{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:26:50Z","timestamp":1789417610047,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.envres.2024.119572","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T20:36:29Z","timestamp":1720211789000},"page":"119572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Towards unbiased interpretations of interactive effects in ecotoxicological studies"],"prefix":"10.1016","volume":"259","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5337-1305","authenticated-orcid":false,"given":"Antoine","family":"Geki\u00e8re","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2032-8081","authenticated-orcid":false,"given":"Guillaume","family":"Ghisbain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2485-0662","authenticated-orcid":false,"given":"Maxence","family":"G\u00e9rard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8880-1838","authenticated-orcid":false,"given":"Denis","family":"Michez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2024.119572_bib1","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1897\/01-386","article-title":"Mixture toxicity and its modeling by quantitative structure\u2010activity relationships","volume":"22","author":"Altenburger","year":"2003","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envres.2024.119572_bib2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.aquatox.2016.10.020","article-title":"Determining lower threshold concentrations for synergistic effects","volume":"182","author":"Bjergager","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envres.2024.119572_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105256","article-title":"Investigating combined toxicity of binary mixtures in bees: meta-analysis of laboratory tests, modelling, mechanistic basis and implications for risk assessment","volume":"133","author":"Carnesecchi","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2024.119572_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096580","article-title":"Quantifying synergy: a systematic review of mixture toxicity studies within environmental toxicology A. Nazir (ed)","volume":"9","author":"Cedergreen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2024.119572_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors","volume":"22","author":"Chou","year":"1984","journal-title":"Adv. Enzym. Regul."},{"key":"10.1016\/j.envres.2024.119572_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167277","article-title":"Combined effect of a neonicotinoid insecticide and a fungicide on honeybee gut epithelium and microbiota, adult survival, colony strength and foraging preferences","volume":"905","author":"Favaro","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.119572_bib7","first-page":"331","article-title":"The search for synergy: a critical review from a response surface perspective","volume":"47","author":"Greco","year":"1995","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.envres.2024.119572_bib8","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1073\/pnas.1311846111","article-title":"High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell\u2013like diffuse large B-cell lymphoma cells","volume":"111","author":"Griner","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.envres.2024.119572_bib9","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1897\/04-431R.1","article-title":"Significance testing of synergistic\/antagonistic, dose level\u2010dependent, or dose ratio\u2010dependent effects in mixture dose\u2010response analysis","volume":"24","author":"Jonker","year":"2005","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envres.2024.119572_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk2771","article-title":"APOBEC3A induces DNA gaps through PRIMPOL and confers gap-associated therapeutic vulnerability","volume":"10","author":"Kawale","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.envres.2024.119572_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148680","article-title":"Sulfoxaflor and nutritional deficiency synergistically reduce survival and fecundity in bumblebees","volume":"795","author":"Linguadoca","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.119572_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106206","article-title":"Ten years of research on synergisms and antagonisms in chemical mixtures: a systematic review and quantitative reappraisal of mixture studies","volume":"146","author":"Martin","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2024.119572_bib13","doi-asserted-by":"crossref","first-page":"27636","DOI":"10.1007\/s11356-022-24061-x","article-title":"Biochemical responses, feeding and survival in the solitary bee Osmia bicornis following exposure to an insecticide and a fungicide alone and in combination","volume":"30","author":"Martins","year":"2022","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.envres.2024.119572_bib14","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1158\/2159-8290.CD-21-0212","article-title":"Independent drug action in combination therapy: implications for precision oncology","volume":"12","author":"Plana","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.envres.2024.119572_bib15","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1002\/ps.6348","article-title":"How to use statistics to claim antagonism and synergism from binary mixture experiments","volume":"77","author":"Ritz","year":"2021","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.envres.2024.119572_bib16","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3390\/toxics3040342","article-title":"Additivity and interactions in ecotoxicity of pollutant mixtures: some patterns, conclusions, and open questions","volume":"3","author":"Rodea-Palomares","year":"2015","journal-title":"Toxics"},{"key":"10.1016\/j.envres.2024.119572_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2017.00158","article-title":"An introduction to terminology and methodology of chemical synergy\u2014perspectives from across disciplines","volume":"8","author":"Roell","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.envres.2024.119572_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156857","article-title":"Lethal, sublethal, and combined effects of pesticides on bees: a meta-analysis and new risk assessment tools","volume":"844","author":"Tosi","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.119572_bib19","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1016\/j.drudis.2021.06.002","article-title":"Using response surface models to analyze drug combinations","volume":"26","author":"Twarog","year":"2021","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.envres.2024.119572_bib20","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1016\/j.drudis.2019.09.002","article-title":"Applying synergy metrics to combination screening data: agreements, disagreements and pitfalls","volume":"24","author":"Vlot","year":"2019","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.envres.2024.119572_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-45279-w","article-title":"Emerging threats and opportunities to managed bee species in European agricultural systems: a horizon scan","volume":"13","author":"Willcox","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2024.119572_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.150292","article-title":"Analysis of honey bee exposure to multiple pesticide residues in the hive environment","volume":"805","author":"Xiao","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.119572_bib23","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.csbj.2015.09.001","article-title":"Searching for drug synergy in complex dose\u2013response landscapes using an interaction potency model","volume":"13","author":"Yadav","year":"2015","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.envres.2024.119572_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cbpc.2018.03.005","article-title":"Influences of acephate and mixtures with other commonly used pesticides on honey bee (Apis mellifera) survival and detoxification enzyme activities","volume":"209","author":"Yao","year":"2018","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.envres.2024.119572_bib25","first-page":"587","article-title":"SynergyFinder plus: toward better interpretation and annotation of drug combination screening datasets","volume":"20","author":"Zheng","year":"2022","journal-title":"Dev. Reprod. Biol."},{"key":"10.1016\/j.envres.2024.119572_bib26","article-title":"Four common pesticides, their mixtures and a formulation solvent in the hive environment have high oral toxicity to honey bee larvae W. Blenau (ed)","volume":"9","author":"Zhu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2024.119572_bib27","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.chemosphere.2011.08.046","article-title":"The joint effects of sulfonamides and their potentiator on Photobacterium phosphoreum: differences between the acute and chronic mixture toxicity mechanisms","volume":"86","author":"Zou","year":"2012","journal-title":"Chemosphere"}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935124014774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935124014774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T04:05:02Z","timestamp":1726891502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935124014774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":27,"alternative-id":["S0013935124014774"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2024.119572","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Towards unbiased interpretations of interactive effects in ecotoxicological studies","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2024.119572","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119572"}}