{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:34:24Z","timestamp":1791207264232,"version":"4.1.0"},"reference-count":121,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303724"],"award-info":[{"award-number":["82303724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022T150233"],"award-info":[{"award-number":["2022T150233"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.envres.2024.120092","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T18:51:58Z","timestamp":1727722318000},"page":"120092","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"P2","title":["Kidney function mediates the association of per- and poly-fluoroalkyl substances (PFAS) and heavy metals with hepatic fibrosis risk"],"prefix":"10.1016","volume":"263","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1699-3321","authenticated-orcid":false,"given":"Zhengqi","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2024.120092_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.671640","article-title":"Cellular mechanisms of liver fibrosis","volume":"12","author":"Acharya","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.envres.2024.120092_bib2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41561-024-01402-8","article-title":"Underestimated burden of per- and polyfluoroalkyl substances in global surface waters and groundwaters","volume":"17","author":"Ackerman Grunfeld","year":"2024","journal-title":"Nat. Geosci."},{"key":"10.1016\/j.envres.2024.120092_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.130805","article-title":"Bioavailability, phytotoxicity and plant uptake of per-and polyfluoroalkyl substances (PFAS): a review","volume":"447","author":"Adu","year":"2023","journal-title":"J. Hazard Mater."},{"issue":"7","key":"10.1016\/j.envres.2024.120092_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2024.108777","article-title":"FIB-4 as a screening and disease monitoring method in pre-fibrotic stages of metabolic dysfunction-associated fatty liver disease (MASLD)","volume":"38","author":"Albert","year":"2024","journal-title":"J. Diabet. Complicat."},{"issue":"6","key":"10.1016\/j.envres.2024.120092_bib5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.diii.2017.03.003","article-title":"Liver fibrosis, cirrhosis, and cirrhosis-related nodules: imaging diagnosis and surveillance","volume":"98","author":"Aub\u00e9","year":"2017","journal-title":"Diagn Interv Imaging"},{"issue":"1","key":"10.1016\/j.envres.2024.120092_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-43161-3","article-title":"Comprehensive health risk analysis of heavy metal pollution using water quality indices and Monte Carlo simulation in R software","volume":"13","author":"Badeenezhad","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2024.120092_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.643972","article-title":"Toxic mechanisms of five heavy metals: mercury, lead, chromium, cadmium, and arsenic","volume":"12","author":"Balali-Mood","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.envres.2024.120092_bib8","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3390\/jox14020031","article-title":"Association of combined PFOA, PFOS, metals and allostatic load on hepatic disease risk","volume":"14","author":"Balogun","year":"2024","journal-title":"J Xenobiot"},{"issue":"10","key":"10.1016\/j.envres.2024.120092_bib9","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.ajpath.2023.06.002","article-title":"Oxidative stress-induced liver damage and remodeling of the liver vasculature","volume":"193","author":"Banerjee","year":"2023","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.envres.2024.120092_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157255","article-title":"A review of omics-based PFAS exposure studies reveals common biochemical response pathways","volume":"845","author":"Beale","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.120092_bib11","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.chemosphere.2017.06.052","article-title":"Health benefit from decreasing exposure to heavy metals and metalloid after strict pollution control measures near a typical river basin area in China","volume":"184","author":"Cao","year":"2017","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.envres.2024.120092_bib12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/HEP.0000000000000563","article-title":"The utility of P-I-R classification in predicting the on-treatment histological and clinical outcomes of patients with hepatitis B and advanced liver fibrosis","volume":"79","author":"Chang","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.envres.2024.120092_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164133","article-title":"Associations of exposure to blood and urinary heavy metal mixtures with psoriasis risk among U.S. adults: a cross-sectional study","volume":"887","author":"Chen","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.envres.2024.120092_bib14","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1007\/s12011-022-03390-5","article-title":"Effects of lead and cadmium combined heavy metals on liver function and lipid metabolism in mice","volume":"201","author":"Chen","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envres.2024.120092_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.worlddev.2023.106470","article-title":"Knowledge protects against pollution: the health effects of the cadmium rice event in China","volume":"175","author":"Chen","year":"2024","journal-title":"World Dev."},{"key":"10.1016\/j.envres.2024.120092_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115812","article-title":"Exploring the association between two groups of metals with potentially opposing renal effects and renal function in middle-aged and older adults: evidence from an explainable machine learning method","volume":"269","author":"Chen","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.envres.2024.120092_bib17","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2023.2216943","article-title":"Close association of PFASs exposure with hepatic fibrosis than steatosis: evidences from NHANES 2017-2018","volume":"55","author":"Cheng","year":"2023","journal-title":"Ann. Med."},{"issue":"2","key":"10.1016\/j.envres.2024.120092_bib18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10238-022-00799-z","article-title":"Liver biopsy for assessment of chronic liver diseases: a synopsis","volume":"23","author":"Chowdhury","year":"2023","journal-title":"Clin. Exp. Med."},{"issue":"5","key":"10.1016\/j.envres.2024.120092_bib19","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41370-023-00536-y","article-title":"Occupational exposure to per- and polyfluoroalkyl substances: a scope review of the literature from 1980-2021","volume":"33","author":"Christensen","year":"2023","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.envres.2024.120092_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2020.126601","article-title":"The sex-specific effects of blood lead, mercury, and cadmium levels on hepatic steatosis and fibrosis: Korean nationwide cross-sectional study","volume":"62","author":"Chung","year":"2020","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"4","key":"10.1016\/j.envres.2024.120092_bib21","doi-asserted-by":"crossref","DOI":"10.1289\/EHP10092","article-title":"Exposure to per- and polyfluoroalkyl substances and markers of liver injury: a systematic review and meta-analysis","volume":"130","author":"Costello","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2024.120092_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134938","article-title":"Factors influencing the distribution, risk, and transport of microplastics and heavy metals for wildlife and habitats in \"island\" landscapes: from source to sink","volume":"476","author":"Cui","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envres.2024.120092_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115301","article-title":"Co-exposure to PCB126 and PFOS increases biomarkers associated with cardiovascular disease risk and liver injury in mice","volume":"409","author":"Deng","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.envres.2024.120092_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.296","article-title":"Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2\/HGF signaling pathway","volume":"11","author":"Dong","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.envres.2024.120092_bib25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jare.2023.02.007","article-title":"Bavachinin protects the liver in NAFLD by promoting regeneration via targeting PCNA","volume":"55","author":"Dong","year":"2024","journal-title":"J. Adv. Res."},{"issue":"12","key":"10.1016\/j.envres.2024.120092_bib26","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1016\/j.ultrasmedbio.2018.07.008","article-title":"Liver ultrasound elastography: an update to the world federation for ultrasound in medicine and biology guidelines and recommendations","volume":"44","author":"Ferraioli","year":"2018","journal-title":"Ultrasound Med. Biol."},{"issue":"2","key":"10.1016\/j.envres.2024.120092_bib27","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/HYPERTENSIONAHA.119.14240","article-title":"High blood pressure and cardiovascular disease","volume":"75","author":"Fuchs","year":"2020","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.envres.2024.120092_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph21040468","article-title":"Association of combined per- and polyfluoroalkyl substances and metals with chronic kidney disease","volume":"21","author":"Haruna","year":"2024","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.envres.2024.120092_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2024.05.119","article-title":"The impact of depression-mediated gut microbiota composition on Irritable Bowel Syndrome: a Mendelian study","author":"Huang","year":"2024","journal-title":"J. Affect. Disord."},{"issue":"6","key":"10.1016\/j.envres.2024.120092_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/foods13060853","article-title":"Polysaccharides as protective agents against heavy metal toxicity","volume":"13","author":"Iddrisu","year":"2024","journal-title":"Foods"},{"issue":"26","key":"10.1016\/j.envres.2024.120092_bib31","doi-asserted-by":"crossref","first-page":"37963","DOI":"10.1007\/s11356-024-33735-7","article-title":"Heavy metal exposure and metabolomics analysis: an emerging frontier in environmental health","volume":"31","author":"Ilyas","year":"2024","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"3","key":"10.1016\/j.envres.2024.120092_bib32","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s40726-023-00269-4","article-title":"PFAS exposures and the human metabolome: a systematic review of epidemiological studies","volume":"9","author":"India-Aldana","year":"2023","journal-title":"Curr Pollut Rep"},{"issue":"8","key":"10.1016\/j.envres.2024.120092_bib33","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s40262-017-0506-8","article-title":"Renal drug transporters and drug interactions","volume":"56","author":"Ivanyuk","year":"2017","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.envres.2024.120092_bib34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.envres.2019.04.034","article-title":"Perfluoroalkyl acids serum concentrations and their relationship to biomarkers of renal failure: serum and urine albumin, creatinine, and albumin creatinine ratios across the spectrum of glomerular function among US adults","volume":"174","author":"Jain","year":"2019","journal-title":"Environ. Res."},{"issue":"12","key":"10.1016\/j.envres.2024.120092_bib35","doi-asserted-by":"crossref","first-page":"12425","DOI":"10.1007\/s11356-019-04666-5","article-title":"Dynamics of associations between perfluoroalkyl substances and uric acid across the various stages of glomerular function","volume":"26","author":"Jain","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"Pt 1","key":"10.1016\/j.envres.2024.120092_bib36","article-title":"Associations between the concentrations of \u03b1-klotho and selected perfluoroalkyl substances in the presence of eGFR based kidney function and albuminuria: data for US adults aged 40-79 years","volume":"838","author":"Jain","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"4s","key":"10.1016\/j.envres.2024.120092_bib37","first-page":"S1","article-title":"KDIGO 2021 clinical practice guideline for the management of glomerular diseases","volume":"100","year":"2021","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.envres.2024.120092_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jscs.2022.101569","article-title":"Cadmium sources, toxicity, resistance and removal by microorganisms-A potential strategy for cadmium eradication","volume":"26","author":"Khan","year":"2022","journal-title":"J. Saudi Chem. Soc."},{"issue":"2","key":"10.1016\/j.envres.2024.120092_bib39","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.aohep.2019.07.013","article-title":"Chronic kidney disease in patients with non-alcoholic fatty liver disease: what the Hepatologist should know?","volume":"19","author":"Kiapidou","year":"2020","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.envres.2024.120092_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138208","article-title":"Exposure to serum perfluoroalkyl substances and biomarkers of liver function: the Korean national environmental health survey 2015-2017","volume":"322","author":"Kim","year":"2023","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.envres.2024.120092_bib41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jhep.2023.04.002","article-title":"Using the ELF test, FIB-4 and NAFLD fibrosis score to screen the population for liver disease","volume":"79","author":"Kjaergaard","year":"2023","journal-title":"J. Hepatol."},{"issue":"13","key":"10.1016\/j.envres.2024.120092_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18136980","article-title":"The association between decreased kidney function and FIB-4 index value, as indirect liver fibrosis indicator, in middle-aged and older subjects","volume":"18","author":"Kotoku","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.envres.2024.120092_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116769","article-title":"Heavy metals, oxidative stress, and the role of AhR signaling","volume":"482","author":"Kou","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envres.2024.120092_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.151003","article-title":"Per- and polyfluoroalkyl substances in water and wastewater: a critical review of their global occurrence and distribution","volume":"809","author":"Kurwadkar","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.envres.2024.120092_bib45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.kint.2021.03.024","article-title":"Epithelial proliferation and cell cycle dysregulation in kidney injury and disease","volume":"100","author":"Lee","year":"2021","journal-title":"Kidney Int."},{"key":"10.1016\/j.envres.2024.120092_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1354577","article-title":"Relationship between blood cadmium levels and bone mineral density in adults: a cross-sectional study","volume":"15","author":"Lei","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"Pt 2","key":"10.1016\/j.envres.2024.120092_bib47","article-title":"Pollution, sources, and human health risk assessment of heavy metals in urban areas around industrialization and urbanization-Northwest China","volume":"308","author":"Li","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2024.120092_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152091","article-title":"Heavy metal-contained wastewater in China: discharge, management and treatment","volume":"808","author":"Li","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.envres.2024.120092_bib49","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/CM9.0000000000002027","article-title":"Non-invasive tests of non-alcoholic fatty liver disease","volume":"135","author":"Li","year":"2022","journal-title":"Chin Med J (Engl)"},{"issue":"1","key":"10.1016\/j.envres.2024.120092_bib50","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/tox.23378","article-title":"Effect of inorganic mercury exposure on reproductive system of male mice: immunosuppression and fibrosis in testis","volume":"37","author":"Li","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envres.2024.120092_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106375","article-title":"Per- and polyfluoroalkyl substances and kidney function: follow-up results from the Diabetes Prevention Program trial","volume":"148","author":"Lin","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2024.120092_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113457","article-title":"Association between serum per- and polyfluoroalkyl substances and thrombograms in young and middle-aged Taiwanese populations","volume":"236","author":"Lin","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2024.120092_bib53","article-title":"Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: a review of current available literature","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.envres.2024.120092_bib54","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1186\/s12889-023-16361-9","article-title":"Association between alcohol consumption and risk of stroke among adults: results from a prospective cohort study in Chongqing, China","volume":"23","author":"Liu","year":"2023","journal-title":"BMC Publ. Health"},{"issue":"1","key":"10.1016\/j.envres.2024.120092_bib55","doi-asserted-by":"crossref","first-page":"8002","DOI":"10.1038\/s41598-024-58678-4","article-title":"Blood urea nitrogen to serum albumin ratio as a new prognostic indicator in type 2 diabetes mellitus patients with chronic kidney disease","volume":"14","author":"Liu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2024.120092_bib56","article-title":"Association between cardiovascular health and Retinopathy in US adults: from NHANES 2005-2008","author":"Liu","year":"2024","journal-title":"Am. J. Ophthalmol."},{"issue":"21","key":"10.1016\/j.envres.2024.120092_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232113320","article-title":"Nonalcoholic fatty liver disease and chronic kidney disease: Epidemiology, pathogenesis, and clinical and research implications","volume":"23","author":"Lonardo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.envres.2024.120092_bib58","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1136\/gutjnl-2018-317593","article-title":"Advances in non-invasive assessment of hepatic fibrosis","volume":"69","author":"Loomba","year":"2020","journal-title":"Gut"},{"issue":"16","key":"10.1016\/j.envres.2024.120092_bib59","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.1021\/acs.est.9b01608","article-title":"Mass spectrometry-based metabolomics reveals occupational exposure to per- and polyfluoroalkyl substances relates to oxidative stress, fatty acid \u03b2-oxidation disorder, and kidney injury in a manufactory in China","volume":"53","author":"Lu","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2024.120092_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2023.101191","article-title":"Mechanisms of organ fibrosis: emerging concepts and implications for novel treatment strategies","volume":"92","author":"Lurje","year":"2023","journal-title":"Mol Aspects Med"},{"issue":"9","key":"10.1016\/j.envres.2024.120092_bib61","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.ekir.2023.07.002","article-title":"Environmental change, changing biodiversity, and infections-lessons for kidney health community","volume":"8","author":"Meena","year":"2023","journal-title":"Kidney Int Rep"},{"issue":"1","key":"10.1016\/j.envres.2024.120092_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-22636-9","article-title":"Prediction of decreased estimated glomerular filtration rate using liver fibrosis markers: a renal biopsy-based study","volume":"12","author":"Mima","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2024.120092_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117707","article-title":"Perfluoroalkyl substances (PFASs) exposure and kidney damage: causal interpretation using the US 2003-2018 National Health and Nutrition Examination Survey (NHANES) datasets","volume":"288","author":"Moon","year":"2021","journal-title":"Environ Pollut"},{"issue":"3","key":"10.1016\/j.envres.2024.120092_bib64","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1007\/s13762-023-05275-z","article-title":"Impact and toxicity of heavy metals on human health and latest trends in removal process from aquatic media","volume":"21","author":"Moukadiri","year":"2024","journal-title":"Int. J. Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2024.120092_bib65","doi-asserted-by":"crossref","DOI":"10.1007\/s00259-024-06785-9","article-title":"Preclinical targeting of liver fibrosis with a (89)Zr-labeled Fibrobody\u00ae directed against platelet derived growth factor receptor-\u03b2","author":"Muns","year":"2024","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"4","key":"10.1016\/j.envres.2024.120092_bib66","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.3390\/ijms15045412","article-title":"Signal transduction of platelet-induced liver regeneration and decrease of liver fibrosis","volume":"15","author":"Murata","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.envres.2024.120092_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136777","article-title":"Liver disease: Induction, progression, immunological mechanisms, and therapeutic interventions","volume":"22","author":"Neshat","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.envres.2024.120092_bib68","doi-asserted-by":"crossref","DOI":"10.1289\/EHP11885","article-title":"A state-of-the-science review of interactions of per- and polyfluoroalkyl substances (PFAS) with renal transporters in health and disease: implications for population variability in PFAS toxicokinetics","volume":"131","author":"Niu","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2024.120092_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134312","article-title":"Kidney function decline mediates the adverse effects of per- and poly-fluoroalkyl substances (PFAS) on uric acid levels and hyperuricemia risk","volume":"471","author":"Niu","year":"2024","journal-title":"J. Hazard Mater."},{"issue":"9","key":"10.1016\/j.envres.2024.120092_bib70","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1007\/s00261-021-03269-4","article-title":"Liver fibrosis assessment: MR and US elastography","volume":"47","author":"Ozturk","year":"2022","journal-title":"Abdom Radiol (NY)"},{"key":"10.1016\/j.envres.2024.120092_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2024.1403878","article-title":"Uric acid mediates the relationship between mixed heavy metal exposure and renal function in older adult people","volume":"12","author":"Pan","year":"2024","journal-title":"Front. Public Health"},{"key":"10.1016\/j.envres.2024.120092_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116254","article-title":"In vivo chronic exposure to inorganic mercury worsens hypercholesterolemia, oxidative stress and atherosclerosis in the LDL receptor knockout mice","volume":"275","author":"Queiroz","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2024.120092_bib73","article-title":"Toxic ties: unraveling the complex relationship between endocrine disrupting chemicals and chronic kidney disease","volume":"338","author":"Ramya","year":"2023","journal-title":"Environ Pollut"},{"key":"10.1016\/j.envres.2024.120092_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173352","article-title":"Associations between prenatal metal and metalloid mixtures in teeth and reductions in childhood lung function","author":"Rosa","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.120092_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.117743","article-title":"Estimation of per- and polyfluoroalkyl substances (PFAS) half-lives in human studies: a systematic review and meta-analysis","volume":"242","author":"Rosato","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2024.120092_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142390","article-title":"Evaluation of 14 PFAS for permeability and organic anion transporter interactions: implications for renal clearance in humans","volume":"361","author":"Ryu","year":"2024","journal-title":"Chemosphere"},{"issue":"9","key":"10.1016\/j.envres.2024.120092_bib77","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1161\/CIRCRESAHA.124.323697","article-title":"Perfluoroalkyl\/polyfluoroalkyl substances: links to cardiovascular disease risk","volume":"134","author":"Schlezinger","year":"2024","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.envres.2024.120092_bib78","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10916-023-01968-7","article-title":"Radiological diagnosis of chronic liver disease and hepatocellular carcinoma: a review","volume":"47","author":"Singh","year":"2023","journal-title":"J. Med. Syst."},{"issue":"4","key":"10.1016\/j.envres.2024.120092_bib79","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/liv.15856","article-title":"Comparison of NAFLD, MAFLD and MASLD characteristics and mortality outcomes in United States adults","volume":"44","author":"Song","year":"2024","journal-title":"Liver Int."},{"key":"10.1016\/j.envres.2024.120092_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113647","article-title":"Association of blood manganese, selenium with steatosis, fibrosis in the national health and nutrition examination survey, 2017-18","volume":"213","author":"Spaur","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2024.120092_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156299","article-title":"Co-exposure to perfluoroalkyl acids and heavy metals mixtures associated with impaired kidney function in adults: a community-based population study in China","volume":"839","author":"Su","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.120092_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cotox.2021.04.004","article-title":"Impact of cadmium pollution on food safety and human health","volume":"27","author":"Suhani","year":"2021","journal-title":"Curr Opin Toxicol"},{"key":"10.1016\/j.envres.2024.120092_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155337","article-title":"Baicalin and N-acetylcysteine regulate choline metabolism via TFAM to attenuate cadmium-induced liver fibrosis","volume":"125","author":"Sun","year":"2024","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.envres.2024.120092_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.dsx.2023.102814","article-title":"Utility of non-invasive liver fibrosis markers to predict the incidence of chronic kidney disease (CKD): a systematic review, meta-analysis, and meta-regression","volume":"17","author":"Supriyadi","year":"2023","journal-title":"Diabetes Metab Syndr"},{"issue":"19","key":"10.1016\/j.envres.2024.120092_bib85","doi-asserted-by":"crossref","first-page":"8264","DOI":"10.1021\/acs.est.4c00094","article-title":"Cross-sectional associations between prenatal per- and poly-fluoroalkyl substances and bioactive lipids in three environmental influences on child health outcomes (ECHO) cohorts","volume":"58","author":"Suthar","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"8","key":"10.1016\/j.envres.2024.120092_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/jpm14080798","article-title":"New biomarkers in liver fibrosis: a pass through the quicksand?","volume":"14","author":"Tagliaferro","year":"2024","journal-title":"J Pers Med"},{"issue":"1","key":"10.1016\/j.envres.2024.120092_bib87","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41574-021-00584-0","article-title":"Non-invasive methods for imaging hepatic steatosis and their clinical importance in NAFLD","volume":"18","author":"Tamaki","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.envres.2024.120092_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108805","article-title":"Diverse mechanisms by which chemical pollutant exposure alters gut microbiota metabolism and inflammation","volume":"190","author":"Teffera","year":"2024","journal-title":"Environ. Int."},{"issue":"9","key":"10.1016\/j.envres.2024.120092_bib89","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000512","article-title":"Population screening for cirrhosis","volume":"8","author":"Thiele","year":"2024","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.envres.2024.120092_bib90","article-title":"Endogenous markers of kidney function and renal drug clearance processes of filtration, secretion, and reabsorption","volume":"31","author":"Thompson","year":"2022","journal-title":"Curr Opin Toxicol"},{"key":"10.1016\/j.envres.2024.120092_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120727","article-title":"Mixed heavy metals exposure affects the renal function mediated by 8-OHG: a cross-sectional study in rural residents of China","volume":"317","author":"Tian","year":"2023","journal-title":"Environ Pollut"},{"issue":"Pt 1","key":"10.1016\/j.envres.2024.120092_bib92","article-title":"Dissecting the role of cadmium, lead, arsenic, and mercury in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis","volume":"238","author":"Tinkov","year":"2023","journal-title":"Environ. Res."},{"issue":"5","key":"10.1016\/j.envres.2024.120092_bib93","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/s41401-022-00874-x","article-title":"Histological assessment based on liver biopsy: the value and challenges in NASH drug development","volume":"43","author":"Tong","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.envres.2024.120092_bib94","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.2147\/JHC.S422565","article-title":"Development and validation of a prediction model for hepatitis B virus-related hepatocellular carcinoma patients receiving postoperative adjuvant transarterial chemoembolization","volume":"10","author":"Tu","year":"2023","journal-title":"J. Hepatocell. Carcinoma"},{"issue":"4","key":"10.1016\/j.envres.2024.120092_bib95","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1053\/j.sult.2021.03.003","article-title":"Liver fibrosis assessment","volume":"42","author":"Virarkar","year":"2021","journal-title":"Semin. Ultrasound CT MR"},{"issue":"1","key":"10.1016\/j.envres.2024.120092_bib96","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00128-020-03088-1","article-title":"A review on cadmium exposure in the population and intervention strategies against cadmium toxicity","volume":"106","author":"Wang","year":"2021","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envres.2024.120092_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.174537","article-title":"Low-grade systemic inflammation links heavy metal exposures to mortality: a multi-metal inflammatory index approach","volume":"947","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"Pt 2","key":"10.1016\/j.envres.2024.120092_bib98","article-title":"Heavy metals and metalloids exposure and liver function in Chinese adults - a nationally representative cross-sectional study","volume":"252","author":"Wang","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2024.120092_bib99","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.toxlet.2023.12.003","article-title":"Perfluorooctanoic acid (PFOA) exposure induces renal filtration and reabsorption disorders via down-regulation of aquaporins","volume":"392","author":"Wang","year":"2024","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.envres.2024.120092_bib100","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s12403-023-00551-2","article-title":"Associations between perfluoroalkyl substances mixed exposure and uric acid and glomerular filtration rate among adolescents and adults","volume":"16","author":"Wang","year":"2024","journal-title":"Exposure and Health"},{"key":"10.1016\/j.envres.2024.120092_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171742","article-title":"Association between per- and polyfluoroalkyl substances exposure and prevalence of chronic obstructive pulmonary disease: the mediating role of serum albumin","volume":"925","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.120092_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115663","article-title":"Environmental impacts, exposure pathways, and health effects of PFOA and PFOS","volume":"267","author":"Wee","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2024.120092_bib103","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1400448","article-title":"Correlation between the triglyceride-glucose index and chronic kidney disease among adults with metabolic-associated fatty liver disease: fourteen-year follow-up","volume":"15","author":"Wei","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"19","key":"10.1016\/j.envres.2024.120092_bib104","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26196060","article-title":"Heavy metals and human health: possible exposure pathways and the competition for protein binding sites","volume":"26","author":"Witkowska","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.envres.2024.120092_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123937","article-title":"Association between per- and poly-fluoroalkyl substances and nonalcoholic fatty liver disease: a nested case-control study in northwest China","volume":"350","author":"Wu","year":"2024","journal-title":"Environ Pollut"},{"key":"10.1016\/j.envres.2024.120092_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2024.05.025","article-title":"Residential greenness and chronic obstructive pulmonary disease in a large cohort in southern China: potential causal links, risk trajectories, and mediation pathways","author":"Wu","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.envres.2024.120092_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170025","article-title":"Facile colorimetric sensor using oxidase-like activity of octahedral Ag(2)O particles for highly selective detection of Pb(II) in water","volume":"915","author":"Xia","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.envres.2024.120092_bib108","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nrneph.2018.11","article-title":"Environmental pollution and kidney diseases","volume":"14","author":"Xu","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.envres.2024.120092_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146958","article-title":"Chronic cadmium exposure at environmental-relevant level accelerates the development of hepatotoxicity to hepatocarcinogenesis","volume":"783","author":"Xu","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.envres.2024.120092_bib110","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jfma.2021.07.013","article-title":"The role of fibrosis index FIB-4 in predicting liver fibrosis stage and clinical prognosis: a diagnostic or screening tool?","volume":"121","author":"Xu","year":"2022","journal-title":"J. Formos. Med. Assoc."},{"key":"10.1016\/j.envres.2024.120092_bib111","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.procbio.2022.01.010","article-title":"Current advancement in biosensing techniques for determination of alanine aminotransferase and aspartate aminotransferase-a mini review","volume":"114","author":"Yadav","year":"2022","journal-title":"Process Biochemistry"},{"key":"10.1016\/j.envres.2024.120092_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2022.133780","article-title":"Heavy metal pollution in the soil of contaminated sites in China: research status and pollution assessment over the past two decades","volume":"373","author":"Yan","year":"2022","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.envres.2024.120092_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108138","article-title":"PPAR\u03b1\/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per- and polyfluoroalkyl substances: an integrated approach","volume":"178","author":"Yang","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2024.120092_bib114","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1369661","article-title":"Exploring blood lipids-immunity associations following HBV vaccination: evidence from a large cross-sectional study","volume":"14","author":"Yang","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.envres.2024.120092_bib115","doi-asserted-by":"crossref","DOI":"10.3350\/cmh.2024.0431","article-title":"Epidemiology of metabolic dysfunction-associated steatotic liver disease","author":"Younossi","year":"2024","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.envres.2024.120092_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161556","article-title":"Heavy metal content and health risk assessment of atmospheric particles in China: a meta-analysis","volume":"867","author":"Yu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2024.120092_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.108004","article-title":"Stem cell therapy in liver regeneration: focus on mesenchymal stem cells and induced pluripotent stem cells","volume":"232","author":"Zhang","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.envres.2024.120092_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167945","article-title":"Dietary exposure to per- and polyfluoroalkyl substances: potential health impacts on human liver","volume":"907","author":"Zhang","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.envres.2024.120092_bib119","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1097\/MEG.0000000000002767","article-title":"Metabolic dysfunction-associated steatotic liver disease-related hepatic fibrosis increases risk of insulin resistance, type 2 diabetes, and chronic kidney disease","volume":"36","author":"Zhang","year":"2024","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"Pt 2","key":"10.1016\/j.envres.2024.120092_bib120","article-title":"Non-linear associations between metabolic syndrome and four typical heavy metals: data from NHANES 2011-2018","volume":"291","author":"Zhou","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2024.120092_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167513","article-title":"Metabolome analysis to investigate the effect of heavy metal exposure and chemoprevention agents on toxic injury caused by a multi-heavy metal mixture in rats","volume":"906","author":"Zhou","year":"2024","journal-title":"Sci. Total Environ."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935124019996?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935124019996?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T22:59:15Z","timestamp":1732834755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935124019996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":121,"alternative-id":["S0013935124019996"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2024.120092","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kidney function mediates the association of per- and poly-fluoroalkyl substances (PFAS) and heavy metals with hepatic fibrosis risk","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2024.120092","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120092"}}