{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:56:18Z","timestamp":1792616178705,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22193051"],"award-info":[{"award-number":["22193051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42394091"],"award-info":[{"award-number":["42394091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22425606"],"award-info":[{"award-number":["22425606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42277208"],"award-info":[{"award-number":["42277208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB0750200"],"award-info":[{"award-number":["XDB0750200"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M781174"],"award-info":[{"award-number":["2025M781174"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.envres.2026.125854","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:16:06Z","timestamp":1791123366000},"page":"125854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["From population to individual: Bulk and single-cell analysis reveal Fe bioavailability, limitation thresholds, and biological responses for marine diatom Chaetoceros debilis"],"prefix":"10.1016","volume":"309","author":[{"given":"Xiangwei","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longjie","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7287-8598","authenticated-orcid":false,"given":"Yongguang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guibin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.envres.2026.125854_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3109\/07388551.2015.1128876","article-title":"Flow cytometry: basic principles and applications","volume":"37","author":"Adan","year":"2017","journal-title":"Crit. Rev. Biotechnol."},{"issue":"5693","key":"10.1016\/j.envres.2026.125854_bib2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1126\/science.1101156","article-title":"The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism","volume":"306","author":"Armbrust","year":"2004","journal-title":"Science"},{"issue":"51","key":"10.1016\/j.envres.2026.125854_bib3","doi-asserted-by":"crossref","first-page":"20633","DOI":"10.1073\/pnas.1309345110","article-title":"Thick-shelled, grazer-protected diatoms decouple ocean carbon and silicon cycles in the iron-limited Antarctic circumpolar current","volume":"110","author":"Assmy","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.envres.2026.125854_bib4","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.5194\/os-15-1159-2019","article-title":"CO2 effects on diatoms: a synthesis of more than a decade of ocean acidification experiments with natural communities","volume":"15","author":"Bach","year":"2019","journal-title":"Ocean Sci."},{"issue":"4","key":"10.1016\/j.envres.2026.125854_bib5","doi-asserted-by":"crossref","first-page":"973","DOI":"10.5194\/os-19-973-2023","article-title":"Global variability of high-nutrient low-chlorophyll regions using neural networks and wavelet coherence analysis","volume":"19","author":"Basterretxea","year":"2023","journal-title":"Ocean Sci."},{"issue":"6805","key":"10.1016\/j.envres.2026.125854_bib6","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/35037500","article-title":"A mesoscale phytoplankton bloom in the polar Southern Ocean stimulated by iron fertilization","volume":"407","author":"Boyd","year":"2000","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.envres.2026.125854_bib7","first-page":"255","article-title":"ICP-MS-based methodology in metallomics: towards single particle analysis, single cell analysis, and spatial metallomics","volume":"43","author":"Chang","year":"2022","journal-title":"At. Spectrosc."},{"issue":"6","key":"10.1016\/j.envres.2026.125854_bib8","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1111\/tpj.15643","article-title":"Precise estimation of chlorophyll a, b, and carotenoid content by deconvolution of the absorption spectrum and new simultaneous equations for Chl determination","volume":"109","author":"Chazaux","year":"2022","journal-title":"Plant J."},{"key":"10.1016\/j.envres.2026.125854_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.339389","article-title":"Dual-elemental analysis of single particles using quadrupole-based inductively coupled plasma-mass spectrometry","volume":"1192","author":"Chun","year":"2022","journal-title":"Anal. Chim. Acta"},{"issue":"5","key":"10.1016\/j.envres.2026.125854_bib10","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1021\/acs.est.5c13719","article-title":"Revealing single-cell heterogeneity of labile Cu(I) accumulation and metabolism in microalgae by image-enabled flow cytometry","volume":"60","author":"Deng","year":"2026","journal-title":"Environ. Sci. Technol."},{"issue":"5374","key":"10.1016\/j.envres.2026.125854_bib11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.281.5374.237","article-title":"Primary production of the biosphere: integrating terrestrial and oceanic components","volume":"281","author":"Field","year":"1998","journal-title":"Science"},{"issue":"19","key":"10.1016\/j.envres.2026.125854_bib12","doi-asserted-by":"crossref","first-page":"13719","DOI":"10.1021\/acs.est.2c03130","article-title":"Targeting metal impurities for the detection and quantification of carbon black particles in water via spICP-MS","volume":"56","author":"Flores","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"14","key":"10.1016\/j.envres.2026.125854_bib13","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1128\/AEM.00487-13","article-title":"Use of agent-based modeling to explore the mechanisms of intracellular phosphorus heterogeneity in cultured phytoplankton","volume":"79","author":"Fredrick","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.envres.2026.125854_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fmicb.2012.00069","article-title":"The organic complexation of iron in the marine environment: a review","volume":"3","author":"Gledhill","year":"2012","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.envres.2026.125854_bib15","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s10811-018-1462-x","article-title":"Effect of biodegradable chelating ligands on Fe uptake in and growth of marine microalgae","volume":"30","author":"Hasegawa","year":"2018","journal-title":"J. Appl. Phycol."},{"issue":"10","key":"10.1016\/j.envres.2026.125854_bib16","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.5194\/bg-6-2281-2009","article-title":"Bioavailability of organically bound Fe to model phytoplankton of the Southern Ocean","volume":"6","author":"Hassler","year":"2009","journal-title":"Biogeosciences"},{"key":"10.1016\/j.envres.2026.125854_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.gca.2015.02.032","article-title":"Formation, stability, and solubility of metal oxide nanoparticles: surface entropy, enthalpy, and free energy of ferrihydrite","volume":"158","author":"Hiemstra","year":"2015","journal-title":"Geochem. Cosmochim. Acta"},{"issue":"6072","key":"10.1016\/j.envres.2026.125854_bib18","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1126\/science.1208277","article-title":"The geological record of ocean acidification","volume":"335","author":"H\u00f6nisch","year":"2012","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.envres.2026.125854_bib19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1071\/EN07012","article-title":"Iron-binding ligands and their role in the ocean biogeochemistry of iron","volume":"4","author":"Hunter","year":"2007","journal-title":"Environ. Chem."},{"issue":"D7","key":"10.1016\/j.envres.2026.125854_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1029\/2004JD005220","article-title":"Studying ocean acidification with conservative, stable numerical schemes for nonequilibrium air-ocean exchange and ocean equilibrium chemistry","volume":"110","author":"Jacobson","year":"2005","journal-title":"J. Geophys. Res. Atmos."},{"key":"10.1016\/j.envres.2026.125854_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55039-4","article-title":"Surface ocean pH and buffer capacity: past, present and future","volume":"9","author":"Jiang","year":"2019","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.envres.2026.125854_bib22","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41579-020-00502-7","article-title":"An evolving view on biogeochemical cycling of iron","volume":"19","author":"Kappler","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"issue":"18","key":"10.1016\/j.envres.2026.125854_bib23","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1021\/es971073u","article-title":"Removal of trivalent and hexavalent chromium by seaweed biosorbent","volume":"32","author":"Kratochvil","year":"1998","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2026.125854_bib24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.talanta.2018.05.071","article-title":"Determination of iron in seawater: from the laboratory to measurements","volume":"188","author":"Lin","year":"2018","journal-title":"Talanta"},{"issue":"4","key":"10.1016\/j.envres.2026.125854_bib25","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/ismej.2014.199","article-title":"Iron bioavailability to phytoplankton: an empirical approach","volume":"9","author":"Lis","year":"2015","journal-title":"ISME J."},{"issue":"19","key":"10.1016\/j.envres.2026.125854_bib26","doi-asserted-by":"crossref","first-page":"7358","DOI":"10.1021\/acs.est.2c08838","article-title":"Exogenous metals atlas in spermatozoa at single-cell resolution in relation to human semen quality","volume":"57","author":"Liu","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2026.125854_bib27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.aca.2019.02.042","article-title":"Quantifying silver nanoparticle association and elemental content in single cells using dual mass mode in quadrupole-based inductively coupled plasma-mass spectrometry","volume":"1061","author":"Lum","year":"2019","journal-title":"Anal. Chim. Acta"},{"issue":"4","key":"10.1016\/j.envres.2026.125854_bib28","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.4319\/lo.2006.51.4.1729","article-title":"Copper-dependent iron transport in coastal and oceanic diatoms","volume":"51","author":"Maldonado","year":"2006","journal-title":"Limnol. Oceanogr."},{"issue":"8","key":"10.1016\/j.envres.2026.125854_bib29","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.4319\/lo.1991.36.8.1793","article-title":"The case for iron","volume":"36","author":"Martin","year":"1991","journal-title":"Limnol. Oceanogr."},{"issue":"3","key":"10.1016\/j.envres.2026.125854_bib30","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1472-4669.2008.00144.x","article-title":"The co-evolution of phytoplankton and trace element cycles in the oceans","volume":"6","author":"Morel","year":"2008","journal-title":"Geobiology"},{"issue":"1","key":"10.1016\/j.envres.2026.125854_bib31","doi-asserted-by":"crossref","first-page":"400","DOI":"10.4319\/lo.2008.53.1.0400","article-title":"The role of unchelated Fe in the iron nutrition of phytoplankton","volume":"53","author":"Morel","year":"2008","journal-title":"Limnol. Oceanogr."},{"issue":"16","key":"10.1016\/j.envres.2026.125854_bib32","doi-asserted-by":"crossref","first-page":"6095","DOI":"10.1021\/es100906z","article-title":"Fe Isotope fractionation during equilibration of Fe-organic complexes","volume":"44","author":"Morgan","year":"2010","journal-title":"Environ. Sci. Technol."},{"issue":"4","key":"10.1016\/j.envres.2026.125854_bib33","doi-asserted-by":"crossref","first-page":"964","DOI":"10.3390\/en13040964","article-title":"Heuristic optimization of culture conditions for stimulating hyper-accumulation of biomass and lipid in Golenkinia SDEC-16","volume":"13","author":"Nie","year":"2020","journal-title":"Energies"},{"issue":"5","key":"10.1016\/j.envres.2026.125854_bib34","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.4319\/lo.2004.49.5.1774","article-title":"A role for manganese in superoxide dismutases and growth of iron-deficient diatoms","volume":"49","author":"Peers","year":"2004","journal-title":"Limnol. Oceanogr."},{"issue":"5","key":"10.1016\/j.envres.2026.125854_bib35","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1529-8817.2009.00732.x","article-title":"Different physiological responses of four marine synechococcus strains (cyanophyceae) to nickel starvation under iron-replete and iron-deplete conditions","volume":"45","author":"Qiu","year":"2009","journal-title":"J. Phycol."},{"issue":"1\u20132","key":"10.1016\/j.envres.2026.125854_bib36","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.marpolbul.2017.05.018","article-title":"Effects of ocean acidification on the physiological performance and carbon production of the Antarctic sea ice diatom Nitzschia sp. ICE-H","volume":"120","author":"Qu","year":"2017","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.envres.2026.125854_bib37","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s11099-015-0095-4","article-title":"A marine phytoplankton Prymnesium parvum upregulates the component proteins of photosystem II under iron stress","volume":"53","author":"Rahman","year":"2015","journal-title":"Photosynthetica"},{"issue":"3","key":"10.1016\/j.envres.2026.125854_bib38","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4319\/lo.1988.33.3.0352","article-title":"Manganese oxidation in pH and O2 microenvironments produced by phytoplankton","volume":"33","author":"Richardson","year":"1988","journal-title":"Limnol. Oceanogr."},{"issue":"3","key":"10.1016\/j.envres.2026.125854_bib39","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1574-6941.1995.tb00282.x","article-title":"Phytoplankton cell size and the development of microenvironments","volume":"16","author":"Richardson","year":"1995","journal-title":"FEMS Microbiol. Ecol."},{"issue":"82","key":"10.1016\/j.envres.2026.125854_bib40","article-title":"Effects of trace metal concentrations on the growth of the coral endosymbiont Symbiodinium kawagutii","volume":"7","author":"Rodriguez","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envres.2026.125854_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.119380","article-title":"Element composition of several marine macrophytes (Crimea, Black Sea) and correlations with the element abundances in sediments and seawater","volume":"257","author":"Ryabushko","year":"2024","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.envres.2026.125854_bib42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/acsmeasuresciau.3c00052","article-title":"Nanoscale luminescence imaging\/detection of single particles: state-of-the-art and future prospects","volume":"4","author":"Saqib","year":"2023","journal-title":"ACS Meas. Sci. Au"},{"issue":"7","key":"10.1016\/j.envres.2026.125854_bib43","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.dsr.2009.03.003","article-title":"Plankton copper requirements and uptake in the subarctic Northeast Pacific Ocean","volume":"56","author":"Semeniuk","year":"2009","journal-title":"Deep-Sea Res., Part A I"},{"issue":"8","key":"10.1016\/j.envres.2026.125854_bib70","doi-asserted-by":"crossref","DOI":"10.1029\/2021GB006979","article-title":"Probing the Bioavailability of Dissolved Iron to Marine Eukaryotic Phytoplankton Using In Situ Single Cell Iron Quotas","volume":"35","author":"Shaked","year":"2021","journal-title":"Global Biogeochem. Cycles"},{"issue":"3","key":"10.1016\/j.envres.2026.125854_bib44","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/jpy.12855","article-title":"The physiological response of marine diatoms to ocean acidification: differential roles of seawater pCO2 and pH","volume":"55","author":"Shi","year":"2019","journal-title":"J. Phycol."},{"issue":"5966","key":"10.1016\/j.envres.2026.125854_bib45","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1126\/science.1183517","article-title":"Effect of ocean acidification on iron availability to marine phytoplankton","volume":"327","author":"Shi","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.envres.2026.125854_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.algal.2019.101651","article-title":"Phosphorus starvation and luxury uptake in green microalgae revisited","volume":"43","author":"Solovchenko","year":"2019","journal-title":"Algal Res."},{"issue":"7009","key":"10.1016\/j.envres.2026.125854_bib47","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nature02954","article-title":"Photosynthetic architecture differs in coastal and oceanic diatoms","volume":"431","author":"Strzepek","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.envres.2026.125854_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemgeo.2024.122448","article-title":"Long-term interaction of metals and phosphate with ferrihydrite in artificial seawater and implications for past and present environments","volume":"670","author":"Sugiyama","year":"2024","journal-title":"Chem. Geol."},{"key":"10.1016\/j.envres.2026.125854_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110592","article-title":"Iron availability is a key factor for freshwater cyanobacterial survival against saline stress","volume":"194","author":"Sun","year":"2021","journal-title":"Environ. Res."},{"issue":"1\u20132","key":"10.1016\/j.envres.2026.125854_bib50","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0304-4203(03)00101-4","article-title":"Effect of pH, light, and temperature on Fe-EDTA chelation and Fe hydrolysis in seawater","volume":"84","author":"Sunda","year":"2003","journal-title":"Mar. Chem."},{"key":"10.1016\/j.envres.2026.125854_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.566691","article-title":"Iron uptake mechanisms in marine phytoplankton","volume":"11","author":"Sutak","year":"2020","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.envres.2026.125854_bib52","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1038\/s41467-024-46297-6","article-title":"Bet hedging in a unicellular microalga","volume":"15","author":"Tang","year":"2024","journal-title":"Nat. Commun."},{"issue":"Part 2","key":"10.1016\/j.envres.2026.125854_bib53","article-title":"Investigation of toxic effect of mercury on Microcystis aeruginosa: correlation between intracellular mercury content at single cells level and algae physiological responses","volume":"858","author":"Tang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2026.125854_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2023.106499","article-title":"Evaluation of Cd2+ stress on Synechocystis sp. PCC6803 based on single-cell elemental accumulation and algal toxicological response","volume":"258","author":"Tao","year":"2023","journal-title":"Aquat. Toxicol."},{"issue":"38","key":"10.1016\/j.envres.2026.125854_bib55","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1039\/D3CC01575K","article-title":"Single-cell multi-element analysis reveals element distribution pattern in human sperm","volume":"59","author":"Tian","year":"2023","journal-title":"Chem. Commun."},{"issue":"18","key":"10.1016\/j.envres.2026.125854_bib56","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1021\/acs.est.3c10884","article-title":"Bioconcentration of inorganic and methyl Mercury by algae revealed using dual-mass single-cell ICP-MS with double isotope tracers","volume":"58","author":"Tian","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.envres.2026.125854_bib57","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41561-017-0028-x","article-title":"Influence of diatom diversity on the ocean biological carbon pump","volume":"11","author":"Tr\u00e9guer","year":"2018","journal-title":"Nat. Geosci."},{"issue":"4582","key":"10.1016\/j.envres.2026.125854_bib58","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1126\/science.219.4582.306","article-title":"Prorocentrin: an extracellular siderophore produced by the marine dinoflagellate Prorocentrum minimum","volume":"219","author":"Trick","year":"1983","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.envres.2026.125854_bib59","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1021\/ac303290s","article-title":"Chemical analysis of single cells","volume":"85","author":"Trouillon","year":"2013","journal-title":"Anal. Chem."},{"issue":"7","key":"10.1016\/j.envres.2026.125854_bib71","doi-asserted-by":"crossref","DOI":"10.1093\/mtomcs\/mfac035","article-title":"Luxury iron uptake and storage in pennate diatoms from the equatorial Pacific Ocean","volume":"14","author":"Twining","year":"2022","journal-title":"Metallomics"},{"issue":"2","key":"10.1016\/j.envres.2026.125854_bib60","doi-asserted-by":"crossref","first-page":"120","DOI":"10.5670\/oceanog.2024.407","article-title":"An ocean of particles characterization of particulate trace elements by the geotraces program","volume":"37","author":"Twining","year":"2024","journal-title":"Oceanography (Wash. D. C.)"},{"key":"10.1016\/j.envres.2026.125854_bib61","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev-marine-121211-172322","article-title":"The trace metal composition of marine phytoplankton","volume":"5","author":"Twining","year":"2013","journal-title":"Ann. Rev. Mar. Sci"},{"key":"10.1016\/j.envres.2026.125854_bib62","doi-asserted-by":"crossref","DOI":"10.1021\/envhealth.5c00839","article-title":"Shape-dependent interactions of gold nanoparticles with microalgae: distinct cellular and molecular responses","author":"Wang","year":"2026","journal-title":"Environ. Health."},{"key":"10.1016\/j.envres.2026.125854_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121013","article-title":"Cell cycle-dependent Cu uptake explained the heterogenous responses of Chlamydomonas to Cu exposure","volume":"319","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.envres.2026.125854_bib64","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1139\/B06-013","article-title":"Differences between two green algae in biological availability of iron bound to strong chelators","volume":"84","author":"Weger","year":"2006","journal-title":"Can. J. Bot."},{"key":"10.1016\/j.envres.2026.125854_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2026.123759","article-title":"Prolonged low pH reprograms carbon and nitrogen metabolism and micronutrient use in Symbiodinium kawagutii and reveals indicators for reef water quality management","volume":"293","author":"Wen","year":"2026","journal-title":"Environ. Res."},{"issue":"7","key":"10.1016\/j.envres.2026.125854_bib66","doi-asserted-by":"crossref","first-page":"12237","DOI":"10.1021\/acsnano.1c03879","article-title":"Cell cycle control of nanoplastics internalization in phytoplankton","volume":"15","author":"Yan","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.envres.2026.125854_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142076","article-title":"The role of morphological changes in algae adaptation to nutrient stress at the single-cell level","volume":"754","author":"Yan","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"19","key":"10.1016\/j.envres.2026.125854_bib68","doi-asserted-by":"crossref","first-page":"5847","DOI":"10.5194\/bg-15-5847-2018","article-title":"Reviews and syntheses: ocean iron fertilization experiments - past, present, and future looking to a future Korean Iron Fertilization experiment in the Southern Ocean (KIFES) project","volume":"15","author":"Yoon","year":"2018","journal-title":"Biogeosciences"},{"key":"10.1016\/j.envres.2026.125854_bib69","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.margen.2014.01.005","article-title":"Characterization of iron-responsive promoters in the marine diatom Phaeodactylum tricornutum","volume":"16","author":"Yoshinaga","year":"2014","journal-title":"Mar. Genom."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126021857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126021857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:27:45Z","timestamp":1792614465000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935126021857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":71,"alternative-id":["S0013935126021857"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2026.125854","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From population to individual: Bulk and single-cell analysis reveal Fe bioavailability, limitation thresholds, and biological responses for marine diatom Chaetoceros debilis","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2026.125854","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125854"}}