{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:28:12Z","timestamp":1784759292605,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005906","name":"Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","award":["2023JBFM05"],"award-info":[{"award-number":["2023JBFM05"]}],"id":[{"id":"10.13039\/501100005906","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.envres.2024.119956","type":"journal-article","created":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T09:57:14Z","timestamp":1725789434000},"page":"119956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"P2","title":["Characterization of the molecular, cellular, and behavioral changes caused by exposure to a saline-alkali environment in the Chinese mitten crab, Eriocheir sinensis"],"prefix":"10.1016","volume":"262","author":[{"given":"Meiyao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachun","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangchun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2024.119956_bib1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cmet.2020.04.018","article-title":"Untangling determinants of enhanced health and lifespan through a multi-omics approach in mice","volume":"32","author":"Aon","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.envres.2024.119956_bib2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jmau.2015.03.004","article-title":"Light and electron microscopic studies on the Y organ of the freshwater crab Travancoriana schirnerae","volume":"3","author":"Arath","year":"2015","journal-title":"Journal of Microscopy and Ultrastructure"},{"key":"10.1016\/j.envres.2024.119956_bib3","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1093\/gerona\/glx246","article-title":"Stearic acid supplementation in high protein to carbohydrate (P:C) ratio diet improves physiological and mitochondrial functions of Drosophila melanogaster parkin null mutants","volume":"74","author":"Bajracharya","year":"2019","journal-title":"Journals of Gerontology Series A-Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.envres.2024.119956_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.150065","article-title":"Understanding human vulnerability to climate change: a global perspective on index validation for adaptation planning","volume":"803","author":"Birkmann","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.119956_bib5","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envres.2024.119956_bib6","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1021\/acschemneuro.0c00439","article-title":"Mass spectrometric profiling of neuropeptides in Callinectes sapidus during Hypoxia Stress","volume":"11","author":"Buchberger","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.envres.2024.119956_bib7","article-title":"Transcriptome and molecular pathway analysis of the hepatopancreas in the pacific white shrimp Litopenaeus vannamei under chronic low-salinity stress","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2024.119956_bib8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.aquaculture.2018.09.056","article-title":"Growth and metabolomic responses of pacific white shrimp (Litopenaeus vannamei) to different dietary fatty acid sources and salinity levels","volume":"499","author":"Chen","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.envres.2024.119956_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107988","article-title":"Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: tales of a vicious cycle","volume":"231","author":"Chidambaram","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.envres.2024.119956_bib10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.fsi.2022.07.060","article-title":"Acute ammonia stress-induced oxidative and heat shock responses modulated by transcription factors in Litopenaeus vannamei","volume":"128","author":"Cui","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.envres.2024.119956_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2022.974217","article-title":"Understanding the effects of salinity and Vibrio harveyi on the gut microbiota profiles of Litopenaeus vannamei","volume":"9","author":"Deris","year":"2022","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.envres.2024.119956_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2022.108043","article-title":"Selenium and human nervous system","volume":"34","author":"Ding","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.envres.2024.119956_bib13","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nbt.1883","article-title":"Full-length transcriptome assembly from RNA-Seq data without a reference genome","volume":"29","author":"Grabherr","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.envres.2024.119956_bib14","first-page":"6663","article-title":"Global predictions of primary soil salinization under changing climate in the 21st century","volume":"12","author":"Hassani","year":"2021","journal-title":"Nature Communcations"},{"key":"10.1016\/j.envres.2024.119956_bib15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40168-020-00988-6","article-title":"Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson's disease","volume":"9","author":"Hou","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.envres.2024.119956_bib16","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1111\/are.14599","article-title":"Alteration of the haemocyte parameters, expression of immune-related and neurohormone bursicon genes of giant river prawn Macrobrachium rosenbergii (de Man) in the response to salinity stress and ammonia stress","volume":"51","author":"Jariyapong","year":"2020","journal-title":"Aquacult. Res."},{"key":"10.1016\/j.envres.2024.119956_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11802-022-4812-x","article-title":"Effect of long-term low-salinity culture on the survival, growth, and nutrient composition of mud crab Scylla paramamosain","volume":"21","author":"Ji","year":"2022","journal-title":"J. Ocean Univ. China"},{"key":"10.1016\/j.envres.2024.119956_bib18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.envres.2024.119956_bib19","series-title":"Climate Change 2023: Synthesis Report. Contribution of Working Groups I, Ii and Iii to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change","first-page":"35","author":"Lee","year":"2023"},{"key":"10.1016\/j.envres.2024.119956_bib20","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1038\/s41467-023-37165-w","article-title":"Alkalinity responses to climate warming destabilise the Earth's thermostat","volume":"14","author":"Lehmann","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2024.119956_bib21","series-title":"Preference of Chinese mitten crab (Eriocheir Sinensis) based on some habitat factors","author":"Li","year":"2022"},{"key":"10.1016\/j.envres.2024.119956_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1152\/physiolgenomics.00191.2013","article-title":"Transcriptome sequencing revealed the genes and pathways involved in salinity stress of Chinese mitten crab, Eriocheir sinensis","volume":"46","author":"Li","year":"2014","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.envres.2024.119956_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2022.108500","article-title":"Effects of dietary Ginkgo biloba leaf extract on growth performance, immunity and environmental stress tolerance of Penaeus vannamei","volume":"132","author":"Liao","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.envres.2024.119956_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179036","article-title":"Effects of salinity on gonadal development, osmoregulation and metabolism of adult male Chinese mitten crab, Eriocheir sinensis","volume":"12","author":"Long","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2024.119956_bib25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.envres.2024.119956_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.125959","article-title":"Zebrafish (Danio rerio) ability to activate ABCC transporters after exposure to glyphosate and its formulation Roundup Transorb","volume":"248","author":"Moraes","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2024.119956_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.07.292","article-title":"TDCIPP exposure affects Artemia franciscana growth and osmoregulation","volume":"694","author":"Morgan","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.119956_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.144914","article-title":"A novel modulation of physiological regulation in cultured Chinese mitten crab (Eriocheir japonica sinensis) in response to consistent salinity changes","volume":"756","author":"Qi","year":"2020","journal-title":"Gene"},{"key":"10.1016\/j.envres.2024.119956_bib29","series-title":"Plasma Metabolic Profiles Predict Future Dementia and Dementia Subtypes: a Prospective Analysis of 274","author":"Qiang","year":"2024"},{"key":"10.1016\/j.envres.2024.119956_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115723","article-title":"Metabolomic responses based on transcriptome of the hepatopancreas in Exopalaemon carinicauda under carbonate alkalinity stress","volume":"268","author":"Qin","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2024.119956_bib31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nmeth.2251","article-title":"Streaming fragment assignment for real-time analysis of sequencing experiments","volume":"10","author":"Roberts","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.envres.2024.119956_bib32","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1242\/jeb.01900","article-title":"Time course of osmoregulatory and metabolic changes during osmotic acclimation in Sparus auratus","volume":"208","author":"Sangiao-Alvarellos","year":"2005","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.envres.2024.119956_bib33","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1186\/s12864-018-4825-4","article-title":"Liver transcriptome analysis reveals extensive transcriptional plasticity during acclimation to low salinity in Cynoglossus semilaevis","volume":"19","author":"Si","year":"2018","journal-title":"BMC Genom."},{"key":"10.1016\/j.envres.2024.119956_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/science.abn9257","article-title":"Taurine deficiency as a driver of aging","volume":"380","author":"Singh","year":"2023","journal-title":"Science."},{"key":"10.1016\/j.envres.2024.119956_bib35","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1017\/S0025315417000169","article-title":"Understanding and forecasting dispersal of non-indigenous marine decapods (Crustacea: Decapoda) in East European and North Asian waters","volume":"97","author":"Spiridonov","year":"2017","journal-title":"J. Mar. Biol. Assoc. U. K."},{"key":"10.1016\/j.envres.2024.119956_bib36","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.ijbiomac.2022.09.124","article-title":"Dynamic transcriptome and LC-MS\/MS analysis revealed the important roles of taurine and glutamine metabolism in response to environmental salinity changes in gills of rainbow trout (Oncorhynchus mykiss)","volume":"221","author":"Tian","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.envres.2024.119956_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2021.111012","article-title":"Comparison of lipids and fatty acids among tissues of two semiterrestrial crabs reveals ecophysiological adaptations in changing coastal environments","volume":"259","author":"Vina-Trillos","year":"2021","journal-title":"Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology"},{"key":"10.1016\/j.envres.2024.119956_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.aqrep.2022.101016","article-title":"Classical aquaporins from Pacific white shrimp (Litopenaeus vannamei): molecular characterization and expression analysis in hypersalinity","volume":"23","author":"Wang","year":"2022","journal-title":"Aquaculture Reports"},{"key":"10.1016\/j.envres.2024.119956_bib39","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.15244\/pjoes\/62357","article-title":"Approaching the truth of the missing carbon sink","volume":"25","author":"Wang","year":"2016","journal-title":"Pol. J. Environ. Stud."},{"key":"10.1016\/j.envres.2024.119956_bib40","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/s41467-020-14788-x","article-title":"Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection","volume":"11","author":"Wei","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2024.119956_bib41","article-title":"Spatiotemporal variation in size and abundance of juvenile Chinese mitten crab (Eriocheir sinensis) in Yangtze Estuary","volume":"11","author":"Wu","year":"2024","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.envres.2024.119956_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2020.107671","article-title":"Effects of post-harvest hypoxic stress on post-landing recovery of live scallops (Mizuhopecten yessoensis) revealed by untargeted metabolomics based on UPLC-Q-TOF-MS","volume":"123","author":"Xu","year":"2021","journal-title":"Food Control"},{"key":"10.1016\/j.envres.2024.119956_bib43","first-page":"36","article-title":"Study on toxicity of salinity and alkalinity on Eriocheir sinensis","volume":"53","author":"Yang","year":"2021","journal-title":"J. NE Agric. Univ."},{"key":"10.1016\/j.envres.2024.119956_bib44","article-title":"Comparative transcriptome analysis reveals osmotic-regulated genes in the gill of Chinese mitten crab (Eriocheir sinensis)","volume":"14","author":"Yang","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2024.119956_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737776","article-title":"Effects of salinity stress on osmotic pressure, free amino acids, and immune-associated parameters of the juvenile Chinese mitten crab, Eriocheir sinensis","volume":"549","author":"Yang","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.envres.2024.119956_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.aqrep.2020.100533","article-title":"Metabolic mechanism of the mud crab (Scylla paramamosain) adapting to salinity sudden drop based on GC-MS technology","volume":"18","author":"Yao","year":"2020","journal-title":"Aquaculture Reports"},{"key":"10.1016\/j.envres.2024.119956_bib47","doi-asserted-by":"crossref","first-page":"eadc9317","DOI":"10.1126\/sciadv.adc9317","article-title":"Brain lipidomics: from functional landscape to clinical significance","volume":"8","author":"Yoon","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.envres.2024.119956_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162109","article-title":"Effects of saline-alkali stress on the tissue structure, antioxidation, immunocompetence and metabolomics of Eriocheir sinensis","volume":"871","author":"Zhang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.119956_bib49","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/s12864-020-06965-5","article-title":"mRNA profile provides novel insights into stress adaptation in mud crab megalopa, Scylla paramamosain after salinity stress","volume":"21","author":"Zhang","year":"2020","journal-title":"BMC Genom."},{"key":"10.1016\/j.envres.2024.119956_bib50","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.cell.2021.01.027","article-title":"Structural insights into the human D1 and D2 dopamine receptor signaling complexes","volume":"184","author":"Zhuang","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.envres.2024.119956_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70834-0","article-title":"N2 fixation dominates nitrogen cycling in a mangrove fiddler crab holobiont","volume":"10","author":"Zilius","year":"2020","journal-title":"Sci. Rep."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935124018619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935124018619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T03:35:41Z","timestamp":1770176141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935124018619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":51,"alternative-id":["S0013935124018619"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2024.119956","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of the molecular, cellular, and behavioral changes caused by exposure to a saline-alkali environment in the Chinese mitten crab, Eriocheir sinensis","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2024.119956","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119956"}}