{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:04:19Z","timestamp":1790863459242,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021743","name":"Reseau canadien de recherche respiratoire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021743","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.envres.2026.125625","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:56:45Z","timestamp":1789052205000},"page":"125625","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Concordant transcriptomics analysis of the lungs and blood after exposure to diesel exhaust: A randomized, controlled human exposure study"],"prefix":"10.1016","volume":"308","author":[{"given":"Michael","family":"Yoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hyung","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher F.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Huff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2455-6575","authenticated-orcid":false,"given":"Christopher","family":"Carlsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2026.125625_bib1","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0112-2021","article-title":"Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD","volume":"31","author":"Aghapour","year":"2022","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.envres.2026.125625_bib2","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00239-2023","article-title":"Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary","volume":"61","author":"Agust\u00ed","year":"2023","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.envres.2026.125625_bib3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1183\/09031936.06.00136904","article-title":"Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans","volume":"27","author":"Behndig","year":"2006","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.envres.2026.125625_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.opresp.2022.100229","article-title":"Impact of air pollution on asthma: a scoping review","volume":"5","author":"Bronte-Moreno","year":"2023","journal-title":"Open Respir Arch"},{"key":"10.1016\/j.envres.2026.125625_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-98729-8","article-title":"The effect of air pollution on the transcriptomics of the immune response to respiratory infection","volume":"11","author":"Croft","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2026.125625_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.775507","article-title":"The cross talk between p53 and mTOR pathways in response to physiological and genotoxic stresses","volume":"9","author":"Cui","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.envres.2026.125625_bib7","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.1038\/s41598-021-86002-x","article-title":"Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway","volume":"11","author":"Daamen","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2026.125625_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101545","article-title":"Oxidative stress pathways of air pollution mediated toxicity: recent insights","volume":"34","author":"Gangwar","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.envres.2026.125625_bib10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41592-023-02166-6","article-title":"Challenges and perspectives in computational deconvolution of genomics data","volume":"21","author":"Garmire","year":"2024","journal-title":"Nat. Methods"},{"key":"10.1016\/j.envres.2026.125625_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118566","article-title":"Woodsmoke and diesel exhaust: distinct transcriptomic profiles in the human airway epithelium","volume":"302","author":"Huff","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envres.2026.125625_bib11","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.jaci.2019.04.012","article-title":"An update on immunologic mechanisms in the respiratory mucosa in response to air pollutants","volume":"143","author":"Huff","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.envres.2026.125625_bib13","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/(SICI)1097-0258(19960715)15:13<1421::AID-SIM266>3.0.CO;2-H","article-title":"An index for assessing blindness in a multi-centre clinical trial: disulfiram for alcohol cessation--a VA cooperative study","volume":"15","author":"James","year":"1996","journal-title":"Stat. Med."},{"key":"10.1016\/j.envres.2026.125625_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1324552","article-title":"Impact of particulate air pollution on airway injury and epithelial plasticity; underlying mechanisms","volume":"15","author":"Kayalar","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envres.2026.125625_bib15","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1289\/ehp.1408224","article-title":"Air pollution from road traffic and systemic inflammation in adults: a cross-sectional analysis in the European ESCAPE project","volume":"123","author":"Lanki","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2026.125625_bib16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.7555\/JBR.31.20160071","article-title":"Effect of exposure to ambient PM2.5 pollution on the risk of respiratory tract diseases: a meta-analysis of cohort studies","volume":"31","author":"Liu","year":"2017","journal-title":"J Biomed Res"},{"key":"10.1016\/j.envres.2026.125625_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12989-022-00454-1","article-title":"Controlled human exposure to diesel exhaust: a method for understanding health effects of traffic-related air pollution","volume":"19","author":"Long","year":"2022","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envres.2026.125625_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-39921-w","article-title":"Particulate matter impairs immune system function by up-regulating inflammatory pathways and decreasing pathogen response gene expression","volume":"13","author":"Mar\u00edn-Palma","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2026.125625_bib19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.envres.2026.125625_bib20","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","article-title":"Determining cell type abundance and expression from bulk tissues with digital cytometry","volume":"37","author":"Newman","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.envres.2026.125625_bib21","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.3390\/antiox11122345","article-title":"Nrf2 and oxidative stress: a general overview of mechanisms and implications in human disease","volume":"11","author":"Ngo","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.envres.2026.125625_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.envres.2017.03.024","article-title":"PM2.5 exposure in highly polluted cities: a case study from New Delhi, India","volume":"156","author":"Pant","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2026.125625_bib23","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1021\/acs.chemrestox.0c00007","article-title":"Particulate matter toxicity is Nrf2 and mitochondria dependent: the roles of metals and polycyclic aromatic hydrocarbons","volume":"33","author":"Pardo","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envres.2026.125625_bib24","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.116.309279","article-title":"Exposure to fine particulate air pollution is associated with endothelial injury and systemic inflammation","volume":"119","author":"Pope","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.envres.2026.125625_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001802","article-title":"Validity of the common cold questionnaire (CCQ) in asthma exacerbations","volume":"3","author":"Powell","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2026.125625_bib26","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1289\/ehp.0800437","article-title":"Effects of ambient air pollution on hemostasis and inflammation","volume":"117","author":"Rude\u017e","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2026.125625_bib27","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1164\/rccm.202104-1079OC","article-title":"Impact of exposure to diesel exhaust on inflammation markers and proteases in former smokers with chronic obstructive pulmonary disease: a randomized, double-blinded, crossover study","volume":"205","author":"Ryu","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.envres.2026.125625_bib28","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1038\/s41591-023-02327-2","article-title":"An integrated cell atlas of the lung in health and disease","volume":"29","author":"Sikkema","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.envres.2026.125625_bib29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/oemed-2016-104197","article-title":"Diesel exhaust causes lung cancer \u2013 now what?","volume":"74","author":"Silverman","year":"2017","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.envres.2026.125625_bib30","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.3390\/ijerph19127511","article-title":"Recent insights into particulate matter (PM2.5)-mediated toxicity in humans: an overview","volume":"19","author":"Thangavel","year":"2022","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envres.2026.125625_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107491","article-title":"Impact of long-term exposure to PM2.5 on peripheral blood gene expression pathways involved in cell signaling and immune response","volume":"168","author":"Vlaanderen","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2026.125625_bib32","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1289\/EHP370","article-title":"Sex-specific associations between particulate matter exposure and gene expression in independent discovery and validation cohorts of middle-aged men and women","volume":"125","author":"Vrijens","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2026.125625_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129031","article-title":"Cardiovascular effects of traffic-related air pollution: a multi-omics analysis from a randomized, crossover trial","volume":"435","author":"Zhang","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envres.2026.125625_bib34","article-title":"Transcriptomic analyses of the biological effects of airborne PM2.5 exposure on human bronchial epithelial cells","volume":"10","author":"Zhou","year":"2015","journal-title":"PLoS One"}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126019560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126019560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:38:17Z","timestamp":1790861897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935126019560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":33,"alternative-id":["S0013935126019560"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2026.125625","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Concordant transcriptomics analysis of the lungs and blood after exposure to diesel exhaust: A randomized, controlled human exposure study","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2026.125625","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"125625"}}