{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:08:53Z","timestamp":1790910533502,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T00:00:00Z","timestamp":1584576000000},"content-version":"vor","delay-in-days":2787,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000913","name":"James S. McDonnell foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000913","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epidemics"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.epidem.2012.07.001","type":"journal-article","created":{"date-parts":[[2012,7,18]],"date-time":"2012-07-18T12:26:03Z","timestamp":1342614363000},"page":"152-157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Ecological and inhost factors promoting distinct parasite life-history strategies in Lyme borreliosis"],"prefix":"10.1016","volume":"4","author":[{"given":"James","family":"Haven","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztian","family":"Magori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10 (October)","key":"10.1016\/j.epidem.2012.07.001_bib0005","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/BF00051830","article-title":"Relative utilization of reptiles and rodents as hosts by immature Ixodes scapularis (Acari: Ixodidae) in the coastal plain of North Carolina, USA","volume":"17","author":"Apperson","year":"1993","journal-title":"Experimental and Applied Acarology"},{"issue":"10 (October)","key":"10.1016\/j.epidem.2012.07.001_bib0010","first-page":"1","article-title":"Surveillance for Lyme disease \u2013 United States, 1992\u20132006","volume":"57","author":"Bacon","year":"2008","journal-title":"MMWR. Surveillance Summaries"},{"issue":"2 (October)","key":"10.1016\/j.epidem.2012.07.001_bib0015","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1534\/genetics.104.028738","article-title":"ospC diversity in Borrelia burgdorferi","volume":"168","author":"Brisson","year":"2004","journal-title":"Genetics"},{"issue":"1631 (January)","key":"10.1016\/j.epidem.2012.07.001_bib0020","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1098\/rspb.2007.1208","article-title":"Conspicuous impacts of inconspicuous hosts on the Lyme disease epidemic","volume":"275","author":"Brisson","year":"2008","journal-title":"Proceedings of the Royal Society Biological Science"},{"issue":"6 (June)","key":"10.1016\/j.epidem.2012.07.001_bib0025","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3201\/eid1606.090329","article-title":"Evolution of Northeastern and Midwestern Borrelia burgdorferi, United States","volume":"16","author":"Brisson","year":"2010","journal-title":"Emerging Infectious Diseases"},{"key":"10.1016\/j.epidem.2012.07.001_bib0030","unstructured":"Committee on Lyme Disease and Other Tick-Borne Diseases: The State of the Science; Institute of Medicine, 2011. Critical Needs and Gaps in Understanding Prevention, Amelioration, and Resolution of Lyme and Other Tick-Borne Diseases: The Short-Term and Long-Term Outcomes: Workshop Report. The National Academies Press, Washington, D.C."},{"issue":"Suppl. 40 (May)","key":"10.1016\/j.epidem.2012.07.001_bib0035","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijmm.2006.01.011","article-title":"Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferi","volume":"296","author":"Cordes","year":"2006","journal-title":"International Journal of Medical Microbiology"},{"key":"10.1016\/j.epidem.2012.07.001_bib0040","series-title":"PBSddesolve: Solver for Delay Differential Equations [Internet]","author":"Couture-Beil","year":"2010"},{"issue":"11 (November)","key":"10.1016\/j.epidem.2012.07.001_bib0045","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1128\/AEM.70.11.6783-6788.2004","article-title":"Interaction and transmission of two Borrelia burgdorferi sensu stricto strains in a tick-rodent maintenance system","volume":"70","author":"Derd\u00e1kov\u00e1","year":"2004","journal-title":"Applied and Environmental Microbiology"},{"issue":"8 (April)","key":"10.1016\/j.epidem.2012.07.001_bib0050","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1128\/AEM.02633-08","article-title":"Climate and tick seasonality are predictors of borrelia burgdorferi genotype distribution","volume":"75","author":"Gatewood","year":"2009","journal-title":"Applied and Environmental Microbiology"},{"issue":"February (2)","key":"10.1016\/j.epidem.2012.07.001_bib0055","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/PEC.0b013e318209f0b3","article-title":"Tick-borne illnesses: a CME update","volume":"27","author":"Graham","year":"2011","journal-title":"Pediatric Emergency Care"},{"key":"10.1016\/j.epidem.2012.07.001_bib0060","series-title":"Lyme Borreliosis: Biology, Epidemiology, and Control","author":"Gray","year":"2002"},{"issue":"4 (April)","key":"10.1016\/j.epidem.2012.07.001_bib0065","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3201\/eid1204.051016","article-title":"Epidemic spread of Lyme borreliosis, northeastern United States","volume":"12","author":"Hanincov\u00e1","year":"2006","journal-title":"Emerging Infectious Diseases"},{"issue":"1 (January)","key":"10.1016\/j.epidem.2012.07.001_bib0070","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1128\/AEM.01567-07","article-title":"Fitness variation of Borrelia burgdorferi sensu stricto strains in mice","volume":"74","author":"Hanincov\u00e1","year":"2008","journal-title":"Applied and Environment Microbiology"},{"issue":"3 (November)","key":"10.1016\/j.epidem.2012.07.001_bib0075","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1534\/genetics.111.130773","article-title":"Pervasive recombination and sympatric genome diversification driven by frequency-dependent selection in Borrelia burgdorferi, the Lyme disease bacterium","volume":"189","author":"Haven","year":"2011","journal-title":"Genetics"},{"issue":"9 (September)","key":"10.1016\/j.epidem.2012.07.001_bib0080","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1111\/j.1558-5646.2010.01001.x","article-title":"Uncoordinated phylogeography of Borrelia burgdorferi and its tick vector, Ixodes scapularis","volume":"64","author":"Humphrey","year":"2010","journal-title":"Evolution"},{"issue":"March (1)","key":"10.1016\/j.epidem.2012.07.001_bib0085","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cll.2009.10.004","article-title":"Human ehrlichiosis and anaplasmosis","volume":"30","author":"Ismail","year":"2010","journal-title":"Clinics in Laboratory Medicine"},{"issue":"12 (December)","key":"10.1016\/j.epidem.2012.07.001_bib0090","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1128\/JCM.01077-06","article-title":"Borrelia burgdorferi genetic markers and disseminated disease in patients with early Lyme disease","volume":"44","author":"Jones","year":"2006","journal-title":"Journal of Clinical Microbiology"},{"issue":"21\u201322 (November)","key":"10.1016\/j.epidem.2012.07.001_bib0095","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00508-006-0691-1","article-title":"Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferi","volume":"118","author":"Kraiczy","year":"2006","journal-title":"Wiener Klinische Wochenschrift"},{"issue":"9 (September)","key":"10.1016\/j.epidem.2012.07.001_bib0100","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nrmicro1475","article-title":"Fundamental processes in the evolutionary ecology of Lyme borreliosis","volume":"4","author":"Kurtenbach","year":"2006","journal-title":"Nature Reviews Microbiology"},{"issue":"4 (October)","key":"10.1016\/j.epidem.2012.07.001_bib0105","doi-asserted-by":"crossref","first-page":"766","DOI":"10.7589\/0090-3558-33.4.766","article-title":"Duration of Borrelia burgdorferi infectivity in white-footed mice for the tick vector Ixodes scapularis under laboratory and field conditions in Ontario","volume":"33","author":"Lindsay","year":"1997","journal-title":"Journal of Wildlife Diseases"},{"issue":"Pt 2 (February)","key":"10.1016\/j.epidem.2012.07.001_bib0110","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1017\/S0031182006001417","article-title":"Vector seasonality, host infection dynamics and fitness of pathogens transmitted by the tick Ixodes scapularis","volume":"134","author":"Ogden","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/j.epidem.2012.07.001_bib0115","doi-asserted-by":"crossref","first-page":"S191","DOI":"10.1017\/S0031182003004694","article-title":"Lyme borreliosis in Europe and North America","volume":"129","author":"Piesman","year":"2004","journal-title":"Parasitology"},{"issue":"39 (September)","key":"10.1016\/j.epidem.2012.07.001_bib0120","doi-asserted-by":"crossref","first-page":"14150","DOI":"10.1073\/pnas.0402745101","article-title":"Genetic exchange and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by three-way genome comparisons and multilocus sequence typing","volume":"101","author":"Qiu","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.epidem.2012.07.001_bib0125","series-title":"R: A language and environment for statistical computing","author":"R Development Core Team","year":"2009"},{"key":"10.1016\/j.epidem.2012.07.001_bib0130","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1603\/0022-2585-38.4.493","article-title":"Birds disperse ixodid (Acari: ixodidae) and Borrelia burgdorferi-infected ticks in Canada","volume":"38","author":"Scott","year":"2001","journal-title":"Journal of Medical Entomology"},{"issue":"11 (November)","key":"10.1016\/j.epidem.2012.07.001_bib0135","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1128\/jcm.31.11.2878-2881.1993","article-title":"Accelerated transmission of Lyme disease spirochetes by partially fed vector ticks","volume":"31","author":"Shih","year":"1993","journal-title":"Journal of Clinical Microbiology"},{"issue":"4 (December)","key":"10.1016\/j.epidem.2012.07.001_bib0140","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1051\/parasite\/2009164259","article-title":"Update on tick-borne bacterial diseases in Europe","volume":"16","author":"Socolovschi","year":"2009","journal-title":"Parasite"},{"issue":"5 (November)","key":"10.1016\/j.epidem.2012.07.001_bib0145","doi-asserted-by":"crossref","first-page":"725","DOI":"10.7326\/0003-4819-107-5-725","article-title":"The clinical evolution of Lyme arthritis","volume":"107","author":"Steere","year":"1987","journal-title":"Annals of Internal Medicine"},{"issue":"9 (November)","key":"10.1016\/j.epidem.2012.07.001_bib0150","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1086\/592279","article-title":"Borrelia burgdorferi genotype predicts the capacity for hematogenous dissemination during early Lyme disease","volume":"198","author":"Wormser","year":"2008","journal-title":"Journal of Infectious Diseases"},{"issue":"1\u20132 (September)","key":"10.1016\/j.epidem.2012.07.001_bib0155","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.gene.2009.05.017","article-title":"Fast, adaptive evolution at a bacterial host-resistance locus: the PFam54 gene array in Borrelia burgdorferi","volume":"445","author":"Wywial","year":"2009","journal-title":"Gene"}],"container-title":["Epidemics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1755436512000333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1755436512000333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:38:27Z","timestamp":1761698307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1755436512000333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S1755436512000333"],"URL":"https:\/\/doi.org\/10.1016\/j.epidem.2012.07.001","relation":{},"ISSN":["1755-4365"],"issn-type":[{"value":"1755-4365","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ecological and inhost factors promoting distinct parasite life-history strategies in Lyme borreliosis","name":"articletitle","label":"Article Title"},{"value":"Epidemics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.epidem.2012.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}