{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:41:14Z","timestamp":1793166074012,"version":"4.5.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30 ES017885"],"award-info":[{"award-number":["P30 ES017885"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 ES028802"],"award-info":[{"award-number":["R01 ES028802"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA046592"],"award-info":[{"award-number":["P30 CA046592"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UG3 CA267907"],"award-info":[{"award-number":["UG3 CA267907"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 ES032470"],"award-info":[{"award-number":["R01 ES032470"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG067592"],"award-info":[{"award-number":["R01 AG067592"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG070897"],"award-info":[{"award-number":["R01 AG070897"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.envres.2024.118956","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T07:13:03Z","timestamp":1713337983000},"page":"118956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"P3","title":["Environmental chemical-wide associations with immune biomarkers in US adults: A cross-sectional analysis"],"prefix":"10.1016","volume":"252","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9422-2912","authenticated-orcid":false,"given":"Lauren Y.M.","family":"Middleton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vy K.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4577-8660","authenticated-orcid":false,"given":"John","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag J.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Kyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5882-4569","authenticated-orcid":false,"given":"Justin A.","family":"Colacino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Bakulski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.envres.2024.118956_bib1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4065\/80.8.1022","article-title":"Effects of biochemically confirmed smoking cessation on white blood cell count","volume":"80","author":"Abel","year":"2005","journal-title":"Mayo Clin. Proc."},{"issue":"1","key":"10.1016\/j.envres.2024.118956_bib2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.29252\/pcnm.8.1.55","article-title":"Study of the relationship between blood lead level and complete blood counts in pregnant women","volume":"8","author":"Amir Ali Akbari","year":"2018","journal-title":"Preventive Care in Nursing and Midwifery"},{"issue":"2","key":"10.1016\/j.envres.2024.118956_bib3","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1289\/ehp.7337","article-title":"Urinary creatinine concentrations in the U.S. Population: implications for urinary biologic monitoring measurements","volume":"113","author":"Barr","year":"2005","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.envres.2024.118956_bib4","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Benjamini","year":"2001","journal-title":"Ann. Stat."},{"issue":"4","key":"10.1016\/j.envres.2024.118956_bib5","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1001\/archinternmed.2007.74","article-title":"Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults","volume":"168","author":"Bleys","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.envres.2024.118956_bib6","series-title":"Williams Hematology, 9e","article-title":"Disorders of neutrophil function","author":"Borregaard","year":"2015"},{"issue":"1\u20132","key":"10.1016\/j.envres.2024.118956_bib7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2014.12.020","article-title":"Variation in the human immune system is largely driven by non-heritable influences","volume":"160","author":"Brodin","year":"2015","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.envres.2024.118956_bib8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF01625543","article-title":"Polychlorinated biphenyl (PCB) partitioning between adipose tissue and serum","volume":"33","author":"Brown","year":"1984","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envres.2024.118956_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116619","article-title":"Associations of exposure to perfluoroalkyl substances individually and in mixtures with persistent infections: recent findings from NHANES 1999\u20132016","volume":"275","author":"Bulka","year":"2021","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.envres.2024.118956_bib10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/ni.3371","article-title":"The cellular composition of the human immune system is shaped by age and cohabitation","volume":"17","author":"Carr","year":"2016","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.envres.2024.118956_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/09513590.2013.852531","article-title":"The immune system and aging: a review","volume":"30","author":"Castelo-Branco","year":"2014","journal-title":"Gynecol. Endocrinol."},{"issue":"12","key":"10.1016\/j.envres.2024.118956_bib12","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1289\/ehp.1002720","article-title":"Polychlorinated biphenyls, lead, and mercury are associated with liver disease in American adults: NHANES 2003-2004","volume":"118","author":"Cave","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2024.118956_bib13","article-title":"NHANES laboratory data","year":"2021","journal-title":"National Health and Nutrition Examination Survey"},{"key":"10.1016\/j.envres.2024.118956_bib14","series-title":"National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Data","year":"2022"},{"issue":"3","key":"10.1016\/j.envres.2024.118956_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16030354","article-title":"Interactive effects between chronic lead exposure and the homeostatic iron regulator transport HFE polymorphism on the human red blood cell mean corpuscular volume (MCV)","volume":"16","author":"Chen","year":"2019","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envres.2024.118956_bib16","series-title":"Laboratory Tests and Diagnostic Procedures","author":"Chernecky","year":"2012"},{"issue":"6","key":"10.1016\/j.envres.2024.118956_bib17","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1097\/EDE.0000000000001534","article-title":"Log-transformation of independent variables: must we?","volume":"33","author":"Choi","year":"2022","journal-title":"Epidemiology"},{"issue":"4","key":"10.1016\/j.envres.2024.118956_bib18","first-page":"428","article-title":"Relationships of lead, copper, zinc, and cadmium levels versus hematopoiesis and iron parameters in healthy adolescents","volume":"35","author":"Choi","year":"2005","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"1","key":"10.1016\/j.envres.2024.118956_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/exposome\/osae001","article-title":"Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs)","volume":"4","author":"Chung","year":"2024","journal-title":"Exposome"},{"key":"10.1016\/j.envres.2024.118956_bib20","series-title":"Williams Hematology","article-title":"Neutropenia and neutrophilia","author":"Dale","year":"2015"},{"issue":"1","key":"10.1016\/j.envres.2024.118956_bib21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.smim.2015.03.003","article-title":"ImmVar project: insights and design considerations for future studies of \u201chealthy\u201d immune variation","volume":"27","author":"De Jager","year":"2015","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.envres.2024.118956_bib22","series-title":"National Center for Biotechnology Information (US)","article-title":"Blood Groups and Red Cell Antigens [Internet]","author":"Dean","year":"2005"},{"key":"10.1016\/j.envres.2024.118956_bib96","series-title":"Fourth National Report on Human Exposure to Environmental Chemicals","author":"Department of Health and Human Services","year":"2009"},{"key":"10.1016\/j.envres.2024.118956_bib23","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.envres.2017.03.048","article-title":"Associations between blood BTEXS concentrations and hematologic parameters among adult residents of the U.S. Gulf States","volume":"156","author":"Doherty","year":"2017","journal-title":"Environ. Res."},{"issue":"2","key":"10.1016\/j.envres.2024.118956_bib24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/EDE.0b013e3181cc86e8","article-title":"Protecting human health from air pollution: shifting from a single-pollutant to a multipollutant approach","volume":"21","author":"Dominici","year":"2010","journal-title":"Epidemiology"},{"issue":"5","key":"10.1016\/j.envres.2024.118956_bib25","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1473-3099(20)30120-1","article-title":"An interactive web-based dashboard to track COVID-19 in real time","volume":"20","author":"Dong","year":"2020","journal-title":"Lancet Infect. Dis."},{"issue":"3","key":"10.1016\/j.envres.2024.118956_bib26","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jemermed.2014.01.034","article-title":"Neutrophil-lymphocyte ratio in patients with pesticide poisoning","volume":"47","author":"Dundar","year":"2014","journal-title":"J. Emerg. Med."},{"key":"10.1016\/j.envres.2024.118956_bib27","series-title":"Handbook on the Toxicology of Metals","first-page":"765","article-title":"Chapter 35\u2014copper","author":"Ellingsen","year":"2015"},{"key":"10.1016\/j.envres.2024.118956_bib28","series-title":"About the TSCA Chemical Substance Inventory","year":"2021"},{"issue":"7","key":"10.1016\/j.envres.2024.118956_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069755","article-title":"Adverse respiratory health and hematological alterations among agricultural workers occupationally exposed to organophosphate pesticides: a cross-sectional study in north India","volume":"8","author":"Fareed","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.envres.2024.118956_bib30","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF02931378","article-title":"Modulatory effects of selenium and zinc on the immune system","volume":"48","author":"Feren\u010d\u00edk","year":"2003","journal-title":"Folia Microbiol."},{"issue":"1\u20132","key":"10.1016\/j.envres.2024.118956_bib31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/15287390500259020","article-title":"Molecular mechanisms involved in the toxic effects of polychlorinated biphenyls (PCBs) and brominated flame retardants (BFRs)","volume":"69","author":"Fonnum","year":"2006","journal-title":"J. Toxicol. Environ. Health, Part A"},{"issue":"1","key":"10.1016\/j.envres.2024.118956_bib32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/jgs.12066","article-title":"Relationship between mean corpuscular volume and cognitive performance in older adults","volume":"61","author":"Gamaldo","year":"2013","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.envres.2024.118956_bib33","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.lfs.2015.10.013","article-title":"Occupational pesticide exposure and adverse health effects at the clinical, hematological and biochemical level","volume":"145","author":"Garc\u00eda-Garc\u00eda","year":"2016","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.envres.2024.118956_bib34","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1053\/jpan.2003.50013","article-title":"Understanding the complete blood count with differential","volume":"18","author":"George-Gay","year":"2003","journal-title":"J. PeriAnesthesia Nurs."},{"issue":"4","key":"10.1016\/j.envres.2024.118956_bib35","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1001\/jama.2011.2034","article-title":"Serum vaccine antibody concentrations in children exposed to perfluorinated compounds","volume":"307","author":"Grandjean","year":"2012","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.envres.2024.118956_bib36","doi-asserted-by":"crossref","DOI":"10.1289\/EHP275","article-title":"Serum vaccine antibody concentrations in adolescents exposed to perfluorinated compounds","volume":"125","author":"Grandjean","year":"2017","journal-title":"Environ. Health Perspect."},{"issue":"31","key":"10.1016\/j.envres.2024.118956_bib37","doi-asserted-by":"crossref","first-page":"30802","DOI":"10.1007\/s11356-017-8958-9","article-title":"Association between exposure to pesticides and disorder on hematological parameters and kidney function in male agricultural workers","volume":"25","author":"Hassanin","year":"2018","journal-title":"Environ. Sci. Pollut. Control Ser."},{"issue":"2","key":"10.1016\/j.envres.2024.118956_bib38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.5414\/CPP42083","article-title":"Changes in hemorheological and biochemical parameters following short-term and long-term smoking cessation induced by nicotine replacement therapy (NRT)","volume":"42","author":"Haustein","year":"2004","journal-title":"Int. J. Clin. Pharm. Ther."},{"issue":"10","key":"10.1016\/j.envres.2024.118956_bib39","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1289\/ehp.1001975","article-title":"Serum concentrations of antibodies against vaccine toxoids in children exposed perinatally to immunotoxicants","volume":"118","author":"Heilmann","year":"2010","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.envres.2024.118956_bib40","doi-asserted-by":"crossref","DOI":"10.1177\/1559325818798282","article-title":"Nonmonotonic dose-response curves occur in dose ranges that are relevant to regulatory decision-making","volume":"16","author":"Hill","year":"2018","journal-title":"Dose Response"},{"key":"10.1016\/j.envres.2024.118956_bib41","series-title":"Major Infectious Diseases","article-title":"Major infectious diseases: key messages from disease control priorities","author":"Holmes","year":"2017"},{"issue":"5","key":"10.1016\/j.envres.2024.118956_bib42","doi-asserted-by":"crossref","first-page":"1452S","DOI":"10.1093\/jn\/133.5.1452S","article-title":"Zinc-altered immune function","volume":"133","author":"Ibs","year":"2003","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.envres.2024.118956_bib43","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s00244-006-0177-1","article-title":"Immunosuppressive effect of subchronic exposure to a mixture of eight heavy metals, found as groundwater contaminants in different areas of India, through drinking water in male rats","volume":"53","author":"Jadhav","year":"2007","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"1","key":"10.1016\/j.envres.2024.118956_bib44","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0954-6111(98)90034-8","article-title":"Blood eosinophil and monocyte counts are related to smoking and lung function","volume":"92","author":"Jensen","year":"1998","journal-title":"Respir. Med."},{"issue":"2","key":"10.1016\/j.envres.2024.118956_bib45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/096032719401300202","article-title":"An immunological study on workers occupationally exposed to cadmium","volume":"13","author":"Karakaya","year":"1994","journal-title":"Hum. Exp. Toxicol."},{"issue":"4","key":"10.1016\/j.envres.2024.118956_bib46","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/j.1539-6924.2005.00652.x","article-title":"Benchmark dose of lead inducing anemia at the workplace","volume":"25","author":"Karita","year":"2005","journal-title":"Risk Anal."},{"issue":"3","key":"10.1016\/j.envres.2024.118956_bib47","first-page":"169","article-title":"Correlation between iron deficiency and lead intoxication in the workers of a car battery plant","volume":"20","author":"Keramati","year":"2010","journal-title":"International Journal of Hematology and Oncology"},{"key":"10.1016\/j.envres.2024.118956_bib48","series-title":"Environmental Influences on the Immune System","first-page":"181","article-title":"Vaccination efficacy and environmental pollution","author":"Kielsen","year":"2016"},{"issue":"1","key":"10.1016\/j.envres.2024.118956_bib49","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1080\/03630242.2014.972019","article-title":"Relationship between blood lead levels and hematological indices in pregnant women","volume":"55","author":"La-Llave-Le\u00f3n","year":"2015","journal-title":"Women Health"},{"key":"10.1016\/j.envres.2024.118956_bib50","series-title":"Williams Hematology, 9e","article-title":"Classification and clinical manifestations of disorders of monocytes and macrophages","author":"Lichtman","year":"2015"},{"issue":"6","key":"10.1016\/j.envres.2024.118956_bib51","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3892\/etm.2010.150","article-title":"Age-related changes in peripheral blood counts in humans","volume":"1","author":"Mahlknecht","year":"2010","journal-title":"Exp. Ther. Med."},{"issue":"2","key":"10.1016\/j.envres.2024.118956_bib52","doi-asserted-by":"crossref","first-page":"132","DOI":"10.5455\/medarh.2017.71.132-136","article-title":"Effect of cigarette smoking on haematological parameters in healthy population","volume":"71","author":"Malenica","year":"2017","journal-title":"Med. Arch."},{"key":"10.1016\/j.envres.2024.118956_bib53","series-title":"Mean Corpuscular Volume","author":"Maner","year":"2020"},{"key":"10.1016\/j.envres.2024.118956_bib54","first-page":"1","article-title":"Total white blood cell counts for persons ages 1-74 years with differential leukocyte counts for adults ages 25-74 years: United States, 1971-75","volume":"220","author":"McGrath","year":"1982","journal-title":"Vital and Health Statistics. Series 11, Data from the National Health Survey"},{"key":"10.1016\/j.envres.2024.118956_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112026","article-title":"Immunotoxicology of cadmium: cells of the immune system as targets and effectors of cadmium toxicity","volume":"149","author":"Mirkov","year":"2021","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.envres.2024.118956_bib56","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.tiv.2009.06.014","article-title":"Lead exposure and its impact on immune system: a review","volume":"23","author":"Mishra","year":"2009","journal-title":"Toxicol. Vitro"},{"issue":"4","key":"10.1016\/j.envres.2024.118956_bib57","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s40572-015-0064-x","article-title":"Cumulative chemical exposures during pregnancy and early development","volume":"2","author":"Mitro","year":"2015","journal-title":"Current Environmental Health Reports"},{"issue":"4","key":"10.1016\/j.envres.2024.118956_bib58","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1021\/jf60206a048","article-title":"Effect of dietary zinc and copper interrelationships on blood parameters of the rat","volume":"24","author":"Murthy","year":"1976","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"10.1016\/j.envres.2024.118956_bib59","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3343\/alm.2018.38.6.503","article-title":"Complete blood count reference intervals and patterns of changes across pediatric, adult, and geriatric ages in korea","volume":"38","author":"Nah","year":"2018","journal-title":"Annals of Laboratory Medicine"},{"issue":"3","key":"10.1016\/j.envres.2024.118956_bib60","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3923\/pjbs.2016.95.105","article-title":"Assessment of pesticide residues in human blood and effects of occupational exposure on hematological and hormonal qualities","volume":"19","author":"Nassar","year":"2016","journal-title":"Pakistan J. Biol. Sci. : PJBS"},{"key":"10.1016\/j.envres.2024.118956_bib61","series-title":"National Report on Human Exposure to Environmental Chemicals: Data Sources and Data Analysis","year":"2022"},{"key":"10.1016\/j.envres.2024.118956_bib62","series-title":"Module 3: Weighting","year":"2018"},{"key":"10.1016\/j.envres.2024.118956_bib63","series-title":"Reliability of Estimates","year":"2024"},{"key":"10.1016\/j.envres.2024.118956_bib64","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.envint.2018.10.042","article-title":"Characterization of age-based trends to identify chemical biomarkers of higher levels in children","volume":"122","author":"Nguyen","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2024.118956_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105496","article-title":"A comprehensive analysis of racial disparities in chemical biomarker concentrations in United States women, 1999\u20132014","volume":"137","author":"Nguyen","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2024.118956_bib66","article-title":"Harmonized US national health and nutrition examination survey 1988-2018 for high throughput exposome-health discovery","volume":"2023","author":"Nguyen","year":"2023","journal-title":"medRxiv"},{"issue":"1","key":"10.1016\/j.envres.2024.118956_bib67","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cell.2013.08.041","article-title":"Genetic variants regulating immune cell levels in health and disease","volume":"155","author":"Orr\u00f9","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.envres.2024.118956_bib68","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.reprotox.2016.08.001","article-title":"Children's white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants","volume":"68","author":"Oulhote","year":"2017","journal-title":"Reprod. Toxicol."},{"issue":"9","key":"10.1016\/j.envres.2024.118956_bib69","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.jclinepi.2015.05.029","article-title":"Assessment of vibration of effects due to model specification can demonstrate the instability of observational associations","volume":"68","author":"Patel","year":"2015","journal-title":"J. Clin. Epidemiol."},{"issue":"5","key":"10.1016\/j.envres.2024.118956_bib70","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1161\/ATVBAHA.118.312338","article-title":"Smoking and increased white and red blood cells","volume":"39","author":"Pedersen","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.envres.2024.118956_bib71","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/00039896.1971.10665962","article-title":"Studies of zinc metabolism in the rat","volume":"23","author":"Petering","year":"1971","journal-title":"Arch. Environ. Health"},{"issue":"1","key":"10.1016\/j.envres.2024.118956_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0245173","article-title":"The association of cadmium and lead exposures with red cell distribution width","volume":"16","author":"Peters","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2024.118956_bib73","series-title":"Henry's Clinical Diagnosis and Management by Laboratory Methods","article-title":"Interpreting laboratory results","author":"Pincus","year":"2017"},{"key":"10.1016\/j.envres.2024.118956_bib74","series-title":"Antioxidant Nutrients and Immune Functions","first-page":"123","article-title":"Effects of copper deficiency on the immune system","author":"Prohaska","year":"1990"},{"key":"10.1016\/j.envres.2024.118956_bib75","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-069X-10-9","article-title":"Knowns and unknowns on burden of disease due to chemicals: a systematic review","volume":"10","author":"Pr\u00fcss-Ust\u00fcn","year":"2011","journal-title":"Environ. Health : A Global Access Science Source"},{"issue":"1","key":"10.1016\/j.envres.2024.118956_bib76","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/toxsci\/kfi222","article-title":"A commercial mixture of the brominated flame retardant pentabrominated diphenyl ether (DE-71) induces respiratory burst in human neutrophil granulocytes in vitro","volume":"87","author":"Reistad","year":"2005","journal-title":"Toxicol. Sci."},{"issue":"1\u20132","key":"10.1016\/j.envres.2024.118956_bib77","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/01480547908993184","article-title":"Some immunological effects of lead, cadmium and methylmercury","volume":"2","author":"Roller","year":"1979","journal-title":"Drug Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.envres.2024.118956_bib78","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/1047-2797(94)90102-3","article-title":"Cigarette smoking and peripheral blood leukocyte differentials","volume":"4","author":"Schwartz","year":"1994","journal-title":"Ann. Epidemiol."},{"issue":"1","key":"10.1016\/j.envres.2024.118956_bib79","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1476-069X-13-114","article-title":"Potential effects of polychlorinated biphenyls (PCBs) and selected organochlorine pesticides (OCPs) on immune cells and blood biochemistry measures: a cross-sectional assessment of the NHANES 2003-2004 data","volume":"13","author":"Serdar","year":"2014","journal-title":"Environ. Health"},{"key":"10.1016\/j.envres.2024.118956_bib80","series-title":"Biomarkers in Inborn Errors of Metabolism: Clinical Aspects and Laboratory Determination","first-page":"399","article-title":"Chapter 17\u2014disorders of trace metals","author":"Smith","year":"2017"},{"key":"10.1016\/j.envres.2024.118956_bib81","author":"Storandt"},{"issue":"3_pt_1","key":"10.1016\/j.envres.2024.118956_bib82","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1164\/ajrccm\/144.3_Pt_1.612","article-title":"T cell subsets in healthy Black smokers and nonsmokers: evidence for ethnic group as an important response modifier","volume":"144","author":"Tollerud","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"issue":"Suppl. l","key":"10.1016\/j.envres.2024.118956_bib83","first-page":"877","article-title":"Approaches to detecting immunotoxic effects of environmental contaminants in humans","volume":"109","author":"Tryphonas","year":"2001","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.envres.2024.118956_bib84","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/sji.12413","article-title":"Effects of ageing on the immune system: infants to elderly","volume":"83","author":"Valiathan","year":"2016","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.envres.2024.118956_bib85","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.reprotox.2019.04.004","article-title":"Heightened susceptibility: a review of how pregnancy and chemical exposures influence maternal health","volume":"92","author":"Varshavsky","year":"2020","journal-title":"Reprod. Toxicol."},{"issue":"6476","key":"10.1016\/j.envres.2024.118956_bib86","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1126\/science.aay3164","article-title":"The exposome and health: where chemistry meets biology","volume":"367","author":"Vermeulen","year":"2020","journal-title":"Science (New York, N.Y.)"},{"issue":"6","key":"10.1016\/j.envres.2024.118956_bib87","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1007\/s11356-019-07066-x","article-title":"Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003-2004","volume":"27","author":"Wahlang","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"3","key":"10.1016\/j.envres.2024.118956_bib88","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/jn\/nxaa368","article-title":"A nonlinear relation between maternal red blood cell manganese concentrations and child blood pressure at age 6\u201312 y: A prospective birth cohort study","volume":"151","author":"Wang","year":"2021","journal-title":"J. Nutr."},{"key":"10.1016\/j.envres.2024.118956_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109208","article-title":"Characterization of trace elements exposure in pregnant women in the United States, NHANES 1999\u20132016","volume":"183","author":"Watson","year":"2020","journal-title":"Environ. Res."},{"issue":"12","key":"10.1016\/j.envres.2024.118956_bib90","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1289\/ehp.001081203","article-title":"Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children","volume":"108","author":"Weisglas-Kuperus","year":"2000","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.envres.2024.118956_bib91","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1469-8137.2008.02738.x","article-title":"Biofortification of crops with seven mineral elements often lacking in human diets \u2013 iron, zinc, copper, calcium, magnesium, selenium and iodine","volume":"182","author":"White","year":"2009","journal-title":"New Phytol."},{"issue":"6","key":"10.1016\/j.envres.2024.118956_bib92","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1289\/ehp.1002727","article-title":"Environmental chemicals in pregnant women in the United States: NHANES 2003\u20132004","volume":"119","author":"Woodruff","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2024.118956_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109275","article-title":"Design and methodology challenges of environment-wide association studies: a systematic review","volume":"183","author":"Zheng","year":"2020","journal-title":"Environ. Res."},{"issue":"4","key":"10.1016\/j.envres.2024.118956_bib94","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/bjh.16430","article-title":"Blood counts in adult and elderly individuals: defining the norms over eight decades of life","volume":"189","author":"Zierk","year":"2020","journal-title":"Br. J. Haematol."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935124008600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935124008600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T01:00:45Z","timestamp":1733965245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935124008600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":95,"alternative-id":["S0013935124008600"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2024.118956","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environmental chemical-wide associations with immune biomarkers in US adults: A cross-sectional analysis","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2024.118956","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118956"}}