{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:57:48Z","timestamp":1792616268331,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004894","name":"E-institutes","doi-asserted-by":"publisher","award":["2023ZKZD52"],"award-info":[{"award-number":["2023ZKZD52"]}],"id":[{"id":"10.13039\/501100004894","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2024YFD2402203"],"award-info":[{"award-number":["2024YFD2402203"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42176144"],"award-info":[{"award-number":["42176144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013159","name":"Technology Foundation for Selected Overseas Scholar Ministry of Human Resources and Social Security","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013159","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["26HB2702900"],"award-info":[{"award-number":["26HB2702900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["26HB2702300"],"award-info":[{"award-number":["26HB2702300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["26HB2704500"],"award-info":[{"award-number":["26HB2704500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005952","name":"Ministry of Human Resources and Social Security","doi-asserted-by":"publisher","award":["110000254220258010"],"award-info":[{"award-number":["110000254220258010"]}],"id":[{"id":"10.13039\/501100005952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005952","name":"Ministry of Human Resources and Social Security","doi-asserted-by":"publisher","award":["110000254220258012"],"award-info":[{"award-number":["110000254220258012"]}],"id":[{"id":"10.13039\/501100005952","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.envres.2026.125832","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:57:38Z","timestamp":1791356258000},"page":"125832","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Multi-level toxicity of 6PPD-Q and TiO2 nanoparticles in Mytilus coruscus: Links among neurochemical, circadian and metabolic responses"],"prefix":"10.1016","volume":"309","author":[{"given":"Mansoor","family":"Khalid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bole","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanza","family":"Gul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Faisal","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-5172","authenticated-orcid":false,"given":"Jae-Seong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-3090","authenticated-orcid":false,"given":"Christian","family":"Bock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sendra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Sub","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoseop","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youji","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.envres.2026.125832_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/toxics13110968","article-title":"Genotoxic and toxicopathological responses to Ethylparaben in plants: potential impacts to crop yields","volume":"13","author":"Almeida","year":"2025","journal-title":"Toxics"},{"issue":"4","key":"10.1016\/j.envres.2026.125832_bib2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.cbpa.2006.02.040","article-title":"Oxidative stress in Perna perna and other bivalves as indicators of environmental stress in the Brazilian marine environment: antioxidants, lipid peroxidation and DNA damage. Comparative biochemistry and physiology. Part A","volume":"146","author":"Alves de Almeida","year":"2007","journal-title":"Molecular & integrative physiology"},{"issue":"2","key":"10.1016\/j.envres.2026.125832_bib3","doi-asserted-by":"crossref","first-page":"R911","DOI":"10.1152\/ajpregu.00124.2007","article-title":"Behavioral, metabolic, and molecular stress responses of marine bivalve Mytilus galloprovincialis during long-term acclimation at increasing ambient temperature","volume":"293","author":"Anestis","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.envres.2026.125832_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2019.02.006","article-title":"In vivo immunomodulatory and antioxidant properties of nanoceria (nCeO2) in the marine mussel Mytilus galloprovincialis","volume":"219","author":"Auguste","year":"2019","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.envres.2026.125832_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.scitotenv.2019.03.133","article-title":"Exposure to TiO2 nanoparticles induces shifts in the microbiota composition of Mytilus galloprovincialis hemolymph","volume":"670","author":"Auguste","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"8","key":"10.1016\/j.envres.2026.125832_bib6","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1080\/15376516.2017.1337258","article-title":"Histopathology and analyses of inflammation intensity in the gills of mussels exposed to silver nanoparticles: role of nanoparticle size, exposure time, and uptake pathways","volume":"27","author":"Bouallegui","year":"2017","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.envres.2026.125832_bib7","first-page":"89","volume":"vol. 8","author":"Canesi","year":"2017"},{"issue":"7","key":"10.1016\/j.envres.2026.125832_bib8","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1021\/acs.est.1c07376","article-title":"New evidence of rubber-derived quinones in water, air, and soil","volume":"56","author":"Cao","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"Pt 1","key":"10.1016\/j.envres.2026.125832_bib9","article-title":"nTiO(2) alleviates the toxic effects of TCPP on mussels by adjusting respiratory metabolism and gut microbiota","volume":"851","author":"Deng","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.envres.2026.125832_bib10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.envres.2026.125832_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3354\/meps09062","article-title":"Physiological energetics of juvenile clams Ruditapes decussatus in a high CO2 coastal ocean","volume":"433","author":"Fern\u00e1ndez-Reiriz","year":"2011","journal-title":"Mar. Ecol. Prog. Ser."},{"issue":"12","key":"10.1016\/j.envres.2026.125832_bib12","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1002\/etc.5487","article-title":"Acute toxicity testing of the tire rubber-derived chemical 6PPD-quinone on Atlantic salmon (Salmo salar) and brown trout (Salmo trutta)","volume":"41","author":"Foldvik","year":"2022","journal-title":"Environ. Toxicol. Chem."},{"issue":"10","key":"10.1016\/j.envres.2026.125832_bib13","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1021\/acs.est.6b05279","article-title":"Assessing the risk of engineered nanomaterials in the environment: development and application of the nanoFate model","volume":"51","author":"Garner","year":"2017","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.envres.2026.125832_bib14","article-title":"CO2-induced pH reduction increases physiological toxicity of nano-TiO2 in the mussel Mytilus coruscus","volume":"7","author":"Hu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2026.125832_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.marenvres.2018.02.029","article-title":"Oxidative stress induced by titanium dioxide nanoparticles increases under seawater acidification in the thick shell mussel Mytilus coruscus","volume":"137","author":"Huang","year":"2018","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.envres.2026.125832_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134107","article-title":"Physiological response of mussel to rayon microfibers and PCB's exposure: overlooked semi-synthetic micropollutant?","volume":"470","author":"Jiang","year":"2024","journal-title":"J. Hazard Mater."},{"issue":"6","key":"10.1016\/j.envres.2026.125832_bib17","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1007\/s11051-013-1692-4","article-title":"Global life cycle releases of engineered nanomaterials","volume":"15","author":"Keller","year":"2013","journal-title":"J. Nanoparticle Res."},{"issue":"Pt 8","key":"10.1016\/j.envres.2026.125832_bib18","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1242\/jeb.205.8.1153","article-title":"Changes in metabolic rate and N excretion in the marine invertebrate Sipunculus nudus under conditions of environmental hypercapnia: identifying effective acid-base variables","volume":"205","author":"Langenbuch","year":"2002","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.envres.2026.125832_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/321213","article-title":"Acetylcholinesterase as a biomarker in environmental and occupational medicine: new insights and future perspectives","author":"Lionetto","year":"2013","journal-title":"BioMed Res. Int."},{"issue":"1","key":"10.1016\/j.envres.2026.125832_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.aquatox.2010.10.006","article-title":"Environmentally induced oxidative stress in aquatic animals","volume":"101","author":"Lushchak","year":"2011","journal-title":"Aquat. Toxicol."},{"issue":"10","key":"10.1016\/j.envres.2026.125832_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11102009","article-title":"Combined effects of temperature and salinity affect the Surviv-Al of Asian green mussel (Perna viridis) through digestive and antioxidant performance","volume":"11","author":"Ma","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.envres.2026.125832_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110188","article-title":"The underrated immune role of bivalve \u2018serous cells\u2019: new insight from inflammatory responses of the Manila clam Ruditapes philippinarum","volume":"159","author":"Matozzo","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.envres.2026.125832_bib23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3354\/meps045289","article-title":"O:N atomic ratio as a tool to describe zooplankton metabolism","volume":"45","author":"Mayzaud","year":"1988","journal-title":"Mar. Ecol. Prog. Ser."},{"issue":"3","key":"10.1016\/j.envres.2026.125832_bib24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4161\/auto.2663","article-title":"Lysosomal and autophagic reactions as predictive indicators of environmental impact in aquatic animals","volume":"2","author":"Moore","year":"2006","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.envres.2026.125832_bib25","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12917-024-04131-7","article-title":"Overview on the role of dietary Spirulina platensis on immune responses against Edwardsiellosis among Oreochromis niloticus fish farms","volume":"20","author":"Okasha","year":"2024","journal-title":"BMC Vet. Res."},{"issue":"4","key":"10.1016\/j.envres.2026.125832_bib26","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1021\/acs.est.1c07451","article-title":"Concentrations of tire additive chemicals and tire road wear particles in an Australian urban tributary","volume":"56","author":"Rauert","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2026.125832_bib27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.marenvres.2013.07.006","article-title":"Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms","volume":"93","author":"Regoli","year":"2014","journal-title":"Mar. Environ. Res."},{"issue":"1","key":"10.1016\/j.envres.2026.125832_bib28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.fsi.2015.03.038","article-title":"The complexity of apoptotic cell death in mollusks: an update","volume":"46","author":"Romero","year":"2015","journal-title":"Fish Shellfish Immunol."},{"issue":"8\u20139","key":"10.1016\/j.envres.2026.125832_bib29","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0145-305X(01)00032-5","article-title":"Cytokines and innate immunity of fish","volume":"25","author":"Secombes","year":"2001","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.envres.2026.125832_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103352","article-title":"Immune status of Oreochromis niloticus subjected to long-term lead nitrate exposure and a Arthrospira platensis treatment trial","volume":"76","author":"Sherif","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.envres.2026.125832_bib31","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/etc.4055","article-title":"Applicability of the fish embryo acute toxicity (FET) test (OECD 236) in the regulatory context of registration, evaluation, authorisation, and restriction of chemicals (REACH)","volume":"37","author":"Sobanska","year":"2018","journal-title":"Environ. Toxicol. Chem."},{"issue":"4","key":"10.1016\/j.envres.2026.125832_bib32","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/icb\/ict028","article-title":"Energy-limited tolerance to stress as a conceptual framework to integrate the effects of multiple stressors","volume":"53","author":"Sokolova","year":"2013","journal-title":"Integr. Comp. Biol."},{"issue":"1","key":"10.1016\/j.envres.2026.125832_bib33","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1186\/s11671-015-1042-9","article-title":"A review on potential neurotoxicity of titanium dioxide nanoparticles","volume":"10","author":"Song","year":"2015","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.envres.2026.125832_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2025.107251","article-title":"Perfluorooctanoate and nano-titanium dioxide modulate male gonadal function in the mussel Mytilus coruscus","volume":"279","author":"Sun","year":"2025","journal-title":"Aquat. Toxicol."},{"issue":"7","key":"10.1016\/j.envres.2026.125832_bib35","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1021\/acs.est.1c06735","article-title":"Circadian rhythm and neurotransmitters are potential pathways through which Ocean acidification and warming affect the metabolism of thick-shell mussels","volume":"56","author":"Tang","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"6525","key":"10.1016\/j.envres.2026.125832_bib36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1126\/science.abd6951","article-title":"A ubiquitous tire rubber-derived chemical induces acute mortality in coho salmon","volume":"371","author":"Tian","year":"2021","journal-title":"Science (New York, N.Y.)"},{"issue":"10","key":"10.1016\/j.envres.2026.125832_bib37","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/nm.2214","article-title":"Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis","volume":"16","author":"Zhang","year":"2010","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.envres.2026.125832_bib38","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1021\/envhealth.5c00035","article-title":"Aging enhances the ecotoxicological effects of biobased microplastic Poly(Lactic acid) and its adsorbed Tris(1-chloro-2-propyl)phosphate on mussels","volume":"3","author":"Zhong","year":"2025","journal-title":"Environ. Health (Lond.)"}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126021638?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126021638?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:31:44Z","timestamp":1792614704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935126021638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":38,"alternative-id":["S0013935126021638"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2026.125832","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-level toxicity of 6PPD-Q and TiO2 nanoparticles in Mytilus coruscus: Links among neurochemical, circadian and metabolic responses","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2026.125832","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125832"}}