{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:42:37Z","timestamp":1791999757959,"version":"4.4.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2003,10]]},"DOI":"10.1016\/j.eplepsyres.2003.08.008","type":"journal-article","created":{"date-parts":[[2003,10,27]],"date-time":"2003-10-27T19:43:33Z","timestamp":1067283813000},"page":"147-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Assessment of copper status in epileptic patients treated with anticonvulsant drugs by measuring the specific oxidase activity of ceruloplasmin"],"prefix":"10.1016","volume":"56","author":[{"given":"Mar\u0131&#x;a J.","family":"Tutor-Crespo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Hermida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.Carlos","family":"Tutor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0009-8981(92)90342-N","article-title":"Enzyme induction by drugs and toxins","volume":"209","author":"Batt","year":"1992","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1159\/000198045","article-title":"Barbiturate-induced choleresis: possible independence from microsomal enzyme induction","volume":"15","author":"Capron","year":"1977","journal-title":"Digestion"},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB3","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1159\/000198158","article-title":"Lack of parallelism between microsomal enzyme induction and phenobarbital-induced hypercholeresis in the rat","volume":"17","author":"Chivrac","year":"1978","journal-title":"Digestion"},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB4","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/clinchem\/44.11.2313","article-title":"Automated measurement of serum ferroxidase activity","volume":"44","author":"Erel","year":"1998","journal-title":"Clin. Chem."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB5","first-page":"77","article-title":"Determinaci\u00f3n del \u00e1cido d-gluc\u00e1rico urinario por un procedimiento enzim\u00e1tico","volume":"2","author":"Fern\u00e1ndez","year":"1982","journal-title":"Clin. Chem. Newslett."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB6","first-page":"190","article-title":"Development and regression of the hepatic microsomal enzyme induction and stimulation of biliary excretion produced by phenobarbital in rats","volume":"247","author":"Fisher","year":"1980","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB7","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1177\/096032718300200308","article-title":"Hypercupraemia induced by antiepileptic drugs","volume":"2","author":"Ghose","year":"1983","journal-title":"Hum. Toxicol."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB8","doi-asserted-by":"crossref","first-page":"9485","DOI":"10.1093\/jn\/133.3.948S","article-title":"Biomarkers of trace mineral intake and status","volume":"133","author":"Hambidge","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev.nutr.22.012502.114457","article-title":"Ceruloplasmin metabolism and function","volume":"22","author":"Hellman","year":"2002","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB10","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1046\/j.1468-1331.1999.t01-1-660705.x","article-title":"Serum and hair trace element levels in patients with epilepsy and healthy subjects: does antiepileptics therapy affect the element concentrations of hair?","volume":"6","author":"Ilhan","year":"1999","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1528-1157.1992.tb01709.x","article-title":"Serum copper and zinc levels in epileptic children with valproate treatment","volume":"33","author":"Kaji","year":"1992","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0009-8981(78)90259-0","article-title":"A new procedure for the visualization of multiple forms of gamma-glutamyltransferase. Results in normals, patients receiving enzyme-inducing drugs and patients having liver parenchymal lesions","volume":"90","author":"Kok","year":"1978","journal-title":"Clim. Chim. Acta"},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB13","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/j.1528-1157.1995.tb02574.x","article-title":"Plasma trace element, plasma glutathione peroxidase, and superoxide dismutase levels in epileptic children receiving antiepileptic drug therapy","volume":"36","author":"Kurekci","year":"1995","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB14","first-page":"61","article-title":"Effect of antiepileptic drugs on serum zinc and copper concentrations in epileptic patients","volume":"31","author":"Kuzuya","year":"1993","journal-title":"Int. J. Clin. Pharmacol. Ther. Toxicol."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0920-1211(02)00155-9","article-title":"Valproic acid increases biliary copper excretion","volume":"51","author":"Kuzuya","year":"2002","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB16","first-page":"119","article-title":"Determinaci\u00f3n de la actividad oxid\u00e1sica de la ceruloplasmina en los analizadores Cobas Bio y Cobas Fara","volume":"25","author":"Louro","year":"1991","journal-title":"Acta Bioquim. Clin. Latinoam."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0009-8981(01)00607-6","article-title":"Assessment of copper status in pregnancy by means of determining the specific oxidase activity of ceruloplasmin","volume":"312","author":"Louro","year":"2001","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB18","first-page":"186","article-title":"Hair analysis. A critical review","volume":"133","author":"Manson","year":"1985","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB19","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1093\/clinchem\/40.8.1479","article-title":"Assessment of copper nutritional status","volume":"40","author":"Milne","year":"1994","journal-title":"Clin. Chem."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB20","unstructured":"Milne, D.B., 1999. Trace elements. In: Burtis, C.A., Ashwood, E.R. (Eds.), Tietz Textbook of Clinical Chemistry (3rd ed.). Philadelphia, Saunders, pp. 1029\u20131055."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB21","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/clinchem\/39.5.883","article-title":"Assessment of copper status: effect of age and gender on reference ranges in healthy adults","volume":"39","author":"Milne","year":"1993","journal-title":"Clin. Chem."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.1365-2214.2002.00009.x","article-title":"Hair-element analysis still on the fringe","volume":"28","author":"Morley","year":"2002","journal-title":"Child Care Health Dev."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB23","first-page":"156","article-title":"Concentration of copper and ceruloplasmin in serum of patients treated for epilepsy","volume":"51","author":"Motta","year":"1998","journal-title":"Wiad Lek."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB24","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/clinchem\/31.6.797","article-title":"Gamma-glutamyltransferase and its isoenzymes: progress and problems","volume":"31","author":"Nemes\u00e1nszky","year":"1985","journal-title":"Clin. Chem."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB25","first-page":"363","article-title":"Multiple forms of serum 5\u2032-nucleotidase in patients receiving anticonvulsant drugs","volume":"28","author":"Novo","year":"1994","journal-title":"L\u2019Eurobiologiste (Paris)"},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB26","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1528-1157.1982.tb05433.x","article-title":"Zinc and copper metabolism in phenytoin therapy","volume":"23","author":"Palm","year":"1982","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB27","unstructured":"Rosalki, S.B., 1976. Plasma enzyme changes and their interpretation in patients receiving anticonvulsant and enzyme-inducing drugs. In: Richens, A., Woodford, F.P. (Eds.), Anticonvulsant Drugs and Enzyme Induction. Associated Scientific Publishers, Amsterdam, pp. 27\u201335."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB28","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/elps.1150100815","article-title":"Electrophoretic behaviour and partial characterization of disease-associated serum forms of gamma-glutamyl transferase","volume":"10","author":"Sacchetti","year":"1989","journal-title":"Electrophoresis"},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB29","first-page":"69","article-title":"Biological functions of ceruloplasmin expressed through copper binding sites and cellular receptor","volume":"7","author":"Saenko","year":"1994","journal-title":"J. Trace Elem. Exp. Med."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1515\/JBCPP.1995.6.3-4.265","article-title":"The effects of antiepileptic drugs on serum zinc and copper levels in children","volume":"6","author":"Sozuer","year":"1995","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB31","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0006-3223(92)90243-S","article-title":"Effects of long-term anticonvulsant therapy on copper, zinc, and magnesium in hair and serum of epileptics","volume":"31","author":"Suzuki","year":"1992","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0731-7085(87)80047-X","article-title":"Determination of human serum ceruloplasmin by measurement of its 3,3\u20325,5\u2032-tatramethylbenzidine oxidase activity","volume":"5","author":"Takayanagi","year":"1987","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB33","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/clinchem\/28.6.1367","article-title":"Serum copper concentration and hepatic enzyme induction during long-term therapy with anticonvulsants","volume":"28","author":"Tutor","year":"1982","journal-title":"Clin. Chem."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB34","doi-asserted-by":"crossref","first-page":"711","DOI":"10.33588\/rn.3508.2002250","article-title":"Estudio de algunos marcadores bioqu\u0131́micos indirectos en la evaluaci\u00f3n de la inducci\u00f3n enzim\u00e1tica por f\u00e1rmacos antiepil\u00e9pticos","volume":"35","author":"Tutor-Crespo","year":"2002","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB35","first-page":"31","article-title":"Magnesium, zinc and copper contents in hair and their serum concentrations in patients with epilepsy","volume":"7","author":"Ulvi","year":"2002","journal-title":"Eastern J. Med."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0920-1211(01)00322-9","article-title":"Serum copper, zinc, selenium, glutathione peroxidase and superoxide dismutase levels in epileptic children before and after 1 year of sodium valproate and carbamazepine therapy","volume":"48","author":"Verrotti","year":"2002","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2003.08.008_BIB37","first-page":"269","article-title":"Effect of long-term administration of anticonvulsants on copper, zinc and ceruloplasmin levels","volume":"4","author":"Werther","year":"1986","journal-title":"Drug Nutr. Interact."}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121103001542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121103001542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:13:45Z","timestamp":1760274825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121103001542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":37,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["S0920121103001542"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2003.08.008","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2003,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of copper status in epileptic patients treated with anticonvulsant drugs by measuring the specific oxidase activity of ceruloplasmin","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2003.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}