{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:08:28Z","timestamp":1790694508238,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2507100"],"award-info":[{"award-number":["2023YFC2507100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270070"],"award-info":[{"award-number":["82270070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903203"],"award-info":[{"award-number":["81903203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103964"],"award-info":[{"award-number":["82103964"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.envres.2025.121898","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T10:52:50Z","timestamp":1747651970000},"page":"121898","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"P2","title":["Beta-amyloid deposition increases in the brain with the progression of silicosis: a [18F] AV45 PET study in mice"],"prefix":"10.1016","volume":"279","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3655-872X","authenticated-orcid":false,"given":"Zekuan","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengwen","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4896-5026","authenticated-orcid":false,"given":"Weiqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengkun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangguang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.envres.2025.121898_bib1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10072-021-05343-7","article-title":"The clinical correlation of proinflammatory and anti-inflammatory biomarkers with Alzheimer disease: a meta-analysis","volume":"43","author":"Anuradha","year":"2022","journal-title":"Neurol. Sci."},{"issue":"10","key":"10.1016\/j.envres.2025.121898_bib2","doi-asserted-by":"crossref","first-page":"E1968","DOI":"10.1073\/pnas.1616070114","article-title":"Serum-borne bioactivity caused by pulmonary multiwalled carbon nanotubes induces neuroinflammation via blood\u2013brain barrier impairment","volume":"114","author":"Aragon","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"7","key":"10.1016\/j.envres.2025.121898_bib3","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1111\/jgs.17345","article-title":"Impact of dementia: health disparities, population trends, care interventions, and economic costs","volume":"69","author":"Aranda","year":"2021","journal-title":"J. Am. Geriatr. Soc."},{"issue":"7","key":"10.1016\/j.envres.2025.121898_bib4","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1096\/fj.201601042RR","article-title":"Pseudomonas aeruginosa infection liberates transmissible, cytotoxic prion amyloids","volume":"31","author":"Balczon","year":"2017","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.envres.2025.121898_bib5","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1152\/physrev.00006.2023","article-title":"Lung endothelium, tau, and amyloids in health and disease","volume":"104","author":"Balczon","year":"2024","journal-title":"Physiol. Rev."},{"issue":"12","key":"10.1016\/j.envres.2025.121898_bib6","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1001\/jamaneurol.2021.3671","article-title":"Differences between plasma and cerebrospinal fluid glial fibrillary acidic protein levels across the alzheimer disease continuum","volume":"78","author":"Benedet","year":"2021","journal-title":"JAMA Neurol."},{"issue":"9","key":"10.1016\/j.envres.2025.121898_bib7","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1093\/brain\/awab114","article-title":"Early stages of tau pathology and its associations with functional connectivity, atrophy and memory","volume":"144","author":"Berron","year":"2021","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.envres.2025.121898_bib8","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1038\/mp.2017.204","article-title":"Blood-derived amyloid-\u03b2 protein induces Alzheimer's disease pathologies","volume":"23","author":"Bu","year":"2018","journal-title":"Mol. Psychiatr."},{"issue":"3\u20134b","key":"10.1016\/j.envres.2025.121898_bib9","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1080\/02724990444000186","article-title":"The role of the perirhinal cortex and hippocampus in learning, memory, and perception","volume":"58","author":"Buckley","year":"2005","journal-title":"The Quarterly Journal of Experimental Psychology Section B"},{"key":"10.1016\/j.envres.2025.121898_bib10","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00259-011-2021-8","article-title":"Using PET with 18 F-AV-45 (florbetapir) to quantify brain amyloid load in a clinical environment","volume":"39","author":"Camus","year":"2012","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"issue":"14","key":"10.1016\/j.envres.2025.121898_bib11","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1212\/WNL.0000000000004539","article-title":"Amyloid-PET in sporadic cerebral amyloid angiopathy: a diagnostic accuracy meta-analysis","volume":"89","author":"Charidimou","year":"2017","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.envres.2025.121898_bib12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s12890-022-02040-9","article-title":"Global and national burden and trends of mortality and disability-adjusted life years for silicosis, from 1990 to 2019: results from the global Burden of Disease study 2019","volume":"22","author":"Chen","year":"2022","journal-title":"BMC Pulm. Med."},{"issue":"12","key":"10.1016\/j.envres.2025.121898_bib13","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1513\/AnnalsATS.201809-589ED","article-title":"Silica exposure, silicosis, and the new occupational safety and health administration silica standard. What pulmonologists need to know","volume":"15","author":"Deslauriers","year":"2018","journal-title":"Annals of the American Thoracic Society"},{"issue":"6","key":"10.1016\/j.envres.2025.121898_bib14","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1037\/h0024599","article-title":"The hippocampus and behavior","volume":"67","author":"Douglas","year":"1967","journal-title":"Psychol. Bull."},{"issue":"4","key":"10.1016\/j.envres.2025.121898_bib15","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/alz.12638","article-title":"2022 Alzheimer's disease facts and figures","volume":"18","author":"Gaugler","year":"2022","journal-title":"Alzheimer's Dementia"},{"issue":"29","key":"10.1016\/j.envres.2025.121898_bib16","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1016\/S1352-2310(01)00301-6","article-title":"The characteristics of PM2. 5 in Beijing, China","volume":"35","author":"He","year":"2001","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.envres.2025.121898_bib17","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00259-015-3208-1","article-title":"Imaging \u03b2-amyloid using [18 F] flutemetamol positron emission tomography: from dosimetry to clinical diagnosis","volume":"43","author":"Heurling","year":"2016","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"issue":"7899","key":"10.1016\/j.envres.2025.121898_bib18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41586-022-04427-4","article-title":"The lung microbiome regulates brain autoimmunity","volume":"603","author":"Hosang","year":"2022","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.envres.2025.121898_bib19","first-page":"333","article-title":"The influencing factors of cognitive impairment in patients with silicosis","volume":"40","author":"Huang","year":"2022","journal-title":"Zhonghua lao Dong wei Sheng zhi ye Bing za zhi= Zhonghua Laodong Weisheng Zhiyebing Zazhi= Chinese Journal of Industrial Hygiene and Occupational Diseases"},{"issue":"4","key":"10.1016\/j.envres.2025.121898_bib20","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jalz.2011.04.007","article-title":"Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease","volume":"7","author":"Jack","year":"2011","journal-title":"Alzheimer's Dement."},{"issue":"5","key":"10.1016\/j.envres.2025.121898_bib21","first-page":"S72","article-title":"Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging","volume":"9","author":"Johnson","year":"2013","journal-title":"Alzheimer's Dement."},{"issue":"23","key":"10.1016\/j.envres.2025.121898_bib22","doi-asserted-by":"crossref","first-page":"R1116","DOI":"10.1016\/j.cub.2015.10.049","article-title":"The hippocampus","volume":"25","author":"Knierim","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.envres.2025.121898_bib23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.envres.2025.121898_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/07482337211058671","article-title":"Maternal exposure to silicon dioxide nanoparticles reduces hippocampal neurogenesis and synaptogenesis and induces neurodegeneration in rat offspring hippocampus","volume":"38","author":"Mahdipour","year":"2022","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.envres.2025.121898_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.720167","article-title":"Ophthalmic biomarkers for Alzheimer's disease: a review","volume":"13","author":"Majeed","year":"2021","journal-title":"Front. Aging Neurosci."},{"issue":"5","key":"10.1016\/j.envres.2025.121898_bib26","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1096\/fj.201500047","article-title":"Microglial priming through the lung\u2013brain axis: the role of air pollution\u2013induced circulating factors","volume":"30","author":"Mumaw","year":"2016","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.envres.2025.121898_bib27","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.3233\/JAD-190625","article-title":"Florbetapir regional distribution in cerebral amyloid angiopathy and Alzheimer's disease: a PET study","volume":"73","author":"Planton","year":"2020","journal-title":"J. Alzheim. Dis."},{"issue":"26","key":"10.1016\/j.envres.2025.121898_bib28","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2117083119","article-title":"Passage of exogeneous fine particles from the lung into the brain in humans and animals","volume":"119","author":"Qi","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.envres.2025.121898_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/ajplegacy.1958.193.1.189","article-title":"Respiratory activity and the hypothalamus","volume":"193","author":"Redgate","year":"1958","journal-title":"American Journal of Physiology-Legacy Content"},{"issue":"2","key":"10.1016\/j.envres.2025.121898_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0298816","article-title":"Tau and A\u03b242 in lavage fluid of pneumonia patients are associated with end-organ dysfunction: a prospective exploratory study","volume":"19","author":"Renema","year":"2024","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.envres.2025.121898_bib31","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1002\/jnr.23054","article-title":"Olfactory dysfunctions in neurodegenerative disorders","volume":"90","author":"Ruan","year":"2012","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.envres.2025.121898_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.711","article-title":"LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis","volume":"12","author":"Shi","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.envres.2025.121898_bib33","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.toxlet.2020.06.014","article-title":"Ambient PM2. 5 chronic exposure leads to cognitive decline in mice: from pulmonary to neuronal inflammation","volume":"331","author":"Shou","year":"2020","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.envres.2025.121898_bib34","doi-asserted-by":"crossref","first-page":"555","DOI":"10.4103\/ijo.IJO_999_19","article-title":"Use of ocular biomarkers as a potential tool for early diagnosis of Alzheimer's disease","volume":"68","author":"Singh","year":"2020","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.envres.2025.121898_bib35","doi-asserted-by":"crossref","first-page":"68276","DOI":"10.1007\/s11356-021-15405-0","article-title":"Ambient PM 2.5-induced brain injury is associated with the activation of PI3K\/AKT\/FoxO1 pathway","volume":"28","author":"Song","year":"2021","journal-title":"Environ. Sci. Pollut. Control Ser."},{"issue":"1","key":"10.1016\/j.envres.2025.121898_bib36","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s12974-022-02662-0","article-title":"Lung inflammation induced by silica particles triggers hippocampal inflammation, synapse damage and memory impairment in mice","volume":"19","author":"Suman","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.envres.2025.121898_bib37","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1148\/radiol.2382041977","article-title":"Integrated PET\/CT: current applications and future directions","volume":"238","author":"von Schulthess","year":"2006","journal-title":"Radiology"},{"issue":"4","key":"10.1016\/j.envres.2025.121898_bib38","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/JAD-122443","article-title":"Amyloid-\u03b2 deposition and olfactory dysfunction in an Alzheimer's disease model","volume":"37","author":"Wu","year":"2013","journal-title":"J. Alzheim. Dis."},{"issue":"4","key":"10.1016\/j.envres.2025.121898_bib39","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1177\/0748233721989896","article-title":"The role of macrophage-derived TGF-\u03b21 on SiO2-induced pulmonary fibrosis: a review","volume":"37","author":"Zhang","year":"2021","journal-title":"Toxicol. Ind. Health"}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125011491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125011491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T08:06:45Z","timestamp":1752566805000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935125011491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":39,"alternative-id":["S0013935125011491"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2025.121898","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beta-amyloid deposition increases in the brain with the progression of silicosis: a [18F] AV45 PET study in mice","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2025.121898","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121898"}}