{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:01:49Z","timestamp":1790240509196,"version":"4.1.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["63241322"],"award-info":[{"award-number":["63241322"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["63241318"],"award-info":[{"award-number":["63241318"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002885","name":"China Meteorological Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002885","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CMMANKUB202401"],"award-info":[{"award-number":["CMMANKUB202401"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42377424"],"award-info":[{"award-number":["42377424"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.envres.2026.123875","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T16:58:09Z","timestamp":1769533089000},"page":"123875","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["PM2.5-bound nitrated and oxygenated PAHs induced lipid metabolism disorder through different target organs"],"prefix":"10.1016","volume":"294","author":[{"given":"Wanting","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6532-1110","authenticated-orcid":false,"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.envres.2026.123875_bib1","first-page":"50","year":"2022","journal-title":"Environ. Protect."},{"issue":"2\u20134","key":"10.1016\/j.envres.2026.123875_bib2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/10406638.2014.994071","article-title":"Overview of polycyclic aromatic compounds (PAC)","volume":"35","author":"Achten","year":"2015","journal-title":"Polycycl. Aromat. Compd."},{"issue":"2","key":"10.1016\/j.envres.2026.123875_bib3","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.mrgentox.2011.02.002","article-title":"The combined effects of BDE47 and BaP on oxidatively generated DNA damage in LO2 cells and the possible molecular mechanism","volume":"721","author":"An","year":"2011","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envres.2026.123875_bib4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/1471-2407-9-187","article-title":"Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention","volume":"9","author":"Androutsopoulos","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.envres.2026.123875_bib5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.scitotenv.2013.11.108","article-title":"PM2.5-bound oxygenated PAHs, nitro-PAHs and parent-PAHs from the atmosphere of a Chinese megacity: seasonal variation, sources and cancer risk assessment","volume":"473\u2013474","author":"Bandowe","year":"2014","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.envres.2026.123875_bib6","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1021\/cr100222q","article-title":"Mechanisms of chemical carcinogenicity and mutagenicity: a review with implications for predictive toxicology","volume":"111","author":"Benigni","year":"2011","journal-title":"Chem. Rev."},{"issue":"1","key":"10.1016\/j.envres.2026.123875_bib7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/kfm303","article-title":"Nonadditive effects of PAHs on early vertebrate development: mechanisms and implications for risk assessment","volume":"105","author":"Billiard","year":"2008","journal-title":"Toxicol. Sci."},{"issue":"7","key":"10.1016\/j.envres.2026.123875_bib8","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1039\/c2cs15309b","article-title":"Endocytosis at the nanoscale","volume":"41","author":"Canton","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.envres.2026.123875_bib9","doi-asserted-by":"crossref","unstructured":"Cesaroni G, Forastiere F, Stafoggia M, et al., Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project. BMJ. 2014 Jan 21;348:f7412. doi: 10.1136\/bmj.f7412.","DOI":"10.1136\/bmj.f7412"},{"key":"10.1016\/j.envres.2026.123875_bib10","article-title":"Synthesis and anticancer activity of rhopaladins' analog RPDPD against the HeLa human cervical cancer cell line","volume":"10","author":"Chen","year":"2022","journal-title":"Front. Chem."},{"issue":"5","key":"10.1016\/j.envres.2026.123875_bib11","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.amjms.2024.01.022","article-title":"ALT poorly predicts nonalcoholic fatty liver Disease (NAFLD) and liver fibrosis as determined by vibration-controlled transient elastography in adult National Health and Nutrition Examination Survey 2017-2018","volume":"367","author":"Condon","year":"2024","journal-title":"Am. J. Med. Sci."},{"issue":"6927","key":"10.1016\/j.envres.2026.123875_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nature01451","article-title":"Regulated portals of entry into the cell","volume":"422","author":"Conner","year":"2003","journal-title":"Nature"},{"issue":"24","key":"10.1016\/j.envres.2026.123875_bib13","doi-asserted-by":"crossref","first-page":"13867","DOI":"10.1007\/s11356-014-2586-4","article-title":"Genotoxicity of oxy-PAHs to Japanese medaka (Oryzias latipes) embryos assessed using the comet assay","volume":"21","author":"Dasgupta","year":"2014","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.envres.2026.123875_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8688643","article-title":"Melatonin alleviates PM2.5-induced hepatic steatosis and metabolic-associated fatty liver disease in ApoE-\/- mice","volume":"2022","author":"Du","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.envres.2026.123875_bib15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0165-1218(96)90103-2","article-title":"Human cell mutagenicity of oxygenated, nitrated and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols","volume":"371","author":"Durant","year":"1996","journal-title":"Mutat. Res."},{"issue":"22","key":"10.1016\/j.envres.2026.123875_bib16","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1016\/S1352-2310(02)00255-8","article-title":"Occurrence and photostability of 3-nitrobenzanthrone associated with atmospheric particles","volume":"36","author":"Feilberg","year":"2002","journal-title":"Atmos. Environ."},{"issue":"9","key":"10.1016\/j.envres.2026.123875_bib17","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.3390\/biomedicines9091083","article-title":"Is a high HDL-cholesterol level always beneficial?","volume":"9","author":"Franczyk","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.envres.2026.123875_bib18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.biomaterials.2016.12.029","article-title":"Macrophage activation status determines the internalization of mesoporous silica particles of different sizes: exploring the role of different pattern recognition receptors","volume":"121","author":"Gallud","year":"2017","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.envres.2026.123875_bib19","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0278-6915(92)90103-R","article-title":"Comparative study of the biodisposition of benzanthrone in different rodent species","volume":"30","author":"Garg","year":"1992","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envres.2026.123875_bib20","first-page":"1369","article-title":"Current state of knowledge in microbial degradation of polycyclic aromatic hydrocarbons (PAHs): a review","volume":"7","author":"Ghosal","year":"2016","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.envres.2026.123875_bib21","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/toxsci\/kfv139","article-title":"Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs","volume":"147","author":"Goodale","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2026.123875_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.143304","article-title":"Studies on the characteristics of polycyclic aromatic hydrocarbons accumulation in lipids and the disturbance of lipid metabolism of Ruditapes philippinarum","volume":"364","author":"He","year":"2024","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.envres.2026.123875_bib23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12989-020-00367-x","article-title":"Effects of particulate matter on atherosclerosis: a link via high-density lipoprotein (HDL) functionality?","volume":"17","author":"Holme","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envres.2026.123875_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115801","article-title":"Lung cancer associated with combustion particles and fine particulate matter (PM2.5) - the roles of polycyclic aromatic hydrocarbons (PAHs) and the aryl hydrocarbon receptor (AhR)","volume":"216","author":"Holme","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.envres.2026.123875_bib25","series-title":"Outdoor Air Pollution a Leading Environmental Cause of Cancer Deaths","year":"2013"},{"issue":"2","key":"10.1016\/j.envres.2026.123875_bib26","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.aohep.2019.08.004","article-title":"The relative expression of hepatocellular and cholestatic liver enzymes in adult patients with liver disease","volume":"19","author":"Iluz-Freundlich","year":"2020","journal-title":"Ann. Hepatol."},{"issue":"6","key":"10.1016\/j.envres.2026.123875_bib27","article-title":"Effect and mechanism of PM2.5 in inducing lipid accumulation in hepatocytes","volume":"32","author":"Jingjing","year":"2015","journal-title":"J. Environ. Health"},{"key":"10.1016\/j.envres.2026.123875_bib28","doi-asserted-by":"crossref","unstructured":"Jinjin Yu, Jian Sun, Yajing Ma, Xinyi Niu, Ruisi Zhu, Huixin Song, Lingyi Liu, Yuzhi Luo, Songyuan Xia, Jingyu Wang, Lingli Li, Sha Wen, Weifeng Li, Xiaofeng Niu, Multi-organ toxicity caused by PM2.5 in mice with cardiovascular diseases: the role of PAHs played from the most polluted episodes in China,J. Environ. Manag.,ISSN 0301-4797,https:\/\/doi.org\/10.1016\/j.jenvman.2025.124330.","DOI":"10.1016\/j.jenvman.2025.124330"},{"issue":"1","key":"10.1016\/j.envres.2026.123875_bib29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1476-069X-12-68","article-title":"The effect of primary organic particles on emergency hospital admissions among the elderly in 3 US cities","volume":"12","author":"Kioumourtzoglou","year":"2013","journal-title":"Environmental health"},{"issue":"2","key":"10.1016\/j.envres.2026.123875_bib30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.toxlet.2003.07.001","article-title":"3-Nitrobenzanthrone (3-NBA) induced micronucleus formation and DNA damage in human hepatoma (HepG2) cells","volume":"146","author":"Lamy","year":"2004","journal-title":"Toxicol. Lett."},{"issue":"1\u20132","key":"10.1016\/j.envres.2026.123875_bib31","first-page":"11","article-title":"3-Nitrobenzanthrone and 3-aminobenzanthrone induce DNA damage and cell signalling in Hepa1c1c7 cells","volume":"684","author":"Landvik","year":"2010","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envres.2026.123875_bib32","doi-asserted-by":"crossref","unstructured":"Fang Li, Binbin Xiang, Yan Jin, Chao Li, Songlei Ren, Yongning Wu, Jingguang Li, Qian Luo, Hepatotoxic effects of inhalation exposure to polycyclic aromatic hydrocarbons on lipid metabolism of C57BL\/6 mice, Environ. Int., https:\/\/doi.org\/10.1016\/j.envint.2019.105000.","DOI":"10.1016\/j.envint.2019.105000"},{"issue":"3","key":"10.1016\/j.envres.2026.123875_bib33","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.clim.2003.08.006","article-title":"Particulate air pollutants and asthma: a paradigm for the role of oxidative stress in PM-induced adverse health effects","volume":"109","author":"Li","year":"2003","journal-title":"Clin. Immunol."},{"issue":"7","key":"10.1016\/j.envres.2026.123875_bib34","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/CIRCULATIONAHA.116.026796","article-title":"Particulate matter exposure and stress hormone levels: a randomized, double-blind, crossover trial of air purification","volume":"136","author":"Li","year":"2017","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.envres.2026.123875_bib35","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.envres.2026.123875_bib36","doi-asserted-by":"crossref","unstructured":"Lu L; Chinese Society of Hepatology and Chinese Medical Association. Guidelines for the Management of Cholestatic Liver Diseases (2021). J Clin Transl Hepatol. 2022 Aug 28;10(4):757-769. doi: 10.14218\/JCTH.2022.00147.","DOI":"10.14218\/JCTH.2022.00147"},{"issue":"11","key":"10.1016\/j.envres.2026.123875_bib37","doi-asserted-by":"crossref","first-page":"8629","DOI":"10.1021\/nn202155y","article-title":"Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome Impairment","volume":"5","author":"Ma","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.envres.2026.123875_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.atmosenv.2022.119433","article-title":"Associations of personal PM2.5 and PM2.5-Bound polycyclic aromatic hydrocarbons exposure with blood lipid profiles: a panel study from middle-aged Chinese adults","volume":"293","author":"Ma","year":"2023","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.envres.2026.123875_bib39","doi-asserted-by":"crossref","unstructured":"Mackenzie L. Morshead, Lisa Truong, Michael T. Simonich, Jessica E. Moran, El. Tanguay,Developmental toxicity of alkylated PAHs and substituted phenanthrenes: structural nuances drive diverse toxicity and AHR activation,Chemosphere,ISSN 0045-6535, https:\/\/doi.org\/10.1016\/j.chemosphere.2024.143894.","DOI":"10.1016\/j.chemosphere.2024.143894"},{"issue":"Pt 2","key":"10.1016\/j.envres.2026.123875_bib40","article-title":"Oxidative stress response in pulmonary cells exposed to different fractions of PM2.5-0.3 from urban, traffic and industrial sites","volume":"216","author":"Moufarrej","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2026.123875_bib41","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.scitotenv.2018.08.094","article-title":"Fine particles exposure and cardiopulmonary morbidity in Jeddah: a time-series analysis","volume":"647","author":"Nayebare","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.envres.2026.123875_bib42","article-title":"Study on protective effect and mechanism of total lignans from Tibetan medicine herpetospermun caudigerum Wall against \u03b1-Naphthylisothiocyanate-Induced liver injury in mice","volume":"34","author":"Nazhi","year":"2023","journal-title":"Tradit. Chin. Drug Res. Clin. Pharmacol."},{"key":"10.1016\/j.envres.2026.123875_bib43","series-title":"Ambient (Outdoor) Air Pollution","year":"2022"},{"issue":"2","key":"10.1016\/j.envres.2026.123875_bib44","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.toxlet.2008.10.028","article-title":"Induction of pro-inflammatory signals by 1-nitropyrene in cultured BEAS-2B cells","volume":"184","author":"Park","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envres.2026.123875_bib45","article-title":"Devil in the diesel: lorries belch out what may be the most carcinogenic chemical ever discovered","volume":"5","author":"Pearce","year":"1997","journal-title":"New Sci."},{"issue":"23","key":"10.1016\/j.envres.2026.123875_bib47","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1016\/S1352-2310(03)00344-3","article-title":"Sources of the atmospheric contaminants, 2-nitrobenzanthrone and 3-nitrobenzanthrone","volume":"37","author":"Phousongphouang","year":"2003","journal-title":"Atmos. Environ."},{"issue":"3","key":"10.1016\/j.envres.2026.123875_bib48","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3390\/cells9030584","article-title":"Signaling pathways and key genes involved in regulation of foam cell formation in atherosclerosis","volume":"9","author":"Poznyak","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.envres.2026.123875_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-137-1-200207020-00006","article-title":"Updated definitions of healthy ranges for serum alanine aminotransferase levels","volume":"137","author":"Prati","year":"2002","journal-title":"Ann. Intern. Med."},{"issue":"8","key":"10.1016\/j.envres.2026.123875_bib50","doi-asserted-by":"crossref","first-page":"152","DOI":"10.21037\/atm.2018.04.13","article-title":"Rosiglitazone inhibits PM2.5-induced cytotoxicity in human lung epithelial A549 cells","volume":"6","author":"Pu","year":"2018","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.envres.2026.123875_bib51","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.3389\/fimmu.2017.01847","article-title":"Defenders and challengers of endothelial barrier function","volume":"8","author":"Rahimi","year":"2017","journal-title":"Front. Immunol."},{"issue":"18","key":"10.1016\/j.envres.2026.123875_bib52","doi-asserted-by":"crossref","first-page":"8877","DOI":"10.5194\/acp-12-8877-2012","article-title":"Particle size distribution of nitrated and oxygenated polycyclic aromatic hydrocarbons (NPAHs and OPAHs) on traffic and suburban sites of a European megacity: paris (France)","volume":"12","author":"Ringuet","year":"2012","journal-title":"Atmos. Chem. Phys."},{"issue":"2","key":"10.1016\/j.envres.2026.123875_bib53","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cld.2012.03.012","article-title":"Approach to a patient with elevated serum alkaline phosphatase","volume":"16","author":"Siddique","year":"2012","journal-title":"Clin. Liver Dis."},{"issue":"2","key":"10.1016\/j.envres.2026.123875_bib54","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/jbmr.3225","article-title":"Alkaline phosphatase: discovery and naming of our favorite enzyme","volume":"33","author":"Siller","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.envres.2026.123875_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.atmosenv.2020.117750","article-title":"PM2.5 source profiles from typical Chinese commercial cooking activities in northern China and its influences on bioreactivity of vascular smooth muscle cells (VSMCs)","volume":"239","author":"Sun","year":"2020","journal-title":"Atmos. Environ."},{"issue":"6","key":"10.1016\/j.envres.2026.123875_bib56","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/mutage\/gel045","article-title":"Mutagenic activities and physicochemical properties of selected nitrobenzanthrones","volume":"21","author":"Takamura-Enya","year":"2006","journal-title":"Mutagenesis"},{"issue":"2","key":"10.1016\/j.envres.2026.123875_bib57","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/jnci\/58.2.449","article-title":"Airborne mutagens bioassayed in Salmonella typhimurium","volume":"58","author":"Talcott","year":"1977","journal-title":"J. Natl. Cancer Inst."},{"issue":"3","key":"10.1016\/j.envres.2026.123875_bib58","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/etc.5560","article-title":"Role of Aryl hydrocarbon receptor and oxidative stress in the regioselective toxicities of hydroxychrysenes in embryonic Japanese medaka (Oryzias latipes)","volume":"42","author":"Tanabe","year":"2023","journal-title":"Environ. Toxicol. Chem."},{"issue":"3","key":"10.1016\/j.envres.2026.123875_bib59","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.imbio.2014.10.011","article-title":"Benzanthrone induced immunotoxicity via oxidative stress and inflammatory mediators in Balb\/c mice","volume":"220","author":"Tewari","year":"2015","journal-title":"Immunobiology"},{"issue":"10","key":"10.1016\/j.envres.2026.123875_bib60","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1161\/HYPERTENSIONAHA.122.19912","article-title":"High HDL (high-density lipoprotein) cholesterol increases cardiovascular risk in hypertensive patients","volume":"79","author":"Trimarco","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.envres.2026.123875_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154461","article-title":"Advances in biological therapies for dyslipidemias and atherosclerosis","volume":"116","author":"Valanti","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.envres.2026.123875_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110154","article-title":"Associations between fine particulate matter constituents and daily cardiovascular mortality in Shanghai, China","volume":"191","author":"Wang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2026.123875_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.136949","article-title":"Source profiles of PM2.5 emitted from four typical open burning sources and its cytotoxicity to vascular smooth muscle cells","volume":"715","author":"Wang","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.envres.2026.123875_bib64","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jhep.2022.02.031","article-title":"Role of XBP1 in regulating the progression of non-alcoholic steatohepatitis","volume":"77","author":"Wang","year":"2022","journal-title":"J. Hepatol."},{"issue":"11","key":"10.1016\/j.envres.2026.123875_bib65","first-page":"5655","article-title":"Benzo(a)pyrene disposition and metabolism in rats following intratracheal instillation","volume":"46","author":"Weyand","year":"1986","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.envres.2026.123875_bib66","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/ije\/dyaa235","article-title":"The impact of particulate matter air pollution (PM2.5) on atherosclerosis in modernizing China: a report from the CATHAY study","volume":"50","author":"Woo","year":"2021","journal-title":"Int. J. Epidemiol."},{"issue":"5","key":"10.1016\/j.envres.2026.123875_bib67","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1021\/acs.est.9b07163","article-title":"Inhibited nitric oxide production of human endothelial nitric oxide synthase by nitrated and oxygenated polycyclic aromatic hydrocarbons","volume":"54","author":"Wu","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.envres.2026.123875_bib68","doi-asserted-by":"crossref","DOI":"10.1002\/sstr.202170007","article-title":"Sulfinylation on superoxide dismutase 1 Cys111: novel mechanism for 1-nitropyrene to promote acute reactive oxygen species generation","volume":"2","author":"Xie","year":"2021","journal-title":"Small Struct."},{"key":"10.1016\/j.envres.2026.123875_bib69","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.envpol.2018.02.086","article-title":"Effects on IL-1\u03b2 signaling activation induced by water and organic extracts of fine particulate matter (PM2.5) in vitro","volume":"237","author":"Xu","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2026.123875_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrep.2021.101168","article-title":"Metformin treatment reverses high fat diet- induced non-alcoholic fatty liver diseases and dyslipidemia by stimulating multiple antioxidant and anti-inflammatory pathways","volume":"28","author":"Yasmin","year":"2021","journal-title":"Biochemistry and Biophysics Reports"},{"key":"10.1016\/j.envres.2026.123875_bib71","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.chemosphere.2018.05.098","article-title":"Metabolic impact induced by total, water soluble and insoluble components of PM2.5 acute exposure in mice","volume":"207","author":"Zhang","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2026.123875_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167700","article-title":"Nitro substituent caused negative impact on occurrence and development of atherosclerotic plaque by PM2.5-bound polycyclic aromatic compounds","volume":"906","author":"Zhang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2026.123875_bib73","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.atmosres.2018.06.015","article-title":"Characterization of PM2.5-bound nitrated and oxygenated polycyclic aromatic hydrocarbons in ambient air of Langfang during periods with and without traffic restriction","volume":"213","author":"Zhao","year":"2018","journal-title":"Atmos. Res."},{"key":"10.1016\/j.envres.2026.123875_bib74","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.chemosphere.2019.03.022","article-title":"Characterization of PM2.5-bound polycyclic aromatic hydrocarbons and their derivatives (Nitro-and oxy-PAHs) emissions from two ship engines under different operating conditions","volume":"225","author":"Zhao","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2026.123875_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110308","article-title":"Validation of PM2.5 model particle through physicochemical evaluation and atherosclerotic plaque formation in ApoE-\/- mice","volume":"192","author":"Zhao","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126002033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126002033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:16:20Z","timestamp":1790237780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935126002033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":74,"alternative-id":["S0013935126002033"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2026.123875","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PM2.5-bound nitrated and oxygenated PAHs induced lipid metabolism disorder through different target organs","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2026.123875","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123875"}}