{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T12:41:38Z","timestamp":1786279298425,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001273","name":"Children with Cancer UK","doi-asserted-by":"publisher","award":["19 - 311"],"award-info":[{"award-number":["19 - 311"]}],"id":[{"id":"10.13039\/501100001273","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.envres.2026.125159","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:18:41Z","timestamp":1783034321000},"page":"125159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Cord-blood black carbon particle burden is associated with a C19MC small extracellular vesicle miRNA signature enriched for neurodevelopmental pathways"],"prefix":"10.1016","volume":"306","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1544-4547","authenticated-orcid":false,"given":"Houman","family":"Kahroba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Vanbrabant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"van Herwijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Kamps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Waiblinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Ameloot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Plusquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Nawrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo M.","family":"de Kok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Krauskopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2026.125159_bib1","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1371\/journal.pgen.0030227","article-title":"Argonaute2 is essential for mammalian gastrulation and proper mesoderm formation","volume":"3","author":"Alisch","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.envres.2026.125159_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/ng1253","article-title":"Dicer is essential for mouse development","volume":"35","author":"Bernstein","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.envres.2026.125159_bib3","article-title":"Maternal exposure to ambient black carbon particles and their presence in maternal and fetal circulation and organs: an analysis of two independent population-based observational studies","volume":"6","author":"Bongaerts","year":"2022","journal-title":"Lancet. Planet. Heal."},{"key":"10.1016\/j.envres.2026.125159_bib4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.envres.2017.02.014","article-title":"Short-term particulate matter exposure induces extracellular vesicle release in overweight subjects","volume":"155","author":"Bonzini","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2026.125159_bib5","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1021\/acs.nanolett.6b00502","article-title":"Biocompatible label-free detection of carbon black particles by femtosecond pulsed laser microscopy","volume":"16","author":"Bov\u00e9","year":"2016","journal-title":"Nano Lett."},{"key":"10.1016\/j.envres.2026.125159_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11654-3","article-title":"Ambient black carbon particles reach the fetal side of human placenta","volume":"10","author":"Bov\u00e9","year":"2019","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.envres.2026.125159_bib7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3310\/nihropenres.13996.1","article-title":"Born and Bred in (BaBi): an efficient, place-based birth e-cohort network","author":"Bridges","year":"2025","journal-title":"NIHR Open Res."},{"key":"10.1016\/j.envres.2026.125159_bib8","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/08820139.2025.2450234","article-title":"MiR-519d-3p from placenta-derived exosomes induce immune intolerance regulating immune cells, contributing to the pathogenesis of Preeclampsia","volume":"54","author":"Cao","year":"2025","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.envres.2026.125159_bib9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.7150\/ntno.82939","article-title":"Combination of precipitation and size exclusion chromatography as an effective method for exosome like extracellular vesicle isolation from pericardial fluids","volume":"7","author":"Chandrasekera","year":"2023","journal-title":"Nanotheranostics"},{"key":"10.1016\/j.envres.2026.125159_bib10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/PPO.0b013e318258b60a","article-title":"The miR-17-92 family of microRNA clusters in development and disease","volume":"18","author":"Concepcion","year":"2012","journal-title":"Cancer J."},{"key":"10.1016\/j.envres.2026.125159_bib11","doi-asserted-by":"crossref","first-page":"244","DOI":"10.12688\/wellcomeopenres.18394.1","article-title":"Born in Bradford's Better Start (BiBBS) interventional birth cohort study: interim cohort profile","volume":"7","author":"Dickerson","year":"2022","journal-title":"Wellcome Open Res."},{"key":"10.1016\/j.envres.2026.125159_bib12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/molehr\/gas013","article-title":"The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes","volume":"18","author":"Donker","year":"2012","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.envres.2026.125159_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107502","article-title":"Extracellular vesicles and their miRNA contents counterbalance the pro-inflammatory effect of air pollution during physiological pregnancy: a focus on Syncytin-1 positive vesicles","volume":"169","author":"Ferrari","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2026.125159_bib14","volume":"10","author":"Foley","year":"2024"},{"key":"10.1016\/j.envres.2026.125159_bib15","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ajog.2016.03.001","article-title":"Placental origins of adverse pregnancy outcomes: potential molecular targets: an executive workshop summary of the Eunice Kennedy Shriver national institute of child health and human development","volume":"215","author":"Ilekis","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.envres.2026.125159_bib16","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1289\/ehp.1003369","article-title":"Black carbon as an additional indicator of the adverse health effects of airborne particles compared with PM10 and PM2.5","volume":"119","author":"Janssen","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2026.125159_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/s12916-023-03050-y","article-title":"Prenatal ambient air pollution exposure and child weight trajectories from the 3rd trimester of pregnancy to 2 years of age: a cohort study","volume":"21","author":"Ji","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.envres.2026.125159_bib18","article-title":"Exosomal miRNAs in prenatal diagnosis: recent advances","volume":"103","author":"Jin","year":"2024","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.envres.2026.125159_bib19","volume":"24","author":"Kahroba","year":"2025"},{"key":"10.1016\/j.envres.2026.125159_bib20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s13148-025-01997-8","article-title":"Distinct DNA methylation in mother-infant dyads exposed to PM2.5 in pregnancy","volume":"17","author":"Klibaner-Schiff","year":"2025","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.envres.2026.125159_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.envres.2026.125159_bib22","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ydbio.2007.08.007","article-title":"Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells","volume":"310","author":"Lu","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.envres.2026.125159_bib23","doi-asserted-by":"crossref","first-page":"10797","DOI":"10.1073\/pnas.1605941113","article-title":"Magnetite pollution nanoparticles in the human brain","volume":"113","author":"Maher","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envres.2026.125159_bib24","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3389\/fgene.2018.00706","article-title":"Imprinted MicroRNA gene clusters in the evolution, development, and functions of Mammalian placenta","volume":"9","author":"Malnou","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.envres.2026.125159_bib25","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/s42003-025-08923-x","article-title":"The Chromosome 19 miRNA cluster guards trophoblasts against overacting innate immunity","volume":"8","author":"Mouillet","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.envres.2026.125159_bib26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3389\/fimmu.2017.00763","article-title":"The toxicological mechanisms of environmental soot (black carbon) and carbon black: focus on Oxidative stress and inflammatory pathways","volume":"8","author":"Niranjan","year":"2017","journal-title":"Front. Immunol."},{"issue":"Suppl. l","key":"10.1016\/j.envres.2026.125159_bib27","first-page":"S69","article-title":"Placenta-specific microRNAs in exosomes \u2013 good things come in nano-packages","volume":"35","author":"Ouyang","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.envres.2026.125159_bib28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12989-017-0214-4","article-title":"Extracellular vesicle-packaged miRNA release after short-term exposure to particulate matter is associated with increased coagulation","volume":"14","author":"Pergoli","year":"2017","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envres.2026.125159_bib29","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1080\/10473289.2006.10464485","article-title":"Health effects of fine particulate air pollution: lines that connect","volume":"56","author":"Pope","year":"2006","journal-title":"J. Air Waste Manag. Assoc."},{"key":"10.1016\/j.envres.2026.125159_bib30","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1038\/s41467-021-25211-4","article-title":"A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration","volume":"12","author":"Raso","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2026.125159_bib31","doi-asserted-by":"crossref","DOI":"10.1186\/s12989-016-0121-0","article-title":"Ambient particulate matter and {microRNAs} in extracellular vesicles: a pilot study of older individuals","volume":"13","author":"Rodosthenous","year":"2015","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envres.2026.125159_bib32","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1164\/rccm.201704-0797OC","article-title":"Children's urinary environmental carbon load: a novel marker reflecting residential ambient air pollution exposure?","volume":"196","author":"Saenen","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.envres.2026.125159_bib33","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cub.2009.12.044","article-title":"MicroRNA function is globally suppressed in mouse oocytes and early embryos","volume":"20","author":"Suh","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.envres.2026.125159_bib34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/15592294.2016.1155012","article-title":"Air pollution-induced placental epigenetic alterations in early life: a candidate miRNA approach","volume":"13","author":"Tsamou","year":"2018","journal-title":"Epigenetics"},{"key":"10.1016\/j.envres.2026.125159_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105860","article-title":"Prenatal particulate air pollution exposure and expression of the miR-17\/92 cluster in cord blood: findings from the ENVIRONAGE birth cohort","volume":"142","author":"Tsamou","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2026.125159_bib36","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1055\/s-0033-1361832","article-title":"Altered expression of miR-518b and miR-519a in the placenta is associated with low fetal birth weight","volume":"31","author":"Wang","year":"2014","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.envres.2026.125159_bib39","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.3390\/cancers15133446","article-title":"Systematic assessment of small RNA profiling in human extracellular vesicles","volume":"15","author":"Wang","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.envres.2026.125159_bib37","article-title":"Trophoblasts modulate the Ca2+ oscillation and contraction of myometrial smooth muscle cells by small extracellular Vesicle- (sEV-) mediated exporting of miR-25-3p during premature labor","volume":"2021","author":"Wang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.envres.2026.125159_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156747","article-title":"Prenatal fine particulate matter exposure associated with placental small extracellular vesicle derived microRNA and child neurodevelopmental delays","volume":"841","author":"Wang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2026.125159_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.envres.2026.125159_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.536913","article-title":"miR-433 inhibits neuronal growth and promotes autophagy in Mouse Hippocampal HT-22 cell line","volume":"11","author":"Xu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.envres.2026.125159_bib42","volume":"9","author":"Xu","year":"2021"}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126014908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126014908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T12:06:35Z","timestamp":1786277195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935126014908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":42,"alternative-id":["S0013935126014908"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2026.125159","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cord-blood black carbon particle burden is associated with a C19MC small extracellular vesicle miRNA signature enriched for neurodevelopmental pathways","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2026.125159","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"125159"}}