{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:56:45Z","timestamp":1792616205194,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010754","name":"Zhejiang Gongshang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.envres.2026.125877","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:01:15Z","timestamp":1791388875000},"page":"125877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Antibiotic resistance profiles and associated factors in aquatic ecosystems with contrasting hydrodynamic settings"],"prefix":"10.1016","volume":"309","author":[{"given":"Jianhao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zejun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2026.125877_bib2","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.3390\/life15101598","article-title":"A one-health perspective of antimicrobial resistance (AMR): human, animals and environmental health","volume":"15","author":"Al-Khalaifah","year":"2025","journal-title":"Life"},{"key":"10.1016\/j.envres.2026.125877_bib1","doi-asserted-by":"crossref","first-page":"D690","DOI":"10.1093\/nar\/gkac920","article-title":"Card 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive antibiotic Resistance Database","volume":"51","author":"Alcock","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envres.2026.125877_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2023.119629","article-title":"Xenogenetic evolutionary of integrons promotes the environmental pollution of antibiotic resistance genes-Challenges, progress and prospects","volume":"231","author":"An","year":"2023","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.121833","article-title":"Streambed immobilization controls the transport of antibiotic resistance genes in flowing water","volume":"259","author":"Badilla-Aguilar","year":"2024","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib5","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1021\/acs.est.5c13541","article-title":"Metagenomic assessment of full-scale wastewater treatment plants identifies sentinel antibiotic resistance gene families for monitoring reclaimed wastewater and treated sludge","volume":"60","author":"Brown","year":"2026","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2026.125877_bib6","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2008731118","article-title":"Conjugative plasmids interact with insertion sequences to shape the horizontal transfer of antimicrobial resistance genes","volume":"118","author":"Che","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.envres.2026.125877_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.174143","article-title":"Hydraulic conditions control the abundance of antibiotic resistance genes and their potential host microorganisms in a frequently regulated river-lake system","volume":"946","author":"Ding","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2026.125877_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117533","article-title":"Spatiotemporal profiling of antibiotics and resistance genes in a river catchment: human population as the main driver of antibiotic and antibiotic resistance gene presence in the environment","volume":"203","author":"Elder","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.116762","article-title":"Fate of antibiotics and antibiotic resistance genes in home water purification systems","volume":"190","author":"Gu","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib10","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.watres.2017.07.002","article-title":"Metagenomic analysis reveals wastewater treatment plants as hotspots of antibiotic resistance genes and mobile genetic elements","volume":"123","author":"Guo","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph192315619","article-title":"Effects of oxytetracycline\/lead pollution alone and in the combined form on antibiotic resistance genes, mobile genetic elements, and microbial communities in the soil","volume":"19","author":"Guo","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.envres.2026.125877_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138101","article-title":"Urban landscape lakes with backwater hide higher antibiotic resistance risk than living water","volume":"492","author":"Han","year":"2025","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.envres.2026.125877_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.soilbio.2018.08.018","article-title":"Antibiotic resistance genes and associated bacterial communities in agricultural soils amended with different sources of animal manures","volume":"126","author":"Han","year":"2018","journal-title":"Soil Biol. Biochem."},{"key":"10.1016\/j.envres.2026.125877_bib14","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1111\/1462-2920.14248","article-title":"Diversity of herbaceous plants and bacterial communities regulates soil resistome across forest biomes","volume":"20","author":"Hu","year":"2018","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.envres.2026.125877_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.169822","article-title":"Ecological effects of antibiotics on aquatic microbial communities: Structure-function response dynamics and multifactorial drivers","volume":"525","author":"Hu","year":"2025","journal-title":"Chem Eng J"},{"key":"10.1016\/j.envres.2026.125877_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127155","article-title":"Elevated levels of antibiotic resistance in groundwater during treated wastewater irrigation associated with infiltration and accumulation of antibiotic residues","volume":"423","author":"Kampouris","year":"2022","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.envres.2026.125877_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117050","article-title":"Unraveling the riverine antibiotic resistome: the downstream fate of anthropogenic inputs","volume":"197","author":"Lee","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib18","doi-asserted-by":"crossref","first-page":"D57","DOI":"10.1093\/nar\/gkp938","article-title":"Aclame: a classification of mobile genetic elements, update 2010","volume":"38","author":"Leplae","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envres.2026.125877_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117463","article-title":"Abiotic transformation and ecotoxicity change of sulfonamide antibiotics in environmental and water treatment processes: a critical review","volume":"202","author":"Li","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107185","article-title":"Population-based variations of a core resistome revealed by urban sewage metagenome surveillance","volume":"163","author":"Li","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2026.125877_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.121289","article-title":"Metagenome sequencing reveals shifts in phage-associated antibiotic resistance genes from influent to effluent in wastewater treatment plants","volume":"253","author":"Li","year":"2024","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib22","doi-asserted-by":"crossref","first-page":"D660","DOI":"10.1093\/nar\/gky1123","article-title":"Iceberg 2.0: an updated database of bacterial integrative and conjugative elements","volume":"47","author":"Liu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envres.2026.125877_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135399","article-title":"Profiles, drivers, and prioritization of antibiotics in China's major rivers","volume":"477","author":"Liu","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envres.2026.125877_bib24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40168-024-02005-6","article-title":"Growth of microbes in competitive lifestyles promotes increased ARGs in soil microbiota: insights based on genetic traits","volume":"13","author":"Liu","year":"2025","journal-title":"Microbiome"},{"key":"10.1016\/j.envres.2026.125877_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112343","article-title":"Distribution of antibiotics in lake water-groundwater - sediment system in Chenhu Lake area","volume":"204","author":"Ma","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2026.125877_bib26","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1021\/envhealth.5c00278","article-title":"Resistance gene dynamics, biogeochemical coupling, and ecological risks in sediments of anthropogenically impacted lake wetlands in China","volume":"4","author":"Mao","year":"2026","journal-title":"Environ. Health"},{"key":"10.1016\/j.envres.2026.125877_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2025.123102","article-title":"Longitudinal metagenomic analysis on antibiotic resistome, mobilome, and microbiome of river ecosystems in a sub-tropical metropolitan city","volume":"274","author":"Mao","year":"2025","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.watres.2015.12.031","article-title":"Occurrence of human-associated Bacteroidetes genetic source tracking markers in raw and treated wastewater of municipal and domestic origin and comparison to standard and alternative indicators of faecal pollution","volume":"90","author":"Mayer","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2026.125616","article-title":"Multidrug-resistant and various high-risk ARGs wastewater effluent exhibit nonnegligible AMR risks","volume":"296","author":"Pan","year":"2026","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00088-17","article-title":"Mobile genetic elements associated with antimicrobial resistance","volume":"31","author":"Partridge","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.envres.2026.125877_bib31","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1021\/acs.est.2c09739","article-title":"Uncovering bacterial hosts of class 1 integrons in an urban coastal aquatic environment with a single-cell fusion-polymerase chain reaction technology","volume":"57","author":"Qi","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2026.125877_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135656","article-title":"Occurrence, distribution, and correlation of antibiotics in the aquatic ecosystem of Poyang Lake Basin, China","volume":"479","author":"Qiu","year":"2024","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.envres.2026.125877_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117720","article-title":"Dynamics of integron structures across a wastewater network-Implications to resistance gene transfer","volume":"206","author":"Quintela-Baluja","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib34","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S1473-3099(25)00118-5","article-title":"The WHO bacterial priority pathogens list 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance","volume":"25","author":"Sati","year":"2025","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.envres.2026.125877_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fenvs.2022.830861","article-title":"Antimicrobials and antibiotic resistance genes in water bodies: pollution, risk, and control","volume":"10","author":"Singh","year":"2022","journal-title":"Front. Environ. Sci."},{"key":"10.1016\/j.envres.2026.125877_bib36","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1021\/acsenvironau.1c00027","article-title":"Bacterial concentrations and water turbulence influence the importance of conjugation versus phage-mediated antibiotic resistance gene transfer in suspended growth systems","volume":"2","author":"Sun","year":"2022","journal-title":"ACS Environ. Au"},{"key":"10.1016\/j.envres.2026.125877_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.131224","article-title":"Metagenomic profiles and health risks of pathogens and antibiotic resistance genes in various industrial wastewaters and the associated receiving surface water","volume":"283","author":"Tang","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2026.125877_bib38","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1038\/ismej.2017.114","article-title":"High abundance and expression of transposases in bacteria from the Baltic Sea","volume":"11","author":"Vigil-Stenman","year":"2017","journal-title":"ISME J."},{"key":"10.1016\/j.envres.2026.125877_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.121583","article-title":"Insight into environmental adaptability of antibiotic resistome from surface water to deep sediments in anthropogenic lakes by metagenomics","volume":"256","author":"Wang","year":"2024","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.121572","article-title":"Spread of antibiotic resistance genes in drinking water reservoirs: insights from a deep metagenomic study using a curated database","volume":"256","author":"Wang","year":"2024","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132528","article-title":"Wastewater treatment plant effluents exert different impacts on antibiotic resistome in water and sediment of the receiving river: metagenomic analysis and risk assessment","volume":"460","author":"Wu","year":"2023","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.envres.2026.125877_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118841","article-title":"Dynamic distribution and driving mechanisms of antibiotic resistance genes in a human-intensive watershed","volume":"222","author":"Yang","year":"2022","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2023.119875","article-title":"Global environmental resistome: distinction and connectivity across diverse habitats benchmarked by metagenomic analyses","volume":"235","author":"Yin","year":"2023","journal-title":"Water Res."},{"key":"10.1016\/j.envres.2026.125877_bib44","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2505446122","article-title":"Fluid flow generates bacterial conjugation hot spots by increasing the rate of shear-driven cell-cell encounters","volume":"122","author":"Zbinden","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.envres.2026.125877_bib45","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1038\/s41467-021-25096-3","article-title":"An omics-based framework for assessing the health risk of antimicrobial resistance genes","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envres.2026.125877_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133555","article-title":"Vertical distribution characteristics and transport paths of antibiotic resistance genes in constructed wetland system","volume":"466","author":"Zhang","year":"2024","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.envres.2026.125877_bib47","article-title":"Cumulative effects of sulfamethoxazole and its metabolite on nitrogen reduction and antibiotic resistance in constructed wetlands: microbial mechanisms and ecological risks","volume":"285","author":"Zhang","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2026.125877_bib48","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.envint.2018.02.039","article-title":"High-throughput profiling of seasonal variations of antibiotic resistance gene transport in a peri-urban river","volume":"114","author":"Zheng","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2026.125877_bib49","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.aca.2012.04.021","article-title":"Optimization of antibiotic analysis in water by solid-phase extraction and high performance liquid chromatography-mass spectrometry\/mass spectrometry","volume":"731","author":"Zhou","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.envres.2026.125877_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152263","article-title":"Metagenomic profiles of the resistome in subtropical estuaries: Co-occurrence patterns, indicative genes, and driving factors","volume":"810","author":"Zhou","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2026.125877_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129356","article-title":"Insights into microbial contamination in multi-type manure-amended soils: the profile of human bacterial pathogens, virulence factor genes and antibiotic resistance genes","volume":"437","author":"Zhu","year":"2022","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.envres.2026.125877_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2026.101358","article-title":"Deciphering the roles of AcrAB-TolC efflux pump in promoting the transmission of antibiotic resistance","volume":"85","author":"Zhu","year":"2026","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.envres.2026.125877_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165441","article-title":"Prevalence of antibiotic resistance genes and virulence factors in the sediment of WWTP effluent-dominated rivers","volume":"897","author":"Zou","year":"2023","journal-title":"Sci. Total Environ."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126022097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935126022097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:30:24Z","timestamp":1792614624000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935126022097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":53,"alternative-id":["S0013935126022097"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2026.125877","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibiotic resistance profiles and associated factors in aquatic ecosystems with contrasting hydrodynamic settings","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2026.125877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125877"}}