{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:27:17Z","timestamp":1789432037404,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["2R01ES010544"],"award-info":[{"award-number":["2R01ES010544"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES031106"],"award-info":[{"award-number":["R01ES031106"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["HT94252310415"],"award-info":[{"award-number":["HT94252310415"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01AG07204401"],"award-info":[{"award-number":["K01AG07204401"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["MJFF-001018"],"award-info":[{"award-number":["MJFF-001018"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.envres.2025.122335","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T08:31:18Z","timestamp":1752568278000},"page":"122335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"P1","title":["Agricultural copper pesticide exposure and DNA methylation in Central Valley of California residents with and without Parkinson's disease"],"prefix":"10.1016","volume":"285","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2962-045X","authenticated-orcid":false,"given":"Yufan","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8717-0245","authenticated-orcid":false,"given":"Yu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4662-0606","authenticated-orcid":false,"given":"Keren","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irish Pearl","family":"Cambronero Del Rosario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myles","family":"Cockburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9581-9032","authenticated-orcid":false,"given":"Laura K.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1930-6619","authenticated-orcid":false,"given":"Adrienne M.","family":"Keener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2961-8918","authenticated-orcid":false,"given":"Jeff","family":"Bronstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6976-7339","authenticated-orcid":false,"given":"Beate R.","family":"Ritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly C.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2025.122335_bib1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1750-1172-7-84","article-title":"Hearing impairment in Stickler syndrome: a systematic review","volume":"7","author":"Acke","year":"2012","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.envres.2025.122335_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2019.126423","article-title":"Assessment of copper, iron, zinc and manganese status and speciation in patients with Parkinson's disease: a pilot study","volume":"59","author":"Ajsuvakova","year":"2020","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.envres.2025.122335_bib3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3390\/biom10020195","article-title":"Copper ions and Parkinson's disease: why is homeostasis So relevant?","volume":"10","author":"Bisaglia","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.envres.2025.122335_bib4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1039\/C4MT00339J","article-title":"Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease","volume":"7","author":"Carboni","year":"2015","journal-title":"Metallomics"},{"key":"10.1016\/j.envres.2025.122335_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13024-022-00560-w","article-title":"LRP1 is a neuronal receptor for \u03b1-synuclein uptake and spread","volume":"17","author":"Chen","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.envres.2025.122335_bib6","doi-asserted-by":"crossref","first-page":"34575","DOI":"10.1074\/jbc.M113.499350","article-title":"The E3 ubiquitin ligase UBE3C enhances proteasome processivity by ubiquitinating partially proteolyzed substrates","volume":"288","author":"Chu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envres.2025.122335_bib7","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/aje\/kwp006","article-title":"Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the Central Valley of California","volume":"169","author":"Costello","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envres.2025.122335_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/archotol.127.1.13","article-title":"Autosomal dominant inherited hearing impairment caused by a missense mutation in COL11A2 (DFNA13)","volume":"127","author":"De Leenheer","year":"2001","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.envres.2025.122335_bib9","doi-asserted-by":"crossref","first-page":"7215","DOI":"10.4049\/jimmunol.179.11.7215","article-title":"Cutting edge: a transcriptional repressor and corepressor induced by the STAT3-Regulated anti-inflammatory signaling Pathway1","volume":"179","author":"El Kasmi","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.envres.2025.122335_bib10","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1093\/bioinformatics\/btt311","article-title":"Gene-set analysis is severely biased when applied to genome-wide methylation data","volume":"29","author":"Geeleher","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envres.2025.122335_bib11","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/mds.27947","article-title":"Meta-analysis of copper and iron in Parkinson's disease brain and biofluids","volume":"35","author":"Genoud","year":"2020","journal-title":"Mov. Disord."},{"key":"10.1016\/j.envres.2025.122335_bib12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuro.2023.02.002","article-title":"Combined chronic copper exposure and aging lead to neurotoxicity in vivo","volume":"95","author":"Gonzalez-Alcocer","year":"2023","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envres.2025.122335_bib13","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/0888-7543(89)90135-3","article-title":"The human alpha 2(XI) collagen gene (COL11A2) maps to the centromeric border of the major histocompatibility complex on chromosome 6","volume":"5","author":"Hanson","year":"1989","journal-title":"Genomics"},{"key":"10.1016\/j.envres.2025.122335_bib14","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1172\/JCI83585","article-title":"EGFR regulates macrophage activation and function in bacterial infection","volume":"126","author":"Hardbower","year":"2016","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.envres.2025.122335_bib15","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.envres.2025.122335_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/acel.12325","article-title":"Accelerated epigenetic aging in Down syndrome","volume":"14","author":"Horvath","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.envres.2025.122335_bib17","doi-asserted-by":"crossref","DOI":"10.18632\/aging.100859","article-title":"Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients","author":"Horvath","year":"2015","journal-title":"Aging"},{"key":"10.1016\/j.envres.2025.122335_bib18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2105-13-86","article-title":"DNA methylation arrays as surrogate measures of cell mixture distribution","volume":"13","author":"Houseman","year":"2012","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.envres.2025.122335_bib19","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/ije\/dyr238","article-title":"Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies","volume":"41","author":"Jaffe","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.envres.2025.122335_bib20","first-page":"1","article-title":"Pesticidal copper (I) oxide: environmental fate and aquatic toxicity","volume":"213","author":"Kiaune","year":"2011","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envres.2025.122335_bib21","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/toxsci\/kfw081","article-title":"Copper exposure perturbs brain inflammatory responses and impairs clearance of amyloid-beta","volume":"152","author":"Kitazawa","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2025.122335_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/01.CIR.99.2.237","article-title":"C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men","volume":"99","author":"Koenig","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.envres.2025.122335_bib23","series-title":"Parkinson's Disease: Pathogenesis and Clinical Aspects","article-title":"Parkinson's disease: etiology, neuropathology, and pathogenesis","author":"Kouli","year":"2018"},{"key":"10.1016\/j.envres.2025.122335_bib24","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jat.1460","article-title":"Mechanisms underlying the inhibition of the cytochrome P450 system by copper ions","volume":"29","author":"Letelier","year":"2009","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envres.2025.122335_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.140049","article-title":"Metallomics analysis of metal exposure and cognitive function in older adults: a combined epidemiological and bioinformatics study","volume":"341","author":"Li","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2025.122335_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160851","article-title":"Proximity to residential and workplace pesticides application and the risk of progression of Parkinson's diseases in Central California","volume":"864","author":"Li","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2025.122335_bib27","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/acn3.299","article-title":"Plasma EGF and cognitive decline in Parkinson's disease and Alzheimer's disease","volume":"3","author":"Lim","year":"2016","journal-title":"Annal. Clin. Translat. Neurol."},{"key":"10.1016\/j.envres.2025.122335_bib28","author":"Liu"},{"key":"10.1016\/j.envres.2025.122335_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13148-021-01004-w","article-title":"Profile of copper-associated DNA methylation and its association with incident acute coronary syndrome","volume":"13","author":"Long","year":"2021","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.envres.2025.122335_bib30","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12950-024-00382-1","article-title":"EGFR of platelet regulates macrophage activation and bacterial phagocytosis function","volume":"21","author":"Luo","year":"2024","journal-title":"J. Inflamm."},{"key":"10.1016\/j.envres.2025.122335_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.116722","article-title":"Metals linked with the most prevalent primary neurodegenerative dementias in the elderly: a narrative review","volume":"236","author":"Mateo","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2025.122335_bib33","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/BF02861716","article-title":"The nature of the fungicidal action of copper and sulfur","volume":"15","author":"McCallan","year":"1949","journal-title":"Bot. Rev."},{"key":"10.1016\/j.envres.2025.122335_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/147251","article-title":"Copper and copper proteins in Parkinson's disease","volume":"2014","author":"Montes","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.envres.2025.122335_bib35","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/bioinformatics\/btt684","article-title":"ChAMP: 450k chip analysis methylation pipeline","volume":"30","author":"Morris","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envres.2025.122335_bib36","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ygeno.2017.02.004","article-title":"Candidate novel long noncoding RNAs, MicroRNAs and putative drugs for Parkinson's disease using a robust and efficient genome-wide association study","volume":"109","author":"Mortezaei","year":"2017","journal-title":"Genomics"},{"key":"10.1016\/j.envres.2025.122335_bib37","series-title":"Panther.Db: a Set of Annotation Maps Describing the Entire PANTHER Gene Ontology","author":"Muller","year":"2023"},{"key":"10.1016\/j.envres.2025.122335_bib38","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1136\/oemed-2021-108046","article-title":"Impact of occupational pesticide exposure assessment method on risk estimates for prostate cancer, non-hodgkin\u2019s lymphoma and Parkinson's disease: results of three meta-analyses","volume":"79","author":"Ohlander","year":"2022","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.envres.2025.122335_bib39","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.3390\/cells9071687","article-title":"Inflammation in Parkinson\u2019s disease: mechanisms and therapeutic implications","volume":"9","author":"Pajares","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.envres.2025.122335_bib40","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.scitotenv.2018.07.143","article-title":"Organophosphate pesticide exposure and differential genome-wide DNA methylation","volume":"645","author":"Paul","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"1 14","key":"10.1016\/j.envres.2025.122335_bib41","first-page":"1","article-title":"A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides","volume":"14","author":"Paul","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2025.122335_bib42","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1289\/ehp.1408976","article-title":"Organophosphate pesticide exposures, nitric oxide synthase gene variants, and gene\u2013pesticide interactions in a case\u2013control study of Parkinson's disease, California (USA)","volume":"124","author":"Paul","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2025.122335_bib43","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/bioinformatics\/btv560","article-title":"missMethyl: an R package for analyzing data from Illumina's HumanMethylation450 platform","volume":"32","author":"Phipson","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envres.2025.122335_bib44","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/iep.12260","article-title":"Immunohistochemical assessment of survivin and Bcl3 expression as potential biomarkers for NF-\u03baB activation in the Barrett metaplasia\u2013dysplasia\u2013adenocarcinoma sequence","volume":"99","author":"Puccio","year":"2018","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.envres.2025.122335_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11122467","article-title":"Association between heavy metal exposure and Parkinson's disease: a review of the mechanisms related to oxidative stress","volume":"11","author":"Pyatha","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.envres.2025.122335_bib46","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1093\/bioinformatics\/bty892","article-title":"methylGSA: a bioconductor package and shiny app for DNA methylation data length bias adjustment in gene set testing","volume":"35","author":"Ren","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envres.2025.122335_bib47","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s40572-016-0083-2","article-title":"Of pesticides and men: a California story of genes and environment in parkinson's disease","volume":"3","author":"Ritz","year":"2016","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.envres.2025.122335_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.971298","article-title":"DNA methylation as a mediator of genetic and environmental influences on Parkinson's disease susceptibility: impacts of alpha-Synuclein, physical activity, and pesticide exposure on the epigenome","volume":"13","author":"Schaffner","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.envres.2025.122335_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1412356","article-title":"Metallomic analysis of brain tissues distinguishes between cases of dementia with lewy bodies, Alzheimer's disease, and Parkinson's disease dementia","volume":"18","author":"Scholefield","year":"2024","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.envres.2025.122335_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.641222","article-title":"Widespread decreases in cerebral copper are common to Parkinson\u2019s disease dementia and Alzheimer's disease dementia","volume":"13","author":"Scholefield","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.envres.2025.122335_bib51","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"10.1016\/j.envres.2025.122335_bib31","doi-asserted-by":"crossref","first-page":"D609","DOI":"10.1093\/nar\/gkae1010","article-title":"UniProt: the Universal Protein Knowledgebase in 2025","volume":"53","year":"2025","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.envres.2025.122335_bib52","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13024-019-0314-8","article-title":"Glial phagocytic clearance in Parkinson's disease","volume":"14","author":"Tremblay","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.envres.2025.122335_bib53","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/jbg.12419","article-title":"Significance testing and genomic inflation factor using high\u2010density genotypes or whole\u2010genome sequence data","volume":"136","author":"van den Berg","year":"2019","journal-title":"J. Anim. Breed. Genet."},{"key":"10.1016\/j.envres.2025.122335_bib54","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13059-016-1131-9","article-title":"Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution","volume":"18","author":"van Iterson","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.envres.2025.122335_bib55","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s10654-011-9574-5","article-title":"Parkinson's disease risk from ambient exposure to pesticides","volume":"26","author":"Wang","year":"2011","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.envres.2025.122335_bib56","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1093\/bioinformatics\/bth449","article-title":"limmaGUI: a graphical user interface for linear modeling of microarray data","volume":"20","author":"Wettenhall","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envres.2025.122335_bib57","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.yrtph.2018.05.005","article-title":"Pesticide exposure and risk of Parkinson's disease: dose-response meta-analysis of observational studies","volume":"96","author":"Yan","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envres.2025.122335_bib58","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/gb-2010-11-2-r14","article-title":"Gene ontology analysis for RNA-seq: accounting for selection bias","volume":"11","author":"Young","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.envres.2025.122335_bib59","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41531-021-00231-5","article-title":"Fine mapping of the HLA locus in Parkinson's disease in Europeans","volume":"7","author":"Yu","year":"2021","journal-title":"npj Parkinson's Dis."},{"key":"10.1016\/j.envres.2025.122335_bib60","article-title":"Identification of hub genes and potential molecular pathogenesis in substantia Nigra in Parkinson's disease via bioinformatics analysis","volume":"2023","author":"Zhou","year":"2023","journal-title":"Parkinsons Dis."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125015865?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125015865?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:52:01Z","timestamp":1777459921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935125015865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":60,"alternative-id":["S0013935125015865"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2025.122335","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Agricultural copper pesticide exposure and DNA methylation in Central Valley of California residents with and without Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2025.122335","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"122335"}}