{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:45:57Z","timestamp":1786988757625,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22376189"],"award-info":[{"award-number":["22376189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22176177"],"award-info":[{"award-number":["22176177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.envres.2025.122575","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T06:31:19Z","timestamp":1754980279000},"page":"122575","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P4","title":["Metabolism exploration of disinfection byproducts halonitromethanes (HNMs) by cytochrome P450 enzymes and toxicity evaluation"],"prefix":"10.1016","volume":"285","author":[{"given":"Lingmin","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangmin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangcai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4253-0144","authenticated-orcid":false,"given":"Haiying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2025.122575_bib1","doi-asserted-by":"crossref","first-page":"5619","DOI":"10.1021\/acs.chemrev.6b00571","article-title":"Enzymatic halogenation and dehalogenation reactions: Pervasive and mechanistically diverse","volume":"117","author":"Agarwal","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.envres.2025.122575_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118316","article-title":"Microseira wollei and Phormidium algae more than doubles DBP concentrations and calculated toxicity in drinking water","volume":"216","author":"Aziz","year":"2022","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2025.122575_bib3","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1021\/acs.jcim.8b00769","article-title":"Deep learning-based prediction of drug-induced cardiotoxicity","volume":"59","author":"Cai","year":"2019","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.envres.2025.122575_bib4","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1021\/acs.chemrestox.6b00384","article-title":"Evaluation of nitrosamide formation in the cytochrome P450-mediated metabolism of tobacco-specific nitrosamines","volume":"29","author":"Carlson","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envres.2025.122575_bib5","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1021\/bi00322a029","article-title":"Biodehalogenation: reactions of cytochrome P-450 with polyhalomethanes","volume":"24","author":"Castro","year":"1985","journal-title":"Biochemistry"},{"key":"10.1016\/j.envres.2025.122575_bib6","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1021\/acs.chemrev.5b00484","article-title":"The halogen bond","volume":"116","author":"Cavallo","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.envres.2025.122575_bib7","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1021\/ci300367a","article-title":"admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties","volume":"52","author":"Cheng","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.envres.2025.122575_bib8","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1021\/om200115y","article-title":"Mechanisms of reactions of a lithium boryl with organohalides","volume":"30","author":"Cheung","year":"2011","journal-title":"Organometallics"},{"key":"10.1016\/j.envres.2025.122575_bib9","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1021\/es070895g","article-title":"Are PFCAs bioaccumulative? A critical review and comparison with regulatory criteria and persistent lipophilic compounds","volume":"42","author":"Conder","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2025.122575_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-99766-3","article-title":"hERG toxicity prediction in early drug discovery using extreme gradient boosting and isometric stratified ensemble mapping","volume":"15","author":"Falc\u00f3n-Cano","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2025.122575_bib11","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1021\/acs.jpclett.5c00497","article-title":"Mechanistic insights into the reactive uptake of bromine nitrate at the air\u2013water interface: Interplay between halogen bonding and solvation","volume":"16","author":"Fang","year":"2025","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.envres.2025.122575_bib12","series-title":"Gaussian 09. Revision A. 1","author":"Frisch","year":"2009"},{"key":"10.1016\/j.envres.2025.122575_bib13","doi-asserted-by":"crossref","first-page":"8155","DOI":"10.1021\/acs.est.6b00524","article-title":"How PBDEs are transformed into dihydroxylated and dioxin metabolites catalyzed by the active center of cytochrome P450s: a DFT study","volume":"50","author":"Fu","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2025.122575_bib14","first-page":"35","article-title":"Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase","volume":"483","author":"Fujita","year":"2001","journal-title":"Mutat. Res-fund Mol. M."},{"key":"10.1016\/j.envres.2025.122575_bib15","doi-asserted-by":"crossref","first-page":"17898","DOI":"10.1021\/acs.est.4c04156","article-title":"Impact of biotransformation on internal concentrations and specificity classification of organic chemicals in the Zebrafish Embryo (Danio rerio)","volume":"58","author":"Grasse","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2025.122575_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s42255-025-01289-8","article-title":"Intracellular metabolic gradients dictate dependence on exogenous pyruvate","author":"Jackson","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.envres.2025.122575_bib17","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/asia.201301608","article-title":"Metabolism of halogenated alkanes by cytochrome p450 enzymes. Aerobic oxidation versus anaerobic reduction","volume":"9","author":"Ji","year":"2014","journal-title":"Chem. Asian J."},{"key":"10.1016\/j.envres.2025.122575_bib18","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.1021\/acs.jmedchem.9b01877","article-title":"Metabolic and pharmaceutical aspects of fluorinated compounds","volume":"63","author":"Johnson","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.envres.2025.122575_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mrgentox.2004.05.007","article-title":"Mutagenicity in Salmonella of halonitromethanes: a recently recognized class of disinfection by-products in drinking water","volume":"562","author":"Kundu","year":"2004","journal-title":"Mutat. Res-gen Tox. En."},{"key":"10.1016\/j.envres.2025.122575_bib20","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1021\/tx960077u","article-title":"An evaluation of the roles of metabolic denitrosation and \u03b1-hydroxylation in the hepatotoxicity of N-nitrosodimethylamine","volume":"9","author":"Lee","year":"1996","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envres.2025.122575_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.122654","article-title":"Dissolved inorganic nitrogen as an overlooked precursor of nitrogenous disinfection byproducts - a critical review","volume":"268","author":"Li","year":"2025","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2025.122575_bib22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1289\/ehp.866967","article-title":"Haloacetonitriles: metabolism, genotoxicity, and tumor-initiating activity","volume":"69","author":"Lin","year":"1986","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2025.122575_bib23","doi-asserted-by":"crossref","first-page":"21836","DOI":"10.1007\/s11356-017-9843-2","article-title":"Effects of pre-oxidation and adsorption on haloacetonitrile and trichloronitromethane formation during subsequent chlorination","volume":"24","author":"Liu","year":"2017","journal-title":"Environ. Sci. Pol."},{"key":"10.1016\/j.envres.2025.122575_bib24","first-page":"11838","article-title":"Computational insight into the activation mechanism of carcinogenic N\u2019-Nitrosonornicotine (NNN) catalyzed by cytochrome P450","volume":"52","author":"Ma","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2025.122575_bib25","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1021\/es00015a008","article-title":"Evaluating the multimedia fate of organic chemicals: a level III fugacity model","volume":"25","author":"Mackay","year":"1991","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2025.122575_bib26","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1007\/BF00507002","article-title":"Conversion of arylhydrazones of bromonitroformaldehyde and arylazatrinitromethanes to 3-aryl-1,2,3,4-oxatriazolium-5-ones","volume":"17","author":"Martynova","year":"1981","journal-title":"Chem. Heterocycl"},{"key":"10.1016\/j.envres.2025.122575_bib27","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.1021\/jp0100304","article-title":"Mechanism of the hydrolysis of halogen nitrates in small water clusters studied by electronic structure methods","volume":"105","author":"McNamara","year":"2001","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.envres.2025.122575_bib28","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1021\/jp054962+","article-title":"Free radical chemistry of disinfection-byproducts. 1. Kinetics of hydrated electron and hydroxyl radical reactions with halonitromethanes in water","volume":"110","author":"Mezyk","year":"2006","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.envres.2025.122575_bib29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1021\/jp907305g","article-title":"Free-radical chemistry of disinfection byproducts. 3. Degradation mechanisms of chloronitromethane, bromonitromethane, and dichloronitromethane","volume":"114","author":"Mincher","year":"2010","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.envres.2025.122575_bib30","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1021\/es703017z","article-title":"Degradation of tertiary alkylamines during chlorination\/chloramination: Implications for formation of aldehydes, nitriles, halonitroalkanes, and nitrosamines","volume":"42","author":"Mitch","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2025.122575_bib31","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.toxlet.2014.02.006","article-title":"Chloropicrin-induced toxic responses in human lung epithelial cells","volume":"226","author":"Pesonen","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envres.2025.122575_bib32","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1021\/es030477l","article-title":"Halonitromethane drinking water disinfection byproducts: chemical Characterization and mammalian cell cytotoxicity and genotoxicity","volume":"38","author":"Plewa","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2025.122575_bib33","doi-asserted-by":"crossref","DOI":"10.1063\/1.3095757","article-title":"An ab initio study of the reaction of HOCO radicals with NO2: addition\/elimination mechanism","volume":"130","author":"Poggi","year":"2009","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.envres.2025.122575_bib34","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.mrrev.2007.09.001","article-title":"Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research","volume":"636","author":"Richardson","year":"2007","journal-title":"Mutat. Res-rev Mutat."},{"key":"10.1016\/j.envres.2025.122575_bib35","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/0006-291X(90)90872-K","article-title":"Activation of promutagenic chemicals by Streptomyces griseus containing cytochrome P-450soy","volume":"166","author":"Sariaslani","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envres.2025.122575_bib36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1383-5718(98)00198-3","article-title":"Glutathione activation of chloropicrin in the Salmonella mutagenicity test","volume":"439","author":"Schneider","year":"1999","journal-title":"Mutat. Res-gen Tox. En."},{"key":"10.1016\/j.envres.2025.122575_bib37","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1021\/cr900121s","article-title":"P450 enzymes: their structure, reactivity, and selectivity\u2014modeled by QM\/MM calculations","volume":"110","author":"Shaik","year":"2010","journal-title":"Chem. Rev."},{"key":"10.1016\/j.envres.2025.122575_bib38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/(SICI)1521-3765(19980210)4:2<193::AID-CHEM193>3.0.CO;2-Q","article-title":"Electronic structure makes a difference: cytochrome P-450 mediated hydroxylations of hydrocarbons as a two-state reactivity paradigm","volume":"4","author":"Shaik","year":"1998","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.envres.2025.122575_bib39","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1021\/cr030722j","article-title":"Theoretical perspective on the structure and mechanism of cytochrome P450 enzymes","volume":"105","author":"Shaik","year":"2005","journal-title":"Chem. Rev."},{"key":"10.1016\/j.envres.2025.122575_bib40","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/carcin\/17.4.839","article-title":"Identification of the cytochrome P450 isozymes involved in the metabolism of N-nitrosodipropyl-, N-nitrosodibutyl- and N-nitroso-n-butyl-n-propylamine","volume":"17","author":"Shu","year":"1996","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.envres.2025.122575_bib41","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/carcin\/22.3.499","article-title":"Metabolism of the \u03b2-oxidized intermediates of N-nitrosodi-n-propylamine: N-nitroso-\u03b2-hydroxypropylpropylamine and N-nitroso-\u03b2-oxopropylpropylamine","volume":"22","author":"Teiber","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.envres.2025.122575_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124391","article-title":"Increased adverse effects during metabolic transformation of short-chain chlorinated paraffins by cytochrome P450: a theoretical insight into 1-chlorodecane","volume":"407","author":"Wang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envres.2025.122575_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.174718","article-title":"Formation of halonitromethanes from different nitrophenol compounds during UV\/post-chlorination: impact factors, DFT calculation, reaction mechanisms, and toxicity","volume":"947","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2025.122575_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137499","article-title":"Formation of halonitromethanes, dichloroacetonitrile, and trichloromethane in the presence of E. coli and nitrophenols during UV\/post-chlorination","volume":"488","author":"Wang","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envres.2025.122575_bib45","doi-asserted-by":"crossref","first-page":"18619","DOI":"10.1021\/acs.est.4c07053","article-title":"Benzo(a)anthracene targeting SLC1A5 to synergistically enhance PAH mixture toxicity","volume":"58","author":"Wang","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2025.122575_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108332","article-title":"New insight into biodegradation mechanism of phenylurea herbicides by cytochrome P450 enzymes: Successive N-demethylation mechanism","volume":"182","author":"Wang","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2025.122575_bib47","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1038\/s41467-025-60578-8","article-title":"Sucrose-driven carbon redox rebalancing eliminates the Crabtree effect and boosts energy metabolism in yeast","volume":"16","author":"Xiao","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2025.122575_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126930","article-title":"New theoretical investigation of mechanism, kinetics, and toxicity in the degradation of dimetridazole and ornidazole by hydroxyl radicals in aqueous phase","volume":"422","author":"Yao","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envres.2025.122575_bib49","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.chemosphere.2018.08.039","article-title":"Rapid and complete dehalogenation of halonitromethanes in simulated gastrointestinal tract and its influence on toxicity","volume":"211","author":"Yin","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2025.122575_bib50","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.chemosphere.2017.06.116","article-title":"Comparative toxicity of chloro- and bromo-nitromethanes in mice based on a metabolomic method","volume":"185","author":"Yin","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2025.122575_bib51","doi-asserted-by":"crossref","first-page":"10075","DOI":"10.1021\/es2012534","article-title":"Screening criteria for long-range transport potential of organic substances in water","volume":"45","author":"Zarfl","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2025.122575_bib52","doi-asserted-by":"crossref","first-page":"5368","DOI":"10.1021\/acs.est.3c00071","article-title":"Emerging metabolic profiles of sulfonamide antibiotics by cytochromes P450: a computational\u2013experimental synergy study on emerging pollutants","volume":"57","author":"Zhang","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2025.122575_bib53","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1021\/es3048976","article-title":"Identifying health effects of exposure to trichloroacetamide using transcriptomics and metabonomics in mice (Mus musculus)","volume":"47","author":"Zhang","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2025.122575_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145579","article-title":"Metabolic activation mechanism of 2,2\u2032,3,3\u2032,6,6\u2032-hexachlorobiphenyl (PCB136) by cytochrome P450 2B6: a QM\/MM approach","volume":"776","author":"Zhu","year":"2021","journal-title":"Sci. Total Environ."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125018274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125018274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:56:20Z","timestamp":1777402580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935125018274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":54,"alternative-id":["S0013935125018274"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2025.122575","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolism exploration of disinfection byproducts halonitromethanes (HNMs) by cytochrome P450 enzymes and toxicity evaluation","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2025.122575","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122575"}}