{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T19:02:18Z","timestamp":1781463738147,"version":"3.54.1"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ21C030002"],"award-info":[{"award-number":["LQ21C030002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32101251"],"award-info":[{"award-number":["32101251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.envres.2025.123580","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T16:30:01Z","timestamp":1765989001000},"page":"123580","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Potential mechanism of delayed endochondral ossification and muscle atrophy induced by nitrate exposure in Bufo gargarizans tadpoles"],"prefix":"10.1016","volume":"291","author":[{"given":"Hongyuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7717-4189","authenticated-orcid":false,"given":"Lei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2025.123580_bib1","doi-asserted-by":"crossref","first-page":"26983","DOI":"10.1007\/s11356-017-0589-7","article-title":"Excessive use of nitrogenous fertilizers: an unawareness causing serious threats to environment and human health","volume":"24","author":"Ahmed","year":"2017","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.envres.2025.123580_bib2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00128-017-2261-9","article-title":"Effects of environmental contamination and acute toxicity of N-Nitrate on early life stages of endemic arboreal frog, Polypedates cruciger (blyth, 1852)","volume":"100","author":"Balangoda","year":"2018","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envres.2025.123580_bib3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cej.2011.01.103","article-title":"A review of emerging adsorbents for nitrate removal from water","volume":"168","author":"Bhatnagar","year":"2011","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.envres.2025.123580_bib4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ydbio.2007.03.021","article-title":"Amphibian metamorphosis","volume":"306","author":"Brown","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.envres.2025.123580_bib5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.trsl.2020.03.001","article-title":"Emerging molecular mediators and targets for age-related skeletal muscle atrophy","volume":"221","author":"Brown","year":"2020","journal-title":"Transl. Res."},{"key":"10.1016\/j.envres.2025.123580_bib6","doi-asserted-by":"crossref","first-page":"E6089","DOI":"10.1073\/pnas.1704949114","article-title":"Biological annihilation via the ongoing sixth mass extinction signaled by vertebrate population losses and declines","volume":"114","author":"Ceballos","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envres.2025.123580_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000244145","article-title":"Differential expression of \u03b1- and \u03b2-Thyroid hormone receptor genes in the developing rat brain under hypothyroidism","volume":"67","author":"Chattopadhyay","year":"2009","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.envres.2025.123580_bib8","article-title":"Molecular mechanisms of chondrocyte proliferation and differentiation","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.envres.2025.123580_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.clinthera.2021.11.012","article-title":"Resistance training as treatment for sarcopenia: examining sex-related differences in physiology and response","volume":"44","author":"Cheng","year":"2022","journal-title":"Clin. Ther."},{"key":"10.1016\/j.envres.2025.123580_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111587","article-title":"Molecular mechanisms of muscle fatigue","volume":"22","author":"Constantin-Teodosiu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2025.123580_bib11","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41559-020-01380-1","article-title":"Human disturbance causes widespread disruption of animal movement","volume":"5","author":"Doherty","year":"2021","journal-title":"Nat. Ecol. Evol."},{"key":"10.1016\/j.envres.2025.123580_bib12","article-title":"Disruption of the thyroid system by the thyroid-disrupting compound Aroclor 1254 in juvenile Japanese flounder (Paralichthys olivaceus)","volume":"9","author":"Dong","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2025.123580_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s12640-012-9322-y","article-title":"Nitric oxide-mediated oxidative damage and the progressive demise of motor neurons in ALS","volume":"22","author":"Drechsel","year":"2012","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.envres.2025.123580_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00223-014-9915-y","article-title":"Skeletal muscle: a brief review of structure and function","volume":"96","author":"Frontera","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.envres.2025.123580_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109410","article-title":"Long-term effects of in ovo exposure to an environmentally relevant dose of atrazine on the thyroid gland of Caiman latirostris","volume":"186","author":"Galoppo","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2025.123580_bib16","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/dvdy.24669","article-title":"Endochondral ossification in hindlimbs during bufo gargarizans metamorphosis: a model of studying skeletal development in vertebrates","volume":"247","author":"Gao","year":"2018","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.envres.2025.123580_bib17","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1128\/MCB.21.14.4748-4760.2001","article-title":"Genetic analysis reveals different functions for the products of the thyroid hormone receptor alpha locus","volume":"21","author":"Gauthier","year":"2001","journal-title":"Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.envres.2025.123580_bib18","first-page":"183","article-title":"A simplified table for staging anuran embryos and larvae with notes on identification","volume":"16","author":"Gosner","year":"1960","journal-title":"Herpetologica"},{"key":"10.1016\/j.envres.2025.123580_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0283636","article-title":"Factors associated with bone thickness: comparison of the cranium and humerus","volume":"18","author":"Goto","year":"2023","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.envres.2025.123580_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095064","article-title":"TR alpha 2 exerts dominant negative effects on hypothalamic Trh transcription in vivo","volume":"9","author":"Guissouma","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2025.123580_bib21","first-page":"1021","article-title":"The hypertrophic chondrocyte: to be or not to be","volume":"36","author":"Hallett","year":"2021","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.envres.2025.123580_bib22","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1242\/dev.045203","article-title":"SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification","volume":"137","author":"Hattori","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.envres.2025.123580_bib23","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.scitotenv.2017.08.127","article-title":"Nitrate accumulation and leaching potential reduced by coupled water and nitrogen management in the Huang-Huai-Hai Plain","volume":"610\u2013611","author":"Huang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2025.123580_bib24","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1177\/0192623320972009","article-title":"Adversity considerations for Thyroid follicular cell hypertrophy and hyperplasia in nonclinical toxicity studies: results from the 6th ESTP international expert workshop","volume":"48","author":"Huisinga","year":"2020","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.envres.2025.123580_bib25","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1007\/s00018-021-03884-w","article-title":"Cortical bone development, maintenance and porosity: genetic alterations in humans and mice influencing chondrocytes, osteoclasts, osteoblasts and osteocytes","volume":"78","author":"Isojima","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.envres.2025.123580_bib26","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1186\/s12903-021-01829-0","article-title":"Mandibular cortical bone structure as risk indicator in fractured and non-fractured 80-year-old men and women","volume":"21","author":"Jonasson","year":"2021","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.envres.2025.123580_bib27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/ggi.13818","article-title":"Promotion of oxidative stress is associated with mitochondrial dysfunction and muscle atrophy in aging mice","volume":"20","author":"Kadoguchi","year":"2020","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.envres.2025.123580_bib28","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4248\/BR201302004","article-title":"Role and mechanisms of actions of thyroid hormone on the skeletal development","volume":"1","author":"Kim","year":"2013","journal-title":"Bone Res."},{"key":"10.1016\/j.envres.2025.123580_bib29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00774-010-0206-z","article-title":"Generation of transgenic mice for conditional overexpression of Sox9","volume":"29","author":"Kim","year":"2011","journal-title":"J. Bone Miner. Metabol."},{"key":"10.1016\/j.envres.2025.123580_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107713","article-title":"Environmental exposure to perchlorate, nitrate and thiocyanate, and thyroid function in Chinese adults: a community-based cross-sectional study","volume":"171","author":"King","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2025.123580_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11040755","article-title":"The role of oxidative stress in skeletal muscle myogenesis and muscle disease","volume":"11","author":"Lian","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.envres.2025.123580_bib32","first-page":"1056","article-title":"Targeted and sustained Sox9 expression in mouse hypertrophic chondrocytes causes severe and spontaneous osteoarthritis by perturbing cartilage homeostasis","volume":"12","author":"Liang","year":"2020","journal-title":"Am. J. Tourism Res."},{"key":"10.1016\/j.envres.2025.123580_bib33","doi-asserted-by":"crossref","first-page":"7039","DOI":"10.1038\/s41467-022-34474-4","article-title":"The evolution of reproductive modes and life cycles in amphibians","volume":"13","author":"Liedtke","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2025.123580_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3182746","article-title":"How muscle structure and composition influence meat and flesh quality","author":"Listrat","year":"2016","journal-title":"Sci. World J."},{"key":"10.1016\/j.envres.2025.123580_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.106036","article-title":"Effects of perchlorate and exogenous T4 exposures on development, metamorphosis and endochondral ossification in Bufo gargarizans larvae","volume":"242","author":"Liu","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envres.2025.123580_bib36","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0736-0266(03)00117-7","article-title":"Chondrocyte apoptosis induced by collagen degradation: inhibition by caspase inhibitors and IGF-1","volume":"22","author":"Lo","year":"2004","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.envres.2025.123580_bib37","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biocel.2007.06.009","article-title":"Endochondral ossification: how cartilage is converted into bone in the developing skeleton","volume":"40","author":"Mackie","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.envres.2025.123580_bib38","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/codi.13400","article-title":"The use of Masson's trichrome staining, second harmonic imaging and two-photon excited fluorescence of collagen in distinguishing intestinal tuberculosis from Crohn's disease","volume":"18","author":"Mao","year":"2016","journal-title":"Colorectal Dis. : the official journal of the Association of Coloproctology of Great Britain and Ireland"},{"key":"10.1016\/j.envres.2025.123580_bib39","first-page":"6449","article-title":"Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation","volume":"25","author":"Martin","year":"2005"},{"key":"10.1016\/j.envres.2025.123580_bib40","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1111\/ene.14393","article-title":"Amyotrophic lateral sclerosis: a clinical review","volume":"27","author":"Masrori","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.envres.2025.123580_bib41","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1242\/dev.128.22.4523","article-title":"BMP and Ihh\/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation","volume":"128","author":"Minina","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.envres.2025.123580_bib42","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bone.2008.07.005","article-title":"Skeletogenesis in Xenopus tropicalis: characteristic bone development in an anuran amphibian","volume":"43","author":"Miura","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.envres.2025.123580_bib43","article-title":"Skeletal muscle: a review of molecular structure and function, in health and disease. Wiley interdisciplinary reviews","volume":"12","author":"Mukund","year":"2020","journal-title":"Systems biology and medicine"},{"key":"10.1016\/j.envres.2025.123580_bib44","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1242\/dev.145615","article-title":"Development of the thyroid gland","volume":"144","author":"Nilsson","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.envres.2025.123580_bib45","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1074\/jbc.REV120.011666","article-title":"Post-translational modifications of Hsp70 family proteins: expanding the chaperone code","volume":"295","author":"Nitika","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envres.2025.123580_bib46","doi-asserted-by":"crossref","first-page":"36563","DOI":"10.1074\/jbc.M304857200","article-title":"Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth Factor-1","volume":"278","author":"Oh","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envres.2025.123580_bib47","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.3390\/ijms21186665","article-title":"Hedgehog signaling in skeletal development: roles of Indian hedgehog and the mode of its action","volume":"21","author":"Ohba","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.envres.2025.123580_bib48","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00244-006-0277-y","article-title":"Alteration of larval development and metamorphosis by nitrate and perchlorate in southern leopard frogs (Rana sphenocephala)","volume":"53","author":"Ortiz-Santaliestra","year":"2007","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envres.2025.123580_bib49","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000489672","article-title":"Cortical or trabecular bone: what's the difference?","volume":"47","author":"Ott","year":"2018","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.envres.2025.123580_bib50","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1007\/s12035-013-8578-4","article-title":"Amyotrophic lateral sclerosis and skeletal muscle: an update","volume":"49","author":"Pansarasa","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.envres.2025.123580_bib51","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.beem.2009.06.003","article-title":"Environmental pollutants and the thyroid","volume":"23","author":"Pearce","year":"2009","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.envres.2025.123580_bib52","first-page":"407","volume":"vol. 26","author":"Peris-Moreno","year":"2021"},{"key":"10.1016\/j.envres.2025.123580_bib53","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.scitotenv.2018.10.423","article-title":"Contamination patterns in river water from rural Beijing: a hydrochemical and multiple stable isotope study","volume":"654","author":"Peters","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2025.123580_bib54","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocon.2013.10.020","article-title":"Movement ecology of amphibians: a missing component for understanding population declines","volume":"169","author":"Pittman","year":"2014","journal-title":"Biol. Conserv."},{"key":"10.1016\/j.envres.2025.123580_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtherbio.2022.103296","article-title":"Timing of parental breeding shapes sensitivity to nitrate pollution in the common frog Rana temporaria","volume":"108","author":"Ruthsatz","year":"2022","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.envres.2025.123580_bib56","doi-asserted-by":"crossref","DOI":"10.1136\/bmjsem-2017-000222","article-title":"Weaker lower extremity muscle strength predicts traumatic knee injury in youth female but not male athletes","volume":"3","author":"Ryman Augustsson","year":"2017","journal-title":"BMJ open sport & exercise medicine"},{"key":"10.1016\/j.envres.2025.123580_bib57","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41580-020-00279-w","article-title":"Mechanisms of bone development and repair","volume":"21","author":"Salhotra","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envres.2025.123580_bib58","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.biocel.2013.04.023","article-title":"Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasome","volume":"45","author":"Sandri","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.envres.2025.123580_bib59","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41467-020-20123-1","article-title":"Mechanisms of muscle atrophy and hypertrophy: implications in health and disease","volume":"12","author":"Sartori","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2025.123580_bib60","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14218","article-title":"Altered oxidative stress and antioxidant defence in skeletal muscle during the first year following spinal cord injury","volume":"7","author":"Savikj","year":"2019","journal-title":"Physiological Reports"},{"key":"10.1016\/j.envres.2025.123580_bib61","volume":"vol. 13","author":"Shen","year":"2022"},{"key":"10.1016\/j.envres.2025.123580_bib62","doi-asserted-by":"crossref","first-page":"29011","DOI":"10.1074\/jbc.M601545200","article-title":"Global translational responses to oxidative stress impact upon multiple levels of protein synthesis","volume":"281","author":"Shenton","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envres.2025.123580_bib63","doi-asserted-by":"crossref","first-page":"33557","DOI":"10.1007\/s11356-021-13168-2","article-title":"Exposure to common pesticides utilized in northern rice fields of Iran affects survival of non-target species, Pelophylax ridibundus (Amphibia: ranidae)","volume":"28","author":"Shojaei","year":"2021","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.envres.2025.123580_bib64","first-page":"2576","volume":"vol. 12","author":"\u0160romov\u00e1","year":"2023"},{"key":"10.1016\/j.envres.2025.123580_bib65","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1126\/science.1103538","article-title":"Status and trends of amphibian declines and extinctions worldwide","volume":"306","author":"Stuart","year":"2004","journal-title":"Science"},{"issue":"8\/9","key":"10.1016\/j.envres.2025.123580_bib66","first-page":"61","article-title":"Nitrate pollution of groundwater long exceeding trigger value: fertilization practices require more transparency and oversight","volume":"10","author":"Sundermann","year":"2020","journal-title":"DIW Weekly Report"},{"key":"10.1016\/j.envres.2025.123580_bib67","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1007\/s10311-021-01239-2","article-title":"Advanced techniques to remove phosphates and nitrates from waters: a review","volume":"19","author":"Velusamy","year":"2021","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.envres.2025.123580_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2023.106477","article-title":"Exposure to nitrate induced growth, intestinal histology and microbiota alterations of Bufo raddei Strauch tadpoles","volume":"258","author":"Wang","year":"2023","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envres.2025.123580_bib69","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.chemosphere.2015.07.037","article-title":"Effects of nitrate on metamorphosis, thyroid and iodothyronine deiodinases expression in Bufo gargarizans larvae","volume":"139","author":"Wang","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2025.123580_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.117684","article-title":"Methimazole disrupted skeletal ossification and muscle fiber transition in Bufo gargarizans larvae","volume":"289","author":"Wei","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2025.123580_bib71","first-page":"10240","volume":"vol. 93","author":"Weir","year":"1996"},{"key":"10.1016\/j.envres.2025.123580_bib72","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s13075-021-02662-0","article-title":"Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment","volume":"23","author":"Wen","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.envres.2025.123580_bib73","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nprot.2009.197","article-title":"Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue","volume":"5","author":"Weydert","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.envres.2025.123580_bib74","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1210\/en.2014-1527","article-title":"Role of thyroid hormone Receptor-\u03b11 in endochondral ossification","volume":"155","author":"Williams","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.envres.2025.123580_bib75","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1043-2760(00)00263-0","article-title":"Gene regulation by thyroid hormone","volume":"11","author":"Wu","year":"2000","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.envres.2025.123580_bib76","author":"Xu"},{"key":"10.1016\/j.envres.2025.123580_bib77","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ijos.2015.14","article-title":"The Hedgehog signalling pathway in bone formation","volume":"7","author":"Yang","year":"2015","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.envres.2025.123580_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105807","article-title":"Skeletal muscle atrophy: from mechanisms to treatments","volume":"172","author":"Yin","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.envres.2025.123580_bib79","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev-ecolsys-112414-054142","article-title":"Patterns, causes, and consequences of Anthropocene defaunation","volume":"47","author":"Young","year":"2016","journal-title":"Annu. Rev. Ecol. Evol. Systemat."},{"key":"10.1016\/j.envres.2025.123580_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144674","article-title":"The deep challenge of nitrate pollution in river water of China","volume":"770","author":"Zhang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2025.123580_bib81","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ghir.2008.08.003","article-title":"Insulin-like growth factor-I reduces stress-induced gastric mucosal injury by inhibiting neutrophil activation in mice","volume":"19","author":"Zhao","year":"2009","journal-title":"Growth Hormone IGF Res."},{"key":"10.1016\/j.envres.2025.123580_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138349","article-title":"Association of perchlorate, thiocyanate, and nitrate with dyslexic risk","volume":"325","author":"Zhu","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2025.123580_bib83","article-title":"Endocrine regulation on bone by thyroid","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.envres.2025.123580_bib84","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.yfrne.2017.10.001","article-title":"Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum","volume":"48","author":"Zsarnovszky","year":"2018","journal-title":"Front. Neuroendocrinol."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125028336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935125028336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T18:43:30Z","timestamp":1781462610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935125028336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":84,"alternative-id":["S0013935125028336"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2025.123580","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential mechanism of delayed endochondral ossification and muscle atrophy induced by nitrate exposure in Bufo gargarizans tadpoles","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2025.123580","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123580"}}