{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T23:51:51Z","timestamp":1773964311523,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19H01613"],"award-info":[{"award-number":["JP19H01613"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Enzyme and Microbial Technology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.enzmictec.2025.110807","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:56:52Z","timestamp":1767167812000},"page":"110807","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effects of overexpression of the human intestinal alkaline phosphatase gene on the expression of related genes in intestinal epithelium-like cells"],"prefix":"10.1016","volume":"195","author":[{"given":"Seiko","family":"Noda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiho","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asako","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadako","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Orimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masae","family":"Goseki-Sone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.enzmictec.2025.110807_bib1","doi-asserted-by":"crossref","first-page":"12002","DOI":"10.1016\/S0021-9258(18)37885-2","article-title":"Structure of the human liver\/bone\/kidney alkaline phosphatase gene","volume":"263","author":"Weiss","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.enzmictec.2025.110807_bib2","doi-asserted-by":"crossref","first-page":"12011","DOI":"10.1016\/S0021-9258(18)37886-4","article-title":"Sequence and characterization of the human intestinal alkaline phosphatase gene","volume":"263","author":"Henthorn","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.enzmictec.2025.110807_bib3","doi-asserted-by":"crossref","first-page":"10599","DOI":"10.1093\/nar\/15.24.10599","article-title":"Promoter structure of the human intestinal alkaline phosphatase gene","volume":"15","author":"Mill\u00e1n","year":"1987","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.enzmictec.2025.110807_bib4","doi-asserted-by":"crossref","first-page":"12020","DOI":"10.1016\/S0021-9258(18)37887-6","article-title":"Nucleotide sequence of the human placental alkaline phosphatase gene: evolution of the 5\u2019 flanking region by deletion\/substitution","volume":"263","author":"Knoll","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.enzmictec.2025.110807_bib5","series-title":"Bone and Mineral Research","first-page":"319","article-title":"Hypophosphatasia","author":"Whyte","year":"1989"},{"key":"10.1016\/j.enzmictec.2025.110807_bib6","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1359\/jbmr.1998.13.12.1827","article-title":"Expression of the mutant (1735T-DEL) tissue-nonspecific alkaline phosphatase gene from hypophosphatasia patients","volume":"13","author":"Goseki-Sone","year":"1998","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.enzmictec.2025.110807_bib7","first-page":"G705","article-title":"Effect of short-chain fatty acids on paracellular permeability in Caco-2 intestinal epithelium model","volume":"272","author":"Mariadason","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.enzmictec.2025.110807_bib8","first-page":"323","article-title":"Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture","volume":"47","author":"Pinto","year":"1983","journal-title":"Biol. Cell"},{"key":"10.1016\/j.enzmictec.2025.110807_bib9","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1073\/pnas.84.5.1234","article-title":"Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase","volume":"84","author":"Henthorn","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.enzmictec.2025.110807_bib10","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1073\/pnas.0712140105","article-title":"RA, Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition","volume":"105","author":"Goldberg","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.enzmictec.2025.110807_bib11","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejphar.2017.12.026","article-title":"Intestinal alkaline phosphatase ameliorates experimental colitis via toll-like receptor 4-dependent pathway","volume":"820","author":"Hwang","year":"2018","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.enzmictec.2025.110807_bib12","doi-asserted-by":"crossref","first-page":"G1439","DOI":"10.1152\/ajpgi.00331.2006","article-title":"Disruption of the murine intestinal alkaline phosphatase gene Akp3 impairs lipid transcytosis and induces visceral fat accumulation and hepatic steatosis","volume":"292","author":"Nakano","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.enzmictec.2025.110807_bib13","doi-asserted-by":"crossref","first-page":"R1738","DOI":"10.1152\/ajpregu.00235.2011","article-title":"Interactions between CD36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet","volume":"301","author":"Lynes","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.enzmictec.2025.110807_bib14","doi-asserted-by":"crossref","first-page":"7003","DOI":"10.1073\/pnas.1220180110","article-title":"Intestinal alkaline phosphatase prevents metabolic syndrome in mice","volume":"110","author":"Kaliannan","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.enzmictec.2025.110807_bib15","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1600-0676.1996.tb00762.x","article-title":"Expression of mRNA encoding intestinal type alkaline phosphatase in rat liver and its increase by fat-feeding","volume":"16","author":"Goseki-Sone","year":"1996","journal-title":"Liver"},{"key":"10.1016\/j.enzmictec.2025.110807_bib16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bone.2004.02.007","article-title":"Enhancement by lactose of intestinal alkaline phosphatase expression in rats","volume":"35","author":"Sogabe","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.enzmictec.2025.110807_bib17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3177\/jnsv.53.219","article-title":"Enhancement effects of vitamin K1 (phylloquinone) or vitamin K2 (menaquinone-4) on intestinal alkaline phosphatase activity in rats","volume":"53","author":"Sogabe","year":"2007","journal-title":"J. Nutr. Sci. Vitam."},{"key":"10.1016\/j.enzmictec.2025.110807_bib18","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3177\/jnsv.57.274","article-title":"Vitamin K1 (phylloquinone) or vitamin K2 (menaquinone-4) induces intestinal alkaline phosphatase gene expression","volume":"57","author":"Haraikawa","year":"2011","journal-title":"J. Nutr. Sci. Vitam."},{"key":"10.1016\/j.enzmictec.2025.110807_bib19","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.nutres.2016.10.001","article-title":"Menaquinone-4 (vitamin K2) up-regulates expression of human intestinal alkaline phosphatase in Caco-2 cells","volume":"36","author":"Noda","year":"2016","journal-title":"Nutr. Res."},{"key":"10.1016\/j.enzmictec.2025.110807_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.nutres.2017.07.005","article-title":"1-alpha,25-Dihydroxyvitamin D3 up-regulates the expression of 2 types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells and may be an important regulator of their expression in gut homeostasis","volume":"46","author":"Noda","year":"2017","journal-title":"Nutr. Res."},{"key":"10.1016\/j.enzmictec.2025.110807_bib21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1517\/17425255.1.2.175","article-title":"Caco-2 cell permeability assays to measure drug absorption","volume":"1","author":"van Breemen","year":"2005","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.enzmictec.2025.110807_bib22","first-page":"323","article-title":"Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture","volume":"47","author":"Pinto","year":"1983","journal-title":"Biol. Cell"},{"key":"10.1016\/j.enzmictec.2025.110807_bib23","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3177\/jnsv.68.284","article-title":"Characterization and structure of alternatively spliced transcript variant of human intestinal alkaline phosphatase (ALPI) Gene","volume":"68","author":"Noda","year":"2022","journal-title":"J. Nutr. Sci. Vitam."},{"key":"10.1016\/j.enzmictec.2025.110807_bib24","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.enzmictec.2025.110807_bib25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinf"},{"key":"10.1016\/j.enzmictec.2025.110807_bib26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.enzmictec.2025.110807_bib27","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/ame2.12475","article-title":"RNA-seq analysis of mitochondria-related genes regulated by AMPK in the human trophoblast cell line BeWo","volume":"8","author":"Wu","year":"2025","journal-title":"Anim. Models Exp. Med."},{"key":"10.1016\/j.enzmictec.2025.110807_bib28","doi-asserted-by":"crossref","first-page":"9462","DOI":"10.3390\/ijms25179462","article-title":"Correlation with apoptosis process through RNA-Seq data analysis of Hep3B hepatocellular carcinoma cells treated with glehnia littoralis extract (GLE)","volume":"25","author":"Park","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.enzmictec.2025.110807_bib29","author":"DAVID","year":"2025","journal-title":"Funct. Annot. Bioinf. Micro Anal."},{"key":"10.1016\/j.enzmictec.2025.110807_bib30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/nar\/27.1.29","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"27","author":"Ogata","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.enzmictec.2025.110807_bib31","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.7150\/jca.31877","article-title":"The role of the slit\/robo signaling pathway","volume":"10","author":"Tong","year":"2019","journal-title":"J. Cancer"},{"key":"10.1016\/j.enzmictec.2025.110807_bib32","article-title":"IMPC-based screening revealed that ROBO1 can regulate osteoporosis by inhibiting osteogenic differentiation","volume":"12","author":"Zhang","year":"2004","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.enzmictec.2025.110807_bib33","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000026981","article-title":"Expression of the axon guidance factor Slit2 and its receptor Robo1 in patients with Hirschsprung disease: an observational study","volume":"100","author":"Kong","year":"2021","journal-title":"Medicine"},{"key":"10.1016\/j.enzmictec.2025.110807_bib34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature12416","article-title":"Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection","volume":"501","author":"Zhou","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.enzmictec.2025.110807_bib35","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.7150\/ijbs.42331","article-title":"Slit2\/Robo1 mitigates DSS-induced ulcerative colitis by activating autophagy in intestinal stem cell","volume":"16","author":"Xie","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.enzmictec.2025.110807_bib36","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0896-6273(92)90237-8","article-title":"Fasciclin IV: sequence, expression, and function during growth cone guidance in the grasshopper embryo","volume":"9","author":"Kolodkin","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.enzmictec.2025.110807_bib37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0092-8674(93)80064-L","article-title":"Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones","volume":"75","author":"Luo","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.enzmictec.2025.110807_bib38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0959-4388(03)00003-5","article-title":"Semaphorin junction: making tracks toward neural connectivity","volume":"13","author":"Pasterkamp","year":"2003","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.enzmictec.2025.110807_bib39","first-page":"107","article-title":"PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development","volume":"7","author":"Gitler","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.enzmictec.2025.110807_bib40","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.1105416","article-title":"Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins","volume":"307","author":"Gu","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.enzmictec.2025.110807_bib41","first-page":"156","article-title":"The role and mechanism-of-action of Sema3E and Plexin-D1 in vascular and neural development, Semin","volume":"24","author":"Oh","year":"2013","journal-title":"Cell Dev. Biol."},{"key":"10.1016\/j.enzmictec.2025.110807_bib42","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.bcp.2019.05.029","article-title":"Semaphorin 3E regulates apoptosis in the intestinal epithelium during the development of colitis","volume":"166","author":"Eissa","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.enzmictec.2025.110807_bib43","doi-asserted-by":"crossref","first-page":"1235-","DOI":"10.1111\/bph.14614","article-title":"Semaphorin-3E attenuates intestinal inflammation through the regulation of the communication between splenic CD11C+ and CD4+ CD25- T-cells","volume":"176","author":"Kermarrec","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.enzmictec.2025.110807_bib44","doi-asserted-by":"crossref","first-page":"6174-","DOI":"10.1523\/JNEUROSCI.5464-10.2011","article-title":"Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain","volume":"31","author":"Hern\u00e1ndez-Miranda","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.enzmictec.2025.110807_bib45","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0092-8674(00)00041-6","article-title":"Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord","volume":"102","author":"Zou","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.enzmictec.2025.110807_bib46","doi-asserted-by":"crossref","first-page":"5753","DOI":"10.1523\/JNEUROSCI.0073-22.2023","article-title":"Axon fasciculation, mediated by transmembrane semaphorins, is critical for the establishment of segmental specificity of corticospinal circuits","volume":"43","author":"Gu","year":"2023","journal-title":"J. Neurosci."},{"key":"10.1016\/j.enzmictec.2025.110807_bib47","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00223-011-9560-7","article-title":"A class III semaphorin (Sema3e) inhibits mouse osteoblast migration and decreases osteoclast formation in vitro","volume":"90","author":"Hughes","year":"2012","journal-title":"Calcif. Tissue Int"},{"key":"10.1016\/j.enzmictec.2025.110807_bib48","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cytogfr.2015.07.001","article-title":"Leukemia inhibitory factor (LIF)","volume":"26","author":"Nicola","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.enzmictec.2025.110807_bib49","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1126\/science.8272873","article-title":"Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components","volume":"263","author":"Stahl","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.enzmictec.2025.110807_bib50","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1172\/JCI63428","article-title":"Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance","volume":"123","author":"Liu","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.enzmictec.2025.110807_bib51","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/j.bbadis.2018.05.004","article-title":"LIFR promotes tumor angiogenesis by up-regulating IL-8 levels in colorectal cancer","volume":"1864","author":"Wu","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.enzmictec.2025.110807_bib52","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.1038\/ncomms6218","article-title":"LIF negatively regulates tumour-suppressor p53 through Stat3\/ID1\/MDM2 in colorectal cancers","volume":"5","author":"Yu","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.enzmictec.2025.110807_bib53","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.gendis.2021.04.003","article-title":"Targeting LIF\/LIFR signaling in cancer","volume":"9","author":"Viswanadhapalli","year":"2021","journal-title":"Genes Dis."}],"updated-by":[{"DOI":"10.1016\/j.enzmictec.2026.110820","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000}},{"DOI":"10.1016\/j.enzmictec.2026.110820","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000}}],"container-title":["Enzyme and Microbial Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141022925002273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141022925002273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T21:24:31Z","timestamp":1773955471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141022925002273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":53,"alternative-id":["S0141022925002273"],"URL":"https:\/\/doi.org\/10.1016\/j.enzmictec.2025.110807","relation":{},"ISSN":["0141-0229"],"issn-type":[{"value":"0141-0229","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of overexpression of the human intestinal alkaline phosphatase gene on the expression of related genes in intestinal epithelium-like cells","name":"articletitle","label":"Article Title"},{"value":"Enzyme and Microbial Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.enzmictec.2025.110807","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110807"}}