{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:27:37Z","timestamp":1792106857165,"version":"4.4.0"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32260863"],"award-info":[{"award-number":["32260863"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360561"],"award-info":[{"award-number":["82360561"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.envres.2025.121134","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T10:50:57Z","timestamp":1740221457000},"page":"121134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Early life imidacloprid and copper exposure affects the gut microbiome, metabolism, and learning ability of honey bees (Apis mellifera)"],"prefix":"10.1016","volume":"273","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4555-2984","authenticated-orcid":false,"given":"Xijie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihe","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengshang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yantao","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonghui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazhou","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2025.121134_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162859","article-title":"Neonicotinoid effects on tropical bees: imidacloprid impairs innate appetitive responsiveness, learning and memory in the stingless bee Melipona quadrifasciata","volume":"877","author":"Aguiar","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"20","key":"10.1016\/j.envres.2025.121134_bib2","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.cub.2008.08.066","article-title":"Long-term global trends in crop yield and production reveal No current pollination shortage but increasing pollinator dependency","volume":"18","author":"Aizen","year":"2008","journal-title":"Curr. Biol."},{"key":"10.1016\/j.envres.2025.121134_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144116","article-title":"Neonicotinoids in the agroecosystem: in-field long-term assessment on honeybee colony strength and microbiome","volume":"762","author":"Alberoni","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.envres.2025.121134_bib4","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3109\/09553002.2014.859761","article-title":"Radiation exposure prior to traumatic brain injury induces responses that differ as a function of animal age","volume":"90","author":"Allen","year":"2014","journal-title":"Int. J. Radiat. Biol."},{"issue":"1","key":"10.1016\/j.envres.2025.121134_bib5","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1038\/s41598-022-08009-2","article-title":"Mild chronic exposure to pesticides alters physiological markers of honey bee health without perturbing the core gut microbiota","volume":"12","author":"Almasri","year":"2022","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.envres.2025.121134_bib6","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s10886-019-01136-7","article-title":"The metabolome of associations between xylem-feeding insects and their bacterial symbionts","volume":"46","author":"Ankrah","year":"2020","journal-title":"J. Chem. Ecol."},{"key":"10.1016\/j.envres.2025.121134_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106503","article-title":"Metabolomics unveils the influence of dietary phytochemicals on residual pesticide concentrations in honey bees","volume":"152","author":"Ardalani","year":"2021","journal-title":"Environ. Int."},{"issue":"19","key":"10.1016\/j.envres.2025.121134_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/foods12193577","article-title":"Unravelling heavy metal dynamics in soil and honey: a case study from maramure\u0219 region, Romania","volume":"12","author":"Bora","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.envres.2025.121134_bib9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jinsphys.2016.01.001","article-title":"The neonicotinoids thiacloprid, imidacloprid, and clothianidin affect the immunocompetence of honey bees (Apis mellifera L.)","volume":"86","author":"Brandt","year":"2016","journal-title":"J. Insect Physiol."},{"issue":"3\u20134","key":"10.1016\/j.envres.2025.121134_bib10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.agee.2011.03.020","article-title":"Pollination services in the UK: how important are honeybees?","volume":"142","author":"Breeze","year":"2011","journal-title":"Agric. Ecosyst. Environ."},{"issue":"4","key":"10.1016\/j.envres.2025.121134_bib11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s13592-022-00934-5","article-title":"Colonization dynamics of the gut flora in western honey bee workers within 7-day post-emergence","volume":"53","author":"Cai","year":"2022","journal-title":"Apidologie"},{"issue":"7","key":"10.1016\/j.envres.2025.121134_bib12","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"issue":"11","key":"10.1016\/j.envres.2025.121134_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/nu9111211","article-title":"Vitamin C and immune function","volume":"9","author":"Carr","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.envres.2025.121134_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106487","article-title":"Crohn's disease-associated Escherichia coli LF82 in the gut damage of germ-free honeybees: a laboratory study","volume":"187","author":"Chang","year":"2024","journal-title":"Microb. Pathog."},{"issue":"3","key":"10.1016\/j.envres.2025.121134_bib15","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1603\/022.038.0302","article-title":"Influence of pesticide residues on honey bee (Hymenoptera: Apidae) colony health in France","volume":"38","author":"Chauzat","year":"2009","journal-title":"Environ. Entomol."},{"issue":"1","key":"10.1016\/j.envres.2025.121134_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12010018","article-title":"Early-life sublethal thiacloprid exposure to honey bee larvae: enduring effects on adult bee cognitive abilities","volume":"12","author":"Chen","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.envres.2025.121134_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130109","article-title":"The sulfoximine insecticide sulfoxaflor exposure reduces the survival status and disrupts the intestinal metabolism of the honeybee Apis mellifera","volume":"442","author":"Cheng","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envres.2025.121134_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2021.636144","article-title":"Early life stress and the fate of kynurenine pathway metabolites","volume":"15","author":"Coplan","year":"2021","journal-title":"Front. Hum. Neurosci."},{"issue":"5848","key":"10.1016\/j.envres.2025.121134_bib19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1126\/science.1146498","article-title":"A metagenomic survey of microbes in honey bee colony collapse disorder","volume":"318","author":"Cox-Foster","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.envres.2025.121134_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173393","article-title":"Intake of imidacloprid in lethal and sublethal doses alters gene expression in Apis mellifera bees","volume":"940","author":"de Castro Lippi","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2025.121134_bib21","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.chemosphere.2016.03.033","article-title":"Laboratory bioassays on the impact of cadmium, copper and lead on the development and survival of honeybee (Apis mellifera L.) larvae and foragers","volume":"152","author":"Di","year":"2016","journal-title":"Chemosphere"},{"issue":"18","key":"10.1016\/j.envres.2025.121134_bib22","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1021\/jf205393x","article-title":"Insecticide residues in pollen and nectar of a cucurbit crop and their potential exposure to pollinators","volume":"60","author":"Dively","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.envres.2025.121134_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.513962","article-title":"The succession of the gut microbiota in insects: a dynamic alteration of the gut microbiota during the whole life cycle of honey bees (Apis cerana)","volume":"12","author":"Dong","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envres.2025.121134_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120340","article-title":"Honeybee (Apis mellifera) resistance to deltamethrin exposure by modulating the gut microbiota and improving immunity","volume":"314","author":"Dong","year":"2022","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.envres.2025.121134_bib25","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02164-15","article-title":"The bee microbiome: impact on bee health and model for evolution and ecology of host-microbe interactions","volume":"7","author":"Engel","year":"2016","journal-title":"mBio"},{"issue":"10","key":"10.1016\/j.envres.2025.121134_bib26","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.jinsphys.2011.07.001","article-title":"Effects of cold immobilization and recovery period on honeybee learning, memory, and responsiveness to sucrose","volume":"57","author":"Frost","year":"2011","journal-title":"J. Insect Physiol."},{"issue":"4","key":"10.1016\/j.envres.2025.121134_bib27","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1093\/jee\/toae108","article-title":"Impact of copper and zinc oral chronic exposure on carniolan honey bee survival and feeding preference","volume":"117","author":"Glavan","year":"2024","journal-title":"J. Econ. Entomol."},{"issue":"6229","key":"10.1016\/j.envres.2025.121134_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/science.1255957","article-title":"Bee declines driven by combined stress from parasites, pesticides, and lack of flowers","volume":"347","author":"Goulson","year":"2015","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.envres.2025.121134_bib29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00128-023-03779-5","article-title":"Heavy metal concentrations of beeswax (Apis mellifera L.) at different ages","volume":"111","author":"Hassona","year":"2023","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"2","key":"10.1016\/j.envres.2025.121134_bib30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/etc.3273","article-title":"Metal contaminant accumulation in the hive: consequences for whole-colony health and brood production in the honey bee (Apis mellifera L.)","volume":"35","author":"Hladun","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"issue":"4","key":"10.1016\/j.envres.2025.121134_bib31","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s10886-015-0569-7","article-title":"Cadmium, copper, and lead accumulation and bioconcentration in the vegetative and reproductive organs of Raphanus sativus: implications for plant performance and pollination","volume":"41","author":"Hladun","year":"2015","journal-title":"J. Chem. Ecol."},{"key":"10.1016\/j.envres.2025.121134_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5745048","article-title":"Effect of Astragalus membranaceus oral solution on lifespan and learning and memory ability of honey bees","volume":"2020","author":"Hong","year":"2020","journal-title":"BioMed Res. Int."},{"issue":"3","key":"10.1016\/j.envres.2025.121134_bib33","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s11274-024-03900-8","article-title":"Strategies for the biological synthesis of D-glucuronic acid and its derivatives","volume":"40","author":"Hu","year":"2024","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.envres.2025.121134_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175931","article-title":"Damage to the behavior and physiological functions of Apis mellifera (Hymenoptera: apidae) by monocrotaline via the modulation of tryptophan metabolism and the corazonin receptor","volume":"952","author":"Hua","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2025.121134_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2024.104342","article-title":"Neonicotinoids: advances in hazards of residues, screening of aptamers and design of aptasensors","volume":"144","author":"Huang","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.envres.2025.121134_bib36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.chemosphere.2018.02.168","article-title":"Concentrations of imidacloprid and thiamethoxam in pollen, nectar and leaves from seed-dressed cotton crops and their potential risk to honeybees (Apis mellifera L.)","volume":"201","author":"Jiang","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2025.121134_bib37","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.foodcont.2016.02.051","article-title":"Mixture-risk-assessment of pesticide residues in retail polyfloral honey","volume":"67","author":"Juan-Borr\u00e1s","year":"2016","journal-title":"Food Control"},{"key":"10.1016\/j.envres.2025.121134_bib38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.chemosphere.2016.10.056","article-title":"Mixtures of herbicides and metals affect the redox system of honey bees","volume":"168","author":"Jumarie","year":"2017","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.envres.2025.121134_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/foods12040706","article-title":"Pesticide residues and metabolites in Greek honey and pollen: bees and human health risk assessment","volume":"12","author":"Kasiotis","year":"2023","journal-title":"Foods"},{"issue":"11","key":"10.1016\/j.envres.2025.121134_bib40","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.4014\/jmb.2306.06040","article-title":"Analyzing gut microbial community in varroa destructor-infested western honeybee (Apis mellifera)","volume":"33","author":"Kim","year":"2023","journal-title":"J. Microbiol. Biotechnol."},{"issue":"4","key":"10.1016\/j.envres.2025.121134_bib41","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.tree.2016.12.009","article-title":"Why bees are so vulnerable to environmental stressors","volume":"32","author":"Klein","year":"2017","journal-title":"Trends Ecol. Evol."},{"issue":"6","key":"10.1016\/j.envres.2025.121134_bib42","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nrmicro.2016.43","article-title":"Gut microbial communities of social bees","volume":"14","author":"Kwong","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"issue":"4","key":"10.1016\/j.envres.2025.121134_bib43","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/chemse\/24.4.429","article-title":"Olfactory discrimination ability and odor structure-activity relationships in honeybees","volume":"24","author":"Laska","year":"1999","journal-title":"Chem. Senses"},{"issue":"1","key":"10.1016\/j.envres.2025.121134_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-67796-y","article-title":"Exploring the interactions between Nosema ceranae infection and the honey bee gut microbiome","volume":"14","author":"Lau","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.envres.2025.121134_bib45","doi-asserted-by":"crossref","first-page":"6588","DOI":"10.1038\/s41467-021-26833-4","article-title":"Gut microbiome drives individual memory variation in bumblebees","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2025.121134_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169318","article-title":"Toxic effects of the heavy metal Cd on Apis cerana cerana (Hymenoptera: apidae): oxidative stress, immune disorders and disturbance of gut microbiota","volume":"912","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2025.121134_bib47","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.88772.4","article-title":"Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey bee Apis mellifera","volume":"12","author":"Li","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.envres.2025.121134_bib48","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pestbp.2019.02.001","article-title":"Brain transcriptome of honey bees (Apis mellifera) exhibiting impaired olfactory learning induced by a sublethal dose of imidacloprid","volume":"156","author":"Li","year":"2019","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.envres.2025.121134_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121920","article-title":"Honey bee foraging ability suppressed by imidacloprid can be ameliorated by adding adenosine","volume":"332","author":"Lin","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2025.121134_bib50","article-title":"Flumethrin exposure perturbs gut microbiota structure and intestinal metabolism in honeybees (Apis mellifera)","volume":"480","author":"Liu","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envres.2025.121134_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142561","article-title":"Co-exposure to cadmium and triazophos induces variations at enzymatic and transcriptional levels in Opsariichthys bidens","volume":"362","author":"Lou","year":"2024","journal-title":"Chemosphere"},{"issue":"12","key":"10.1016\/j.envres.2025.121134_bib52","doi-asserted-by":"crossref","first-page":"5666","DOI":"10.1111\/1462-2920.16223","article-title":"Exploring the biodiversity of Bifidobacterium asteroides among honey bee microbiomes","volume":"24","author":"Lugli","year":"2022","journal-title":"Environ. Microbiol."},{"issue":"1","key":"10.1016\/j.envres.2025.121134_bib53","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00441-020-03396-2","article-title":"Learning-dependent plasticity in the antennal lobe improves discrimination and recognition of odors in the honeybee","volume":"383","author":"Marachlian","year":"2021","journal-title":"Cell Tissue Res."},{"issue":"5","key":"10.1016\/j.envres.2025.121134_bib54","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s13592-018-0585-z","article-title":"Effects of bee density and sublethal imidacloprid exposure on cluster temperatures of caged honey bees","volume":"49","author":"Meikle","year":"2018","journal-title":"Apidologie"},{"issue":"6359","key":"10.1016\/j.envres.2025.121134_bib55","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1126\/science.aan3684","article-title":"A worldwide survey of neonicotinoids in honey","volume":"358","author":"Mitchell","year":"2017","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.envres.2025.121134_bib56","doi-asserted-by":"crossref","DOI":"10.1242\/jeb.241869","article-title":"Metal pollutants have additive negative effects on honey bee cognition","volume":"224","author":"Monchanin","year":"2021","journal-title":"J. Exp. Biol."},{"issue":"3","key":"10.1016\/j.envres.2025.121134_bib57","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41579-023-00990-3","article-title":"The honeybee microbiota and its impact on health and disease","volume":"22","author":"Motta","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"issue":"3","key":"10.1016\/j.envres.2025.121134_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009754","article-title":"High levels of miticides and agrochemicals in North American apiaries: implications for honey bee health","volume":"5","author":"Mullin","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2025.121134_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113787","article-title":"Insects' potential: understanding the functional role of their gut microbiome","volume":"194","author":"Mu\u00f1oz-Benavent","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.envres.2025.121134_bib60","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.neuropharm.2015.12.004","article-title":"Stress-related regulation of the kynurenine pathway: relevance to neuropsychiatric and degenerative disorders","volume":"112","author":"O'Farrell","year":"2017","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.envres.2025.121134_bib61","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00441-020-03385-5","article-title":"Olfactory coding in honeybees","volume":"383","author":"Paoli","year":"2021","journal-title":"Cell Tissue Res."},{"issue":"23","key":"10.1016\/j.envres.2025.121134_bib62","doi-asserted-by":"crossref","first-page":"7378","DOI":"10.1128\/AEM.01861-14","article-title":"Routes of acquisition of the gut microbiota of the honey bee Apis mellifera","volume":"80","author":"Powell","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"issue":"13","key":"10.1016\/j.envres.2025.121134_bib63","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00545-18","article-title":"Imidacloprid decreases honey bee survival rates but does not affect the gut microbiome","volume":"84","author":"Raymann","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"issue":"1891","key":"10.1016\/j.envres.2025.121134_bib64","article-title":"Of molecules, memories and migration: M1 acetylcholine receptors facilitate spatial memory formation and recall during migratory navigation","volume":"285","author":"Roth","year":"2018","journal-title":"Proc. Biol. Sci."},{"issue":"3","key":"10.1016\/j.envres.2025.121134_bib65","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1264\/jsme2.ME18169","article-title":"The honeybee gut microbiota is altered after chronic exposure to different families of insecticides and infection by Nosema ceranae","volume":"34","author":"Rouz\u00e9","year":"2019","journal-title":"Microb. Environ."},{"issue":"12","key":"10.1016\/j.envres.2025.121134_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108443","article-title":"Neonicotinoid-contaminated puddles of water represent a risk of intoxication for honey bees","volume":"9","author":"Samson-Robert","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2025.121134_bib67","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fnsys.2017.00055","article-title":"The effects of fat body tyramine level on gustatory responsiveness of honeybees (Apis mellifera) differ between behavioral castes","volume":"11","author":"Scheiner","year":"2017","journal-title":"Front. Syst. Neurosci."},{"issue":"3","key":"10.1016\/j.envres.2025.121134_bib68","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/00218839.2020.1866233","article-title":"The neonicotinoid imidacloprid alone alters the cognitive behavior in Apis mellifera L. and the combined exposure of imidacloprid and Varroa destructor mites synergistically contributes to trial attrition","volume":"60","author":"Schwartz","year":"2020","journal-title":"J. Apicult. Res."},{"issue":"7","key":"10.1016\/j.envres.2025.121134_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11071825","article-title":"Microbial-derived tryptophan metabolites and their role in neurological disease: anthranilic acid and anthranilic acid derivatives","volume":"11","author":"Shaw","year":"2023","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.envres.2025.121134_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-65507-1","article-title":"Dietary nanocomposite of vitamin C and vitamin E enhanced the performance of Nile tilapia","volume":"14","author":"Sherif","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2025.121134_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124111","article-title":"Toxicity evaluation of neonicotinoids to earthworm (Eisenia fetida) behaviors by a novel locomotion tracking assay","volume":"351","author":"Siregar","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2025.121134_bib72","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.ento.010908.164537","article-title":"Honey bees as a model for vision, perception, and cognition","volume":"55","author":"Srinivasan","year":"2010","journal-title":"Annu. Rev. Entomol."},{"issue":"12","key":"10.1016\/j.envres.2025.121134_bib73","doi-asserted-by":"crossref","DOI":"10.3390\/insects15120927","article-title":"Acetamiprid exposure disrupts gut microbiota in adult and larval worker honeybees (Apis mellifera L.)","volume":"15","author":"Su","year":"2024","journal-title":"Insects"},{"key":"10.1016\/j.envres.2025.121134_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.105772","article-title":"A potential trade-off between offense and defense in honeybee innate immunity: reduced phagocytosis in honeybee hemocytes correlates with a protective response after exposure to imidacloprid and amitraz","volume":"199","author":"Sukkar","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"issue":"7","key":"10.1016\/j.envres.2025.121134_bib75","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.14147","article-title":"Neuroprotective and antioxidant effects of pitaya fruit on Cu-induced stress in adult zebrafish","volume":"46","author":"Tamagno","year":"2022","journal-title":"J. Food Biochem."},{"issue":"1","key":"10.1016\/j.envres.2025.121134_bib76","doi-asserted-by":"crossref","DOI":"10.1093\/ismejo\/wrae030","article-title":"Gut microbiota contribute to variations in honey bee foraging intensity","volume":"18","author":"Vernier","year":"2024","journal-title":"ISME J."},{"issue":"1\u20132","key":"10.1016\/j.envres.2025.121134_bib77","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.marpolbul.2016.01.043","article-title":"Contamination, toxicity and speciation of heavy metals in an industrialized urban river: implications for the dispersal of heavy metals","volume":"104","author":"Wu","year":"2016","journal-title":"Mar. Pollut. Bull."},{"issue":"9","key":"10.1016\/j.envres.2025.121134_bib78","doi-asserted-by":"crossref","DOI":"10.3390\/insects15090644","article-title":"Combined toxic effects of lead and glyphosate on Apis cerana cerana","volume":"15","author":"Xue","year":"2024","journal-title":"Insects"},{"key":"10.1016\/j.envres.2025.121134_bib79","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ecoenv.2017.07.045","article-title":"Translocation of heavy metals from soils into floral organs and rewards of Cucurbita pepo: implications for plant reproductive fitness","volume":"145","author":"Xun","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2025.121134_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.112826","article-title":"Occurrence and human health risk assessment of mineral elements and pesticides residues in bee pollen","volume":"161","author":"Zafeiraki","year":"2022","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.envres.2025.121134_bib81","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.oneear.2020.12.005","article-title":"Worldwide occurrence records suggest a global decline in bee species richness","volume":"4","author":"Zattara","year":"2021","journal-title":"One Earth"},{"key":"10.1016\/j.envres.2025.121134_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137112","article-title":"The interaction and response of gut microbes to exposure to chiral ethiprole in honeybees (Apis mellifera)","volume":"486","author":"Zhang","year":"2025","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.envres.2025.121134_bib83","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1038\/s41467-022-29760-0","article-title":"Honeybee gut Lactobacillus modulates host learning and memory behaviors via regulating tryptophan metabolism","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2025.121134_bib84","article-title":"Antibiotic exposure alters the honeybee gut microbiota and may interfere with the honeybee behavioral caste transition","author":"Zhang","year":"2024","journal-title":"Insect Sci."},{"issue":"2","key":"10.1016\/j.envres.2025.121134_bib85","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02438-21","article-title":"Distinct roles of honeybee gut bacteria on host metabolism and neurological processes","volume":"10","author":"Zhang","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.envres.2025.121134_bib86","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.bbi.2019.02.009","article-title":"Kynurenic acid\/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress","volume":"79","author":"Zheng","year":"2019","journal-title":"Brain Behav. Immun."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125003858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125003858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:02:12Z","timestamp":1777402932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935125003858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":86,"alternative-id":["S0013935125003858"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2025.121134","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early life imidacloprid and copper exposure affects the gut microbiome, metabolism, and learning ability of honey bees (Apis mellifera)","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2025.121134","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121134"}}