{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:48:56Z","timestamp":1791913736955,"version":"4.3.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["2019\/040"],"award-info":[{"award-number":["2019\/040"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010575","name":"Consejo Nacional de Rectores","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010575","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.envres.2023.117665","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:17:05Z","timestamp":1700525825000},"page":"117665","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["A case study on pharmaceutical residues and antimicrobial resistance genes in Costa Rican rivers: A possible route of contamination for feline and other species"],"prefix":"10.1016","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8003-6358","authenticated-orcid":false,"given":"Seiling","family":"Vargas-Villalobos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2918-227X","authenticated-orcid":false,"given":"David","family":"Fabregat-Safont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Salas-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Quesada-Alvarado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Botero-Coy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8810-5071","authenticated-orcid":false,"given":"Fernando","family":"Esper\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"Mart\u00edn-Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Monr\u00f3s-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Ruepert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Estrada-K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josu\u00e9","family":"Rivera-Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Chaverri-Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0883-1832","authenticated-orcid":false,"given":"Kinndle","family":"Blanco-Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.envres.2023.117665_bib1","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1080\/10643389.2019.1692611","article-title":"Understanding human health risks caused by antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARG) in water environments: current knowledge and questions to be answered","volume":"50","author":"Amarasiri","year":"2020","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2023.117665_bib2","doi-asserted-by":"crossref","DOI":"10.7589\/JWD-D-21-00182","article-title":"Identification of anthropogenic impact on natural habitats by antimicrobial","author":"Angulo","year":"2023","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.envres.2023.117665_bib3","series-title":"Demonstration of antibiotic-induced tolerance development in tropical agroecosystems through physiological profiling of sediment microbial communities (e228v1)","author":"Arias-Andr\u00e9s","year":"2014"},{"issue":"9","key":"10.1016\/j.envres.2023.117665_bib5","article-title":"Agricultural contamination impacts antibiotic resistance gene abundances in river bed sediment temporally","volume":"94","author":"Beattie","year":"2018","journal-title":"FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Ecol."},{"issue":"4","key":"10.1016\/j.envres.2023.117665_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jece.2021.105548","article-title":"Investigation of pharmaceuticals in a conventional wastewater treatment plant: removal efficiency, seasonal variation and impact of a nearby hospital","volume":"9","author":"Bijlsma","year":"2021","journal-title":"J. Environ. Chem. Eng."},{"issue":"7","key":"10.1016\/j.envres.2023.117665_bib8","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1111\/zph.12340","article-title":"Antimicrobial resistance genes in pigeons from public parks in Costa Rica","volume":"64","author":"Blanco-Pe\u00f1a","year":"2017","journal-title":"Zoonoses and Public Health"},{"key":"10.1016\/j.envres.2023.117665_bib9","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.scitotenv.2018.06.088","article-title":"An investigation into the occurrence and removal of pharmaceuticals in Colombian 'wastewater","volume":"642","author":"Botero-Coy","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"12","key":"10.1016\/j.envres.2023.117665_bib85","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1093\/jac\/dks326","article-title":"Exposure to diverse antimicrobials induces the expression of qnbrB1, qnrD and smaqnr genes by SOS-dependent regulation","volume":"67","author":"Briales","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.envres.2023.117665_bib10","series-title":"Wastewater-based Epidemiology, an Analytical Chemical Approach for the Investigation of Human Consumption of Lifestyle Chemicals","author":"Causanilles Llanes","year":"2018"},{"key":"10.1016\/j.envres.2023.117665_bib13","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.watres.2018.02.003","article-title":"Complex pollution of antibiotic resistance genes due to beta-lactam and aminoglycoside use in aquaculture farming","volume":"134","author":"Chen","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2023.117665_bib14","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.watres.2017.07.004","article-title":"The potential implications of reclaimed wastewater reuse for irrigation on the agricultural environment: the knowns and unknowns of the fate of antibiotics and antibiotic resistant bacteria and resistance genes - a review","volume":"123","author":"Christou","year":"2017","journal-title":"Water Res."},{"issue":"1","key":"10.1016\/j.envres.2023.117665_bib15","first-page":"85","article-title":"Hazard prioritization and risk characterization of antibiotics in an irrigated Costa Rican region used for intensive crop, livestock and aquaculture farming","volume":"35","author":"de la Cruz","year":"2014","journal-title":"J. Environ. Biol."},{"key":"10.1016\/j.envres.2023.117665_bib18","first-page":"88","article-title":"16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides","volume":"vol. 45","author":"Doi","year":"2007"},{"issue":"19","key":"10.1016\/j.envres.2023.117665_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/w13192693","article-title":"Anthropogenic activities and the problem of antibiotic resistance in Latin America: a water issue","volume":"13","author":"Dom\u00ednguez","year":"2021","journal-title":"Water"},{"key":"10.1016\/j.envres.2023.117665_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340739","article-title":"Analytical key issues and challenges in the LC-MS\/MS determination of antibiotics in wastewater","volume":"1239","author":"Fabregat-Safont","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.envres.2023.117665_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106004","article-title":"Occurrence and ecological risks of pharmaceuticals in a Mediterranean river in Eastern Spain","volume":"144","author":"Fonseca","year":"2020","journal-title":"Environ. Int."},{"issue":"6","key":"10.1016\/j.envres.2023.117665_bib26","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1080\/19440049.2014.907504","article-title":"Unravelling a vicious circle: animal feed marketed in Costa Rica contains irregular concentrations of tetracyclines and abundant oxytetracycline-resistant Gram-positive bacteria","volume":"31","author":"Granados-Chinchilla","year":"2014","journal-title":"Food Addit. Contam. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment"},{"issue":"2","key":"10.1016\/j.envres.2023.117665_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.tree.2015.10.009","article-title":"Luikart, g., Genomics in Conservation: Case Studies and Bridging the Gap between Data and Application","volume":"31","author":"Garner","year":"2016","journal-title":"Trends Ecol. Evol."},{"issue":"3","key":"10.1016\/j.envres.2023.117665_bib27","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/etc.5289","article-title":"Antimicrobial resistance in rivers: a review of the genes detected and new challenges","volume":"41","author":"Grenni","year":"2022","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envres.2023.117665_bib28","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.3389\/fmicb.2018.03191","article-title":"Analysis of bacterial community characteristics, abundance of antibiotics and antibiotic resistance genes along a pollution gradient of Ba River in xi'an, China","volume":"9","author":"Guan","year":"2018","journal-title":"Front. Microbiol."},{"issue":"7","key":"10.1016\/j.envres.2023.117665_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002158","article-title":"Selection of resistant bacteria at very low antibiotic concentrations","volume":"7","author":"Gullberg","year":"2011","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.envres.2023.117665_bib34","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41467-018-07992-3","article-title":"Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments","volume":"10","author":"Karkman","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2023.117665_bib36","series-title":"Pheatmap: Pretty Heatmaps (1.0.12)","author":"Kolde","year":"2019"},{"key":"10.1016\/j.envres.2023.117665_bib37","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.scitotenv.2018.08.130","article-title":"Performance of secondary wastewater treatment methods for the removal of contaminants of emerging concern implicated in crop uptake and antibiotic resistance spread: a review","volume":"648","author":"Krzeminski","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2023.117665_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v025.i01","article-title":"FactoMineR: an R package for multivariate analysis","volume":"25","author":"L\u00ea","year":"2008","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.envres.2023.117665_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152567","article-title":"Removal efficiency for emerging contaminants in a WWTP from Madrid (Spain) after secondary and tertiary treatment and environmental impact on the Manzanares River","volume":"812","author":"Lopez","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2023.117665_bib43","first-page":"33","volume":"vol. 5","author":"Marquez","year":"2000"},{"issue":"1","key":"10.1016\/j.envres.2023.117665_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/w11010071","article-title":"Monitoring antimicrobial resistance dissemination in aquatic systems","volume":"11","author":"Ng","year":"2019","journal-title":"Water"},{"issue":"8","key":"10.1016\/j.envres.2023.117665_bib51","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/zph.12639","article-title":"Antimicrobial resistance genes present in the faecal microbiota of free-living Galapagos tortoises (Chelonoidis porteri)","volume":"66","author":"Nieto-Claudin","year":"2019","journal-title":"Zoonoses and Public Health"},{"key":"10.1016\/j.envres.2023.117665_bib53","series-title":"Vegan Community Ecology Package Version 2.6-2","author":"Oksanen","year":"2022"},{"issue":"3","key":"10.1016\/j.envres.2023.117665_bib54","first-page":"9","article-title":"Flora bacteriana de La cavidad oral del mono Tit\u00cd (Saimiri oerstedii) Y su perfil de sensibilidad A antibi\u00f3ticos","volume":"14","author":"Palacios","year":"2007","journal-title":"Neotrop. Primates"},{"issue":"8","key":"10.1016\/j.envres.2023.117665_bib55","doi-asserted-by":"crossref","first-page":"E1796","DOI":"10.3390\/molecules25081796","article-title":"Selected pharmaceuticals in different aquatic compartments: Part II-toxicity and environmental risk assessment","volume":"25","author":"Pereira","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.envres.2023.117665_bib57","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.envint.2017.10.016","article-title":"Review of antibiotic resistance in China and its environment","volume":"110","author":"Qiao","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2023.117665_bib58","series-title":"An\u00e1lisis del \u00edndice del estado actual de las coberturas vegetales para la cuenca del r\u00edo Guacav\u00eda ubicada entre los municipios Restrepo y Cumaral (Meta), Paratebueno y medina (Cundinamarca)","author":"Quijano Pinz\u00f3n","year":"2016"},{"key":"10.1016\/j.envres.2023.117665_bib59","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.psep.2021.07.025","article-title":"Multi-residue analysis of pharmaceuticals in water samples by liquid chromatography- mass spectrometry: quality assessment and application to the risk assessment of urban-influenced surface waters in a metropolitan area of Central America","volume":"153","author":"Ram\u00edrez Morales","year":"2021","journal-title":"Process Saf. Environ. Protect."},{"key":"10.1016\/j.envres.2023.117665_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.129574","article-title":"Pharmaceuticals in farms and surrounding surface water bodies: hazard and ecotoxicity in a swine production area in Costa Rica","volume":"272","author":"Ram\u00edrez-Morales","year":"2021","journal-title":"Chemosphere"},{"issue":"9","key":"10.1016\/j.envres.2023.117665_bib61","doi-asserted-by":"crossref","first-page":"5870","DOI":"10.1128\/AEM.00963-06","article-title":"Lettuce for human consumption collected in Costa Rica contains complex communities of culturable oxytetracycline- and gentamicin-resistant bacteria","volume":"72","author":"Rodr\u00edguez","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.envres.2023.117665_bib62","doi-asserted-by":"crossref","DOI":"10.1089\/vbz.2017.2145","article-title":"High prevalence of multidrug-resistant community-acquired methicillin-resistant staphylococcus aureus at the largest veterinary teaching hospital in Costa Rica","volume":"17","author":"Rojas","year":"2017","journal-title":"Vector Borne Zoonotic Dis."},{"key":"10.1016\/j.envres.2023.117665_bib63","unstructured":"SANTE\/12682\/2019. (s. f.). Guidance document on analytical quality control and method validation procedures for pesticide residues and analysis in food and feed."},{"key":"10.1016\/j.envres.2023.117665_bib66","series-title":"Instituto Geogr\u00e1fico Nacional. SISTEMA NACIONAL DE INFORMACI\u00d3N TERRITORIAL (SNIT)","year":"2021"},{"issue":"20","key":"10.1016\/j.envres.2023.117665_bib67","doi-asserted-by":"crossref","first-page":"6709","DOI":"10.1016\/j.watres.2011.10.004","article-title":"Reconnaissance of selected PPCP compounds in Costa Rican surface waters","volume":"45","author":"Spongberg","year":"2011","journal-title":"Water Res."},{"issue":"6","key":"10.1016\/j.envres.2023.117665_bib68","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1021\/es902893f","article-title":"Identification of antibiotic-resistance-gene molecular signatures suitable as tracers of pristine river, urban, and agricultural sources","volume":"44","author":"Storteboom","year":"2010","journal-title":"Environ. Sci. Technol."},{"issue":"Part 1","key":"10.1016\/j.envres.2023.117665_bib70","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.scitotenv.2018.09.248","article-title":"Photolysis of four \u03b2-lactam antibiotics under simulated environmental conditions: degradation, transformation products and antibacterial activity","volume":"651","author":"Timm","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.envres.2023.117665_bib72","first-page":"277","article-title":"The antibiotic resistance crisis","volume":"40","author":"Ventola","year":"2015","journal-title":"Pharmacy and Therapeutics"},{"issue":"2","key":"10.1016\/j.envres.2023.117665_bib77","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1473-3099(12)70317-1","article-title":"The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria","volume":"13","author":"Wellington","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.envres.2023.117665_bib78","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2009"},{"issue":"8","key":"10.1016\/j.envres.2023.117665_bib79","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113947119","article-title":"Pharmaceutical pollution of the ' 'world's rivers","volume":"119","author":"Wilkinson","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935123024696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935123024696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:07:51Z","timestamp":1791911271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935123024696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":47,"alternative-id":["S0013935123024696"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2023.117665","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A case study on pharmaceutical residues and antimicrobial resistance genes in Costa Rican rivers: A possible route of contamination for feline and other species","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2023.117665","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117665"}}