{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:13:36Z","timestamp":1773872016384,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006738","name":"Medicinska Fakulteten, Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018694","name":"European Commission Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["101058697"],"award-info":[{"award-number":["101058697"]}],"id":[{"id":"10.13039\/100018694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019580","name":"Swedish Research Council Formas","doi-asserted-by":"publisher","award":["216-2014-1709"],"award-info":[{"award-number":["216-2014-1709"]}],"id":[{"id":"10.13039\/100019580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019580","name":"Swedish Research Council Formas","doi-asserted-by":"publisher","award":["2017\\u201300896"],"award-info":[{"award-number":["2017\\u201300896"]}],"id":[{"id":"10.13039\/100019580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019580","name":"Swedish Research Council Formas","doi-asserted-by":"publisher","award":["2019\\u201302344"],"award-info":[{"award-number":["2019\\u201302344"]}],"id":[{"id":"10.13039\/100019580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.envres.2025.123431","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:58:08Z","timestamp":1764172688000},"page":"123431","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pregnancy blood pressure trajectories in relation to high PFAS exposure: A longitudinal study from the Ronneby Mother-Child Cohort"],"prefix":"10.1016","volume":"290","author":[{"given":"Erich","family":"Batzella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelise J.","family":"Blomberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-7935","authenticated-orcid":false,"given":"Cristina","family":"Canova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-9890","authenticated-orcid":false,"given":"Christian","family":"Lindh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Mattsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3940-7847","authenticated-orcid":false,"given":"Christel","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2025.123431_bib1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/aje\/kwr151","article-title":"Blood pressure in different gestational trimesters, fetal growth, and the risk of adverse birth outcomes","volume":"174","author":"Bakker","year":"2011","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envres.2025.123431_bib2","article-title":"Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies","volume":"i1753","author":"Bartsch","year":"2016","journal-title":"Br. Med. J."},{"key":"10.1016\/j.envres.2025.123431_bib3","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.numecd.2023.06.006","article-title":"Trajectory of blood pressure levels and weight gain in pregnant women: a group-based approach","volume":"33","author":"Beltrame","year":"2023","journal-title":"Nutr. Metabol. Cardiovasc. Dis."},{"key":"10.1016\/j.envres.2025.123431_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106442","article-title":"Exposure to perfluoroalkyl substances and blood pressure in pregnancy among 1436 women from the Odense Child Cohort","volume":"151","author":"Birukov","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2025.123431_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152565","article-title":"Early life exposure to per- and polyfluoroalkyl substances (PFAS) and latent health outcomes: a review including the placenta as a target tissue and possible driver of peri- and postnatal effects","volume":"443","author":"Blake","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2025.123431_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105789","article-title":"Association of perfluoroalkyl substances with gestational hypertension and preeclampsia in the MIREC study","volume":"141","author":"Borghese","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2025.123431_bib7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.envres.2025.123431_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108628","article-title":"First trimester plasma per- and polyfluoroalkyl substances (PFAS) and blood pressure trajectories across the second and third trimesters of pregnancy","volume":"186","author":"Burdeau","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2025.123431_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106091","article-title":"Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults","volume":"145","author":"Chen","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2025.123431_bib10","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1289\/ehp.1206372","article-title":"Serum perfluorooctanoic acid and perfluorooctane sulfonate concentrations in relation to birth outcomes in the mid-Ohio Valley, 2005\u20132010","volume":"121","author":"Darrow","year":"2013","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.envres.2025.123431_bib46","article-title":"Gestational hypertension, preeclampsia, and gestational diabetes mellitus after high exposure to perfluoroalkyl substances from drinking water in Ronneby, Sweden","volume":"239","author":"Ebel","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2025.123431_bib11","doi-asserted-by":"crossref","DOI":"10.2903\/j.efsa.2020.6223","article-title":"Risk to human health related to the presence of perfluoroalkyl substances in food","volume":"18","author":"EFSA Panel on Contaminants in the Food Chain (EFSA CONTAM Panel)","year":"2020","journal-title":"EFSA J."},{"key":"10.1016\/j.envres.2025.123431_bib12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.envres.2015.06.014","article-title":"Phthalate exposure and childrens neurodevelopment: a systematic review","volume":"142","author":"Ejaredar","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2025.123431_bib13","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/etc.4890","article-title":"Per\u2010 and polyfluoroalkyl substance toxicity and human health review: current state of knowledge and strategies for informing future research","volume":"40","author":"Fenton","year":"2021","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envres.2025.123431_bib14","doi-asserted-by":"crossref","DOI":"10.1161\/HYP.0000000000000208","article-title":"Hypertension in pregnancy: diagnosis, blood pressure goals, and pharmacotherapy: a scientific statement from the American heart association","volume":"79","author":"Garovic","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.envres.2025.123431_bib15","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.tem.2020.03.003","article-title":"Placenta disrupted: endocrine disrupting chemicals and pregnancy","volume":"31","author":"Gingrich","year":"2020","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.envres.2025.123431_bib16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ijheh.2011.08.011","article-title":"Placental transfer of perfluorinated compounds is selective \u2013 a Norwegian Mother and Child sub-cohort study","volume":"215","author":"G\u00fctzkow","year":"2012","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envres.2025.123431_bib17","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.placenta.2009.12.009","article-title":"Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: gestational diabetes mellitus, intrauterine growth restriction and preeclampsia","volume":"31","author":"Holdsworth-Carson","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.envres.2025.123431_bib18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12940-018-0445-3","article-title":"Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy","volume":"18","author":"Huang","year":"2019","journal-title":"Environ. Health"},{"key":"10.1016\/j.envres.2025.123431_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105656","article-title":"Perfluoroalkyl substances in early pregnancy and risk of hypertensive disorders of pregnancy: a prospective cohort study","volume":"138","author":"Huo","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2025.123431_bib20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0002-9149(71)90428-0","article-title":"Systolic versus diastolic blood pressure and risk of coronary heart disease","volume":"27","author":"Kannel","year":"1971","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.envres.2025.123431_bib21","doi-asserted-by":"crossref","DOI":"10.1289\/EHP5838","article-title":"A quantile-based g-Computation approach to addressing the effects of exposure mixtures","volume":"128","author":"Keil","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2025.123431_bib22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12940-017-0289-2","article-title":"Prenatal and postnatal bisphenol A exposure and social impairment in 4-year-old children","volume":"16","author":"Lim","year":"2017","journal-title":"Environ. Health"},{"key":"10.1016\/j.envres.2025.123431_bib23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.reprotox.2011.05.003","article-title":"Antiproliferative and proapoptotic effects of bisphenol A on human trophoblastic JEG-3 cells","volume":"32","author":"Morice","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envres.2025.123431_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106716","article-title":"Temporal trends, 2000\u20132017, of perfluoroalkyl acid (PFAA) concentrations in serum of Swedish adolescents","volume":"155","author":"Nor\u00e9n","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2025.123431_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107335","article-title":"Early-pregnancy plasma per- and polyfluoroalkyl substance (PFAS) concentrations and hypertensive disorders of pregnancy in the project viva cohort","volume":"165","author":"Preston","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2025.123431_bib26","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v078.i02","article-title":"Estimation of extended mixed models using latent classes and latent processes: the R package lcmm","volume":"78","author":"Proust-Lima","year":"2017","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.envres.2025.123431_bib27","series-title":"R Core Team, 2016. R: a Language and Environment for Statistical Computing","year":"2016"},{"key":"10.1016\/j.envres.2025.123431_bib28","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ijheh.2018.03.010","article-title":"Maternal urinary phthalate metabolites during pregnancy and thyroid hormone concentrations in maternal and cord sera: the HOME study","volume":"221","author":"Romano","year":"2018","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envres.2025.123431_bib29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/toxics8020043","article-title":"Per- and polyfluoroalkyl substances in early pregnancy and risk for preeclampsia: a case-control study in Southern Sweden","volume":"8","author":"Rylander","year":"2020","journal-title":"Toxics"},{"key":"10.1016\/j.envres.2025.123431_bib30","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1289\/ehp.1104752","article-title":"Relationship of perfluorooctanoic acid exposure to pregnancy outcome based on birth records in the Mid-Ohio Valley","volume":"120","author":"Savitz","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2025.123431_bib31","doi-asserted-by":"crossref","first-page":"6227","DOI":"10.1038\/s41598-017-06606-0","article-title":"Trajectory of blood pressure change during pregnancy and the role of pre-gravid blood pressure: a functional data analysis approach","volume":"7","author":"Shen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2025.123431_bib32","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/etc.4046","article-title":"Toward improved analysis of concentration data: embracing nondetects","volume":"37","author":"Shoari","year":"2017","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envres.2025.123431_bib33","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/aje\/kwt432","article-title":"Perfluoroalkyl substances during pregnancy and validated preeclampsia among nulliparous women in the Norwegian mother and child cohort study","volume":"179","author":"Starling","year":"2014","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envres.2025.123431_bib34","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/aje\/kwp212","article-title":"Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome","volume":"170","author":"Stein","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envres.2025.123431_bib35","doi-asserted-by":"crossref","DOI":"10.1515\/JPM.2007.003","article-title":"The combined effect of maternal smoking and obesity on the risk of preeclampsia","volume":"35","author":"Stone","year":"2007","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.envres.2025.123431_bib36","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s40572-020-00279-0","article-title":"Perfluoroalkyl substances (PFAS) and their effects on the placenta, pregnancy, and child development: a potential mechanistic role for placental peroxisome proliferator\u2013activated receptors (PPARs)","volume":"7","author":"Szilagyi","year":"2020","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.envres.2025.123431_bib37","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/toxsci\/kfaa043","article-title":"Per- and polyfluoroalkyl substances differentially inhibit placental trophoblast migration and invasion in vitro","volume":"175","author":"Szilagyi","year":"2020","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2025.123431_bib38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/jb\/mvp049","article-title":"Placenta expressing the greatest quantity of bisphenol A receptor ERR among the human reproductive tissues: predominant expression of Type-1 ERR isoform","volume":"146","author":"Takeda","year":"2009","journal-title":"J. Biochem."},{"key":"10.1016\/j.envres.2025.123431_bib39","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ejogrb.2017.01.021","article-title":"Blood pressure patterns in women with gestational hypertension or mild preeclampsia at term","volume":"210","author":"Van Der Tuuk","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.envres.2025.123431_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106747","article-title":"Exposure to endocrine disrupting chemicals (EDCs) and cardiometabolic indices during pregnancy: the HOME study","volume":"156","author":"Vuong","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2025.123431_bib41","doi-asserted-by":"crossref","first-page":"9179","DOI":"10.1038\/s41598-019-45483-7","article-title":"Early pregnancy serum levels of perfluoroalkyl substances and risk of preeclampsia in Swedish women","volume":"9","author":"Wikstr\u00f6m","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2025.123431_bib42","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/toxsci\/kfn166","article-title":"Activation of mouse and human peroxisome proliferator\u2212activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths","volume":"106","author":"Wolf","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2025.123431_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106333","article-title":"Serum perfluoroalkyl substances in residents following long-term drinking water contamination from firefighting foam in Ronneby, Sweden","volume":"147","author":"Xu","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2025.123431_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.114284","article-title":"Associations of perfluoroalkyl and polyfluoroalkyl substances with gestational hypertension and blood pressure during pregnancy: a cohort study","volume":"215","author":"Yang","year":"2022","journal-title":"Environ. Res."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125026842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125026842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:49:45Z","timestamp":1773845385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935125026842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":45,"alternative-id":["S0013935125026842"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2025.123431","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pregnancy blood pressure trajectories in relation to high PFAS exposure: A longitudinal study from the Ronneby Mother-Child Cohort","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2025.123431","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"123431"}}