{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:46:01Z","timestamp":1786988761317,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ZIAES101575"],"award-info":[{"award-number":["ZIAES101575"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["874583"],"award-info":[{"award-number":["874583"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["101136566"],"award-info":[{"award-number":["101136566"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003061","name":"Erasmus Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001828","name":"Erasmus Universiteit Rotterdam","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001828","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.envres.2026.124304","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T07:32:17Z","timestamp":1773991937000},"page":"124304","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Fetal exposure to bisphenols and phthalates and risk of respiratory conditions in infancy. The Generation R Next Study"],"prefix":"10.1016","volume":"299","author":[{"given":"Pratibha","family":"Varma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-7877","authenticated-orcid":false,"given":"Tarik","family":"Karramass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-597X","authenticated-orcid":false,"given":"Leonardo","family":"Trasande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly K.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurunthachalam","family":"Kannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2918-323X","authenticated-orcid":false,"given":"Amrit Kaur","family":"Sakhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W.V.","family":"Jaddoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6731-9452","authenticated-orcid":false,"given":"Liesbeth","family":"Duijts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2026.124304_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107178","article-title":"In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts","volume":"162","author":"Abellan","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2026.124304_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.176311","article-title":"Prenatal exposure to phthalates and childhood wheeze and asthma in the PROGRESS cohort","volume":"954","author":"Alcala","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2026.124304_bib3","doi-asserted-by":"crossref","DOI":"10.1183\/09031936.95.08030483","article-title":"International study of asthma and allergies in childhood (ISAAC): rationale and methods","author":"Asher","year":"1995","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.envres.2026.124304_bib4","first-page":"360","article-title":"Phthalates impact human health: epidemiological evidences and plausible mechanism of action","volume":"vol. 340","author":"Benjamin","year":"2017"},{"issue":"1","key":"10.1016\/j.envres.2026.124304_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Roy. Stat. Soc. B"},{"key":"10.1016\/j.envres.2026.124304_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.121712","article-title":"Periconception bisphenol and phthalate concentrations in women and men, time to pregnancy, and risk of miscarriage","volume":"278","author":"Blaauwendraad","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2026.124304_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.121712","article-title":"Periconception bisphenol and phthalate concentrations in women and men, time to pregnancy, and risk of miscarriage","volume":"278","author":"Blaauwendraad","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2026.124304_bib8","article-title":"Exposure to endocrine-disrupting plasticisers and lung function in children and adolescents: a systematic review and meta-analysis","volume":"243","author":"Boissiere-O'Neill","year":"2024","journal-title":"Environ. Res."},{"issue":"9","key":"10.1016\/j.envres.2026.124304_bib9","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.36157","article-title":"Preconception and early-pregnancy body mass index in women and men, time to pregnancy, and risk of miscarriage","volume":"7","author":"Boxem","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.envres.2026.124304_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.envint.2018.03.016","article-title":"Associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic diseases among children aged 6 and 7 years","volume":"115","author":"Buckley","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2026.124304_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121794","article-title":"Prenatal exposure to synthetic phenols and phthalates and child respiratory health from 2 to 36 months of life","volume":"330","author":"Coiffier","year":"2023","journal-title":"Environ. Pollut."},{"issue":"Suppl. A","key":"10.1016\/j.envres.2026.124304_bib12","doi-asserted-by":"crossref","first-page":"S259","DOI":"10.1016\/S1526-0542(04)90049-8","article-title":"Lung development and fetal lung growth","volume":"5","author":"Copland","year":"2004","journal-title":"Paediatr. Respir. Rev."},{"key":"10.1016\/j.envres.2026.124304_bib13","series-title":"Brief Symptom Inventory","author":"Derogatis","year":"1975"},{"issue":"3","key":"10.1016\/j.envres.2026.124304_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2012.12.1573","article-title":"Prenatal and postnatal bisphenol A exposure and asthma development among inner-city children","volume":"131","author":"Donohue","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.envres.2026.124304_bib15","doi-asserted-by":"crossref","DOI":"10.1289\/EHP10077","article-title":"Prenatal phthalate exposure and child weight and adiposity from in utero to 6 years of age","volume":"130","author":"Ferguson","year":"2022","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.envres.2026.124304_bib16","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/resp.14386","article-title":"Longitudinal effects of prenatal exposure to plastic-derived chemicals and their metabolites on asthma and lung function from childhood into adulthood","volume":"28","author":"Foong","year":"2023","journal-title":"Respirology"},{"issue":"2","key":"10.1016\/j.envres.2026.124304_bib17","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jaci.2014.09.030","article-title":"Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy","volume":"135","author":"Gascon","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.envres.2026.124304_bib18","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/1047322X.1990.10389587","article-title":"Estimation of average concentration in the presence of nondetectable values","volume":"5","author":"Hornung","year":"1990","journal-title":"Appl. Occup. Environ. Hyg"},{"issue":"4","key":"10.1016\/j.envres.2026.124304_bib19","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/s41390-022-01940-0","article-title":"Development of the immune system in the human embryo","volume":"92","author":"Hossain","year":"2022","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.envres.2026.124304_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121853","article-title":"Bisphenol and phthalate exposure during pregnancy and the development of childhood lung function and asthma. The Generation R Study","volume":"332","author":"Karramass","year":"2023","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.envres.2026.124304_bib21","doi-asserted-by":"crossref","DOI":"10.1289\/EHP5838","article-title":"A quantile-based g-computation approach to addressing the effects of exposure mixtures","volume":"128","author":"Keil","year":"2020","journal-title":"Environ. Health Perspect."},{"issue":"10","key":"10.1016\/j.envres.2026.124304_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111383","article-title":"Bisphenol a exposure and asthma development in school-age children: a longitudinal study","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.envres.2026.124304_bib23","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s10654-016-0224-9","article-title":"The Generation R Study: design and cohort update 2017","volume":"31","author":"Kooijman","year":"2016","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.envres.2026.124304_bib24","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.toxrep.2023.02.017","article-title":"Bisphenols, but not phthalate esters, modulate gene expression in activated human MAIT cells in vitro","volume":"10","author":"Krause","year":"2023","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.envres.2026.124304_bib25","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.scitotenv.2017.10.042","article-title":"Bisphenol A distribution in serum, urine, placenta, breast milk, and umbilical cord serum in a birth panel of mother\u2013neonate pairs","volume":"626","author":"Lee","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2026.124304_bib26","article-title":"The Global Asthma Report 2022","volume":"vol. 26","author":"Mikkelsen","year":"2022"},{"key":"10.1016\/j.envres.2026.124304_bib27","article-title":"Education level","author":"Netherlands","year":"2023","journal-title":"Statistics Netherlands"},{"key":"10.1016\/j.envres.2026.124304_bib28","first-page":"496","article-title":"Effects of phthalates on the development and expression of allergic disease and asthma","volume":"vol 112","author":"North","year":"2014"},{"issue":"2","key":"10.1016\/j.envres.2026.124304_bib29","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1289\/ehp.1509693","article-title":"Environmental chemicals in urine and blood: improving methods for creatinine and lipid adjustment","volume":"124","author":"O'Brien","year":"2016","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.envres.2026.124304_bib30","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S2352-4642(21)00311-4","article-title":"Global, regional, and national causes of under-5 mortality in 2000\u201319: an updated systematic analysis with implications for the Sustainable Development Goals","volume":"6","author":"Perin","year":"2022","journal-title":"Lancet Child Adolesc. Health"},{"issue":"3","key":"10.1016\/j.envres.2026.124304_bib31","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1289\/ehp.1103634","article-title":"Exposure to phthalates and phenols during pregnancy and offspring size at birth","volume":"120","author":"Philippat","year":"2011","journal-title":"Environ. Health Perspect."},{"issue":"10","key":"10.1016\/j.envres.2026.124304_bib32","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1289\/ehp.1206335","article-title":"Prenatal exposure to environmental phenols: concentrations in amniotic fluid and variability in urinary concentrations during pregnancy","volume":"121","author":"Philippat","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2026.124304_bib33","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.envres.2017.11.051","article-title":"Bisphenol and phthalate concentrations and its determinants among pregnant women in a population-based cohort in the Netherlands, 2004\u20135","volume":"161","author":"Philips","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2026.124304_bib34","first-page":"379","article-title":"The impact of bisphenol A and phthalates on allergy, asthma, and immune function: a review of latest findings","volume":"vol. 2","author":"Robinson","year":"2015"},{"key":"10.1016\/j.envres.2026.124304_bib35","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.molimm.2012.09.013","article-title":"Review: endocrine disrupting chemicals and immune responses: a focus on bisphenol-A and its potential mechanisms","volume":"53","author":"Rogers","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.envres.2026.124304_bib36","first-page":"634","article-title":"EDC-induced mechanisms of immunotoxicity: a systematic review","volume":"vol. 51","author":"Sabuz Vidal","year":"2021"},{"key":"10.1016\/j.envres.2026.124304_bib37","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.envint.2018.02.037","article-title":"Levels, variability and determinants of environmental phenols in pairs of Norwegian mothers and children","volume":"114","author":"Sakhi","year":"2018","journal-title":"Environ. Int."},{"issue":"3-5","key":"10.1016\/j.envres.2026.124304_bib38","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jsbmb.2011.08.007","article-title":"Endocrine disrupting chemicals and disease susceptibility","volume":"127","author":"Schug","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.envres.2026.124304_bib39","series-title":"Current Environmental Health Reports","article-title":"Synthetic chemicals: what we have learned and still need to learn about their associations with childhood allergy and asthma","author":"Shah","year":"2023"},{"issue":"6","key":"10.1016\/j.envres.2026.124304_bib40","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1289\/ehp.1104175","article-title":"Prenatal exposure to bisphenol A and child wheeze from birth to 3 years of age","volume":"120","author":"Spanier","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2026.124304_bib41","author":"Van Buuren"},{"issue":"2","key":"10.1016\/j.envres.2026.124304_bib42","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/thoraxjnl-2017-210149","article-title":"A population-based prospective cohort study examining the influence of early-life respiratory tract infections on school-age lung function and asthma","volume":"73","author":"Van Meel","year":"2018","journal-title":"Thorax"},{"key":"10.1016\/j.envres.2026.124304_bib43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.reprotox.2007.07.010","article-title":"Human exposure to bisphenol A (BPA)","volume":"24","author":"Vandenberg","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envres.2026.124304_bib44","author":"Von Elm","year":"2007","journal-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies"},{"issue":"1","key":"10.1016\/j.envres.2026.124304_bib45","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-015-0060-x","article-title":"Effects of phthalate exposure on asthma may be mediated through alterations in DNA methylation","volume":"7","author":"Wang","year":"2015","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.envres.2026.124304_bib46","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.reprotox.2010.09.004","article-title":"Environmental toxicants and the developing immune system: a missing link in the global battle against infectious disease?","volume":"31","author":"Winans","year":"2011","journal-title":"Reprod. Toxicol."},{"issue":"4","key":"10.1016\/j.envres.2026.124304_bib47","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1289\/ehp.10829","article-title":"Exposure to bisphenol A prenatally or in adulthood promotes TH2 cytokine production associated with reduction of CD4+CD25+ regulatory T cells","volume":"116","author":"Yan","year":"2008","journal-title":"Environ. Health Perspect."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126006341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126006341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T04:11:15Z","timestamp":1779509475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935126006341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":47,"alternative-id":["S0013935126006341"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2026.124304","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fetal exposure to bisphenols and phthalates and risk of respiratory conditions in infancy. The Generation R Next Study","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2026.124304","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"124304"}}