{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:45:06Z","timestamp":1783035906092,"version":"3.54.6"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Enzyme and Microbial Technology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.enzmictec.2023.110323","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T16:34:36Z","timestamp":1694104476000},"page":"110323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Rational design of biocatalysts based on covalent immobilization of acylase enzymes"],"prefix":"10.1016","volume":"171","author":[{"given":"Patricio","family":"Castillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bessy V.","family":"Cuti\u00f1o-Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Gonz\u00e1lez-Bacerio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda de los \u00c1ngeles","family":"Ch\u00e1vez Planes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"D\u00edaz Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Guis\u00e1n Seijas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"del Monte-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.enzmictec.2023.110323_bib1","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0957-4166(02)00325-7","article-title":"Modulation of the enantioselectivity of Candida antarctica B lipase via conformational engineering: kinetic resolution of (\u00b1)-\u03b1-hydroxy-phenylacetic acid derivatives","volume":"13","author":"Palomo","year":"2002","journal-title":"Tetrahedron. Asymm."},{"key":"10.1016\/j.enzmictec.2023.110323_bib2","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/S0957-4166(02)00645-6","article-title":"Enzymatic resolution of (\u00b1)-trans-4-(4\u00b4-fluorophenyl)-6-oxopiperidin-3-ethyl carboxilate, intermediate in synthesis of (-)-Paroxetine","volume":"13","author":"Palomo","year":"2002","journal-title":"Tetrahedron. Asymm."},{"key":"10.1016\/j.enzmictec.2023.110323_bib3","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1002\/adsc.200700055","article-title":"Regioselective hydrolysis of peracetylated \u03b2-monosaccharides by immobilized lipases. Key Role of the immobilization protocol","volume":"349","author":"Palomo","year":"2007","journal-title":"Adv. Synth. Cat."},{"key":"10.1016\/j.enzmictec.2023.110323_bib4","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.enzmictec.2007.01.018","article-title":"Improvement of enzyme activity, stability and selectivity via immobilization techniques","volume":"40","author":"Mateo","year":"2007","journal-title":"Enzyme Microb. Technol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biotechadv.2006.11.005","article-title":"Biocatalysts: Measurement, modeling design of heterogeneity","volume":"25","author":"van Roon","year":"2007","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.enzmictec.2023.110323_bib6","first-page":"3","article-title":"A review of the use of genetically engineered enzymes in electrochemical biosensors, Semin","volume":"20","author":"Camp\u00e1s","year":"2009","journal-title":"Cell Dev. Biol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/157017909787314885","article-title":"Modulation of enzymes selectivity via immobilization","volume":"6","author":"Palomo","year":"2009","journal-title":"Curr. Org. Synth."},{"key":"10.1016\/j.enzmictec.2023.110323_bib8","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.9002.1","article-title":"Recent advances in covalent, site-specific protein immobilization","volume":"5","author":"Meldal","year":"2016","journal-title":"F1000Res."},{"key":"10.1016\/j.enzmictec.2023.110323_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.804698","article-title":"Highly efficient one-step protein immobilization on polymer membranes supported by response surface methodology","volume":"9","author":"Schmidt","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.enzmictec.2023.110323_bib10","first-page":"1","article-title":"Immobilized biocatalysts: Novel approaches and tools for binding enzymes to supports","author":"Torres-Salas","year":"2011","journal-title":"Adv. Mat. XX"},{"key":"10.1016\/j.enzmictec.2023.110323_bib11","unstructured":"M. Heinemann, Experimental analysis, modelling and dynamic simulation of thermodynamic and kinetic phenomena in gel-stabilized enzyme carriers, Doctoral Thesis (2003) RWTH Aachen University."},{"key":"10.1016\/j.enzmictec.2023.110323_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-4347(98)00434-4","article-title":"Oriented immobilization of biologically active proteins as a tool for revealing protein interactions function","volume":"722","author":"Turkova","year":"1999","journal-title":"J. Chromat. B"},{"key":"10.1016\/j.enzmictec.2023.110323_bib13","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1472-6750-7-54","article-title":"New active site oriented glyoxyl-agarose derivatives of Escherichia coli penicillin G acylase","volume":"7","author":"Cecchini","year":"2007","journal-title":"BMC Biotech."},{"key":"10.1016\/j.enzmictec.2023.110323_bib14","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/ejoc.200801204","article-title":"Coupling of site-directed mutagenesis immobilisation for the rational design of more efficient biocatalysts: The case of immobilised 3G3K PGA from E. coli","author":"Serra","year":"2009","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.enzmictec.2023.110323_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.enzmictec.2010.10.003","article-title":"Control of protein immobilization: Coupling immobilization and site-directed mutagenesis to improve biocatalyst or biosensor performance","volume":"48","author":"Hernandez","year":"2011","journal-title":"Enzyme Microb. Technol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib16","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3390\/catal13030625","article-title":"Rational design of a biocatalyst based on immobilized CALB onto nanostructured SiO2","volume":"13","author":"Llerena Suster","year":"2023","journal-title":"Catalysts"},{"key":"10.1016\/j.enzmictec.2023.110323_bib17","series-title":"Carrier-Bound Immobilised Enzymes: Principles, Application and Design","author":"Cao","year":"2005"},{"key":"10.1016\/j.enzmictec.2023.110323_bib18","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1351\/pac199567020345","article-title":"Biocatalysis in non-conventional media: Medium engineering aspects","volume":"67","author":"Vermue","year":"1995","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.enzmictec.2023.110323_bib19","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1472-6750-8-72","article-title":"The stabilizing effects of immobilization in D-amino acid oxidase from Trigonopsis variabilis","volume":"8","author":"Dib","year":"2008","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib20","first-page":"185","article-title":"Rational design strategy on immobilized derivatives synthesis. Their implementation via RDID1.0 program","volume":"3","author":"del Monte","year":"2010","journal-title":"Ser. Cient. Univ. Cienc. Inf."},{"key":"10.1016\/j.enzmictec.2023.110323_bib21","series-title":"Lipases and phospholipases: Methods and protocols, Methods in Molecular Biology","first-page":"243","article-title":"Rational design strategy as a novel immobilization methodology applied to lipases and phospholipases","volume":"1835","author":"del Monte-Mart\u00ednez","year":"2018"},{"key":"10.1016\/j.enzmictec.2023.110323_bib22","article-title":"Modeling and experimental validation of covalent immobilization of Trametes maxima laccase on glyoxyl and MANA-Sepharose CL 4B supports, for the use in bioconversion of residual colorants","author":"Cuti\u00f1o-Avila","year":"2021","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.enzmictec.2023.110323_bib23","first-page":"237","article-title":"Enzymes from higher eukaryotes for industrial biocatalysis","volume":"42","author":"Liu","year":"2004","journal-title":"Food Technol. Biotechnol.."},{"key":"10.1016\/j.enzmictec.2023.110323_bib24","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1039\/C3CS60075K","article-title":"Enzyme immobilisation in biocatalysis: why, what and how","volume":"42","author":"Sheldon","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.enzmictec.2023.110323_bib25","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1007\/s00253-017-8692-8","article-title":"Efficient synthesis of \u03b2-lactam antibiotics with very low product hydrolysis by a mutant Providencia rettgeri penicillin G acylase","volume":"102","author":"Pan","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF01886764","article-title":"Aminoacylase I from porcine kidney: Identification and characterization of two major protein domains","volume":"14","author":"Palm","year":"1995","journal-title":"J. Protein Chem."},{"key":"10.1016\/j.enzmictec.2023.110323_bib27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1432-1033.1990.tb19207.x","article-title":"Primary structure requirements for the maturation in vivo of penicillin acylase from Escherichia coli ATCC 11105","volume":"192","author":"Sizmann","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.enzmictec.2023.110323_bib28","series-title":"Industrial Enzymes. Structure, Function and Applications","first-page":"583","article-title":"Penicillin acylases","author":"Spence","year":"2007"},{"key":"10.1016\/j.enzmictec.2023.110323_bib29","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.2174\/092986710793205435","article-title":"Use of enzymes in the production of semi-synthetic penicillins and cephalosporins: Drawbacks and perspectives","volume":"17","author":"Volpato","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.enzmictec.2023.110323_bib30","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00253-011-3817-y","article-title":"Efficient biocatalyst for large-scale synthesis of cephalosporins, obtained by combining immobilization and site-directed mutagenesis of penicillin acylase","volume":"95","author":"Cecchini","year":"2012","journal-title":"Appl. Microbiol. Biotechnol.."},{"key":"10.1016\/j.enzmictec.2023.110323_bib31","series-title":"Enzymatic Peptide Synthesis","author":"Kullmann","year":"1987"},{"key":"10.1016\/j.enzmictec.2023.110323_bib32","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/07388559209040626","article-title":"The control of bracken","volume":"12","author":"Burge","year":"1992","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2307\/2404361","article-title":"Control of bracken and the restoration of healthland. I-III. Control of bracken, regenetarion of the healthland community, bracken litter disturbance and healthland restoration","volume":"29","author":"Lowdays","year":"1992","journal-title":"J. Appl. Ecol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib34","first-page":"86","article-title":"Obtenci\u00f3n de aminoacilasa 1 de ri\u00f1\u00f3n porcino y su utilizaci\u00f3n en la s\u00edntesis biocatal\u00edtica del sulfanilil carbamato de metilo","volume":"17","author":"M\u00e1rquez","year":"2003","journal-title":"Rev. Biol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib35","article-title":"Modeling and experimental validation of covalent immobilization of Trametes versicolor laccase in gold nanoparticles","volume":"12","author":"Gonz\u00e1lez-Abradelo","year":"2022","journal-title":"Ann. Cuba. Acad. Sci."},{"key":"10.1016\/j.enzmictec.2023.110323_bib36","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0141-0229(88)90018-X","article-title":"Aldehyde-agarose gels as activated supports for immobilization-stabilization of enzymes","volume":"10","author":"Guis\u00e1n","year":"1988","journal-title":"Enz. Microb. Technol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib37","first-page":"3","article-title":"Selective and oriented immobilization of (phospho)lipases from the Caribbean Sea anemone Stichodactyla helianthus (Ellis, 1768) by interfacial adsorption","volume":"43","author":"del Monte-Mart\u00ednez","year":"2012","journal-title":"Rev. CENIC Cienc. Biol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib38","first-page":"250","article-title":"Isolation and kinetics of penicillin amidase from","volume":"276","author":"Balasingham","year":"1972","journal-title":"E. coli. Biochem. Biophys. Acta"},{"key":"10.1016\/j.enzmictec.2023.110323_bib39","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"86","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.enzmictec.2023.110323_bib40","unstructured":"P. Castillo, Utilizaci\u00f3n de la aminoacilasa de ri\u00f1\u00f3n porcino en la hidr\u00f3lisis selectiva del derivado 4-acetilado del sulfanilil carbamato de metilo, para producir el principio activo del herbicida Asulam, Doctoral Thesis, Escuela Polit\u00e9cnica Nacional, Quito, Ecuador, 2003."},{"key":"10.1016\/j.enzmictec.2023.110323_bib41","doi-asserted-by":"crossref","first-page":"8937","DOI":"10.1128\/AEM.71.12.8937-8940.2005","article-title":"Improvement of catalytic properties of Escherichia coli penicillin G acylase immobilized on glyoxyl agarose by addition of a six-amino-acid tag","volume":"71","author":"Scaramozzino","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib42","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1080\/10826068.2017.1315600","article-title":"Rational design and synthesis of affinity matrices based on proteases immobilized onto cellulose membranes","volume":"47","author":"del Monte-Mart\u00ednez","year":"2017","journal-title":"Prep. Biochem. Biotechnol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib43","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jbiotec.2007.08.039","article-title":"Saturation mutagenesis reveals the importance of residues \u03b1R145 and \u03b1F146 of penicillin acylase in the synthesis of \u03b2-lactam antibiotics","volume":"133","author":"Jager","year":"2008","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib44","series-title":"Enzyme biocatalysis: Principles and applications","author":"Illanes","year":"2008"},{"key":"10.1016\/j.enzmictec.2023.110323_bib45","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1039\/B711564B","article-title":"Understanding enzyme immobilization","volume":"38","author":"Hanefeld","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.enzmictec.2023.110323_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ecoenv.2016.10.023","article-title":"Immobilization of Penaeus merguiensis alkaline phosphatase on gold nanorods for heavy metal detection","volume":"136","author":"Homaei","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.enzmictec.2023.110323_bib47","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.ijbiomac.2019.02.163","article-title":"Improved features of a highly stable protease from Penaeus vannamei by immobilization on glutaraldehyde activated graphene oxide nanosheets","volume":"130","author":"Ranjbari","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112754","article-title":"Zinc sulfide-chitosan hybrid nanoparticles as a robust surface for immobilization of Sillago sihama \u03b1-amylase","volume":"218","author":"Bahri","year":"2022","journal-title":"Coll. Surf. B: Biointerfaces"},{"key":"10.1016\/j.enzmictec.2023.110323_bib49","series-title":"Advances in Food Biotechnology","first-page":"145","article-title":"Enzyme immobilization and its application in the food industry","author":"Homaei","year":"2015"},{"key":"10.1016\/j.enzmictec.2023.110323_bib50","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00449-021-02647-y","article-title":"Industrial applications of immobilized nano-biocatalysts","volume":"45","author":"Razzaghi","year":"2022","journal-title":"Bioprocess Biosyst. Eng."},{"key":"10.1016\/j.enzmictec.2023.110323_bib51","first-page":"1","article-title":"Diffusional restrictions in glyoxyl-agarose immobilized penicillin G acylase of different particle size and protein loading, Elect","volume":"13","author":"Illanes","year":"2010","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib52","series-title":"Studies in Organic Chemistry: Stability and Stabilization of Enzymes","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/B978-0-444-89372-7.50012-9","article-title":"Enzyme stabilization by multipoint covalent attachment to activated pre-existing supports","volume":"17","author":"Guis\u00e1n","year":"1993"},{"key":"10.1016\/j.enzmictec.2023.110323_bib53","first-page":"133","article-title":"Estabilidad t\u00e9rmica de biocatalizadores inmovilizados de penicilino amidasa","volume":"11","author":"del Monte-Mart\u00ednez","year":"1997","journal-title":"Rev. Biol."},{"key":"10.1016\/j.enzmictec.2023.110323_bib54","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/adsc.200505042","article-title":"Immobilization of penicillin G acylase: The key to optimum performance","volume":"347","author":"Kallenberg","year":"2005","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.enzmictec.2023.110323_bib55","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1021\/bm100259a","article-title":"Characterization and study of the orientation of immobilized enzymes by tryptic digestion and HPLC-MS: Design of an efficient catalyst for the synthesis of cephalosporins","volume":"11","author":"Temporini","year":"2010","journal-title":"Biomacromolecules"}],"container-title":["Enzyme and Microbial Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014102292300131X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014102292300131X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T01:48:05Z","timestamp":1758851285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014102292300131X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":55,"alternative-id":["S014102292300131X"],"URL":"https:\/\/doi.org\/10.1016\/j.enzmictec.2023.110323","relation":{},"ISSN":["0141-0229"],"issn-type":[{"value":"0141-0229","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rational design of biocatalysts based on covalent immobilization of acylase enzymes","name":"articletitle","label":"Article Title"},{"value":"Enzyme and Microbial Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.enzmictec.2023.110323","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110323"}}