{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T04:09:26Z","timestamp":1768795766714,"version":"3.49.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.eplepsyres.2008.05.011","type":"journal-article","created":{"date-parts":[[2008,7,23]],"date-time":"2008-07-23T04:22:46Z","timestamp":1216786966000},"page":"188-197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["GABAA receptor properties in catastrophic infantile epilepsy"],"prefix":"10.1016","volume":"81","author":[{"given":"Laura A.","family":"Jansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey D.","family":"Peugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey G.","family":"Ojemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2008.05.011_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neuroscience.2006.11.041","article-title":"Differential expression patterns of chloride transporters, Na+\u2013K+\u20132Cl-cotransporter and K+\u2013Cl-cotransporter, in epilepsy-associated malformations of cortical development","volume":"145","author":"Aronica","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib2","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/308734a0","article-title":"Release of endogenous Zn2+ from brain tissue during activity","volume":"308","author":"Assaf","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1113\/jphysiol.1983.sp014852","article-title":"A transient calcium-dependent chloride current in the immature Xenopus oocyte","volume":"342","author":"Barish","year":"1983","journal-title":"J. Physiol."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0031-6997(24)01363-2","article-title":"International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acid A receptors: classification on the basis of subunit structure and receptor function","volume":"50","author":"Barnard","year":"1998","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0028-3908(02)00172-7","article-title":"The influence of subunit composition on the interaction of neurosteroids with GABA(A) receptors","volume":"43","author":"Belelli","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1684\/j.1950-6945.2006.tb00167.x","article-title":"Basic developmental rules and their implications for epilepsy in the immature brain","volume":"8","author":"Ben-Ari","year":"2006","journal-title":"Epileptic Disord."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib7","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/2661","article-title":"Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy","volume":"4","author":"Brooks-Kayal","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib8","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1046\/j.1471-4159.2001.00329.x","article-title":"Gamma-aminobutyric acid(A) receptor subunit expression predicts functional changes in hippocampal dentate granule cells during postnatal development","volume":"77","author":"Brooks-Kayal","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib9","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0387-7604(01)00312-6","article-title":"How do the many etiologies of West syndrome lead to excitability and seizures? The corticotropin releasing hormone excess hypothesis","volume":"23","author":"Brunson","year":"2001","journal-title":"Brain Dev."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib10","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1126\/science.271.5247.369","article-title":"Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model","volume":"271","author":"Buhl","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib11","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.1523\/JNEUROSCI.2687-05.2005","article-title":"Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia","volume":"25","author":"Calcagnotto","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.yebeh.2006.05.012","article-title":"Epileptogenesis in pediatric cortical dysplasia: the dysmature cerebral developmental hypothesis","volume":"9","author":"Cepeda","year":"2006","journal-title":"Epilepsy Behav."},{"issue":"Suppl. 5","key":"10.1016\/j.eplepsyres.2008.05.011_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1528-1167.2007.01293.x","article-title":"Immature neurons and GABA networks may contribute to epileptogenesis in pediatric cortical dysplasia","volume":"48","author":"Cepeda","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib14","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/jnr.10604","article-title":"Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia","volume":"72","author":"Cepeda","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib15","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1046\/j.1460-9568.2003.02597.x","article-title":"Dentate granule cell GABA(A) receptors in epileptic hippocampus: enhanced synaptic efficacy and altered pharmacology","volume":"17","author":"Cohen","year":"2003","journal-title":"Eur. J. Neurosci."},{"issue":"Suppl. 5","key":"10.1016\/j.eplepsyres.2008.05.011_bib16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.0013-9580.2004.05004.x","article-title":"Pharmacologic treatment of the catastrophic epilepsies","volume":"45","author":"Conry","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib17","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1212\/WNL.56.7.906","article-title":"Differential expression of glutamate and GABA-A receptor subunit mRNA in cortical dysplasia","volume":"56","author":"Crino","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib18","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1750-3639.2002.tb00437.x","article-title":"Neurodevelopmental disorders as a cause of seizures: neuropathologic, genetic, and mechanistic considerations","volume":"12","author":"Crino","year":"2002","journal-title":"Brain Pathol."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib19","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1212\/01.WNL.0000130459.91445.91","article-title":"Posterior quadrantic dysplasia or hemi-hemimegalencephaly: a characteristic brain malformation","volume":"62","author":"D\u2019Agostino","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib20","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1124\/jpet.106.104844","article-title":"Identification of structures within GABAA receptor alpha subunits that regulate the agonist action of pentobarbital","volume":"318","author":"Drafts","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib21","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/nm1301","article-title":"NKCC1 transporter facilitates seizures in the developing brain","volume":"11","author":"Dzhala","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0163-7258(03)00037-8","article-title":"Formation and plasticity of GABAergic synapses: physiological mechanisms and pathophysiological implications","volume":"98","author":"Fritschy","year":"2003","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0920-1211(98)00009-6","article-title":"Physiological analysis of Rasmussen's encephalitis: patch clamp recordings of altered inhibitory neurotransmitter function in resected frontal cortical tissue","volume":"31","author":"Gibbs","year":"1998","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib24","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1152\/jn.1997.77.4.1924","article-title":"Differential epilepsy-associated alterations in postsynaptic GABA(A) receptor function in dentate granule and CA1 neurons","volume":"77","author":"Gibbs","year":"1997","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib25","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1152\/jn.1996.75.4.1458","article-title":"Characterization of GABAA receptor function in human temporal cortical neurons","volume":"75","author":"Gibbs","year":"1996","journal-title":"J. Neurophysiol."},{"issue":"Suppl. 5","key":"10.1016\/j.eplepsyres.2008.05.011_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.0013-9580.2004.05005.x","article-title":"Following catastrophic epilepsy patients from childhood to adulthood","volume":"45","author":"Glauser","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib27","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1111\/j.1528-1167.2005.53704.x","article-title":"Hemispherectomy for catastrophic epilepsy in infants","volume":"46","author":"Gonzalez-Martinez","year":"2005","journal-title":"Epilepsia"},{"issue":"Suppl. 1","key":"10.1016\/j.eplepsyres.2008.05.011_bib28","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1111\/j.1528-1157.2000.tb02167.x","article-title":"Differential sensitivity of recombinant GABA(A) receptors expressed in Xenopus oocytes to modulation by topiramate","volume":"41","author":"Gordey","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib29","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0022-3565(24)37581-0","article-title":"Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin","volume":"286","author":"Huang","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S1471-4892(02)00015-2","article-title":"GABA(A) receptor function and pharmacology in epilepsy and status epilepticus","volume":"3","author":"Jones-Davis","year":"2003","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib31","doi-asserted-by":"crossref","first-page":"7532","DOI":"10.1523\/JNEUROSCI.17-19-07532.1997","article-title":"Rapid seizure-induced reduction of benzodiazepine and Zn2+ sensitivity of hippocampal dentate granule cell GABAA receptors","volume":"17","author":"Kapur","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib32","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0026-895X(24)12168-2","article-title":"Postnatal development of hippocampal dentate granule cell gamma-aminobutyric acid A receptor pharmacological properties","volume":"55","author":"Kapur","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0920-1211(00)00170-4","article-title":"Ganaxolone for treating intractable infantile spasms: a multicenter, open-label, add-on trial","volume":"42","author":"Kerrigan","year":"2000","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1113\/jphysiol.2003.059246","article-title":"Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy","volume":"557","author":"Leroy","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib35","doi-asserted-by":"crossref","unstructured":"Lettori, D., Battaglia, D., Sacco, A., Veredice, C., Chieffo, D., Massimi, L., Tartaglione, T., Chiricozzi, F., Staccioli, S., Mittica, A., Di Rocco, C., Guzzetta, F., 2007. Early hemispherectomy in catastrophic epilepsy A neuro-cognitive and epileptic long-term follow-up. Seizure.","DOI":"10.1016\/j.seizure.2007.06.006"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib36","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1212\/01.WNL.0000127773.72699.C8","article-title":"Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society","volume":"62","author":"Mackay","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib37","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1523\/JNEUROSCI.4945-06.2007","article-title":"Neurosteroid synthesis-mediated regulation of GABA(A) receptors: relevance to the ovarian cycle and stress","volume":"27","author":"Maguire","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib38","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1073\/pnas.92.11.5224","article-title":"Incorporation of acetylcholine receptors and Cl-channels in Xenopus oocytes injected with Torpedo electroplaque membranes","volume":"92","author":"Marsal","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"Suppl. 6","key":"10.1016\/j.eplepsyres.2008.05.011_bib39","first-page":"S162","article-title":"Neurons recorded from pediatric epilepsy surgery patients with cortical dysplasia","volume":"41","author":"Mathern","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib40","doi-asserted-by":"crossref","first-page":"C670","DOI":"10.1152\/ajpcell.2001.281.2.C670","article-title":"Functional and molecular characterization of the K\u2013Cl cotransporter of Xenopus laevis oocytes","volume":"281","author":"Mercado","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib41","doi-asserted-by":"crossref","first-page":"13238","DOI":"10.1073\/pnas.192445299","article-title":"Expression of functional neurotransmitter receptors in Xenopus oocytes after injection of human brain membranes","volume":"99","author":"Miledi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib42","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1098\/rspb.1982.0089","article-title":"Synthesis of chick brain GABA receptors by frog oocytes","volume":"216","author":"Miledi","year":"1982","journal-title":"Proc. R. Soc. Lond. B: Biol. Sci."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib43","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0306-4522(03)00043-5","article-title":"Increased neurosteroid sensitivity of hippocampal GABAA receptors during postnatal development","volume":"118","author":"Mtchedlishvili","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib44","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1212\/01.WNL.0000114506.49267.BB","article-title":"Mechanisms of epileptogenicity in cortical dysplasias","volume":"62","author":"Najm","year":"2004","journal-title":"Neurology"},{"issue":"Suppl. 2","key":"10.1016\/j.eplepsyres.2008.05.011_bib45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1528-1167.2007.01064.x","article-title":"Pathophysiological mechanisms of focal cortical dysplasia: a critical review of human tissue studies and animal models","volume":"48","author":"Najm","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib46","doi-asserted-by":"crossref","first-page":"10183","DOI":"10.1073\/pnas.0403683101","article-title":"Phosphatase inhibitors remove the run-down of gamma-aminobutyric acid type A receptors in the human epileptic brain","volume":"101","author":"Palma","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib47","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1073\/pnas.0409442102","article-title":"BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes","volume":"102","author":"Palma","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib48","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1073\/pnas.0438006100","article-title":"Microtransplantation of membranes from cultured cells to Xenopus oocytes: a method to study neurotransmitter receptors embedded in native lipids","volume":"100","author":"Palma","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib49","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1212\/01.WNL.0000114507.30388.7E","article-title":"Terminology and classification of the cortical dysplasias","volume":"62","author":"Palmini","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib50","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1523\/JNEUROSCI.06-08-02290.1986","article-title":"Actions of pentobarbital on rat brain receptors expressed in Xenopus oocytes","volume":"6","author":"Parker","year":"1986","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib51","doi-asserted-by":"crossref","first-page":"15219","DOI":"10.1073\/pnas.0507339102","article-title":"Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy","volume":"102","author":"Ragozzino","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib52","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.neuroscience.2005.01.005","article-title":"Long-term effects of diazepam and phenobarbital treatment during development on GABA receptors, transporters and glutamic acid decarboxylase","volume":"132","author":"Raol","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib53","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/sj.bjp.0704766","article-title":"The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents","volume":"136","author":"Rigo","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/01.wco.0000162847.91531.9c","article-title":"The latest on infantile spasms","volume":"18","author":"Riikonen","year":"2005","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib55","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0074-7742(02)49014-9","article-title":"Neurosteroids and infantile spasms: the deoxycorticosterone hypothesis","volume":"49","author":"Rogawski","year":"2002","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib56","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev.pharmtox.44.101802.121429","article-title":"Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics","volume":"44","author":"Rudolph","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib57","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.neuropharm.2005.04.026","article-title":"Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects","volume":"49","author":"Shen","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib58","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0920-1211(98)00045-X","article-title":"GABA(A) receptor function in epileptic human dentate granule cells: comparison to epileptic and control rat","volume":"32","author":"Shumate","year":"1998","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib59","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.neuropharm.2005.12.006","article-title":"Subunit selectivity of topiramate modulation of heteromeric GABA(A) receptors","volume":"50","author":"Simeone","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib60","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1177\/1073858404263463","article-title":"Zn2+ ions: modulators of excitatory and inhibitory synaptic activity","volume":"10","author":"Smart","year":"2004","journal-title":"Neuroscientist"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib61","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1476-5381.1996.tb15221.x","article-title":"Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination","volume":"117","author":"Thompson","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib62","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1023\/A:1010925331768","article-title":"Effects of CRH and ACTH administration on plasma and brain neurosteroid levels","volume":"26","author":"Torres","year":"2001","journal-title":"Neurochem. Res."},{"issue":"Suppl. 3","key":"10.1016\/j.eplepsyres.2008.05.011_bib63","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1046\/j.1528-1157.2001.042suppl.3008.x","article-title":"GABAergic mechanisms in epilepsy","volume":"42","author":"Treiman","year":"2001","journal-title":"Epilepsia"},{"issue":"Suppl. 5","key":"10.1016\/j.eplepsyres.2008.05.011_bib64","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.0013-9580.2004.05003.x","article-title":"Nonpharmacologic treatment of the catastrophic epilepsies of childhood","volume":"45","author":"Wheless","year":"2004","journal-title":"Epilepsia"},{"issue":"Suppl. 1","key":"10.1016\/j.eplepsyres.2008.05.011_bib65","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1111\/j.1528-1157.2000.tb02165.x","article-title":"Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism","volume":"41","author":"White","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2008.05.011_bib66","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuroscience.2004.01.040","article-title":"Effects of status epilepticus on hippocampal GABAA receptors are age-dependent","volume":"125","author":"Zhang","year":"2004","journal-title":"Neuroscience"}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121108001599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121108001599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:19:31Z","timestamp":1760275171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121108001599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":66,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0920121108001599"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2008.05.011","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GABAA receptor properties in catastrophic infantile epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2008.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}