{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:38:10Z","timestamp":1783690690249,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1016\/j.eplepsyres.2004.02.001","type":"journal-article","created":{"date-parts":[[2004,4,17]],"date-time":"2004-04-17T19:13:19Z","timestamp":1082229199000},"page":"155-165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Behavioral effects of bicuculline microinjection in the dorsal versus ventral hippocampal formation of rats, and control of seizures by nigral muscimol"],"prefix":"10.1016","volume":"58","author":[{"given":"Marcelo Cairr\u00e3o Araujo","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00ea","family":"de Oliveira Beleboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Coutinho-Netto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner Ferreira","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto","family":"Garcia-Cairasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB1","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1016\/S0968-0896(01)00148-1","article-title":"Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-\u03a9 asymmetrically substituted nipecotic acid derivatives","volume":"9","author":"Andersen","year":"2001","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0006-8993(01)02252-1","article-title":"Kainic acid-induced dorsal and ventral hippocampal seizures in rats","volume":"900","author":"Akaike","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB3","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0031-9384(97)00303-X","article-title":"Kindling of the dorsal and the ventral hippocampus: effects on learning performance in rats","volume":"62","author":"Becker","year":"1997","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0306-4522(85)90299-4","article-title":"Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy","volume":"14","author":"Ben-Ari","year":"1985","journal-title":"Neuroscience"},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0031-9384(88)90038-8","article-title":"Defense reaction induced by microinjections of bicuculline into the inferior colliculus","volume":"44","author":"Brand\u00e3o","year":"1988","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0031-9384(00)00418-2","article-title":"Changes in the auditory-evoked potentials induced by fear-evoking stimulations","volume":"72","author":"Brand\u00e3o","year":"2001","journal-title":"Physiol. Behav."},{"issue":"6","key":"10.1016\/j.eplepsyres.2004.02.001_BIB7","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1076\/phbi.40.6.472.8436","article-title":"Anticonvulsant and GABA uptake inhibition properties of P. bistriata and S. raptoria spiders venom fractions","volume":"40","author":"Cairr\u00e3o","year":"2002","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB8","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s002130000544","article-title":"Effects of opioid blockade on defensive behavior elicited by electrical stimulation of the aversive substrates of the inferior colliculus in Rattus norvergicus (Rodentia, Muridae)","volume":"152","author":"Coimbra","year":"2000","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB9","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/2261222a0","article-title":"GABA, bicuculline and central inhibition","volume":"226","author":"Curtis","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB10","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/S0028-3908(00)00075-7","article-title":"GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors","volume":"39","author":"Dalby","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0301-0082(94)90020-5","article-title":"Endogenous control of epilepsy: the nigral inhibitory system","volume":"42","author":"Depaulis","year":"1994","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0920-1211(96)00043-5","article-title":"Introduction to temporal lobe epilepsy","volume":"26","author":"Engel","year":"1996","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0920-1211(97)00093-4","article-title":"Decreased brainstem seizure thresholds and facilitated seizure propagation in mice exposed to repeated flurothyl-induced generalized forebrain seizures","volume":"30","author":"Ferland","year":"1998","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB14","first-page":"2414","article-title":"Mechanisms of seizure control mediated by gamma aminobutyric acid: the role of the substantia nigra","volume":"44","author":"Gale","year":"1985","journal-title":"Fed. Proc."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB15","doi-asserted-by":"crossref","unstructured":"Gale, K., Browning, R.A., 1988. Anatomical and neurochemical substrates of clonic and tonic seizures. In: Dichter, M. (Ed.), Mechanisms of Epileptogenesis from Membranes to Man. Plenum, New York, pp. 111\u2013152.","DOI":"10.1007\/978-1-4684-5556-4_8"},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0920-1211(96)00050-2","article-title":"Neuroethological and morphological (Neo-Timm staining) correlates of limbic recruitment during the development of audiogenic kindling in seizure susceptible Wistar rats","volume":"26","author":"Garcia-Cairasco","year":"1996","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB17","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0378-5955(02)00371-4","article-title":"A critical review on the participation of inferior colliculus in acoustic-motor and acoustic-limbic networks involved in the expression of acute and kindled audiogenic seizures","volume":"168","author":"Garcia-Cairasco","year":"2002","journal-title":"Hearing Res."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB18","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0006-8993(85)91309-5","article-title":"Epileptiform burst responses in ventral vs. dorsal hippocampal slices","volume":"361","author":"Gilbert","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB19","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1126\/science.7146907","article-title":"Substantia nigra: site of anticonvulsant activity by gamma aminobutyric acid","volume":"218","author":"Iadarola","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0163-7258(95)02043-8","article-title":"GABAA receptor pharmacology","volume":"69","author":"Johnston","year":"1996","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB21","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1212\/WNL.52.6.1191","article-title":"Lamotrigine-induced tourettism","volume":"52","author":"Lombroso","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB22","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1146\/annurev.ne.17.030194.003033","article-title":"GABAA receptor channels","volume":"17","author":"Macdonald","year":"1994","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB23","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1523\/JNEUROSCI.04-09-02410.1984","article-title":"Evidence implicating substantia nigra in regulation of kindled seizure threshold","volume":"4","author":"McNamara","year":"1984","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4886(89)90118-0","article-title":"Seizures evoked from area tempestas are subject to control by GABA and glutamate receptors in substantia nigra","volume":"105","author":"Maggio","year":"1989","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(91)90567-F","article-title":"Lack of proconvulsant action of GABA depletion in substantia nigra in several seizure models","volume":"547","author":"Maggio","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0361-9230(95)02136-1","article-title":"Effects of lesions of amygdaloid nuclei and substantia nigra on aversive responses induced by electrical stimulation of the inferior colliculus","volume":"40","author":"Maisonnette","year":"1996","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB27","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/275230a0","article-title":"Striatal dopamine release and contraversive rotation elicited by intranigrally applied muscimol","volume":"275","author":"Martin","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB28","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1528-1157.2000.tb00254.x","article-title":"Lamotrigine-induced tic disorder: report of five pediatric cases","volume":"41","author":"Menezes","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0920-1211(00)00107-8","article-title":"Audiogenic kindling in the Wistar rat: a potential model for recruitment of limbic structures","volume":"39","author":"Moraes","year":"2000","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0006-8993(94)91164-9","article-title":"Maturation and segregation of brain networks that modify seizures","volume":"665","author":"Mosh\u00e9","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB31","unstructured":"Paxinos, G., Watson, C., 1986. The Rat Brain in Stereotaxic Coordinates, 2nd ed. Academic Press, California."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB32","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation: II, motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephal. Clin. Neurophysiol."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1017\/S0317167100025117","article-title":"Afterdischarge thresholds and kindling rates in dorsal and ventral hippocampus and dentate gyrus","volume":"4","author":"Racine","year":"1977","journal-title":"Can. J. Neurol."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB34","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0306-4522(03)00191-X","article-title":"Hippocampal cell proliferation and epileptogenesis after audiogenic kindling are not accompanied by mossy fiber sprouting or fluoro-jade staining","volume":"119","author":"Romcy-Pereira","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB35","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1528-1157.2002.26901.x","article-title":"Neuronal networks in human epilepsy: evidence of and implications for treatment","volume":"43","author":"Spencer","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB36","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/0006-8993(89)90211-4","article-title":"Evidence for the involvement of nigral GABAA receptors in seizures of adult rats","volume":"480","author":"Sperber","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB37","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0166-4328(05)80320-1","article-title":"Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. I. Effects of midcollicular knife cuts","volume":"52","author":"Tsutsui","year":"1992","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0014-2999(96)00341-X","article-title":"Developmental regulation of regional functionality of substantia nigra GABAA receptors involved in seizures","volume":"309","author":"Vel\u0131\u0301skov\u00e1","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB39","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0920-1211(97)00096-X","article-title":"Regional and age specific effects of zolpidem microinfusions in the substantia nigra on seizures","volume":"30","author":"Vel\u0131\u0301skov\u00e1","year":"1998","journal-title":"Epilepsy Res."},{"issue":"12","key":"10.1016\/j.eplepsyres.2004.02.001_BIB40","doi-asserted-by":"crossref","first-page":"5054","DOI":"10.1523\/JNEUROSCI.19-12-05054.1999","article-title":"Interleukin-1\u03b2 immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures","volume":"19","author":"Vezzani","year":"1999","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.eplepsyres.2004.02.001_BIB41","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1046\/j.1528-1157.43.s.5.14.x","article-title":"Functional role of inflammatory cytokines and antiinflamatory molecules in seizures and epileptogenesis","volume":"43","author":"Vezzani","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2004.02.001_BIB42","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1528-1157.1992.tb01688.x","article-title":"Age-dependent differences in the anticonvulsant effects of 2-amino-7-phosphono-heptanoic acid of ketamine infusions into the substantia nigra of rats","volume":"33","author":"Wurpel","year":"1992","journal-title":"Epilepsia"}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121104000282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121104000282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:13:21Z","timestamp":1760274801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121104000282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":42,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["S0920121104000282"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2004.02.001","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2004,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Behavioral effects of bicuculline microinjection in the dorsal versus ventral hippocampal formation of rats, and control of seizures by nigral muscimol","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2004.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}