{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:58:09Z","timestamp":1789999089179,"version":"4.0.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Tarbiat Modares University and Ministry of Sciences, Researches, and Technology, Iran"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Enzyme and Microbial Technology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.enzmictec.2020.109727","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T17:17:04Z","timestamp":1608225424000},"page":"109727","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["An enzyme-mediated controlled release system for curcumin based on cyclodextrin\/cyclodextrin degrading enzyme"],"prefix":"10.1016","volume":"144","author":[{"given":"Sahar","family":"Roozbehi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Dadashzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6774-0837","authenticated-orcid":false,"given":"Reza H.","family":"Sajedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.enzmictec.2020.109727_bib0005","series-title":"FASTtrack Pharmaceutics: Drug Delivery and Targeting","author":"Perrie","year":"2012"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0010","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.addr.2008.03.012","article-title":"Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers","volume":"60","author":"Slowing","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0015","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1002\/anie.200600734","article-title":"The supramolecular chemistry of organic-inorganic hybrid materials","volume":"45","author":"Descalzo","year":"2006","journal-title":"Angew. Chemie - Int. Ed."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0020","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.cej.2007.07.074","article-title":"Mesoporous silicate materials as substrates for molecular machines and drug delivery","volume":"137","author":"Angelos","year":"2008","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0025","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1039\/c0nr00156b","article-title":"Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles - Opportunities & challenges","volume":"2","author":"Rosenholm","year":"2010","journal-title":"Nanoscale."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0030","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1021\/nl2036047","article-title":"Remotely activated protein-producing nanoparticles","volume":"12","author":"Schroeder","year":"2012","journal-title":"Nano Lett."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0035","doi-asserted-by":"crossref","first-page":"9335","DOI":"10.1021\/nn302148p","article-title":"Lipid-peptide vesicle nanoscale hybrids for triggered drug release by mild hyperthermia in vitro and in vivo","volume":"6","author":"Al-Ahmady","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0040","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1021\/nn1029229","article-title":"Smart drug delivery through DNA\/magnetic nanoparticle gates","volume":"5","author":"Ruiz-Hern\u00e1ndez","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0045","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jconrel.2011.12.002","article-title":"Multifunctional PEGylated 2C5-immunoliposomes containing pH-sensitive bonds and TAT peptide for enhanced tumor cell internalization and cytotoxicity","volume":"160","author":"Koren","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0050","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1021\/ja211279u","article-title":"Lipase-sensitive polymeric triple-layered nanogel for \u201con-demand\u201d drug delivery","volume":"134","author":"Xiong","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0055","doi-asserted-by":"crossref","first-page":"8042","DOI":"10.1021\/am502154w","article-title":"Composite of functional mesoporous silica and DNA: an enzyme-responsive controlled release drug carrier system","volume":"6","author":"Zhang","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0060","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","article-title":"Regulators of the tumor microenvironment","volume":"141","author":"Kessenbrock","year":"2010","journal-title":"Cell."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0065","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/284067a0","article-title":"Metastatic potential correlates with enzymatic degradation of basement membrane collagen","volume":"284","author":"Liotta","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0070","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nmat3776","article-title":"Stimuli-responsive nanocarriers for drug delivery","volume":"12","author":"Mura","year":"2013","journal-title":"Nat. Mater."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0075","doi-asserted-by":"crossref","first-page":"11038","DOI":"10.1021\/la401671m","article-title":"Interactions between solid surfaces mediated by polyethylene oxide polymers: effect of polymer concentration","volume":"29","author":"Wei","year":"2013","journal-title":"Langmuir"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0080","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1359-6446(04)03276-3","article-title":"Dendrimers and dendritic polymers in drug delivery","volume":"10","author":"Gillies","year":"2005","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0085","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.colsurfb.2018.07.013","article-title":"Folate receptor-mediated celastrol and irinotecan combination delivery using liposomes for effective chemotherapy","volume":"170","author":"Soe","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0090","doi-asserted-by":"crossref","first-page":"5428","DOI":"10.1021\/la400033s","article-title":"Formation and degradation of multicomponent multicore micelles: insights from dissipative particle dynamics simulations","volume":"29","author":"Chen","year":"2013","journal-title":"Langmuir"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0095","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.carbpol.2012.02.036","article-title":"Curcumin\/xanthan-galactomannan hydrogels: rheological analysis and biocompatibility","volume":"93","author":"Da-Lozzo","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0100","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1021\/la804215v","article-title":"Effective stabilization of curcumin by association to plasma proteins: human serum albumin and fibrinogen","volume":"25","author":"Leung","year":"2009","journal-title":"Langmuir"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0105","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1021\/ja908117a","article-title":"Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin","volume":"132","author":"Brown","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2147\/NSA.S99986","article-title":"Synthesis, characterization, applications, and challenges of iron oxide nanoparticles","volume":"9","author":"Ali","year":"2016","journal-title":"Nanotechnol. Sci. Appl."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0115","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1039\/C1NR11188D","article-title":"Gold nanoparticles: preparation, properties, and applications in bionanotechnology","volume":"4","author":"Yeh","year":"2012","journal-title":"Nanoscale."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s11671-015-0873-8","article-title":"Application of functional quantum dot nanoparticles as fluorescence probes in cell labeling and tumor diagnostic imaging","volume":"10","author":"Zhao","year":"2015","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0125","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/198268","article-title":"A comprehensive review on cyclodextrin-based carriers for delivery of chemotherapeutic cytotoxic anticancer drugs","volume":"2015","author":"Gidwani","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0130","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0169-409X(98)00058-1","article-title":"Cyclodextrin-based controlled drug release system","volume":"36","author":"Hirayama","year":"1999","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0135","doi-asserted-by":"crossref","first-page":"10940","DOI":"10.1021\/cr500081p","article-title":"Review: a history of cyclodextrins","volume":"114","author":"Crini","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0140","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1002\/jps.23077","article-title":"Cyclodextrins as functional excipients: methods to enhance complexation efficiency","volume":"101","author":"Loftsson","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0145","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.colsurfb.2018.08.065","article-title":"Understanding the antimicrobial activity of water soluble \u03b3-cyclodextrin\/alamethicin complex","volume":"172","author":"Zhang","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0150","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00396-013-3124-5","article-title":"Inclusion complexes of rosmarinic acid and cyclodextrins: stoichiometry, association constants, and antioxidant potential","volume":"292","author":"Medronho","year":"2014","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0155","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijpharm.2012.06.055","article-title":"Cyclodextrins","volume":"453","author":"Kurkov","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0160","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.cis.2013.08.001","article-title":"The formation of host-guest complexes between surfactants and cyclodextrins","volume":"205","author":"Valente","year":"2014","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0165","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0939-6411(02)00166-2","article-title":"Phase solubility studies of pure (-)-\u03b1-bisabolol and camomile essential oil with \u03b2-cyclodextrin","volume":"55","author":"Waleczek","year":"2003","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0170","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/j.apsusc.2015.09.189","article-title":"Targeted delivery and pH-responsive release of stereoisomeric anti-cancer drugs using \u03b2-cyclodextrin assemblied Fe3O4nanoparticles","volume":"357","author":"Wang","year":"2015","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0175","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0928-0987(01)00214-7","article-title":"Cyclodextrin complexation: influence on the solubility, stability, and cytotoxicity of camptothecin, an antineoplastic agent","volume":"15","author":"Kang","year":"2002","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0180","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1166\/jbn.2015.2110","article-title":"Co-delivery of docetaxel and berbamine by chitosan\/sulfobutylether-cyclodextrin nanoparticles for enhancing bioavailability and anticancer activities","volume":"11","author":"Wu","year":"2015","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0185","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1248\/cpb.c13-00950","article-title":"Synthesis and inclusion study of a novel \u03b3-cyclodextrin derivative as a potential thermo-sensitive carrier for doxorubicin","volume":"62","author":"Xu","year":"2014","journal-title":"Chem. Pharm. Bull. (Tokyo)."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0190","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1039\/b816209c","article-title":"Cyclodextrin-covered gold nanoparticles for targeted delivery of an anti-cancer drug","volume":"19","author":"Park","year":"2009","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0195","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2174\/092986710790149738","article-title":"Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications","volume":"17","author":"Bar-Sela","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0200","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/S0731-7085(96)02024-9","article-title":"Stability of curcumin in buffer solutions and characterization of its degradation products","volume":"15","author":"Wang","year":"1997","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0205","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.colsurfb.2010.03.039","article-title":"\u03b2-Cyclodextrin-curcumin self-assembly enhances curcumin delivery in prostate cancer cells","volume":"79","author":"Yallapu","year":"2010","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijbiomac.2013.04.063","article-title":"Substrate preference of a Geobacillus maltogenic amylase: a kinetic and thermodynamic analysis","volume":"60","author":"Nasrollahi","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0215","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.2478\/s11756-008-0171-3","article-title":"Differences and similarities in enzymes from the neopullulanase subfamily isolated from thermophilic species","volume":"63","author":"Nordberg Karlsson","year":"2008","journal-title":"Biologia (Bratisl)."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0220","doi-asserted-by":"crossref","first-page":"21891","DOI":"10.1074\/jbc.M201623200","article-title":"Cyclomaltodextrinase, neopullulanase, and maltogenic amylase are nearly indistinguishable from each other","volume":"277","author":"Lee","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0225","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1021\/ac60147a030","article-title":"Use of dinitrosalicylic acid reagent for determination of reducing sugar","volume":"31","author":"Release","year":"1959","journal-title":"Anal. Chem."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0230","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.colsurfb.2010.03.039","article-title":"\u03b2-Cyclodextrin-curcumin self-assembly enhances curcumin delivery in prostate cancer cells","volume":"79","author":"Yallapu","year":"2010","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0235","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jphotochem.2005.04.002","article-title":"Fluorescence enhancement of curcumin upon inclusion into parent and modified cyclodextrins","volume":"173","author":"Baglole","year":"2005","journal-title":"J. Photochem. Photobiol. A: Chem."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0240","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0009-2614(93)85489-B","article-title":"Normal and twisted intramolecular charge-transfer fluorescence of 4-dimethylaminobenzonitrile in \u03b1-cyclodextrine cavities","volume":"212","author":"Al-Hassan","year":"1993","journal-title":"Chem. Phys. Lett."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0245","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1021\/j150613a012","article-title":"Fluorescence enhancement of benzene derivatives by forming inclusion complexes with. beta.-Cyclodextrin in aqueous solutions","volume":"85","author":"Hoshino","year":"1981","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-3155-5-3","article-title":"Polymeric nanoparticle-encapsulated curcumin (\u201cnanocurcumin\u201d): a novel strategy for human cancer therapy","volume":"5","author":"Bisht","year":"2007","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0255","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/bit.22011","article-title":"Preparation and anti-tumor efficiency evaluation of doxorubicin-loaded bacterial magnetosomes: magnetic nanoparticles as drug carriers isolated from Magnetospirillum gryphiswaldense","volume":"101","author":"Sun","year":"2008","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0260","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1517\/17425240903222218","article-title":"Recent advances and future directions in amphiphilic cyclodextrin nanoparticles","volume":"6","author":"Bilensoy","year":"2009","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0265","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ijpharm.2014.08.018","article-title":"Anti-tumor drug delivery system based on cyclodextrin-containing pH-responsive star polymer: in vitro and in vivo evaluation","volume":"474","author":"Xiong","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms4702","article-title":"Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy","volume":"5","author":"Namgung","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0275","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1208\/s12248-009-9128-x","article-title":"Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?","volume":"11","author":"Ravindran","year":"2009","journal-title":"AAPS J."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0280","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s40242-018-7293-0","article-title":"Controlled release of curcumin via folic acid conjugated magnetic drug delivery system","volume":"34","author":"Song","year":"2018","journal-title":"Chem. Res. Chinese Univ."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0285","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000115967","article-title":"Resistance to chemotherapy in cancer: a complex and integrated cellular response","volume":"81","author":"Mellor","year":"2008","journal-title":"Pharmacology"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0290","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1007\/s11064-007-9376-z","article-title":"Curcumin suppressed anti-apoptotic signals and activated cysteine proteases for apoptosis in human malignant glioblastoma U87MG cells","volume":"32","author":"Karmakar","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0295","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2006.08.013","article-title":"Curcumin activated both receptor-mediated and mitochondria-mediated proteolytic pathways for apoptosis in human glioblastoma T98G cells","volume":"407","author":"Karmakar","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0300","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/bjc.2012.379","article-title":"Curcumin-cyclodextrin complexes potentiate gemcitabine effects in an orthotopic mouse model of lung cancer","volume":"107","author":"Rocks","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.enzmictec.2020.109727_bib0305","first-page":"394","article-title":"An approach to improve the physicochemical properties of drugs and applications of cyclodextrin complexes","volume":"12","author":"Vikas","year":"2018","journal-title":"Asian J. Pharm. Free Full Text Artic. from Asian J Pharm."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0310","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1002\/jps.22033","article-title":"The solubility \u2013 permeability interplay in using cyclodextrins as pharmaceutical solubilizers\u202f: mechanistic modeling and application to progesterone","volume":"99","author":"Dahan","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0315","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.2042-7158.2011.01279.x","article-title":"Pharmaceutical applications of cyclodextrins: effects on drug permeation through biological membranes","volume":"63","author":"Loftsson","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0320","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1208\/s12248-012-9444-4","article-title":"Highly stabilized curcumin nanoparticles tested in an in vitro blood\u2013brain barrier model and in Alzheimer\u2019s disease Tg2576 mice","volume":"15","author":"Cheng","year":"2013","journal-title":"AAPS J."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0325","first-page":"80","article-title":"In vitro anti-cancer activity of native curcumin and \u201cProtein-Curcumin\u201d systems: a perspective on drug-delivery application","volume":"2","author":"Ashrafi Kooshk","year":"2013","journal-title":"J. Reports Pharm. Sci."},{"key":"10.1016\/j.enzmictec.2020.109727_bib0330","doi-asserted-by":"crossref","first-page":"7108","DOI":"10.1158\/1078-0432.CCR-09-1749","article-title":"Contribution of degradation products to the anticancer activity of curcumin","volume":"15","author":"Shen","year":"2009","journal-title":"Clin. Cancer Res."}],"container-title":["Enzyme and Microbial Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141022920302209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141022920302209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T01:41:24Z","timestamp":1758850884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141022920302209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":66,"alternative-id":["S0141022920302209"],"URL":"https:\/\/doi.org\/10.1016\/j.enzmictec.2020.109727","relation":{},"ISSN":["0141-0229"],"issn-type":[{"value":"0141-0229","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An enzyme-mediated controlled release system for curcumin based on cyclodextrin\/cyclodextrin degrading enzyme","name":"articletitle","label":"Article Title"},{"value":"Enzyme and Microbial Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.enzmictec.2020.109727","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109727"}}