{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:39:02Z","timestamp":1777595942876,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.eplepsyres.2008.11.003","type":"journal-article","created":{"date-parts":[[2008,12,20]],"date-time":"2008-12-20T05:24:57Z","timestamp":1229750697000},"page":"207-214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Sexual differentiation of cortical spreading depression propagation after acute and kindled audiogenic seizures in the Wistar audiogenic rat (WAR)"],"prefix":"10.1016","volume":"83","author":[{"given":"Rubem Carlos Ara\u00fajo","family":"Guedes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ant\u00f4nio Cortes","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c2ngela","family":"Am\u00e2ncio-dos-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norberto","family":"Garc\u00eda-Cairasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2008.11.003_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.expneurol.2006.02.014","article-title":"Fluoxetine inhibits cortical spreading depression in weaned and adult rats suckled under favorable and unfavorable lactation conditions","volume":"200","author":"Amancio-dos-Santos","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1468-2982.2008.01556.x","article-title":"Spreading depression enhances human neocortical excitability in vitro","volume":"28","author":"Berger","year":"2008","journal-title":"Cephalalgia"},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1528-1157.1975.tb04727.x","article-title":"Blockage of cortical spreading depression by picrotoxin foci of paroxysmal activity","volume":"16","author":"Bures","year":"1975","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neulet.2006.03.029","article-title":"Characterization of cortical spreading depression in adult well-nourished and malnourished rats submitted to the association of pilocarpine-induced epilepsy plus streptozotocin-induced hyperglycemia","volume":"401","author":"Costa-Cruz","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/10284150412331281031","article-title":"Malnutrition and REM-sleep deprivation modulate in rats the impairment of spreading depression by a single sub-convulsing dose of pilocarpine","volume":"7","author":"De-Vasconcelos","year":"2004","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1023\/A:1021099432759","article-title":"Quantitative study of the response to genetic selection of the Wistar audiogenic rat strain (WAR)","volume":"33","author":"Doretto","year":"2003","journal-title":"Behav. Genet."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0920-1211(00)00107-8","article-title":"Audiogenic kindling in the Wistar rat: a potential model for recruitment of limbic structures","volume":"39","author":"Dutra Moraes","year":"2000","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib8","first-page":"311","article-title":"Neuronal networks in the genetically epilepsy-prone rat","volume":"79","author":"Faingold","year":"1999","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib9","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.neuroscience.2004.01.042","article-title":"Limbic epileptogenicity, cell loss and axonal reorganization induced by audiogenic and amygdala kindling in Wistar audiogenic rats (WAR strain)","volume":"125","author":"Galvis-Alonso","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib10","first-page":"171","article-title":"Role of the substantia nigra in audiogenic seizures: a neuroethological analysis in the rat","volume":"16","author":"Garcia-Cairasco","year":"1983","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0166-4328(93)90090-D","article-title":"Midbrain substrates of audiogenic seizures in rats","volume":"58","author":"Garcia-Cairasco","year":"1993","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0920-1211(96)00050-2","article-title":"Neuroethological and morphological (Neo-Timm staining) correlates of limbic recruitment during the development of audiogenic kindling in seizure susceptible Wistar rats","volume":"26","author":"Garcia-Cairasco","year":"1996","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib13","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0378-5955(02)00371-4","article-title":"A critical review on the participation of inferior colliculus in acoustic motor limbic network and kindled audiogenic seizures","volume":"168","author":"Garcia-Cairasco","year":"2002","journal-title":"Hearing Res."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.yebeh.2004.04.005","article-title":"Neuroethological study of status epilepticus induced by systemic pilocarpine in Wistar audiogenic rats (WAR strain)","volume":"5","author":"Garcia-Cairasco","year":"2004","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib15","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/0013-4694(79)90202-5","article-title":"Effects of changes in cortical excitability upon the epileptic bursts in generalized penicillin epilepsy of the cat","volume":"46","author":"Gloor","year":"1979","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib16","series-title":"Nutritional Neurosciences: Overview of an Emerging Field","first-page":"39","article-title":"Electrophysiological methods: application in nutritional neuroscience","author":"Guedes","year":"2005"},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0920-1211(96)01017-0","article-title":"Blockade of spreading depression in chronic epileptic rats: reversion by diazepam","volume":"27","author":"Guedes","year":"1997","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib18","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neulet.2008.07.011","article-title":"Sleep-deprivation enhances in adult rats the antagonistic affects of pilocarpine on cortical spreading depression: a dose\u2013response study","volume":"442","author":"Guedes","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib19","series-title":"Spreading Depression","first-page":"17","article-title":"GABAergic mechanisms involved in cortical spreading depression in normal and early malnourished rats","author":"Guedes","year":"1992"},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1039\/b102706a","article-title":"Control of the excitability of neuronal tissue by weak external forces","volume":"120","author":"Hanke","year":"2001","journal-title":"Faraday Discuss."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S1474-4422(06)70348-9","article-title":"Chronic disorders with episodic manifestations: focus on epilepsy and migraine","volume":"5","author":"Haut","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0006-8993(75)90286-3","article-title":"Undershoots following stimulus-induced rises of extracellular potassium concentration in cerebral cortex of cat","volume":"93","author":"Heinemann","year":"1975","journal-title":"Brain Res."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0006-8993(79)90622-X","article-title":"Circulation of cortical spreading depression around electrically stimulated areas and epileptic foci in the neocortex of rats","volume":"173","author":"Koroleva","year":"1979","journal-title":"Brain Res."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0013-4694(80)90038-3","article-title":"Blockade of cortical spreading depression in electrically and chemically stimulated areas of cerebral cortex in rats","volume":"48","author":"Koroleva","year":"1980","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0006-8993(93)90780-Q","article-title":"Reduced incidence of cortical spreading depression in the course of pentylenetetrazol kindling in rats","volume":"608","author":"Koroleva","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib26","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/jn.1944.7.6.359","article-title":"Spreading depression of activity in the cerebral cortex","volume":"7","author":"Le\u00e3o","year":"1944","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0920-1211(02)00072-4","article-title":"New insights from the use of pilocarpine and kainate models","volume":"50","author":"Leite","year":"2002","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib28","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0014-4886(87)90290-1","article-title":"Kindling of audiogenic seizures in Wistar rats: an EEG study","volume":"97","author":"Marescaux","year":"1987","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib29","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0014-4886(92)90197-X","article-title":"Repetition of audiogenic seizures in genetically epilepsy-prone rats induces cortical epileptiform activity and additional seizure behaviors","volume":"115","author":"Naritoku","year":"1992","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib30","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation. II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib31","first-page":"709","article-title":"Common pathophysiologic mechanisms in migraine and epilepsy","volume":"65","author":"Rogawski","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib32","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0306-4522(03)00191-X","article-title":"Hippocampal cell proliferation and epileptogenesis after audiogenic kindling are not accompanied by mossy fiber sprouting or Fluoro-Jade staining","volume":"119","author":"Romcy-Pereira","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib33","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.eplepsyres.2006.08.001","article-title":"EEG wavelet analyses of the striatum-substantia nigra pars reticulata-superior colliculus circuitry: audiogenic seizures and anticonvulsant drug administration in Wistar audiogenic rats (War strain)","volume":"72","author":"Rossetti","year":"2006","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.nbd.2006.08.013","article-title":"The effect of estrogen and progesterone on spreading depression in rat neocortical tissues","volume":"25","author":"Sachs","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib35","first-page":"129","article-title":"Peculiarities of development of rat's audiogenic convulsive responses in the period of gestation","volume":"136","author":"Samseishvili","year":"2006","journal-title":"Georgian Med News"},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib36","first-page":"96","article-title":"Development of audiogenic kindling during the gestation period","volume":"138","author":"Samseishvili","year":"2006","journal-title":"Georgian Med News"},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib37","first-page":"545","article-title":"The seizures induced by pilocarpine: behavioral, electroencephalographic and neuropathological studies in rodents","volume":"39","author":"Turski","year":"1987","journal-title":"Pol. J. Pharmacol. Pharm."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib38","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.physbeh.2005.08.017","article-title":"Audiogenic seizures associated with a cortical spreading depression wave suppress spike-wave discharges in rats","volume":"86","author":"Vinogradova","year":"2005","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib39","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.eplepsyres.2006.05.014","article-title":"Unilateral cortical spreading depression is an early marker of audiogenic kindling in awake rats","volume":"71","author":"Vinogradova","year":"2006","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2008.11.003_bib40","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1111\/j.1526-4610.2005.4501008.x","article-title":"Brain hyperexcitability: the basis for antiepileptic drugs in migraine prevention","volume":"45","author":"Welch","year":"2005","journal-title":"Headache"}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121108003252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121108003252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:20:50Z","timestamp":1760275250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121108003252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":40,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0920121108003252"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2008.11.003","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sexual differentiation of cortical spreading depression propagation after acute and kindled audiogenic seizures in the Wistar audiogenic rat (WAR)","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2008.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}