{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T22:10:38Z","timestamp":1769811038783,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.eplepsyres.2009.07.005","type":"journal-article","created":{"date-parts":[[2009,8,14]],"date-time":"2009-08-14T05:39:40Z","timestamp":1250228380000},"page":"31-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"title":["Antiepileptic drugs in epilepsy and other disorders\u2014A population-based study of prescriptions"],"prefix":"10.1016","volume":"87","author":[{"given":"Cecilie","family":"Johannessen Landmark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e5l G.","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisif","family":"Rytter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svein I.","family":"Johannessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2009.07.005_bib1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1177\/155005940703800214","article-title":"Antiepileptic drugs and mood stability","volume":"38","author":"Anmann","year":"2007","journal-title":"Clin. EEG Neurosci."},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib2","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.yebeh.2003.07.003","article-title":"Epilepsy and migraine","volume":"4","author":"Bigal","year":"2003","journal-title":"Epilepsy Behav."},{"issue":"5","key":"10.1016\/j.eplepsyres.2009.07.005_bib3","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1528-1167.2005.43604.x","article-title":"Depression and anxiety disorders in pediatric epilepsy","volume":"46","author":"Caplan","year":"2005","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.eplepsyres.2009.07.005_bib4","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1176\/ps.49.2.196","article-title":"Compliance with medication regimens for mental and physical disorders","volume":"49","author":"Cramer","year":"1998","journal-title":"Psychiatr. Serv."},{"issue":"3","key":"10.1016\/j.eplepsyres.2009.07.005_bib5","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1528-1167.2007.01414.x","article-title":"Prevalence and cost of nonadherence with antiepileptic drugs in an adult managed care population","volume":"49","author":"Davis","year":"2008","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.eplepsyres.2009.07.005_bib6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0165-0327(00)00225-1","article-title":"Adherence to treatment regimen in depressed patients treated with amitriptyline or fluoxetine","volume":"65","author":"Demyttenaere","year":"2001","journal-title":"J. Affect. Disord."},{"issue":"3\/4","key":"10.1016\/j.eplepsyres.2009.07.005_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000112859","article-title":"The Tasmanian epilepsy register\u2014a community-based cohort. Background and methodology for patient recruitment from the Australian national prescription database","volume":"29","author":"D'Souza","year":"2007","journal-title":"Neuroepidemiology"},{"issue":"5","key":"10.1016\/j.eplepsyres.2009.07.005_bib8","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1365-2125.2008.03102.x","article-title":"Prescription drug use among fathers and mothers before and during pregnancy. A population-based cohort study of 106,000 pregnancies in Norway 2004\u20132006","volume":"65","author":"Engeland","year":"2008","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib9","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.yebeh.2006.09.008","article-title":"Effect of lamotrigine on depressive symptoms in adult patients with epilepsy","volume":"10","author":"Ettinger","year":"2007","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.0013-9580.2004.06204.x","article-title":"Efficacy and tolerability of the new antiepileptic drugs, I: treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society","volume":"45","author":"French","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib11","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.0013-9580.2004.06304.x","article-title":"Efficacy and tolerability of the new antiepileptic drugs, II: treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society","volume":"45","author":"French","year":"2004","journal-title":"Epilepsia"},{"issue":"12","key":"10.1016\/j.eplepsyres.2009.07.005_bib12","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1111\/j.1742-1241.2007.01589.x","article-title":"Efficacy and safety of pregabalin in treatment refractory patients with various neuropathic pain entities in clinical routine","volume":"61","author":"Freynhagen","year":"2007","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib13","article-title":"The association between depression and epilepsy in a nationally representative sample","author":"Fuller-Thomson","year":"2008","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.eplepsyres.2009.07.005_bib14","first-page":"129","article-title":"Establishment of the nationwide Norwegian Prescription Database (NorPD)\u2014new opportunities for research in pharmacoepidemiology in Norway","volume":"18","author":"Furu","year":"2008","journal-title":"Norwegian J. Epidemiol."},{"issue":"7","key":"10.1016\/j.eplepsyres.2009.07.005_bib15","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00228-007-0301-9","article-title":"Use of anti-asthmatic medications as a proxy for prevalence of asthma in children and adolescents in Norway: a nationwide prescription database analysis","volume":"63","author":"Furu","year":"2007","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.eplepsyres.2009.07.005_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1177\/0145445507309023","article-title":"Improving treatment adherence in bipolar disorder: a review of current psychosocial treatment efficacy and recommendations for future treatment development","volume":"32","author":"Gaudiano","year":"2008","journal-title":"Behav. Modif."},{"issue":"1","key":"10.1016\/j.eplepsyres.2009.07.005_bib17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1192\/bjp.bp.107.048504","article-title":"Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials","volume":"194","author":"Geddes","year":"2009","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib18","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/j.1528-1167.2006.00585.x","article-title":"ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes","volume":"47","author":"Glauser","year":"2006","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.eplepsyres.2009.07.005_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00228-008-0565-8","article-title":"Starting insomnia treatment: the use of benzodiazepines versus z-hypnotics. A prescription database study of predictors","volume":"65","author":"Hausken","year":"2009","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.eplepsyres.2009.07.005_bib20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1345\/aph.1K354","article-title":"Beliefs about medicines and adherence among Swedish migraineurs","volume":"42","author":"Hedenrud","year":"2008","journal-title":"Ann. Pharmacother."},{"issue":"2\/3","key":"10.1016\/j.eplepsyres.2009.07.005_bib21","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.eplepsyres.2008.03.016","article-title":"Prevalence of treated epilepsy in western medicine among the adult population in Taiwan: a study conducted using antiepileptic drug prescription data","volume":"80","author":"Hsieh","year":"2008","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2008.11.018","article-title":"Antiepileptic drug utilization in Taiwan: analysis of prescription using National Health Insurance database","author":"Hsieh","year":"2009","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/155005940403500112","article-title":"Affective disorder and epilepsy comorbidity: implications for development of treatments, preventions and diagnostic approaches","volume":"35","author":"Jobe","year":"2004","journal-title":"Clin. EEG Neurosci."},{"issue":"6","key":"10.1016\/j.eplepsyres.2009.07.005_bib24","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1586\/14737175.8.6.929","article-title":"Value of therapeutic drug montoring in epilepsy","volume":"8","author":"Johannessen","year":"2008","journal-title":"Exp. Rev. Neurother."},{"issue":"1","key":"10.1016\/j.eplepsyres.2009.07.005_bib25","first-page":"RA1","article-title":"Targets for antiepileptic drugs in the synapse","volume":"13","author":"Johannessen Landmark","year":"2007","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2165\/00023210-200822010-00003","article-title":"Antiepileptic drugs in non-epilepsy disorders: relations between mechanisms of action and clinical efficacy","volume":"22","author":"Johannessen Landmark","year":"2008","journal-title":"CNS Drugs"},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib27","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.seizure.2007.02.006","article-title":"Clinical use of antiepileptic drugs at a referral center for epilepsy","volume":"16","author":"Johannessen Landmark","year":"2007","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1535-7597.2005.05106.x","article-title":"Depression in epilepsy: a neurobiological perspective","volume":"5","author":"Kanner","year":"2005","journal-title":"Epilepsy Curr."},{"issue":"6","key":"10.1016\/j.eplepsyres.2009.07.005_bib29","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1468-2982.2008.01571.x","article-title":"Anticonvulsants in migraine prophylaxis: a Cochrane review","volume":"28","author":"Mulleners","year":"2008","journal-title":"Cephalalgia"},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1600-0447.2005.00523.x","article-title":"Lamotrigine and antiepileptic drugs as mood stabilizers in bipolar disorder","volume":"111","author":"Muzina","year":"2005","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib31","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1474-4422(03)00409-5","article-title":"Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs","volume":"2","author":"Patsalos","year":"2003","journal-title":"Lancet Neurol."},{"issue":"8","key":"10.1016\/j.eplepsyres.2009.07.005_bib32","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S1474-4422(03)00483-6","article-title":"Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs","volume":"2","author":"Patsalos","year":"2003","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.eplepsyres.2009.07.005_bib33","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-2125.2005.02529.x","article-title":"Clinically relevant drug interactions with antiepileptic drugs","volume":"61","author":"Perucca","year":"2006","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.eplepsyres.2009.07.005_bib34","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0149-2918(07)80088-9","article-title":"Topiramate prescribing patterns among medicaid patients: diagnoses, comorbidities, and dosing","volume":"29","author":"Poston","year":"2007","journal-title":"Clin. Ther."},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1176\/jnp.17.1.20","article-title":"Mood disorders and their treatment in patients with epilepsy","volume":"17","author":"Prueter","year":"2005","journal-title":"J. Neuropsych. Clin. Neurosci."},{"issue":"22","key":"10.1016\/j.eplepsyres.2009.07.005_bib36","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1212\/01.wnl.0000313157.15089.e6","article-title":"Treatment in Geriatric Epilepsy Research (TIGER) team, trends in antiepileptic drug prescribing for older patients with new-onset epilepsy: 2000\u20132004","volume":"70","author":"Pugh","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib37","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1034\/j.1600-0404.2001.00197.x","article-title":"Antiepileptic drug utilization: a Danish prescription database analysis","volume":"104","author":"Rochat","year":"2001","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib38","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nm1074","article-title":"The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions","volume":"10","author":"Rogawski","year":"2004","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.eplepsyres.2009.07.005_bib39","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1111\/j.1468-1331.2007.01970.x","article-title":"Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000\u20132005","volume":"14","author":"Savica","year":"2007","journal-title":"Eur. J. Neurol."},{"issue":"Suppl. 4","key":"10.1016\/j.eplepsyres.2009.07.005_bib40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1528-1167.2005.463009.x","article-title":"Depression and mania in patients with epilepsy","volume":"46","author":"Schmitz","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib41","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1046\/j.1526-4610.2001.01154-3.x","article-title":"Shared mechanisms and comorbidities in neurologic and psychiatric disorders","volume":"41","author":"Silberstein","year":"2001","journal-title":"Headache"},{"issue":"4","key":"10.1016\/j.eplepsyres.2009.07.005_bib42","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1001\/archneur.61.4.490","article-title":"Topiramate in migraine prevention: results of a large controlled trial","volume":"61","author":"Silberstein","year":"2004","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib43","article-title":"Introduction of low dose transdermal buprenorphine\u2014did it influence use of potentially addictive drugs in chronic non-malignant pain patients?","author":"Skurtveit","year":"2008","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib44","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1684\/j.1950-6945.2004.tb00053.x","article-title":"Antiepileptic drugs: indications other than epilepsy","volume":"6","author":"Spina","year":"2004","journal-title":"Epileptic Disord."},{"issue":"1","key":"10.1016\/j.eplepsyres.2009.07.005_bib45","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.clinthera.2007.01.013","article-title":"Pregabalin: a novel \u03b3-butyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders","volume":"29","author":"Tassone","year":"2007","journal-title":"Clin. Ther."},{"issue":"12","key":"10.1016\/j.eplepsyres.2009.07.005_bib46","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1111\/j.1528-1167.2007.01222.x","article-title":"Psychiatric comorbidity in epilepsy: a population based analysis","volume":"48","author":"Tellez-Zenteno","year":"2007","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.eplepsyres.2009.07.005_bib47","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1176\/appi.ajp.157.3.338","article-title":"Compliance with antidepressant medication in the treatment of major depressive disorder in primary care: a randomized comparison of fluoxetine and a tricyclic antidepressant","volume":"157","author":"Thompson","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib48","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1600-0404.2006.00639.x","article-title":"Trends in utilization of antiepileptic drugs in Denmark","volume":"113","author":"Tsiropoulos","year":"2006","journal-title":"Acta Neurol. Scand."},{"issue":"10","key":"10.1016\/j.eplepsyres.2009.07.005_bib49","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00228-008-0480-z","article-title":"Antiepileptic drug utilization in children from 1997\u20132005\u2014a study from The Netherlands","volume":"64","author":"van de Vrie-Hoekstra","year":"2008","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2009.07.005_bib50","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1111\/j.1526-4610.2005.4501006.x","article-title":"Molecular pharmacology of topiramate: managing seizures and preventing migraine","volume":"45","author":"White","year":"2005","journal-title":"Headache"},{"issue":"5","key":"10.1016\/j.eplepsyres.2009.07.005_bib51","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2165\/00023210-200822050-00005","article-title":"An update on the pharmacological management of post-herpetic neuralgia and painful diabetic neuropathy","volume":"22","author":"Zin","year":"2008","journal-title":"CNS Drugs"}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121109001971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121109001971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:21:19Z","timestamp":1760275279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121109001971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0920121109001971"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2009.07.005","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiepileptic drugs in epilepsy and other disorders\u2014A population-based study of prescriptions","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2009.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}