the hepatotoxicity of cadmium and mercury in rabbits","volume":"26","author":"Mumtaz","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envres.2023.117134_bib81","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cbi.2015.04.006","article-title":"Ameliorative efficacy of tetrahydrocurcumin against arsenic induced oxidative damage, dyslipidemia and hepatic mitochondrial toxicity in rats","volume":"235","author":"Muthumani","year":"2015","journal-title":"Chem. Biol. Interact."},{"issue":"10S","key":"10.1016\/j.envres.2023.117134_bib82","doi-asserted-by":"crossref","DOI":"10.14309\/01.ajg.0000868344.55510.4d","article-title":"Hepatic steatosis and acute liver injury in chronic arsenic exposure","volume":"117","author":"Nguyen","year":"2022","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.envres.2023.117134_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119780","article-title":"Cadmium, lead, and mercury mixtures interact with non-alcoholic fatty liver diseases","volume":"309","author":"Nguyen","year":"2022","journal-title":"Environ. Pollut."},{"issue":"52","key":"10.1016\/j.envres.2023.117134_bib84","doi-asserted-by":"crossref","first-page":"78555","DOI":"10.1007\/s11356-022-21090-4","article-title":"Effects of chemical mixtures on liver function biomarkers in the Korean adult population: thresholds and molecular mechanisms for non-alcoholic fatty liver disease involved","volume":"29","author":"Nguyen","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"1","key":"10.1016\/j.envres.2023.117134_bib85","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1021\/acs.chemrestox.1c00306","article-title":"MicroRNA expression influences methylmercury-induced lipid accumulation and mitochondrial toxicity in Caenorhabditis elegans","volume":"35","author":"Nielsen","year":"2022","journal-title":"Chem. Res. Toxicol."},{"issue":"4","key":"10.1016\/j.envres.2023.117134_bib86","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/tox.23731","article-title":"Cadmium modulates steatosis, fibrosis, and oncogenic signaling in liver cancer cells by activating notch and AKT\/mTOR pathways","volume":"38","author":"Niture","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envres.2023.117134_bib87","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9564297","article-title":"Role of autophagy in cadmium-induced hepatotoxicity and liver diseases","volume":"2021","author":"Niture","year":"2021","journal-title":"J. Toxicol."},{"key":"10.1016\/j.envres.2023.117134_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114973","article-title":"Oleanolic acid inhibits mercury chloride induced-liver ferroptosis by regulating ROS\/iron overload","volume":"258","author":"Ouyang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.envres.2023.117134_bib89","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/jbt.21785","article-title":"Effects of naringenin on oxidative stress and histopathological changes in the liver of lead acetate administered rats","volume":"30","author":"Ozkaya","year":"2016","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.envres.2023.117134_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128947","article-title":"Association between environmental exposure to cadmium and risk of suspected non-alcoholic fatty liver disease","volume":"266","author":"Park","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2023.117134_bib91","first-page":"23","article-title":"Adult non-alcoholic fatty liver disease (NAFLD)","author":"Pedersen","year":"2019","journal-title":"The Human Gut-Liver-Axis in Health and Disease"},{"issue":"10","key":"10.1016\/j.envres.2023.117134_bib92","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s41419-018-1004-0","article-title":"Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway","volume":"9","author":"Qiu","year":"2018","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib93","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/toxres\/tfad028","article-title":"Hepatoprotective effect of avicularin on lead-induced steatosis, oxidative stress, and inflammation in mice associated with the MAPK\/HSP60\/NLRP3 and SREBP1c pathway","volume":"12","author":"Qiu","year":"2023","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.envres.2023.117134_bib94","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ecoenv.2018.10.054","article-title":"Selenium and zinc protections against metal-(loids)-induced toxicity and disease manifestations: a review","volume":"168","author":"Rahman","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"8","key":"10.1016\/j.envres.2023.117134_bib95","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1007\/s10620-021-07203-y","article-title":"Environmental toxicants and NAFLD: a neglected yet significant relationship","volume":"67","author":"Rajak","year":"2022","journal-title":"Dig. Dis. Sci."},{"issue":"4","key":"10.1016\/j.envres.2023.117134_bib96","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.aohep.2020.03.006","article-title":"Blood lead level is associated with advanced liver fibrosis in patients with non-alcoholic fatty liver disease: a nationwide survey (NHANES 2011-2016)","volume":"19","author":"Reja","year":"2020","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.envres.2023.117134_bib97","doi-asserted-by":"crossref","first-page":"S1615","DOI":"10.14309\/01.ajg.0000601440.80672.c8","article-title":"Mercury exposure and risk of non-alcoholic fatty liver disease and advanced fibrosis: findings from the 2011-2016 national health and nutrition examination survey","volume":"114","author":"Reja","year":"2019","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.envres.2023.117134_bib98","first-page":"S563","article-title":"968 lead (Pb) exposure and risk of non-alcoholic fatty liver disease and advanced fibrosis: an association modified by race\/ethnicity and gender in NHANES 2011-2016","volume":"114","author":"Reja","year":"2019","journal-title":"Am. J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib99","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1007\/s12011-020-02222-8","article-title":"Effects of selenium on arsenic-induced liver lesions in broilers","volume":"199","author":"Ren","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envres.2023.117134_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.129735","article-title":"Molecular mechanism of heavy metals (lead, chromium, arsenic, mercury, nickel and cadmium) - induced hepatotoxicity - a review","volume":"271","author":"Renu","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2023.117134_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118438","article-title":"An appraisal on molecular and biochemical signalling cascades during arsenic-induced hepatotoxicity","volume":"260","author":"Renu","year":"2020","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.envres.2023.117134_bib102","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S2468-1253(22)00165-0","article-title":"The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis","volume":"7","author":"Riazi","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.envres.2023.117134_bib103","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.tox.2018.02.007","article-title":"Cadmium exposure exacerbates hyperlipidemia in cholesterol-overloaded hepatocytes via autophagy dysregulation","volume":"398\u2013399","author":"Rosales-Cruz","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2023.117134_bib104","doi-asserted-by":"crossref","DOI":"10.1007\/s12011-023-03629-9","article-title":"Association between non-alcoholic fatty liver disease and heavy metal exposure: a systematic review","author":"Sadighara","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.envres.2023.117134_bib105","doi-asserted-by":"crossref","DOI":"10.7243\/2056-3779-1-1","article-title":"Fetal exposure to arsenic results in hyperglycemia, hypercholesterolemia, and nonalcoholic fatty liver disease in adult mice","volume":"1","author":"Sanchez-Soria","year":"2014","journal-title":"J. Toxicol. Health"},{"issue":"2","key":"10.1016\/j.envres.2023.117134_bib106","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.taap.2006.12.029","article-title":"Arsenic induces apoptosis in mouse liver is mitochondria dependent and is abrogated by N-acetylcysteine","volume":"220","author":"Santra","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.envres.2023.117134_bib107","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1081\/CLT-100100949","article-title":"Hepatic damage caused by chronic arsenic toxicity in experimental animals","volume":"38","author":"Santra","year":"2000","journal-title":"J. Toxicol. Clin. Toxicol."},{"issue":"8","key":"10.1016\/j.envres.2023.117134_bib108","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1007\/s12011-022-03471-5","article-title":"ROS and ERK pathway mechanistic approach on hepatic insulin resistance after chronic oral exposure to cadmium NOAEL dose","volume":"201","author":"Sarmiento-Ortega","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"issue":"10","key":"10.1016\/j.envres.2023.117134_bib109","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1007\/s12011-021-03027-z","article-title":"Oral subacute exposure to cadmium LOAEL dose induces insulin resistance and impairment of the hormonal and metabolic liver-adipose Axis in wistar rats","volume":"200","author":"Sarmiento-Ortega","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.envres.2023.117134_bib110","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-15680-y","article-title":"Short-term mercury exposure disrupts muscular and hepatic lipid metabolism in a migrant songbird","volume":"12","author":"Seewagen","year":"2022","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.envres.2023.117134_bib111","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00244-023-00982-7","article-title":"Effects of environmental cadmium exposure on the liver in Korean adults: cross-sectional and longitudinal studies","volume":"84","author":"Seo","year":"2023","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"2","key":"10.1016\/j.envres.2023.117134_bib112","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1021\/pr400719u","article-title":"Metabolomic analysis of the effects of chronic arsenic exposure in a mouse model of diet-induced Fatty liver disease","volume":"13","author":"Shi","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.envres.2023.117134_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152927","article-title":"Health repercussions of environmental exposure to lead: methylation perspective","volume":"461","author":"Shiek","year":"2021","journal-title":"Toxicology"},{"issue":"7","key":"10.1016\/j.envres.2023.117134_bib114","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1136\/gutjnl-2020-322786","article-title":"Mortality in biopsy-confirmed nonalcoholic fatty liver disease: results from a nationwide cohort","volume":"70","author":"Simon","year":"2021","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.envres.2023.117134_bib115","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1177\/0748233720970437","article-title":"Blood mercury and liver enzymes: a pan-India retrospective correlation study","volume":"36","author":"Sivapandi","year":"2020","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.envres.2023.117134_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153339","article-title":"The mechanism of the cadmium-induced toxicity and cellular response in the liver","volume":"480","author":"Souza-Arroyo","year":"2022","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib117","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1002\/hep.31809","article-title":"In utero exposure to mercury is associated with increased susceptibility to liver injury and inflammation in childhood","volume":"74","author":"Stratakis","year":"2021","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.envres.2023.117134_bib118","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169958","article-title":"Lead exposure induces weight gain in adult rats, accompanied by DNA hypermethylation","volume":"12","author":"Sun","year":"2017","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.envres.2023.117134_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102835","article-title":"Melatonin alleviates cadmium-induced nonalcoholic fatty liver disease in ducks by alleviating autophagic flow arrest via PPAR-\u03b1 and reducing oxidative stress","volume":"102","author":"Sun","year":"2023","journal-title":"Poultry Sci."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib120","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.taap.2011.09.019","article-title":"Chronic subhepatotoxic exposure to arsenic enhances hepatic injury caused by high fat diet in mice","volume":"257","author":"Tan","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envres.2023.117134_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124959","article-title":"Autophagic-CTSB-inflammasome axis modulates hepatic stellate cells activation in arsenic-induced liver fibrosis","volume":"242","author":"Tao","year":"2020","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.envres.2023.117134_bib122","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12876-020-01386-w","article-title":"Changes in inflammatory cytokines, antioxidants and liver stiffness after chelation therapy in individuals with chronic lead poisoning","volume":"20","author":"Teerasarntipan","year":"2020","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.envres.2023.117134_bib123","doi-asserted-by":"crossref","first-page":"32","DOI":"10.12703\/r\/10-32","article-title":"Adipotropic effects of heavy metals and their potential role in obesity","volume":"10","author":"Tinkov","year":"2021","journal-title":"Fac. Rev."},{"key":"10.1016\/j.envres.2023.117134_bib124","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.envpol.2017.12.114","article-title":"Gut as a target for cadmium toxicity","volume":"235","author":"Tinkov","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2023.117134_bib125","doi-asserted-by":"crossref","DOI":"10.3390\/biom13101549","article-title":"Interaction of heavy metal lead with gut microbiota: implications for autism spectrum disorder","author":"Tizabi","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.envres.2023.117134_bib126","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/1471-2164-11-212","article-title":"Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation","volume":"11","author":"Ung","year":"2010","journal-title":"BMC Genom."},{"issue":"21","key":"10.1016\/j.envres.2023.117134_bib127","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1002\/1873-3468.13538","article-title":"Chronic exposure to Pb2+ perturbs ChREBP transactivation and coerces hepatic dyslipidemia","volume":"593","author":"Vineeth Daniel","year":"2019","journal-title":"FEBS Lett."},{"key":"10.1016\/j.envres.2023.117134_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113611","article-title":"PM2.5 air pollution exposure and nonalcoholic fatty liver disease in the Nationwide Inpatient Sample","volume":"213","author":"VoPham","year":"2022","journal-title":"Environ. Res."},{"issue":"6","key":"10.1016\/j.envres.2023.117134_bib129","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1007\/s11356-019-07066-x","article-title":"Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003-2004","volume":"27","author":"Wahlang","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envres.2023.117134_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113257","article-title":"Chronic lead exposure induces fatty liver disease associated with the variations of gut microbiota","volume":"232","author":"Wan","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2023.117134_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111521","article-title":"Puerarin attenuates cadmium-induced hepatic lipid metabolism disorder by inhibiting oxidative stress and inflammation in mice","volume":"222","author":"Wan","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.envres.2023.117134_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113772","article-title":"Role of endoplasmic reticulum stress in cadmium-induced hepatocyte apoptosis and the protective effect of quercetin","volume":"241","author":"Wang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2023.117134_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113451","article-title":"Chronic lead exposure exacerbates hepatic glucolipid metabolism disorder and gut microbiota dysbiosis in high-fat-diet mice","volume":"170","author":"Wang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envres.2023.117134_bib134","article-title":"Identification of the regulatory network and potential markers for type 2 diabetes mellitus related to internal exposure to metals in Chinese adults","author":"Wang","year":"2023","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.envres.2023.117134_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109824","article-title":"Ferroptosis mediated by the interaction between Mfn2 and IRE\u03b1 promotes arsenic-induced nonalcoholic steatohepatitis","volume":"188","author":"Wei","year":"2020","journal-title":"Environ. Res."},{"issue":"11","key":"10.1016\/j.envres.2023.117134_bib136","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrgastro.2013.149","article-title":"From NAFLD to NASH to cirrhosis-new insights into disease mechanisms","volume":"10","author":"Wree","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib137","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3181\/0710-RM-269","article-title":"High dietary fat exacerbates arsenic-induced liver fibrosis in mice","volume":"233","author":"Wu","year":"2008","journal-title":"Exp. Biol. Med. (Maywood)."},{"key":"10.1016\/j.envres.2023.117134_bib138","article-title":"The molecular mechanism of hepatic lipid metabolism disorder caused by NaAsO2 through regulating the ERK\/PPAR signaling pathway","volume":"2022","author":"Wu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.envres.2023.117134_bib139","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.scitotenv.2018.03.053","article-title":"Chronic exposure to low concentrations of lead induces metabolic disorder and dysbiosis of the gut microbiota in mice","volume":"631\u2013632","author":"Xia","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2023.117134_bib140","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1133194","article-title":"Associations of metal mixtures with metabolic-associated fatty liver disease and non-alcoholic fatty liver disease: NHANES 2003-2018","volume":"11","author":"Xie","year":"2023","journal-title":"Front. Public Health"},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib141","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/s10653-020-00612-4","article-title":"Assessing the potential value of Rosa Roxburghii Tratt in arsenic-induced liver damage based on elemental imbalance and oxidative damage","volume":"43","author":"Xu","year":"2021","journal-title":"Environ. Geochem. Health"},{"issue":"26","key":"10.1016\/j.envres.2023.117134_bib142","doi-asserted-by":"crossref","first-page":"39768","DOI":"10.1007\/s11356-022-18950-4","article-title":"Association between urinary cadmium concentrations and liver function in adolescents","volume":"29","author":"Xu","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envres.2023.117134_bib143","article-title":"Lead exposure as a causative factor for metabolic associated fatty liver disease (MAFLD) and a lead exposure related nomogram for MAFLD prevalence","volume":"10","author":"Yang","year":"2022","journal-title":"Front. Public Health"},{"issue":"12","key":"10.1016\/j.envres.2023.117134_bib144","doi-asserted-by":"crossref","first-page":"6412","DOI":"10.3390\/ijerph18126412","article-title":"Association between blood mercury levels and non-alcoholic fatty liver disease in non-obese populations: the Korean national environmental health survey (KoNEHS) 2012-2014","volume":"18","author":"Yang","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envres.2023.117134_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115855","article-title":"Whole life exposure to low dose cadmium alters diet-induced NAFLD","volume":"436","author":"Young","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.envres.2023.117134_bib146","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jhep.2019.06.021","article-title":"The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: a systematic review and meta-analysis","volume":"71","author":"Younossi","year":"2019","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.envres.2023.117134_bib147","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.envres.2023.117134_bib148","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111389","article-title":"Puerarin induces Nrf2 as a cytoprotective mechanism to prevent cadmium-induced autophagy inhibition and NLRP3 inflammasome activation in AML12 hepatic cells","volume":"217","author":"Yu","year":"2021","journal-title":"J. Inorg. Biochem."},{"issue":"1","key":"10.1016\/j.envres.2023.117134_bib149","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12940-017-0304-7","article-title":"Blood lead level is associated with non-alcoholic fatty liver disease in the Yangtze River Delta region of China in the context of rapid urbanization","volume":"16","author":"Zhai","year":"2017","journal-title":"Environ. Health."},{"key":"10.1016\/j.envres.2023.117134_bib150","doi-asserted-by":"crossref","DOI":"10.1007\/s12011-023-03577-4","article-title":"Glutathione might attenuate arsenic-induced liver injury by modulating the foxa2-XIAP Axis to reduce oxidative stress and mitochondrial apoptosis","author":"Zhang","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"issue":"7","key":"10.1016\/j.envres.2023.117134_bib151","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/jat.3612","article-title":"Subchronic cadmium exposure upregulates the mRNA level of genes associated to hepatic lipid metabolism in adult female CD1 mice","volume":"38","author":"Zhang","year":"2018","journal-title":"J. Appl. Toxicol."},{"issue":"10","key":"10.1016\/j.envres.2023.117134_bib152","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1021\/acs.chemrestox.5b00237","article-title":"Subchronic exposure of mice to cadmium perturbs their hepatic energy metabolism and gut microbiome","volume":"28","author":"Zhang","year":"2015","journal-title":"Chem. Res. Toxicol."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib153","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/tox.23420","article-title":"SIRT1\/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells","volume":"37","author":"Zhao","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envres.2023.117134_bib154","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137639","article-title":"Subchronic oral mercury caused intestinal injury and changed gut microbiota in mice","volume":"721","author":"Zhao","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2023.117134_bib155","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106555","article-title":"Effects of environmental contaminants in water resources on nonalcoholic fatty liver disease","volume":"154","author":"Zheng","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2023.117134_bib156","article-title":"Arsenic causes mitochondrial biogenesis obstacles by inhibiting the AMPK\/PGC-1\u03b1 signaling pathway and also induces apoptosis and dysregulated mitophagy in the duck liver","volume":"230","author":"Zhong","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2023.117134_bib157","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147780","article-title":"Arsenic exposure induces intestinal barrier damage and consequent activation of gut-liver axis leading to inflammation and pyroptosis of liver in ducks","volume":"788","author":"Zhong","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2023.117134_bib158","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146082","article-title":"Arsenic or\/and antimony induced mitophagy and apoptosis associated with metabolic abnormalities and oxidative stress in the liver of mice","volume":"777","author":"Zhong","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"35","key":"10.1016\/j.envres.2023.117134_bib159","doi-asserted-by":"crossref","first-page":"53633","DOI":"10.1007\/s11356-022-19698-7","article-title":"Associations between lead, cadmium, mercury, and arsenic exposure and alanine aminotransferase elevation in the general adult population: an exposure-response analysis","volume":"29","author":"Zhou","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"3","key":"10.1016\/j.envres.2023.117134_bib160","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/s10311-021-01383-9","article-title":"Heavy metal-induced lipogenic gene aberration, lipid dysregulation and obesogenic effect: a review","volume":"20","author":"Zhou","year":"2022","journal-title":"Environ. Chem. Lett."},{"issue":"4","key":"10.1016\/j.envres.2023.117134_bib161","first-page":"840","article-title":"Influence of low-level lead exposure on liver function and blood lipids in rats with nonalcoholic fatty liver disease","volume":"35","author":"Zhu","year":"2019","journal-title":"J. Clin. Hepatol"},{"key":"10.1016\/j.envres.2023.117134_bib162","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115040","article-title":"Saturated fatty acids synergizes cadmium to induce macrophages M1 polarization and hepatic inflammation","volume":"259","author":"Zhu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2023.117134_bib163","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113306","article-title":"Chronic exposure to low-dose cadmium facilitated nonalcoholic steatohepatitis in mice by suppressing fatty acid desaturation","volume":"233","author":"Zhu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.envres.2023.117134_bib164","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s12011-020-02045-7","article-title":"Effects of cadmium and\/or lead on autophagy and liver injury in rats","volume":"198","author":"Zou","year":"2020","journal-title":"Biol. Trace Elem. Res."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935123019382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935123019382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T16:18:04Z","timestamp":1777047484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935123019382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":164,"alternative-id":["S0013935123019382"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2023.117134","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dissecting the role of cadmium, lead, arsenic, and mercury in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2023.117134","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117134"}}