{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:49:38Z","timestamp":1792126178603,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.envres.2025.121694","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T19:03:26Z","timestamp":1745607806000},"page":"121694","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Long-term exposure to air pollution and esophageal cancer incidence: A large-scale prospective cohort study"],"prefix":"10.1016","volume":"278","author":[{"given":"Xuwei","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanchan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3103-3724","authenticated-orcid":false,"given":"Xiaoxu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5214-3109","authenticated-orcid":false,"given":"Joshua","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-5334","authenticated-orcid":false,"given":"Zhijian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ying","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.envres.2025.121694_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"8","key":"10.1016\/j.envres.2025.121694_bib2","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1164\/rccm.202107-1770OC","article-title":"Traffic-related air pollution and lung cancer incidence: the California multiethnic cohort study","volume":"206","author":"Cheng","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.envres.2025.121694_bib3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3390\/ijerph21020205","article-title":"Benzene exposure and lung cancer risk: a systematic review and meta-analysis of human studies","volume":"21","author":"Chiavarini","year":"2024","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"4","key":"10.1016\/j.envres.2025.121694_bib4","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1053\/j.gastro.2007.06.061","article-title":"Nitric oxide and acid induce double-strand DNA breaks in Barrett's esophagus carcinogenesis via distinct mechanisms","volume":"133","author":"Clemons","year":"2007","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.envres.2025.121694_bib5","doi-asserted-by":"crossref","DOI":"10.1289\/EHP7246","article-title":"Fine particulate matter exposure and cancer incidence: analysis of SEER cancer registry data from 1992\u20132016","volume":"128","author":"Coleman","year":"2020","journal-title":"Environ. Health Perspect."},{"issue":"8","key":"10.1016\/j.envres.2025.121694_bib6","first-page":"767","article-title":"Cancer mortality risk, fine particulate air pollution, and smoking in a large, representative cohort of US adults","volume":"31","author":"Coleman","year":"2020","journal-title":"Cancer Causes Control"},{"issue":"1","key":"10.1016\/j.envres.2025.121694_bib7","article-title":"Outdoor air pollution and risk of incident adult hematologic cancer subtypes in a large US prospective cohort","volume":"2022","author":"Diver","year":"2022","journal-title":"ISEE Conf Abstr."},{"issue":"1","key":"10.1016\/j.envres.2025.121694_bib8","article-title":"Associations of outdoor air pollution and cancer incidence in a large US prospective cohort","volume":"2023","author":"Diver","year":"2023","journal-title":"ISEE Conf Abstr."},{"key":"10.1016\/j.envres.2025.121694_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113906","article-title":"Urinary nitrate and sodium in a high-risk area for upper gastrointestinal cancers: golestan cohort study","volume":"214","author":"Etemadi","year":"2022","journal-title":"Environ. Res."},{"issue":"2","key":"10.1016\/j.envres.2025.121694_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1039\/b208564j","article-title":"The heterogeneous hydrolysis of NO2 in laboratory systems and in outdoor and indoor atmospheres: an integrated mechanism","volume":"5","author":"Finlayson-Pitts","year":"2003","journal-title":"Phys. Chem. Chem. Phys."},{"issue":"1","key":"10.1016\/j.envres.2025.121694_bib11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.publhealth.20.1.145","article-title":"TIME-DEPENDENT covariates in the cox proportional-hazards regression model","volume":"20","author":"Fisher","year":"1999","journal-title":"Annu. Rev. Publ. Health"},{"issue":"1","key":"10.1016\/j.envres.2025.121694_bib12","doi-asserted-by":"crossref","first-page":"G107","DOI":"10.1152\/ajpgi.00124.2021","article-title":"Nitric oxide could promote development of Barrett's esophagus by S-nitrosylation-induced inhibition of Rho-ROCK signaling in esophageal fibroblasts","volume":"322","author":"Fujiya","year":"2022","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"6","key":"10.1016\/j.envres.2025.121694_bib13","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S2468-1253(20)30007-8","article-title":"The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990\u20132017: a systematic analysis for the global burden of disease study 2017","volume":"5","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"10258","key":"10.1016\/j.envres.2025.121694_bib14","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the global burden of disease study 2019","volume":"396","year":"2020","journal-title":"Lancet. Lond. Engl."},{"issue":"11","key":"10.1016\/j.envres.2025.121694_bib15","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1289\/ehp.1408882","article-title":"Lung cancer and exposure to nitrogen dioxide and traffic: a systematic review and meta-analysis","volume":"123","author":"Hamra","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2025.121694_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.etap.2017.10.001","article-title":"Effects of particulate matter from straw burning on lung fibrosis in mice","volume":"56","author":"Hu","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"7","key":"10.1016\/j.envres.2025.121694_bib17","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1164\/rccm.202011-4063OC","article-title":"Air pollution, genetic factors, and the risk of lung cancer: a prospective study in the UK biobank","volume":"204","author":"Huang","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.envres.2025.121694_bib18","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/jgh.12548","article-title":"Involvement of luminal nitric oxide in the pathogenesis of the gastroesophageal reflux disease spectrum","volume":"29","author":"Iijima","year":"2014","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.envres.2025.121694_bib19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/ijc.32220","article-title":"A prospective study of tea drinking temperature and risk of esophageal squamous cell carcinoma","volume":"146","author":"Islami","year":"2020","journal-title":"Int. J. Cancer"},{"issue":"10","key":"10.1016\/j.envres.2025.121694_bib20","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1289\/ehp.02110991","article-title":"Mortality from lung cancer in workers exposed to sulfur dioxide in the pulp and paper industry","volume":"110","author":"Lee","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2025.121694_bib21","article-title":"Causal effects of exposure to ambient air pollution on cancer risk: insights from genetic evidence","volume":"912","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2025.121694_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110415","article-title":"The associations of air pollution and socioeconomic factors with esophageal cancer in China based on a spatiotemporal analysis","volume":"196","author":"Li","year":"2021","journal-title":"Environ. Res."},{"issue":"3","key":"10.1016\/j.envres.2025.121694_bib23","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1007\/s11356-021-15942-8","article-title":"The lag effect of exposure to PM2.5 on esophageal cancer in urban-rural areas across China","volume":"29","author":"Li","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"13","key":"10.1016\/j.envres.2025.121694_bib24","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/S1470-2045(13)70487-X","article-title":"The carcinogenicity of outdoor air pollution","volume":"14","author":"Loomis","year":"2013","journal-title":"Lancet Oncol."},{"issue":"12","key":"10.1016\/j.envres.2025.121694_bib25","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/S1470-2045(17)30832-X","article-title":"Carcinogenicity of benzene","volume":"18","author":"Loomis","year":"2017","journal-title":"Lancet Oncol."},{"issue":"11","key":"10.1016\/j.envres.2025.121694_bib26","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1093\/carcin\/bgs241","article-title":"Inducible nitric oxide synthase (iNOS) and nitric oxide (NO) are important mediators of reflux-induced cell signalling in esophageal cells","volume":"33","author":"McAdam","year":"2012","journal-title":"Carcinogenesis"},{"issue":"3","key":"10.1016\/j.envres.2025.121694_bib27","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1053\/j.gastro.2022.05.054","article-title":"The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality in 2020 and projections to 2040: new estimates from GLOBOCAN 2020","volume":"163","author":"Morgan","year":"2022","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.envres.2025.121694_bib28","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1002\/ijc.31564","article-title":"Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European study of cohorts for air pollution effects (ESCAPE)","volume":"143","author":"Nagel","year":"2018","journal-title":"Int. J. Cancer"},{"issue":"11","key":"10.1016\/j.envres.2025.121694_bib29","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1002\/ijc.34864","article-title":"Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: the ELAPSE project","volume":"154","author":"Nagel","year":"2024","journal-title":"Int. J. Cancer"},{"issue":"11","key":"10.1016\/j.envres.2025.121694_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e21576","article-title":"Biological exposure indices of occupational exposure to benzene: a systematic review","volume":"9","author":"Rahimpoor","year":"2023","journal-title":"Heliyon"},{"issue":"9","key":"10.1016\/j.envres.2025.121694_bib31","doi-asserted-by":"crossref","first-page":"e633","DOI":"10.1016\/S2542-5196(21)00149-2","article-title":"Benzene exposure and Non-Hodgkin lymphoma: a systematic review and meta-analysis of human studies","volume":"5","author":"Rana","year":"2021","journal-title":"Lancet Planet. Health"},{"issue":"44","key":"10.1016\/j.envres.2025.121694_bib32","doi-asserted-by":"crossref","first-page":"67325","DOI":"10.1007\/s11356-022-20587-2","article-title":"The spatiotemporal correlation of PM2.5 concentration on esophageal cancer hospitalization rate in Fujian province of China","volume":"29","author":"Rao","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"11","key":"10.1016\/j.envres.2025.121694_bib33","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1136\/oem.2007.037929","article-title":"Occupational exposures and risk of oesophageal cancer by histological type: a case-control study in eastern Spain","volume":"65","author":"Santibanez","year":"2008","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.envres.2025.121694_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.119213","article-title":"Occupational benzene exposure and colorectal cancer: a systematic review and meta-analysis","volume":"257","author":"Sassano","year":"2024","journal-title":"Environ. Res."},{"issue":"5","key":"10.1016\/j.envres.2025.121694_bib35","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1053\/j.gastro.2018.12.024","article-title":"Individual and combined effects of environmental risk factors for esophageal cancer based on results from the Golestan cohort study","volume":"156","author":"Sheikh","year":"2019","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.envres.2025.121694_bib36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1053\/j.gastro.2023.03.233","article-title":"Long-term exposure to fine particulate matter and incidence of esophageal cancer: a prospective study of 0.5 million Chinese adults","volume":"165","author":"Sun","year":"2023","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.envres.2025.121694_bib37","doi-asserted-by":"crossref","DOI":"10.1289\/EHP1249","article-title":"Ambient air pollution and cancer mortality in the cancer prevention study II","volume":"125","author":"Turner","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2025.121694_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.139362","article-title":"Low-level ambient sulfur dioxide exposure and genetic susceptibility associated with incidence of idiopathic pulmonary fibrosis: a national prospective cohort study","volume":"337","author":"Wang","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2025.121694_bib39","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.chemosphere.2018.12.016","article-title":"Synergistic effects of sulfur dioxide and polycyclic aromatic hydrocarbons on pulmonary pro-fibrosis via mir-30c-1-3p\/transforming growth factor \u03b2 type II receptor axis","volume":"219","author":"Wu","year":"2019","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.envres.2025.121694_bib40","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1442-2050.2010.01080.x","article-title":"Long-term exposure to sodium nitrite and risk of esophageal carcinoma: a cohort study for 30 years: sodium nitrite and esophageal carcinoma","volume":"24","author":"Xie","year":"2011","journal-title":"Dis. Esophagus"},{"issue":"3","key":"10.1016\/j.envres.2025.121694_bib41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/CEJ.0000000000000158","article-title":"An evidence-based assessment for the association between long-term exposure to outdoor air pollution and the risk of lung cancer","volume":"25","author":"Yang","year":"2016","journal-title":"Eur. J. Cancer Prev."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125009454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125009454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:43:35Z","timestamp":1792125815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935125009454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":41,"alternative-id":["S0013935125009454"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2025.121694","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term exposure to air pollution and esophageal cancer incidence: A large-scale prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2025.121694","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121694"}}