{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T01:09:46Z","timestamp":1782436186852,"version":"3.54.5"},"reference-count":144,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"am","delay-in-days":268,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA022453"],"award-info":[{"award-number":["P30 CA022453"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30ES020957"],"award-info":[{"award-number":["P30ES020957"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42ES030991"],"award-info":[{"award-number":["P42ES030991"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R00ES028734"],"award-info":[{"award-number":["R00ES028734"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006710","name":"Wayne State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011415","name":"Office of the Vice President for Research, Wayne State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017302","name":"Barbara Ann Karmanos Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017302","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.envres.2024.118492","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T16:16:29Z","timestamp":1708186589000},"page":"118492","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Loss of flavin-containing monooxygenase 3 modulates dioxin-like polychlorinated biphenyl 126-induced oxidative stress and hepatotoxicity"],"prefix":"10.1016","volume":"250","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1524-4820","authenticated-orcid":false,"given":"Manisha","family":"Agarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4826-3400","authenticated-orcid":false,"given":"Katherine","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1445-791X","authenticated-orcid":false,"given":"Krishnarao","family":"Maddipati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Westrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5583-8092","authenticated-orcid":false,"given":"Michael C.","family":"Petriello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2024.118492_bib1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jpba.2018.06.027","article-title":"'Trigonelline inhibits intestinal microbial metabolism of choline and its associated cardiovascular risk","volume":"159","author":"Anwar","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.envres.2024.118492_bib2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1289\/ehp.1205421","article-title":"'Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL\/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice","volume":"121","author":"Baker","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2024.118492_bib3","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1161\/CIRCRESAHA.108.184036","volume":"103","author":"Benndorf","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.envres.2024.118492_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cmet.2012.12.011","article-title":"'Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation","volume":"17","author":"Bennett","year":"2013","journal-title":"Cell Metabol."},{"key":"10.1016\/j.envres.2024.118492_bib5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s00204-005-0025-5","article-title":"'Tissue distribution and function of the Aryl hydrocarbon receptor repressor (AhrR) in C57BL\/6 and Aryl hydrocarbon receptor deficient mice","volume":"80","author":"Bernshausen","year":"2006","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envres.2024.118492_bib6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.toxlet.2012.09.027","article-title":"The dynamics of accumulation of PCBs in cultured adipocytes vary with the cell lipid content and the lipophilicity of the congener","volume":"216","author":"Bourez","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envres.2024.118492_bib7","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/toxsci\/kfl100","article-title":"'Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL\/6 mice","volume":"94","author":"Boverhof","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2024.118492_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev.publhealth.22.1.15","article-title":"'U-shaped dose-responses in biology, toxicology, and public health","volume":"22","author":"Calabrese","year":"2001","journal-title":"Annu. Rev. Publ. Health"},{"key":"10.1016\/j.envres.2024.118492_bib9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1191\/0960327102ht217oa","article-title":"Defining hormesis","volume":"21","author":"Calabrese","year":"2002","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.envres.2024.118492_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103228","article-title":"'Trimethylamine N-oxide: a link among diet, gut microbiota, gene regulation of liver and intestine cholesterol homeostasis and HDL function","volume":"19","author":"Canyelles","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2024.118492_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/REVEH.2006.21.1.1","article-title":"'Polychlorinated biphenyls (PCBs): routes of exposure and effects on human health","volume":"21","author":"Carpenter","year":"2006","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.envres.2024.118492_bib12","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1289\/ehp.1002720","article-title":"Polychlorinated biphenyls, lead, and mercury are associated with liver disease in American adults: NHANES 2003-2004","volume":"118","author":"Cave","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2024.118492_bib13","doi-asserted-by":"crossref","DOI":"10.1289\/EHP9467","article-title":"Circulating MicroRNAs, polychlorinated biphenyls, and environmental liver disease in the Anniston community health survey","volume":"130","author":"Cave","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2024.118492_bib14","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1124\/dmd.108.023457","article-title":"'Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver","volume":"36","author":"Celius","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.envres.2024.118492_bib15","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/01.ATV.0000122852.22604.78","article-title":"'Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited","volume":"24","author":"Ceriello","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.envres.2024.118492_bib16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/tox.10107","article-title":"'Inhibition of CYP 1A2-dependent MROD activity in rat liver microsomes: an explanation of the hepatic sequestration of a limited subset of halogenated aromatic hydrocarbons","volume":"18","author":"Chen","year":"2003","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envres.2024.118492_bib17","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006347","article-title":"'Trimethylamine-N-Oxide induces vascular inflammation by activating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway","volume":"6","author":"Chen","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.envres.2024.118492_bib18","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.cmet.2019.08.021","article-title":"'Trimethylamine N-oxide binds and activates PERK to promote metabolic dysfunction","volume":"30","author":"Chen","year":"2019","journal-title":"Cell Metabol."},{"key":"10.1016\/j.envres.2024.118492_bib19","article-title":"'Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2024.118492_bib20","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.scitotenv.2018.10.387","article-title":"Gut microbiota dysbiosis correlates with a low-dose PCB126-induced dyslipidemia and non-alcoholic fatty liver disease","volume":"653","author":"Chi","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.118492_bib21","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.3748\/wjg.v20.i25.8082","article-title":"'Oxidative stress as a crucial factor in liver diseases","volume":"20","author":"Cicho\u017c-Lach","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.envres.2024.118492_bib22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/toxsci\/kfy076","article-title":"'Liver disease in a residential cohort with elevated polychlorinated biphenyl exposures","volume":"164","author":"Clair","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2024.118492_bib23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1478-3231.1999.tb00053.x","article-title":"'Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers","volume":"19","author":"Cotrim","year":"1999","journal-title":"Liver"},{"key":"10.1016\/j.envres.2024.118492_bib24","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0248-8663(00)80056-9","article-title":"'[Isoprostanes: new markers of oxidative stress. Fundamental and clinical aspects]","volume":"21","author":"Cracowski","year":"2000","journal-title":"Rev. Med. Interne"},{"key":"10.1016\/j.envres.2024.118492_bib25","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.chemosphere.2018.10.196","article-title":"'Hepatic metabolomics reveals that liver injury increases PCB 126-induced oxidative stress and metabolic dysfunction","volume":"217","author":"Deng","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2024.118492_bib26","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/00004872-200018060-00002","article-title":"'Role of oxidative stress in cardiovascular diseases","volume":"18","author":"Dhalla","year":"2000","journal-title":"J. Hypertens."},{"key":"10.1016\/j.envres.2024.118492_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/taap.1995.1025","article-title":"'Dose-response relationships of tissue distribution and induction of CYP1A1 and CYP1A2 enzymatic activities following acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice","volume":"130","author":"Diliberto","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envres.2024.118492_bib28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1006\/bbrc.1997.6973","article-title":"'Role of CYP1A2 in hepatic sequestration of dioxin: studies using CYP1A2 knock-out mice","volume":"236","author":"Diliberto","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envres.2024.118492_bib29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3945\/ajcn.112.034918","article-title":"'Major metabolite of F2-isoprostane in urine may be a more sensitive biomarker of oxidative stress than isoprostane itself","volume":"96","author":"Dorjgochoo","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.envres.2024.118492_bib30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jbt.2570100308","article-title":"'Gender differences in hepatic expression of flavin-containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice","volume":"10","author":"Falls","year":"1995","journal-title":"J. Biochem. Toxicol."},{"key":"10.1016\/j.envres.2024.118492_bib31","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/ajcn\/85.5.1275","article-title":"'Sex and menopausal status influence human dietary requirements for the nutrient choline","volume":"85","author":"Fischer","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.envres.2024.118492_bib32","first-page":"657","article-title":"'Complete PCB congener distributions for 17 Aroclor mixtures determined by 3 HRGC systems optimized for comprehensive","volume":"19","author":"Frame","year":"1996","journal-title":"quantitative, congener\u2010specific analysis"},{"key":"10.1016\/j.envres.2024.118492_bib33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/toxsci\/kfv215","article-title":"'PCB126-Induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats","volume":"149","author":"Gadupudi","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2024.118492_bib34","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jbiosc.2014.03.001","article-title":"'Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet","volume":"118","author":"Gao","year":"2014","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.envres.2024.118492_bib35","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.scitotenv.2017.05.068","article-title":"Reassessment and update of emission factors for unintentional dioxin-like polychlorinated biphenyls","volume":"605\u2013606","author":"Gong","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.118492_bib36","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/mutage\/gen035","article-title":"'Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls","volume":"23","author":"Green","year":"2008","journal-title":"Mutagenesis"},{"key":"10.1016\/j.envres.2024.118492_bib37","doi-asserted-by":"crossref","DOI":"10.1289\/EHP7030","article-title":"'Cardiovascular effects of polychlorinated biphenyls and their major metabolites","volume":"128","author":"Grimm","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2024.118492_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23126719","article-title":"'Aryl hydrocarbon receptor in oxidative stress as a double agent and its biological and therapeutic significance","volume":"23","author":"Grishanova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2024.118492_bib39","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3945\/ajcn.111.020156","article-title":"'Choline intake in a large cohort of patients with nonalcoholic fatty liver disease","volume":"95","author":"Guerrerio","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.envres.2024.118492_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16224361","article-title":"'Persistent organic pollutants in food: contamination sources, health effects and detection methods","volume":"16","author":"Guo","year":"2019","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envres.2024.118492_bib41","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1124\/dmd.107.016253","article-title":"'Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines","volume":"35","author":"Haarmann-Stemmann","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.envres.2024.118492_bib42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.reprotox.2016.10.001","article-title":"'Metabolism disrupting chemicals and metabolic disorders","volume":"68","author":"Heindel","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envres.2024.118492_bib43","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1385\/CT:5:2:153","article-title":"'Modification of environmental toxicity by nutrients: implications in atherosclerosis","volume":"5","author":"Hennig","year":"2005","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.envres.2024.118492_bib44","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1089\/scd.2012.0306","article-title":"'Differentiation of human adipose-derived stem cells into fat involves reactive oxygen species and Forkhead box O1 mediated upregulation of antioxidant enzymes","volume":"22","author":"Higuchi","year":"2013","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.envres.2024.118492_bib45","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1172\/JCI117179","article-title":"'Massive xanthomatosis and atherosclerosis in cholesterol-fed low-density lipoprotein receptor-negative mice","volume":"93","author":"Ishibashi","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.envres.2024.118492_bib46","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11030-005-9003-3","article-title":"'Modeling the bioconcentration factors and bioaccumulation factors of polychlorinated biphenyls with posetic quantitative super-structure\/activity relationships (QSSAR)","volume":"10","author":"Ivanciuc","year":"2006","journal-title":"Mol. Divers."},{"key":"10.1016\/j.envres.2024.118492_bib47","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1021\/es035461+","article-title":"'Toxicokinetics of PCDD, PCDF, and coplanar PCB congeners in Baikal seals, Pusa sibirica: age-related accumulation, maternal transfer, and hepatic sequestration","volume":"38","author":"Iwata","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2024.118492_bib48","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/cphy.c160038","article-title":"'Adipose tissue as a site of toxin accumulation","volume":"7","author":"Jackson","year":"2017","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.envres.2024.118492_bib49","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00044-020-02581-w","article-title":"'Dioxin-like and non-dioxin-like PCBs differentially regulate the hepatic proteome and modify diet-induced nonalcoholic fatty liver disease severity","volume":"29","author":"Jin","year":"2020","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.envres.2024.118492_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111864","article-title":"'The fibrotic effects of TMAO on human Renal Fibroblasts is mediated by NLRP3, Caspase-1 and the PERK\/Akt\/mTOR pathway","volume":"22","author":"Kapetanaki","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2024.118492_bib51","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cca.2003.11.004","article-title":"'3,3',4,4',5-Pentachlorobiphenyl (PCB 126) impacts hepatic lipid peroxidation, membrane fluidity and beta-adrenoceptor kinetics in chick embryos","volume":"137","author":"Katynski","year":"2004","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.envres.2024.118492_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2015.09.004","article-title":"'Progression of micronutrient alteration and hepatotoxicity following acute PCB126 exposure","volume":"338","author":"Klaren","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2024.118492_bib53","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.cca.2011.04.013","article-title":"'The role of oxidative stress in non-alcoholic steatohepatitis","volume":"412","author":"Koek","year":"2011","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.envres.2024.118492_bib54","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijheh.2016.09.006","article-title":"Quantification of all 209 PCB congeners in blood-Can indicators be used to calculate the total PCB blood load?","volume":"220","author":"Kraft","year":"2017","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envres.2024.118492_bib55","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.pharmthera.2005.01.001","article-title":"'Mammalian flavin-containing monooxygenases: structure\/function, genetic polymorphisms and role in drug metabolism","volume":"106","author":"Krueger","year":"2005","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.envres.2024.118492_bib56","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.envres.2014.07.023","article-title":"'Persistent organic pollutants and liver dysfunction biomarkers in a population-based human sample of men and women","volume":"134","author":"Kumar","year":"2014","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2024.118492_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopen.2018.05.001","article-title":"'Ahr signaling pathways and regulatory functions","volume":"7","author":"Larigot","year":"2018","journal-title":"Biochim Open"},{"key":"10.1016\/j.envres.2024.118492_bib58","doi-asserted-by":"crossref","first-page":"24441","DOI":"10.1074\/jbc.274.35.24441","article-title":"Isoprostanes: formation, analysis and use as indices of lipid peroxidation in vivo","volume":"274","author":"Lawson","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envres.2024.118492_bib59","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1210\/er.2013-1084","article-title":"'Chlorinated persistent organic pollutants, obesity, and type 2 diabetes","volume":"35","author":"Lee","year":"2014","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.envres.2024.118492_bib60","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.envres.2018.02.002","article-title":"'Hyperpigmentation and higher incidence of cutaneous malignancies in moderate-high PCB- and dioxin exposed individuals","volume":"164","author":"Leijs","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2024.118492_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabet.2020.07.010","article-title":"'Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes","volume":"47","author":"Le\u00f3n-Mimila","year":"2021","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.envres.2024.118492_bib62","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cbi.2016.08.019","article-title":"'Protective effects of ursolic acid against hepatotoxicity and endothelial dysfunction in mice with chronic high choline diet consumption","volume":"258","author":"Li","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envres.2024.118492_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.733507","article-title":"'Trimethylamine-N-Oxide pathway: a potential target for the treatment of MAFLD","volume":"8","author":"Li","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.envres.2024.118492_bib64","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.chemosphere.2016.05.037","article-title":"'Emission of unintentionally produced persistent organic pollutants (UPOPs) from municipal waste incinerators in China","volume":"158","author":"Li","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2024.118492_bib65","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cmet.2006.03.007","article-title":"The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis","volume":"3","author":"Li","year":"2006","journal-title":"Cell Metabol."},{"key":"10.1016\/j.envres.2024.118492_bib66","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1194\/jlr.R700019-JLR200","article-title":"'Phosphatidylcholine and choline homeostasis","volume":"49","author":"Li","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.envres.2024.118492_bib67","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-3-319-41334-1_6","article-title":"'Indole-3-Carbinol and its role in chronic diseases","volume":"928","author":"Licznerska","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.envres.2024.118492_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/nu12082448","article-title":"Protective effects of black raspberry (Rubus occidentalis) extract against Hypercholesterolemia and hepatic inflammation in rats fed high-fat and high-choline diets","volume":"12","author":"Lim","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.envres.2024.118492_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/srep27882","article-title":"'Long-term in vivo polychlorinated biphenyl 126 exposure induces oxidative stress and alters proteomic profile on islets of Langerhans","volume":"6","author":"Loiola","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2024.118492_bib70","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1096\/fj.14-254383","article-title":"Eicosanomic profiling reveals dominance of the epoxygenase pathway in human amniotic fluid at term in spontaneous labor","volume":"28","author":"Maddipati","year":"2014","journal-title":"Faseb. J."},{"key":"10.1016\/j.envres.2024.118492_bib71","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.prostaglandins.2011.01.003","article-title":"'Stability and analysis of eicosanoids and docosanoids in tissue culture media","volume":"94","author":"Maddipati","year":"2011","journal-title":"Prostag. Other Lipid Mediat."},{"key":"10.1016\/j.envres.2024.118492_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12040364","volume":"vol. 12","author":"Massey","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.envres.2024.118492_bib73","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/iep.12008","article-title":"'An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis","volume":"94","author":"Matsumoto","year":"2013","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.envres.2024.118492_bib74","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.1038\/ncomms7498","article-title":"Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis","volume":"6","author":"Miao","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2024.118492_bib75","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10070365","article-title":"'Polychlorinated Biphenyls (PCBs) in the Environment: Occupational and Exposure Events","volume":"vol. 10","author":"Montano","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.envres.2024.118492_bib76","doi-asserted-by":"crossref","first-page":"703","DOI":"10.2174\/092986707780059607","article-title":"Insights into oxidative stress: the isoprostanes","volume":"14","author":"Montuschi","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.envres.2024.118492_bib77","doi-asserted-by":"crossref","first-page":"10721","DOI":"10.1073\/pnas.89.22.10721","article-title":"'Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids","volume":"89","author":"Morrow","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envres.2024.118492_bib78","doi-asserted-by":"crossref","first-page":"16710","DOI":"10.1074\/jbc.273.27.16710","article-title":"'Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner","volume":"273","author":"Motojima","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envres.2024.118492_bib79","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0968-0004(98)01349-8","article-title":"'Mechanisms of lipid-body formation","volume":"24","author":"Murphy","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.envres.2024.118492_bib80","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1467-789X.2009.00657.x","article-title":"'Non-alcoholic fatty liver disease from pathogenesis to management: an update","volume":"11","author":"Musso","year":"2010","journal-title":"Obes. Rev."},{"key":"10.1016\/j.envres.2024.118492_bib81","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jnutbio.2013.10.003","article-title":"'Green tea diet decreases PCB 126-induced oxidative stress in mice by up-regulating antioxidant enzymes","volume":"25","author":"Newsome","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.envres.2024.118492_bib82","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1590\/S0100-879X2006000200004","article-title":"'Liver mitochondrial dysfunction and oxidative stress in the pathogenesis of experimental nonalcoholic fatty liver disease","volume":"39","author":"Oliveira","year":"2006","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.envres.2024.118492_bib83","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"'Dynamics and functions of lipid droplets","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envres.2024.118492_bib84","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.immuni.2023.01.023","article-title":"'Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes","volume":"56","author":"Panda","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.envres.2024.118492_bib85","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.yrtph.2013.08.007","article-title":"'A sensitivity analysis using alternative toxic equivalency factors to estimate U.S. dietary exposures to dioxin-like compounds","volume":"67","author":"Parvez","year":"2013","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envres.2024.118492_bib86","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00584.2019","article-title":"'Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism","volume":"318","author":"Pathak","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.envres.2024.118492_bib87","series-title":"USDA Database for the Choline Content of Common Foods","author":"Patterson","year":"2008"},{"key":"10.1016\/j.envres.2024.118492_bib88","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.scitotenv.2014.06.113","article-title":"'Predictors of serum polychlorinated biphenyl concentrations in Anniston residents","volume":"496","author":"Pavuk","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.118492_bib89","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"'Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.envres.2024.118492_bib90","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/toxsci\/kfx275","article-title":"'Dioxin-like PCB 126 increases systemic inflammation and accelerates atherosclerosis in lean LDL receptor-deficient mice","volume":"162","author":"Petriello","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2024.118492_bib91","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jnutbio.2016.03.016","article-title":"'Dioxin-like pollutants increase hepatic flavin containing monooxygenase (FMO3) expression to promote synthesis of the pro-atherogenic nutrient biomarker trimethylamine N-oxide from dietary precursors","volume":"33","author":"Petriello","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.envres.2024.118492_bib92","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.2174\/1381612811319150009","article-title":"Redox homeostasis and epigenetics in non-alcoholic fatty liver disease (NAFLD)","volume":"19","author":"Podrini","year":"2013","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.envres.2024.118492_bib93","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.4254\/wjh.v7.i10.1325","article-title":"'Oxidative stress: new insights on the association of non-alcoholic fatty liver disease and atherosclerosis","volume":"7","author":"Polimeni","year":"2015","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.envres.2024.118492_bib94","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.envint.2007.10.004","article-title":"'Monitoring concentrations of persistent organic pollutants in the general population: the international experience","volume":"34","author":"Porta","year":"2008","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2024.118492_bib95","doi-asserted-by":"crossref","first-page":"10853","DOI":"10.1073\/pnas.0904187106","article-title":"'FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response","volume":"106","author":"Potthoff","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envres.2024.118492_bib96","first-page":"1","year":"2006","journal-title":"Natl. Toxicol. Progr. Tech. Rep."},{"key":"10.1016\/j.envres.2024.118492_bib97","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.freeradbiomed.2018.08.007","article-title":"'F(2)-isoprostanes affect macrophage migration and CSF-1 signalling","volume":"126","author":"Proudfoot","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envres.2024.118492_bib98","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.cmet.2023.03.013","article-title":"'DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates","volume":"35","author":"Qu","year":"2023","journal-title":"Cell Metabol."},{"key":"10.1016\/j.envres.2024.118492_bib99","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.arr.2007.04.004","article-title":"'Exercise, oxidative stress and hormesis","volume":"7","author":"Radak","year":"2008","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.envres.2024.118492_bib100","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/toxsci\/kfg227","article-title":"Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and Ahr-DNA binding activity in vascular endothelial cells","volume":"76","author":"Ramadass","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2024.118492_bib101","first-page":"131","article-title":"'Superoxide radical as an intermediate in the oxidation of hydroxylamines by mixed function amine oxidase","volume":"15","author":"Rauckman","year":"1979","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.envres.2024.118492_bib102","doi-asserted-by":"crossref","first-page":"G852","DOI":"10.1152\/ajpgi.00521.2005","article-title":"'Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation","volume":"290","author":"Reddy","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.envres.2024.118492_bib103","first-page":"46","article-title":"'Species and sex differences in expression of flavin-containing monooxygenase form 3 in liver and kidney microsomes","volume":"27","author":"Ripp","year":"1999","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.envres.2024.118492_bib104","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0891-5849(99)00264-6","article-title":"'Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo","volume":"28","author":"Roberts","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envres.2024.118492_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106843","article-title":"'Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury","volume":"157","author":"Roth","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2024.118492_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108909","article-title":"'Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice","volume":"181","author":"Ruan","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2024.118492_bib107","doi-asserted-by":"crossref","first-page":"19846","DOI":"10.3390\/ijms141019846","article-title":"'Development of nonalcoholic hepatopathy: contributions of oxidative stress and advanced glycation end products","volume":"14","author":"Santos","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2024.118492_bib108","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.aquatox.2006.01.012","article-title":"Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners","volume":"77","author":"Schlezinger","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envres.2024.118492_bib109","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1124\/mol.56.3.588","article-title":"Oxidative inactivation of cytochrome P-450 1A (CYP1A) stimulated by 3,3',4,4'-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As","volume":"56","author":"Schlezinger","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.envres.2024.118492_bib110","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2008.08.068","article-title":"Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells","volume":"375","author":"Sekiya","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envres.2024.118492_bib111","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/S0891-5849(02)01014-6","article-title":"'Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor","volume":"33","author":"Senft","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envres.2024.118492_bib112","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.2147\/DMSO.S264851","article-title":"'Understanding the multiple effects of PCBs on lipid metabolism","volume":"13","author":"Shan","year":"2020","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.envres.2024.118492_bib113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2022.01.060","article-title":"'Changes of flavin-containing monooxygenases and trimethylamine-N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine","volume":"594","author":"Shi","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envres.2024.118492_bib114","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1194\/jlr.M051680","article-title":"'Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis","volume":"56","author":"Shih","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.envres.2024.118492_bib115","doi-asserted-by":"crossref","DOI":"10.1038\/srep14917","article-title":"'Absorption of PCB126 by upper airways impairs G protein-coupled receptor-mediated immune response","volume":"5","author":"Shimada","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2024.118492_bib116","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bcp.2014.02.006","article-title":"'Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide","volume":"89","author":"Siddens","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.envres.2024.118492_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110211","article-title":"'Biomarkers of metabolic disorders and neurobehavioral diseases in a PCB- exposed population: what we learned and the implications for future research","volume":"191","author":"Simhadri","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2024.118492_bib118","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/etc.4908","article-title":"'Toxic effects of polychlorinated biphenyl congeners and Aroclors on Embryonic growth and development","volume":"40","author":"Singleman","year":"2021","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envres.2024.118492_bib119","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1006\/bbrc.1999.1518","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated oxidative stress in CYP1A2 knockout (CYP1A2-\/-) mice","volume":"264","author":"Slezak","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envres.2024.118492_bib120","first-page":"1","article-title":"'GC\/\u039cECD analysis and confirmation of PCBs in fish tissue with Agilent J&W DB-35ms and DB-XLB GC Columns","volume":"2","author":"Smith","year":"2012","journal-title":"Aligent Application Note Food Analysis"},{"key":"10.1016\/j.envres.2024.118492_bib121","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0041-008X(90)90112-8","article-title":"'2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced oxidative stress in female rats","volume":"106","author":"Stohs","year":"1990","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envres.2024.118492_bib122","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3109\/10715762.2013.837577","article-title":"'Involvement of free radicals and oxidative stress in NAFLD\/NASH","volume":"47","author":"Sumida","year":"2013","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.envres.2024.118492_bib123","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1038\/s41590-020-0802-6","article-title":"'Environmental pollutants and the immune response","volume":"21","author":"Suzuki","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.envres.2024.118492_bib124","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900257","article-title":"'Trimethylamine N-oxide Aggravates liver steatosis through modulation of bile acid metabolism and inhibition of Farnesoid X receptor signaling in nonalcoholic fatty liver disease","volume":"63","author":"Tan","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.envres.2024.118492_bib125","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1124\/mol.105.018705","article-title":"'Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries","volume":"69","author":"Tijet","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.envres.2024.118492_bib126","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0006-2952(01)00668-2","article-title":"'Effects of selected polychlorinated biphenyl (PCB) congeners on hepatic glutathione, glutathione-related enzymes, and selenium status: implications for oxidative stress","volume":"62","author":"Twaroski","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.envres.2024.118492_bib127","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/0003-9861(86)90375-9","article-title":"'Formation of hydrogen peroxide and N-hydroxylated amines catalyzed by pulmonary flavin-containing monooxygenases in the presence of primary alkylamines","volume":"251","author":"Tynes","year":"1986","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.envres.2024.118492_bib128","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1179\/1351000213Y.0000000050","article-title":"The relationship between oxidative stress and nonalcoholic fatty liver disease: its effects on the development of nonalcoholic steatohepatitis","volume":"18","author":"Ucar","year":"2013","journal-title":"Redox Rep."},{"key":"10.1016\/j.envres.2024.118492_bib129","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/toxsci\/kfz150","article-title":"'Atropselective oxidation of 2,2',3,3',4,6'-hexachlorobiphenyl (PCB 132) to hydroxylated metabolites by human liver microsomes and its implications for PCB 132 Neurotoxicity","volume":"171","author":"Uwimana","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2024.118492_bib130","doi-asserted-by":"crossref","first-page":"10540","DOI":"10.1016\/S0021-9258(18)82232-3","article-title":"'Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia","volume":"268","author":"van den Maagdenberg","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envres.2024.118492_bib131","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.toxlet.2013.05.001","article-title":"'Tissue distribution of dioxin-like compounds: potential impacts on systemic relative potency estimates","volume":"220","author":"van Ede","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envres.2024.118492_bib132","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1289\/ehp.1510194","article-title":"'Transgenic overexpression of aryl hydrocarbon receptor repressor (AhrR) and Ahr-mediated induction of CYP1A1, Cytokines, and acute toxicity","volume":"124","author":"Vogel","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2024.118492_bib133","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.freeradbiomed.2005.02.015","article-title":"'Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats","volume":"38","author":"V\u00f6lkel","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envres.2024.118492_bib134","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/toxsci\/kfx180","article-title":"'s highlight: PCB126 exposure increases risk for Peripheral vascular diseases in a liver injury mouse model","volume":"160","author":"Wahlang","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2024.118492_bib135","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cotox.2019.06.001","article-title":"'Polychlorinated biphenyls and nonalcoholic fatty liver disease","volume":"14","author":"Wahlang","year":"2019","journal-title":"Curr Opin Toxicol"},{"key":"10.1016\/j.envres.2024.118492_bib136","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tox.2017.02.001","article-title":"A compromised liver alters polychlorinated biphenyl-mediated toxicity","volume":"380","author":"Wahlang","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2024.118492_bib137","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.toxlet.2003.12.039","article-title":"'Immunological effects of environmental exposure to polychlorinated biphenyls and dioxins in Dutch school children","volume":"149","author":"Weisglas-Kuperus","year":"2004","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envres.2024.118492_bib138","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0300-483X(02)00274-3","article-title":"'PCB-induced neurodevelopmental toxicity in human infants and its potential mediation by endocrine dysfunction","volume":"181\u2013182","author":"Winneke","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2024.118492_bib139","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1021\/es504766p","article-title":"'Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice","volume":"49","author":"Wu","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2024.118492_bib140","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/hep.32538","article-title":"'Intestinal peroxisome proliferator-activated receptor \u03b1-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis","volume":"77","author":"Yan","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.envres.2024.118492_bib141","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.taap.2004.01.018","article-title":"'Mechanisms that regulate production of reactive oxygen species by cytochrome P450","volume":"199","author":"Zangar","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envres.2024.118492_bib142","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1753-4887.2009.00246.x","article-title":"'Choline: an essential nutrient for public health","volume":"67","author":"Zeisel","year":"2009","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.envres.2024.118492_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101428","article-title":"'CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing","volume":"57","author":"Zeng","year":"2022","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.envres.2024.118492_bib144","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.3748\/wjg.v25.i20.2450","article-title":"'Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats","volume":"25","author":"Zhao","year":"2019","journal-title":"World J. Gastroenterol."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935124003967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935124003967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T16:22:35Z","timestamp":1715962955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935124003967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":144,"alternative-id":["S0013935124003967"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2024.118492","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of flavin-containing monooxygenase 3 modulates dioxin-like polychlorinated biphenyl 126-induced oxidative stress and hepatotoxicity","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2024.118492","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118492"}}