{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:47:44Z","timestamp":1793299664782,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2013362"],"award-info":[{"award-number":["2013362"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1117976"],"award-info":[{"award-number":["1117976"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009317","name":"Faculty of Health and Medical Sciences, University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001075","name":"Channel 7 Children&apos;s Research Foundation","doi-asserted-by":"publisher","award":["45642590"],"award-info":[{"award-number":["45642590"]}],"id":[{"id":"10.13039\/501100001075","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.envres.2026.124043","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:27:31Z","timestamp":1771054051000},"page":"124043","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Perfluoroalkyl and polyfluoroalkyl substances (PFAS) in trace levels via drinking water diminishes mouse embryo mitochondria function across three generations"],"prefix":"10.1016","volume":"296","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0196-0965","authenticated-orcid":false,"given":"Yasmyn E.","family":"Winstanley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7554-6868","authenticated-orcid":false,"given":"Donna L.","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole O.","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9997-6873","authenticated-orcid":false,"given":"Erin","family":"Barrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley S.","family":"Connaughton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4930-7658","authenticated-orcid":false,"given":"Darryl L.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9967-0084","authenticated-orcid":false,"given":"Sarah A.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-3696","authenticated-orcid":false,"given":"Cameron J.","family":"Shearer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1538-4604","authenticated-orcid":false,"given":"Rebecca L.","family":"Robker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.envres.2026.124043_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph22060917","article-title":"Epigenetic consequences of in utero PFAS exposure: implications for development and long-term health","volume":"22","author":"Abdulkadir","year":"2025","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"2","key":"10.1016\/j.envres.2026.124043_bib2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/biolre\/ioac024","article-title":"Oocyte mitochondria-key regulators of oocyte function and potential therapeutic targets for improving fertility","volume":"106","author":"Adhikari","year":"2022","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.envres.2026.124043_bib3","series-title":"PFAS National Primary Drinking Water Regulation. 89 FR 32532","author":"Agency","year":"2024"},{"issue":"3","key":"10.1016\/j.envres.2026.124043_bib4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/humrep\/deaa300","article-title":"Mitochondria-targeted therapeutics, MitoQ and BGP-15, reverse aging-associated meiotic spindle defects in mouse and human oocytes","volume":"36","author":"Al-Zubaidi","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.envres.2026.124043_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2025.1526918","article-title":"Associations of per- and polyfluoroalkyl substances in follicular fluid with polycystic ovarian syndrome in infertile women May be mediated by sex hormones","volume":"13","author":"Bian","year":"2025","journal-title":"Front. Public Health"},{"issue":"8","key":"10.1016\/j.envres.2026.124043_bib6","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1007\/s10815-022-02555-4","article-title":"The effect of discrete wavelengths of visible light on the developing Murine embryo","volume":"39","author":"Campugan","year":"2022","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.envres.2026.124043_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125208","article-title":"Perfluorooctanoic acid alters progesterone activity in human endometrial cells and induces reproductive alterations in young women","volume":"242","author":"Di Nisio","year":"2020","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.envres.2026.124043_bib8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41538-024-00319-1","article-title":"Comprehensive analysis of PFAS presence from environment to plate","volume":"8","author":"Dimitrakopoulou","year":"2024","journal-title":"NPJ Sci Food"},{"issue":"7","key":"10.1016\/j.envres.2026.124043_bib9","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1093\/aje\/kwac052","article-title":"Perfluoroalkyl substances and incident natural menopause in midlife women: the mediating role of sex hormones","volume":"191","author":"Ding","year":"2022","journal-title":"Am. J. Epidemiol."},{"issue":"7","key":"10.1016\/j.envres.2026.124043_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166802","article-title":"Mitochondrial dysfunction in the offspring of Obese mothers and it's transmission through damaged oocyte mitochondria: integration of mechanisms","volume":"1869","author":"Elias-Lopez","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.envres.2026.124043_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.125737","article-title":"Placental PFAS concentrations are associated with perturbations of placental DNA methylation","volume":"368","author":"Everson","year":"2025","journal-title":"Environ. Pollut."},{"issue":"6580","key":"10.1016\/j.envres.2026.124043_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/science.abg9065","article-title":"Per- and polyfluoroalkyl substances in the environment","volume":"375","author":"Evich","year":"2022","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.envres.2026.124043_bib13","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1093\/humrep\/den490","article-title":"Maternal levels of perfluorinated chemicals and subfecundity","volume":"24","author":"Fei","year":"2009","journal-title":"Hum. Reprod."},{"issue":"2","key":"10.1016\/j.envres.2026.124043_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13353","article-title":"Adverse PFAS effects on mouse oocyte in vitro maturation are associated with carbon-chain length and inclusion of a sulfonate group","volume":"56","author":"Feng","year":"2023","journal-title":"Cell Prolif."},{"issue":"2","key":"10.1016\/j.envres.2026.124043_bib15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1515\/reveh-2023-0174","article-title":"The association between maternal perfluoroalkylated substances exposure and neonatal birth weight: a system review and meta-analysis","volume":"40","author":"Fu","year":"2025","journal-title":"Rev. Environ. Health"},{"issue":"7","key":"10.1016\/j.envres.2026.124043_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12070455","article-title":"Effects of Per- and polyfluoroalkylated substances on female reproduction","volume":"12","author":"Gonzalez-Alvarez","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.envres.2026.124043_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.855348","article-title":"Association between exposure to Per- and Polyfluoroalkyl substances and birth outcomes: a systematic review and meta-analysis","volume":"10","author":"Gui","year":"2022","journal-title":"Front. Public Health"},{"issue":"5","key":"10.1016\/j.envres.2026.124043_bib18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/s41370-023-00579-1","article-title":"Associations between lifestyle factors and levels of per- and polyfluoroalkyl substances (PFASs), phthalates and parabens in follicular fluid in women undergoing fertility treatment","volume":"33","author":"Hallberg","year":"2023","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"5","key":"10.1016\/j.envres.2026.124043_bib19","doi-asserted-by":"crossref","first-page":"R159","DOI":"10.1530\/REP-18-0431","article-title":"Mitochondria in early development: linking the microenvironment, metabolism and the epigenome","volume":"157","author":"Harvey","year":"2019","journal-title":"Reproduction"},{"key":"10.1016\/j.envres.2026.124043_bib20","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fphys.2016.00028","article-title":"Placental adaptation: what can we learn from birthweight:placental weight ratio?","volume":"7","author":"Hayward","year":"2016","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.envres.2026.124043_bib21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/toxsci\/kfad053","article-title":"Public health evaluation of PFAS exposures and breastfeeding: a systematic literature review","volume":"194","author":"Hoadley","year":"2023","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2026.124043_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109963","article-title":"Per- and poly-fluoroalkyl substances (PFASs) in follicular fluid from women experiencing infertility in Australia","volume":"190","author":"Kim","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2026.124043_bib23","series-title":"Fluorinated Surfactants and Repellents","author":"Kissa","year":"2001"},{"issue":"6","key":"10.1016\/j.envres.2026.124043_bib24","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1210\/jc.2010-2401","article-title":"Implications of early menopause in women exposed to perfluorocarbons","volume":"96","author":"Knox","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"10.1016\/j.envres.2026.124043_bib25","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1093\/humrep\/det382","article-title":"Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction","volume":"28","author":"Kristensen","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.envres.2026.124043_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.151003","article-title":"Per- and polyfluoroalkyl substances in water and wastewater: a critical review of their global occurrence and distribution","volume":"809","author":"Kurwadkar","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"38","key":"10.1016\/j.envres.2026.124043_bib27","doi-asserted-by":"crossref","first-page":"89805","DOI":"10.1007\/s11356-023-28458-0","article-title":"Associations between maternal exposure to perfluoroalkylated substances (PFASs) and infant birth weight: a meta-analysis","volume":"30","author":"Lan","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"2","key":"10.1016\/j.envres.2026.124043_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12020104","article-title":"Association between Perfluoroalkyl substances in follicular fluid and polycystic ovary syndrome in infertile women","volume":"12","author":"Li","year":"2024","journal-title":"Toxics"},{"issue":"19","key":"10.1016\/j.envres.2026.124043_bib29","doi-asserted-by":"crossref","first-page":"8160","DOI":"10.1021\/es1038694","article-title":"Association of Perfluorooctanoic acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with age of puberty among children living near a chemical plant","volume":"45","author":"Lopez-Espinosa","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2026.124043_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116159","article-title":"Parental plasma concentrations of perfluoroalkyl substances and in vitro fertilization outcomes","volume":"269","author":"Ma","year":"2021","journal-title":"Environ. Pollut."},{"issue":"5","key":"10.1016\/j.envres.2026.124043_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/toxics11050455","article-title":"Maternal serum, cord and human milk levels of Per- and polyfluoroalkyl substances (PFAS), association with predictors and effect on newborn anthropometry","volume":"11","author":"Mahfouz","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.envres.2026.124043_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108577","article-title":"Mixtures of per- and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome","volume":"186","author":"Maxwell","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2026.124043_bib33","series-title":"Australian Drinking Water Guidelines 6","year":"2025"},{"issue":"2","key":"10.1016\/j.envres.2026.124043_bib34","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/humrep\/deae284","article-title":"Damage mechanisms of bisphenols on the quality of Mammalian oocytes","volume":"40","author":"Pandey","year":"2025","journal-title":"Hum. Reprod."},{"issue":"9","key":"10.1016\/j.envres.2026.124043_bib35","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1007\/s00018-013-1298-0","article-title":"Intergenerational programming of metabolic disease: evidence from human populations and experimental animal models","volume":"70","author":"Patti","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.envres.2026.124043_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.120868","article-title":"Sex-specific effects of in utero exposure to per- and polyfluoroalkyl substances on placental development","volume":"270","author":"Perez","year":"2025","journal-title":"Environ. Res."},{"issue":"5","key":"10.1016\/j.envres.2026.124043_bib37","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.146.5.905","article-title":"Megabase chromatin domains involved in DNA double-strand breaks in vivo","volume":"146","author":"Rogakou","year":"1999","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.envres.2026.124043_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2016.05.065","article-title":"Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations","volume":"16","author":"Saben","year":"2016","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.envres.2026.124043_bib39","doi-asserted-by":"crossref","DOI":"10.1093\/eep\/dvaf010","article-title":"Prenatal per- and polyfluoroalkyl substance exposures and DNA methylation among newborns in the environmental influences on child health outcomes program","volume":"11","author":"Schrott","year":"2025","journal-title":"Environ Epigenet"},{"key":"10.1016\/j.envres.2026.124043_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124474","article-title":"Exposure of women undergoing in-vitro fertilization to per-and polyfluoroalkyl substances: evidence on negative effects on fertilization and high-quality embryos","volume":"359","author":"Shen","year":"2024","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.envres.2026.124043_bib41","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1289\/ehp.1306707","article-title":"Polyfluoroalkyl chemicals and menopause among women 20-65 years of age (NHANES)","volume":"122","author":"Taylor","year":"2014","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.envres.2026.124043_bib42","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/humrep\/deu350","article-title":"Maternal exposure to perfluorinated chemicals and reduced fecundity: the MIREC study","volume":"30","author":"Velez","year":"2015","journal-title":"Hum. Reprod."},{"issue":"Pt 3","key":"10.1016\/j.envres.2026.124043_bib43","article-title":"The effects of perfluoroalkyl and polyfluoroalkyl substances on female fertility: a systematic review and meta-analysis","volume":"216","author":"Wang","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2026.124043_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112807","article-title":"Perfluorooctane sulfonate affects mouse oocyte maturation in vitro by promoting oxidative stress and apoptosis induced bymitochondrial dysfunction","volume":"225","author":"Wei","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2026.124043_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/frph.2024.1394099","article-title":"Drinking water quality impacts oocyte viability and embryo development","volume":"6","author":"Winstanley","year":"2024","journal-title":"Front. Reprod. Health"},{"issue":"1","key":"10.1016\/j.envres.2026.124043_bib46","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1038\/s41467-025-57794-7","article-title":"Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization","volume":"16","author":"Winstanley","year":"2025","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.envres.2026.124043_bib47","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1242\/dev.114850","article-title":"Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors","volume":"142","author":"Wu","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.envres.2026.124043_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108829","article-title":"Mixed exposure to PFOA and PFOS induces oocyte apoptosis and subfertility in mice by activating the Hippo signaling pathway","volume":"132","author":"Yan","year":"2025","journal-title":"Reprod. Toxicol."},{"issue":"12","key":"10.1016\/j.envres.2026.124043_bib49","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1002\/tox.23652","article-title":"Perfluorooctanoic acid exposure in vivo perturbs mitochondrial metabolic during oocyte maturation","volume":"37","author":"Zhang","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envres.2026.124043_bib50","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","article-title":"Mitochondrial membrane potential","volume":"552","author":"Zorova","year":"2018","journal-title":"Anal. Biochem."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126003713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126003713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:06:48Z","timestamp":1777417608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935126003713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":50,"alternative-id":["S0013935126003713"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2026.124043","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perfluoroalkyl and polyfluoroalkyl substances (PFAS) in trace levels via drinking water diminishes mouse embryo mitochondria function across three generations","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2026.124043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"124043"}}