{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:14:54Z","timestamp":1789668894988,"version":"4.0.1"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1154837"],"award-info":[{"award-number":["APP1154837"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1173892"],"award-info":[{"award-number":["APP1173892"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1189415"],"award-info":[{"award-number":["APP1189415"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.envres.2026.124528","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T23:03:20Z","timestamp":1776726200000},"page":"124528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Multigenerational exposure to per- and polyfluoroalkyl substances (PFAS) negatively impacts the reproductive health of male mice"],"prefix":"10.1016","volume":"301","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6923-4524","authenticated-orcid":false,"given":"Leah","family":"Gillespie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0876-5150","authenticated-orcid":false,"given":"Jacinta H.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie A.","family":"Trigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6293-6160","authenticated-orcid":false,"given":"John E.","family":"Schjenken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-1989","authenticated-orcid":false,"given":"Shannon P.","family":"Smyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana R.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone J.","family":"Stanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0704-1648","authenticated-orcid":false,"given":"Logan","family":"McElhone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin C.","family":"Conine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fay","family":"Waldrip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4722-6897","authenticated-orcid":false,"given":"Erin J.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher V.","family":"Dayas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewan N.A.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Louise","family":"Gannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6978-6123","authenticated-orcid":false,"given":"Geoffry N.","family":"De Iuliis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6327-3618","authenticated-orcid":false,"given":"Andrew L.","family":"Eamens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Dun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett D.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun D.","family":"Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-9781","authenticated-orcid":false,"given":"Mark P.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Nixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.envres.2026.124528_bib1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1006\/hbeh.2002.1838","article-title":"Testosterone rapidly reduces anxiety in Male house mice (Mus musculus)","volume":"42","author":"Aikey","year":"2002","journal-title":"Horm. Behav."},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0012-1606(03)00210-0","article-title":"Gestation stage-dependent intrauterine trophoblast cell invasion in the rat and mouse: novel endocrine phenotype and regulation","volume":"260","author":"Ain","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.envres.2026.124528_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109920","article-title":"Structure-based virtual screening of perfluoroalkyl and polyfluoroalkyl substances (PFASs) as endocrine disruptors of androgen receptor activity using molecular docking and machine learning","volume":"190","author":"Azhagiya Singam","year":"2020","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3109\/10408444.2014.952400","article-title":"Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: a systematic review","volume":"45","author":"Bach","year":"2015","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envres.2026.124528_bib5","series-title":"Organofluorine Chemistry: Principles and Commercial Applications","author":"Banks","year":"1994"},{"issue":"11\u201312","key":"10.1016\/j.envres.2026.124528_bib6","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1289\/ehp.1306615","article-title":"Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant","volume":"121","author":"Barry","year":"2013","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.envres.2026.124528_bib7","doi-asserted-by":"crossref","first-page":"dvy010","DOI":"10.1093\/eep\/dvy010","article-title":"Alterations in sperm DNA methylation, non-coding RNA expression, and histone retention mediate vinclozolin-induced epigenetic transgenerational inheritance of disease","volume":"4","author":"Ben Maamar","year":"2018","journal-title":"Environ. Epigenet."},{"key":"10.1016\/j.envres.2026.124528_bib8","series-title":"Methods in Mammalian Embryology","first-page":"86","article-title":"The culture of mouse embryos in vitro","author":"Biggers","year":"1971"},{"issue":"24","key":"10.1016\/j.envres.2026.124528_bib9","doi-asserted-by":"crossref","first-page":"14062","DOI":"10.1021\/es403094q","article-title":"Uptake of perfluoroalkyl acids into edible crops via land applied biosolids: field and greenhouse studies","volume":"47","author":"Blaine","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"11","key":"10.1016\/j.envres.2026.124528_bib10","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1096\/fj.12-210989","article-title":"Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner","volume":"26","author":"Bolton","year":"2012","journal-title":"FASEB J."},{"issue":"8","key":"10.1016\/j.envres.2026.124528_bib11","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.3390\/ani11082327","article-title":"All the pups we cannot see: cannibalism masks perinatal death in laboratory mouse breeding but infanticide is rare","volume":"11","author":"Brajon","year":"2021","journal-title":"Animals"},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/oby.21258","article-title":"Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: the HOME study","volume":"24","author":"Braun","year":"2016","journal-title":"Obesity"},{"issue":"4","key":"10.1016\/j.envres.2026.124528_bib13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins","volume":"7","author":"Buck","year":"2011","journal-title":"Integrated Environ. Assess. Manag."},{"issue":"4","key":"10.1016\/j.envres.2026.124528_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001633","article-title":"Fetal growth and risk of stillbirth: a population-based case-control study","volume":"11","author":"Bukowski","year":"2014","journal-title":"PLoS Med."},{"issue":"11","key":"10.1016\/j.envres.2026.124528_bib15","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1289\/ehp.10598","article-title":"Polyfluoroalkyl chemicals in the U.S. population: data from the national health and nutrition examination survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000","volume":"115","author":"Calafat","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2026.124528_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.799043","article-title":"Assessment of the emerging threat posed by perfluoroalkyl and polyfluoroalkyl substances to Male reproduction in humans","volume":"12","author":"Calvert","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib17","doi-asserted-by":"crossref","DOI":"10.1530\/RAF-23-0087","article-title":"Assessment of the impact of direct in vitro PFAS treatment on mouse spermatozoa","volume":"5","author":"Calvert","year":"2024","journal-title":"Reprod Fertil"},{"key":"10.1016\/j.envres.2026.124528_bib18","doi-asserted-by":"crossref","DOI":"10.1530\/RAF-23-0087","article-title":"Assessment of the impact of direct in vitro PFAS treatment on mouse spermatozoa","author":"Calvert","year":"2024","journal-title":"Reproduction and Fertility"},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12864-016-3394-7","article-title":"Small RNA sequencing of cryopreserved semen from single bull revealed altered miRNAs and piRNAs expression between High- and low-motile sperm populations","volume":"18","author":"Capra","year":"2017","journal-title":"BMC Genom."},{"key":"10.1016\/j.envres.2026.124528_bib20","series-title":"National Health and Nutrition Examination Survey (NHANES)","year":"2023"},{"key":"10.1016\/j.envres.2026.124528_bib21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.reprotox.2021.06.016","article-title":"Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring: a Faroese cohort study","volume":"104","author":"Christensen","year":"2021","journal-title":"Reprod. Toxicol."},{"issue":"4","key":"10.1016\/j.envres.2026.124528_bib22","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.devcel.2018.06.024","article-title":"Small RNAs gained during epididymal transit of sperm are essential for embryonic development in mice","volume":"46","author":"Conine","year":"2018","journal-title":"Dev. Cell"},{"issue":"4","key":"10.1016\/j.envres.2026.124528_bib23","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.devcel.2018.06.024","article-title":"Small RNAs gained during epididymal transit of sperm are essential for embryonic development in mice","volume":"46","author":"Conine","year":"2018","journal-title":"Dev. Cell"},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib24","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1242\/jcs.02704","article-title":"FGFR-1 signaling is involved in spermiogenesis and sperm capacitation","volume":"119","author":"Cotton","year":"2006","journal-title":"J. Cell Sci."},{"issue":"8","key":"10.1016\/j.envres.2026.124528_bib25","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.theriogenology.2011.06.025","article-title":"Differential expression of porcine sperm microRNAs and their association with sperm morphology and motility","volume":"76","author":"Curry","year":"2011","journal-title":"Theriogenology"},{"key":"10.1016\/j.envres.2026.124528_bib26","first-page":"179","article-title":"Perfluorinated substances in human food and other sources of human exposure","volume":"208","author":"D'Hollander","year":"2010","journal-title":"Rev. Environ. Contam. Toxicol."},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib27","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1038\/s41598-020-58827-5","article-title":"Large-for-gestational-age phenotypes and obesity risk in adulthood: a study of 195,936 women","volume":"10","author":"Derraik","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2026.124528_bib28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.clinms.2018.12.003","article-title":"Simultaneous measurement of 18 steroids in human and mouse serum by liquid chromatography-mass spectrometry without derivatization to profile the classical and alternate pathways of androgen synthesis and metabolism","volume":"11","author":"Desai","year":"2019","journal-title":"Clin. Mass Spectrom."},{"issue":"3","key":"10.1016\/j.envres.2026.124528_bib29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s12519-019-00249-z","article-title":"Risk factors for recurrent macrosomia and child outcomes","volume":"15","author":"Fang","year":"2019","journal-title":"World J Pediatr"},{"issue":"12","key":"10.1016\/j.envres.2026.124528_bib30","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1289\/ehp.0800379","article-title":"The C8 health project: design, methods, and participants","volume":"117","author":"Frisbee","year":"2009","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.envres.2026.124528_bib31","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijheh.2008.04.007","article-title":"Perfluorinated compounds--exposure assessment for the general population in Western countries","volume":"212","author":"Fromme","year":"2009","journal-title":"Int. J. Hyg Environ. Health"},{"issue":"4","key":"10.1016\/j.envres.2026.124528_bib32","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0031-9384(71)90112-0","article-title":"Stimulus control of cannibalism and maternal behavior in anosmic mice","volume":"7","author":"Gandelman","year":"1971","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib33","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/s42003-025-08865-4","article-title":"Exposure of mice to environmentally relevant per- and polyfluoroalkyl substances (PFAS) alters the sperm epigenome","volume":"8","author":"Gillespie","year":"2025","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib50","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/s42003-025-08865-4","article-title":"Exposure of mice to environmentally relevant per-and polyfluoroalkyl substances (PFAS) alters the sperm epigenome","volume":"8","author":"Gillespie","year":"2025","journal-title":"Communications Biology"},{"issue":"9","key":"10.1016\/j.envres.2026.124528_bib34","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/and.12371","article-title":"Chromosomal aneuploidies and DNA fragmentation of human spermatozoa from patients exposed to perfluorinated compounds","volume":"47","author":"Governini","year":"2015","journal-title":"Andrologia"},{"issue":"40","key":"10.1016\/j.envres.2026.124528_bib35","doi-asserted-by":"crossref","first-page":"67394","DOI":"10.18632\/oncotarget.18672","article-title":"Sperm-carried RNAs play critical roles in mouse embryonic development","volume":"8","author":"Guo","year":"2017","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.envres.2026.124528_bib36","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1289\/ehp.1104034","article-title":"Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: a prospective cohort study","volume":"120","author":"Halldorsson","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"1\u20132","key":"10.1016\/j.envres.2026.124528_bib37","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.mce.2009.02.021","article-title":"Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: low doses induce elevated serum leptin and insulin, and overweight in mid-life","volume":"304","author":"Hines","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.envres.2026.124528_bib38","doi-asserted-by":"crossref","first-page":"R97","DOI":"10.1530\/REP-16-0495","article-title":"Effects of maternal obesity on placental function and fetal development","volume":"153","author":"Howell","year":"2017","journal-title":"Reproduction"},{"issue":"9","key":"10.1016\/j.envres.2026.124528_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138383","article-title":"Cardiovascular and cerebrovascular disease associated microRNAs are dysregulated in placental tissues affected with gestational hypertension, preeclampsia and intrauterine growth restriction","volume":"10","author":"Hromadnikova","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.envres.2026.124528_bib40","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1021\/acs.estlett.6b00260","article-title":"Detection of Poly- and perfluoroalkyl substances (PFASs) in U.S. drinking water linked to industrial sites, military fire training areas, and wastewater treatment plants","volume":"3","author":"Hu","year":"2016","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.envres.2026.124528_bib41","series-title":"International Agency for Research on Cancer","year":"2018"},{"key":"10.1016\/j.envres.2026.124528_bib42","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3389\/fnbeh.2014.00244","article-title":"Exercise reverses the effects of early life stress on orexin cell reactivity in Male but not female rats","volume":"8","author":"James","year":"2014","journal-title":"Front. Behav. Neurosci."},{"issue":"2","key":"10.1016\/j.envres.2026.124528_bib43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2605.2008.00870.x","article-title":"Emerging endocrine disrupters: perfluoroalkylated substances","volume":"31","author":"Jensen","year":"2008","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.envres.2026.124528_bib44","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.scitotenv.2018.04.380","article-title":"A short review on human exposure to and tissue distribution of per- and polyfluoroalkyl substances (PFASs)","volume":"636","author":"Jian","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib45","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neuro.2007.10.008","article-title":"Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice","volume":"29","author":"Johansson","year":"2008","journal-title":"Neurotoxicology"},{"issue":"10","key":"10.1016\/j.envres.2026.124528_bib46","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1289\/ehp.1307893","article-title":"The navigation Guide\u2014evidence-based medicine meets environmental health: systematic review of human evidence for PFOA effects on fetal growth","volume":"122","author":"Johnson","year":"2014","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.envres.2026.124528_bib47","series-title":"The PFAS Health Study: Systematic Literature Review","author":"Kirk","year":"2018"},{"key":"10.1016\/j.envres.2026.124528_bib48","volume":"vol. 97","author":"Kissa","year":"2001"},{"issue":"8","key":"10.1016\/j.envres.2026.124528_bib49","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2523071123","article-title":"Stability of epigenetic transgenerational inheritance of adult-onset disease and parturition abnormalities","volume":"123","author":"Korolenko","year":"2026","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.envres.2026.124528_bib51","volume":"10","author":"Li","year":"2022","journal-title":"Correction: Li et al. In-Vitro and In-Silico Assessment of Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous Film-Forming Foam (AFFF) Binding to Human Serum Albumin. Toxics"},{"key":"10.1016\/j.envres.2026.124528_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114130","article-title":"Association between prenatal exposure to perfluoroalkyl substances and anogenital distance in female neonates","volume":"245","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"12","key":"10.1016\/j.envres.2026.124528_bib53","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2024-092888","article-title":"Risk factors of large for gestational age among pregnant women with gestational diabetes mellitus: a protocol for systematic review and meta-analysis","volume":"14","author":"Liang","year":"2024","journal-title":"BMJ Open"},{"key":"10.1016\/j.envres.2026.124528_bib54","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.reprotox.2016.08.019","article-title":"Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort","volume":"68","author":"Lind","year":"2017","journal-title":"Reprod. Toxicol."},{"issue":"19","key":"10.1016\/j.envres.2026.124528_bib55","doi-asserted-by":"crossref","first-page":"7954","DOI":"10.1021\/es2011622","article-title":"Polyfluorinated compounds: past, present, and future","volume":"45","author":"Lindstrom","year":"2011","journal-title":"Environ. Sci. Technol."},{"issue":"8","key":"10.1016\/j.envres.2026.124528_bib56","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1007\/s11356-014-2570-z","article-title":"Anogenital distance and its application in environmental health research","volume":"21","author":"Liu","year":"2014","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib57","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1289\/ehp.1307621","article-title":"Perfluorochemicals and human semen quality: the LIFE study","volume":"123","author":"Louis","year":"2015","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.envres.2026.124528_bib58","article-title":"Prenatal exposure to bisphenol A: is there an association between bisphenol A in second trimester amniotic fluid and fetal growth?","volume":"59","author":"Loukas","year":"2023","journal-title":"Medicina (Kaunas)"},{"issue":"10","key":"10.1016\/j.envres.2026.124528_bib59","doi-asserted-by":"crossref","DOI":"10.1111\/and.14184","article-title":"Differentially expressed microRNA in testicular tissues of hyperuricaemia rats","volume":"53","author":"Ma","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.envres.2026.124528_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.675775","article-title":"The association between high birth weight and long-term outcomes-implications for assisted reproductive technologies: a systematic review and meta-analysis","volume":"9","author":"Magnusson","year":"2021","journal-title":"Front. Pediatr."},{"issue":"5","key":"10.1016\/j.envres.2026.124528_bib61","doi-asserted-by":"crossref","first-page":"532","DOI":"10.30802\/AALAS-JAALAS-18-000129","article-title":"Effects of soy in laboratory rodent diets on the basal, affective, and cognitive behavior of C57BL\/6 mice","volume":"58","author":"Mallien","year":"2019","journal-title":"J Am Assoc Lab Anim Sci"},{"issue":"5","key":"10.1016\/j.envres.2026.124528_bib62","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/biolre\/ioz008","article-title":"Investigation into the presence and functional significance of proinsulin C-peptide in the female germline\u2020","volume":"100","author":"Martin","year":"2019","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.envres.2026.124528_bib63","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1055\/s-0044-1801363","article-title":"PFAS exposure and Male reproductive health: implications for sperm epigenetics","volume":"42","author":"Maxwell","year":"2024","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.envres.2026.124528_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108577","article-title":"Mixtures of per- and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome","volume":"186","author":"Maxwell","year":"2024","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.envres.2026.124528_bib65","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000348677","article-title":"Novel PCR assay for determining the genetic sex of mice","volume":"7","author":"McFarlane","year":"2013","journal-title":"Sex. Dev."},{"issue":"2","key":"10.1016\/j.envres.2026.124528_bib66","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1210\/en.2018-00836","article-title":"Circulating exosomal miRNA profile during term and preterm birth pregnancies: a longitudinal study","volume":"160","author":"Menon","year":"2019","journal-title":"Endocrinology"},{"issue":"1663","key":"10.1016\/j.envres.2026.124528_bib67","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0074","article-title":"The role and interaction of imprinted genes in human fetal growth","volume":"370","author":"Moore","year":"2015","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"3","key":"10.1016\/j.envres.2026.124528_bib68","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1289\/EHP246","article-title":"Prenatal exposure to perfluoroalkyl substances and adiposity in early and mid-childhood","volume":"125","author":"Mora","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2026.124528_bib69","series-title":"Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology","year":"2018"},{"issue":"9","key":"10.1016\/j.envres.2026.124528_bib70","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environmental health perspectives"},{"issue":"12","key":"10.1016\/j.envres.2026.124528_bib71","doi-asserted-by":"crossref","DOI":"10.1289\/EHP4431","article-title":"Profiles of emerging and legacy Per-\/Polyfluoroalkyl substances in matched serum and semen samples: new implications for human semen quality","volume":"127","author":"Pan","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2026.124528_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.116175","article-title":"Association between perfluoroalkyl and polyfluoroalkyl substances exposure and fetal overgrowth: a prospective birth cohort study conducted in China","volume":"232","author":"Pan","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2026.124528_bib73","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.envint.2013.06.004","article-title":"Accumulation of perfluoroalkyl substances in human tissues","volume":"59","author":"P\u00e9rez","year":"2013","journal-title":"Environ. Int."},{"issue":"7","key":"10.1016\/j.envres.2026.124528_bib74","doi-asserted-by":"crossref","first-page":"154a","DOI":"10.1021\/es012317k","article-title":"Growing concern over perfluorinated chemicals","volume":"35","author":"Renner","year":"2001","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib75","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1530\/jrf.0.0540103","article-title":"Daily sperm production and epididymal sperm reserves of pubertal and adult rats","volume":"54","author":"Robb","year":"1978","journal-title":"Reproduction"},{"key":"10.1016\/j.envres.2026.124528_bib76","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.placenta.2015.12.002","article-title":"Abnormal labyrinthine zone in the Hectd1-null placenta","volume":"38","author":"Sarkar","year":"2016","journal-title":"Placenta"},{"key":"10.1016\/j.envres.2026.124528_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1212898","article-title":"Placental deficiency of the (Pro)renin receptor ((P)RR) reduces placental development and functional capacity","volume":"11","author":"Schofield","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.envres.2026.124528_bib78","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00204-018-2350-5","article-title":"Anogenital distance as a toxicological or clinical marker for fetal androgen action and risk for reproductive disorders","volume":"93","author":"Schwartz","year":"2019","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib79","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.physbeh.2012.04.014","article-title":"Nutrition, weight gain and eating behavior in pregnancy: a review of experimental evidence for long-term effects on the risk of obesity in offspring","volume":"107","author":"Sen","year":"2012","journal-title":"Physiol. Behav."},{"issue":"6271","key":"10.1016\/j.envres.2026.124528_bib80","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1126\/science.aad6780","article-title":"Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals","volume":"351","author":"Sharma","year":"2016","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.envres.2026.124528_bib81","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/humrep\/16.5.972","article-title":"Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects","volume":"16","author":"Skakkebaek","year":"2001","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.envres.2026.124528_bib82","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2022.881584","article-title":"A critical review and meta-analysis of impacts of Per- and polyfluorinated substances on the brain and behavior","volume":"4","author":"Starnes","year":"2022","journal-title":"Front Toxicol"},{"issue":"5","key":"10.1016\/j.envres.2026.124528_bib83","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.physbeh.2010.04.008","article-title":"Perinatal environment and its influences on metabolic programming of offspring","volume":"100","author":"Tamashiro","year":"2010","journal-title":"Physiol. Behav."},{"issue":"11","key":"10.1016\/j.envres.2026.124528_bib84","doi-asserted-by":"crossref","DOI":"10.3390\/cimb47110944","article-title":"Perfluoroalkyl substances (PFAS) and lipid metabolism in experimental animal models: a scoping review on the mechanisms behind the induced hepatotoxicity","volume":"47","author":"Tancreda","year":"2025","journal-title":"Curr. Issues Mol. Biol."},{"issue":"2","key":"10.1016\/j.envres.2026.124528_bib85","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/toxsci\/kfg121","article-title":"Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations","volume":"74","author":"Thibodeaux","year":"2003","journal-title":"Toxicol. Sci."},{"issue":"7","key":"10.1016\/j.envres.2026.124528_bib86","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1093\/humrep\/dez058","article-title":"Maternal plasma concentrations of perfluoroalkyl and polyfluoroalkyl substances during pregnancy and anogenital distance in Male infants","volume":"34","author":"Tian","year":"2019","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109787","article-title":"Acrylamide modulates the mouse epididymal proteome to drive alterations in the sperm small non-coding RNA profile and dysregulate embryo development","volume":"37","author":"Trigg","year":"2021","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109787","article-title":"Acrylamide modulates the mouse epididymal proteome to drive alterations in the sperm small non-coding RNA profile and dysregulate embryo development","volume":"37","author":"Trigg","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.envres.2026.124528_bib89","series-title":"Brett Nixon Sub-chronic Elevation in Ambient Temperature Drives Alterations to the Sperm Epigenome and Accelerates Early Embryonic Development in Mice","author":"Trigg","year":"2024"},{"issue":"9","key":"10.1016\/j.envres.2026.124528_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114698","article-title":"Epididymal acquired sperm microRNAs modify post-fertilization embryonic gene expression","volume":"43","author":"Trigg","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.envres.2026.124528_bib91","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.chemosphere.2019.04.139","article-title":"Novel remediation of per-and polyfluoroalkyl substances (PFASs) from contaminated groundwater using Cannabis sativa L.(hemp) protein powder","volume":"229","author":"Turner","year":"2019","journal-title":"Chemosphere"},{"issue":"15","key":"10.1016\/j.envres.2026.124528_bib92","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.1021\/es900228k","article-title":"Tracking the pathways of human exposure to perfluorocarboxylates","volume":"43","author":"Vestergren","year":"2009","journal-title":"Environ. Sci. Technol."},{"issue":"Pt 3","key":"10.1016\/j.envres.2026.124528_bib93","article-title":"Exposure of male mice to perfluorooctanoic acid induces anxiety-like behaviors by increasing corticotropin-releasing factor in the basolateral amygdala complex","volume":"287","author":"Wang","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2026.124528_bib94","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuropharm.2018.09.033","article-title":"Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin\/hypocretin cells","volume":"154","author":"Yeoh","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.envres.2026.124528_bib95","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ygeno.2020.12.024","article-title":"Expression analysis of microRNAs and their target mRNAs of testes with high and low sperm motility in domestic pigeons (Columba livia)","volume":"113","author":"Yin","year":"2021","journal-title":"Genomics"},{"issue":"4","key":"10.1016\/j.envres.2026.124528_bib96","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061627","article-title":"Pre-pregnancy body mass index in relation to infant birth weight and offspring overweight\/obesity: a systematic review and meta-analysis","volume":"8","author":"Yu","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.envres.2026.124528_bib97","first-page":"635","article-title":"Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development","volume":"143","author":"Yuan","year":"2015","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib98","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s12864-020-6714-x","article-title":"DolphinNext: a distributed data processing platform for high throughput genomics","volume":"21","author":"Yukselen","year":"2020","journal-title":"BMC Genom."},{"issue":"5","key":"10.1016\/j.envres.2026.124528_bib99","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/mp.2016.136","article-title":"Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice","volume":"22","author":"Zhang","year":"2017","journal-title":"Mol. Psychiatr."},{"issue":"44","key":"10.1016\/j.envres.2026.124528_bib100","doi-asserted-by":"crossref","first-page":"99704","DOI":"10.1007\/s11356-023-29446-0","article-title":"Environmental exposure to per- and perfluoroalkyl substances in early pregnancy and newborn anogenital distance: a prospective cohort study","volume":"30","author":"Zhang","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envres.2026.124528_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107951","article-title":"Insight into the binding model of per- and polyfluoroalkyl substances to proteins and membranes","volume":"175","author":"Zhao","year":"2023","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.envres.2026.124528_bib102","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1186\/s12884-021-04069-w","article-title":"MicroRNA-513c-5p is involved in the pathogenesis of preeclampsia by regulating of low-density lipoprotein receptor-associated protein 6","volume":"21","author":"Zhou","year":"2021","journal-title":"BMC Pregnancy Childbirth"}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126008595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126008595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:51:53Z","timestamp":1783057913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935126008595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":102,"alternative-id":["S0013935126008595"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2026.124528","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multigenerational exposure to per- and polyfluoroalkyl substances (PFAS) negatively impacts the reproductive health of male mice","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2026.124528","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"124528"}}