{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:18:41Z","timestamp":1781248721734,"version":"3.54.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.envres.2025.120777","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T11:18:49Z","timestamp":1736162329000},"page":"120777","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The hygienic insecticide dimefluthrin induced neurodevelopmental deficits and behavioral disorders in zebrafish (Danio rerio) larvae"],"prefix":"10.1016","volume":"268","author":[{"given":"Ruirui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5270-311X","authenticated-orcid":false,"given":"Qingfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiagao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6804-1840","authenticated-orcid":false,"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2025.120777_bib1","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nature03010","article-title":"Synaptic computation","volume":"431","author":"Abbott","year":"2004","journal-title":"nature"},{"key":"10.1016\/j.envres.2025.120777_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110479","article-title":"Nano selenium ameliorates oxidative stress and inflammatory response associated with cypermethrin-induced neurotoxicity in rats","volume":"195","author":"Ali","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2025.120777_bib13","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.30574\/wjarr.2023.18.2.0959","article-title":"Teratogenic effect of electric mosquito repellents on mouse (Mus musculus) fetuses","volume":"18","author":"Aprilia","year":"2023","journal-title":"World J. Adv. Res. Rev."},{"key":"10.1016\/j.envres.2025.120777_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104747","article-title":"Neurobehavioral changes arising from early life dopamine signaling perturbations","volume":"137","author":"Areal","year":"2020","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.envres.2025.120777_bib4","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.33263\/BRIAC126.77967803","article-title":"The effect of insect repellent exposure on leukocyte profile and histopathologic findings in lungs","volume":"12","author":"Ary Andini","year":"2021","journal-title":"Biointerface Research in Applied Chemistry"},{"key":"10.1016\/j.envres.2025.120777_bib5","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.15562\/bmj.v12i2.4315","article-title":"Histopathological findings of the liver and kidneys of wistar rat exposed to insect repellent","volume":"12","author":"Ary Andini","year":"2023","journal-title":"Bali Med. J."},{"key":"10.1016\/j.envres.2025.120777_bib6","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/s41588-022-01089-w","article-title":"Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements","volume":"54","author":"Baranasic","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.envres.2025.120777_bib7","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/s41467-017-01046-w","article-title":"Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior","volume":"8","author":"Bocchi","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2025.120777_bib8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41531-021-00161-2","article-title":"Dynamic control of the dopamine transporter in neurotransmission and homeostasis","volume":"7","author":"Bu","year":"2021","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.envres.2025.120777_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.120240","article-title":"Biomarker responses in fish caged in a rice field during a bifenthrin application","volume":"263","author":"Cazenave","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2025.120777_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.940484","article-title":"Zebrafish as a model organism for neurodegenerative disease","volume":"15","author":"Chia","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.envres.2025.120777_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/toxsci\/kfp258","article-title":"Developmental neurotoxicity of pyrethroid insecticides in zebrafish embryos","volume":"113","author":"DeMicco","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2025.120777_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170408","article-title":"Early-life perfluorooctanoic acid exposure disrupts the function of dopamine transporter protein with glycosylation changes implicating the links between decreased dopamine levels and disruptive behaviors in larval zebrafish","volume":"917","author":"Du","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2025.120777_bib15","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0041-008X(82)90294-0","article-title":"Pyrethroid toxicology: protective effects of diazepam and phenobarbital in the mouse and the cockroach","volume":"66","author":"Gammon","year":"1982","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envres.2025.120777_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142315","article-title":"Titanium dioxide nanoparticle affects motor behavior, neurodevelopment and axonal growth in zebrafish (Danio rerio) larvae","volume":"754","author":"Gu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2025.120777_bib17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/jat.4062","article-title":"Developmental neurotoxicity and toxic mechanisms induced by olaquindox in zebrafish","volume":"41","author":"Guo","year":"2020","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envres.2025.120777_bib18","series-title":"Zebrafish Model Reveals Potentialhealth Risk of Deltamethrin: Identification of Toxic Target Organ and its Molecular Mechanism Zhejiang University","author":"Hongcui","year":"2020"},{"key":"10.1016\/j.envres.2025.120777_bib19","series-title":"Effects of Deltamethrin Mediated by Dopamine Signaling on Reproductive Endocrine Disrupting in Zebrafish","author":"Hu","year":"2022"},{"key":"10.1016\/j.envres.2025.120777_bib20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainres.2015.10.052","article-title":"Minocycline ameliorates prenatal valproic acid induced autistic behaviour, biochemistry and blood brain barrier impairments in rats","volume":"1630","author":"Kumar","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.envres.2025.120777_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107124","article-title":"The association of prenatal and childhood pyrethroid pesticide exposure with school-age ADHD traits","volume":"161","author":"Lee","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2025.120777_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s42485-022-00088-z","article-title":"alpha-synuclein enfolds tyrosine hydroxylase and dopamine ss-hydroxylase, potentially reducing dopamine and norepinephrine synthesis","volume":"13","author":"Lehrer","year":"2022","journal-title":"J Proteins Proteom"},{"key":"10.1016\/j.envres.2025.120777_bib23","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1016\/j.chemosphere.2015.11.025","article-title":"Pyrethroids in indoor air during application of various mosquito repellents: occurrence, dissipation and potential exposure risk","volume":"144","author":"Li","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2025.120777_bib24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.chemosphere.2018.12.011","article-title":"Cardiovascular toxicity and anxiety-like behavior induced by deltamethrin in zebrafish (Danio rerio) larvae","volume":"219","author":"Li","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2025.120777_bib25","article-title":"Cardiotoxicity risk induced by sanitary insecticide Dimefluthrin","author":"Li","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2025.120777_bib26","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1021\/acs.jafc.2c05625","article-title":"Functional characterization of knockdown resistance mutation L1014S in the German cockroach, Blattella germanica (linnaeus)","volume":"71","author":"Liu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.envres.2025.120777_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.118239","article-title":"Dopaminergic and serotoninergic systems as preferential targets of the pyrethroid tefluthrin exposure in the rat brain","volume":"247","author":"Maximiliano","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2025.120777_bib28","doi-asserted-by":"crossref","unstructured":"Neuroimmune communication. Nat. Immunol. 18, 115.","DOI":"10.1038\/ni.3676"},{"key":"10.1016\/j.envres.2025.120777_bib29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jpsychires.2019.11.006","article-title":"Acute embryonic exposure of zebrafish to permethrin induces behavioral changes related to anxiety and aggressiveness in adulthood","volume":"121","author":"Nunes","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.envres.2025.120777_bib30","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.bbr.2018.08.028","article-title":"Dopamine D1 and D2 receptor antagonism during development alters later behavior in zebrafish","volume":"356","author":"Oliveri","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.envres.2025.120777_bib31","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1038\/s41467-023-43271-6","article-title":"Dopamine receptor activation regulates reward expectancy signals during cognitive control in primate prefrontal neurons","volume":"14","author":"Ott","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2025.120777_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.117746","article-title":"4-Methylbenzylidene camphor induced neurobehavioral toxicity in zebrafish (Danio rerio) embryos","volume":"242","author":"Prakash","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2025.120777_bib33","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41467-024-44989-7","article-title":"iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity","volume":"15","author":"Rylaarsdam","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2025.120777_bib34","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4269\/ajtmh.22-0639","article-title":"Use of household insecticides against mosquitoes in dengue-endemic areas in Sri Lanka","volume":"110","author":"S\u0101nu","year":"2024","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.envres.2025.120777_bib35","first-page":"187","article-title":"Larval exposure to lambda cyhalothrin affects nutritional physiology in silkworm model (Bombyx mori. L)","volume":"7","author":"Seethapathy","year":"2022","journal-title":"International Journal of Entomology Research"},{"key":"10.1016\/j.envres.2025.120777_bib36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1289\/ehp.7254","article-title":"Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs","volume":"113","author":"Shafer","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2025.120777_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138944","article-title":"Neurotoxicity of an emerging organophosphorus flame retardant, resorcinol bis(diphenyl phosphate), in zebrafish larvae","volume":"334","author":"Shi","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2025.120777_bib38","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1111\/ejn.16202","article-title":"Transporters involved in adult rat cortical astrocyte dopamine uptake: kinetics, expression and pharmacological modulation","volume":"59","author":"Socan","year":"2024","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.envres.2025.120777_bib39","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neubiorev.2015.11.003","article-title":"Dopamine and anorexia nervosa","volume":"60","author":"Sodersten","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.envres.2025.120777_bib40","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41380-018-0102-9","article-title":"Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1","volume":"24","author":"Sun","year":"2019","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.envres.2025.120777_bib41","first-page":"81","article-title":"Dimefluthrin: a new pyrethroid insecticide and innovative mosquito control agent","volume":"25","author":"Tatsuya Mori","year":"2014","journal-title":"Japanese Society of Environmental Entomology and Zoology"},{"key":"10.1016\/j.envres.2025.120777_bib42","first-page":"1565","article-title":"Neurotransmitter systems in zebrafish model as a target for neurobehavioural studies","volume":"69","author":"Verma","year":"2022","journal-title":"Mater. Today: Proc."},{"key":"10.1016\/j.envres.2025.120777_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125416","article-title":"The pyrethroid esfenvalerate induces hypoactivity and decreases dopamine transporter expression in embryonic\/larval zebrafish (Danio rerio)","volume":"243","author":"Wang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2025.120777_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115892","article-title":"Effects of exposure to 3,6-DBCZ on neurotoxicity and AhR pathway during early life stages of zebrafish (Danio rerio)","volume":"270","author":"Wang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2025.120777_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.133016","article-title":"Stereoselective toxicity of acetochlor chiral isomers on the nervous system of zebrafish larvae","volume":"464","author":"Wang","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envres.2025.120777_bib46","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1002\/jat.4514","article-title":"Neurodevelopmental toxicity of bisphenol AF in zebrafish larvae and the protective effects of curcumin","volume":"43","author":"Yang","year":"2023","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envres.2025.120777_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112799","article-title":"Dorsal BNST DRD2(+) neurons mediate sex-specific anxiety-like behavior induced by chronic social isolation","volume":"42","author":"Zheng","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.envres.2025.120777_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107488","article-title":"Identification and optimization of nitrophenolic analogues as dopamine metabolic enzyme inhibitors for the treatment of Parkinson's disease","volume":"148","author":"Zou","year":"2024","journal-title":"Bioorg. Chem."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125000283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125000283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T03:32:16Z","timestamp":1762140736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935125000283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":47,"alternative-id":["S0013935125000283"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2025.120777","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The hygienic insecticide dimefluthrin induced neurodevelopmental deficits and behavioral disorders in zebrafish (Danio rerio) larvae","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2025.120777","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120777"}}