{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:20:33Z","timestamp":1761016833621,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.eplepsyres.2009.07.011","type":"journal-article","created":{"date-parts":[[2009,8,27]],"date-time":"2009-08-27T04:49:36Z","timestamp":1251348576000},"page":"54-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment?"],"prefix":"10.1016","volume":"87","author":[{"given":"O\u011fuzhan","family":"\u00d6z","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeki","family":"G\u00f6k\u00e7il","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semai","family":"Bek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdin\u00e7","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeki","family":"Odaba\u015f\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.eplepsyres.2009.07.011_bib1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1528-1157.1984.tb03480.x","article-title":"Heart disease mortality and morbidity in patients with epilepsy","volume":"25","author":"Annegers","year":"1984","journal-title":"Epilepsia"},{"issue":"1\u20132","key":"10.1016\/j.eplepsyres.2009.07.011_bib2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0920-1211(01)00288-1","article-title":"Antiepileptic drugs as independent predictors of plasma total homocysteine levels","volume":"47","author":"Apeland","year":"2001","journal-title":"Epilepsy Res."},{"issue":"5","key":"10.1016\/j.eplepsyres.2009.07.011_bib3","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1034\/j.1600-0404.2001.103005294.x","article-title":"Folate, homocysteine and methionine loading in patients on carbamazepine","volume":"103","author":"Apeland","year":"2001","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib4","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1111\/j.1528-1157.2000.tb00119.x","article-title":"Tetatogenic effects of antiepileptic drugs: use of an International Database on Malformations and Drug Exposure (MADRE)","volume":"41","author":"Arpino","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib5","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1161\/01.CIR.95.8.2068","article-title":"Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease","volume":"95","author":"Boger","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00004691-199104000-00010","article-title":"Sudden unexpected death in epilepsy: a series from an epilepsy surgery program and speculation on the relationship to sudden cardiac death","volume":"8","author":"Dasheiff","year":"1991","journal-title":"J. Clin. Neurophysiol."},{"issue":"2","key":"10.1016\/j.eplepsyres.2009.07.011_bib7","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1152\/ajpheart.01348.2007","article-title":"Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia","volume":"295","author":"Dayal","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib8","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1212\/WNL.45.6.1155","article-title":"Effects of long-term treatment with antiepileptic drugs on serum lipid levels in children with epilepsy","volume":"45","author":"Eir\u00eds","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib9","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1001\/jama.1997.03540460039030","article-title":"Plasma homocysteine as a risk factor for vascular disease","volume":"277","author":"Graham","year":"1997","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.eplepsyres.2009.07.011_bib10","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1111\/j.1528-1167.2005.00264.x","article-title":"Hyperhomocysteinemia in children treated with antiepileptic drugs is normalized by folic acid supplementation","volume":"46","author":"Huemer","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib11","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1001\/archneur.1993.00540060030012","article-title":"Serum lipid levels during carbamazepine medication","volume":"50","author":"Isoj\u00e4rvi","year":"1993","journal-title":"Arch. Neurol."},{"issue":"8","key":"10.1016\/j.eplepsyres.2009.07.011_bib12","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0009-9120(97)00116-1","article-title":"Homocyst(e)ine levels in patients on phenytoin therapy","volume":"30","author":"James","year":"1997","journal-title":"Clin. Biochem."},{"issue":"June (2)","key":"10.1016\/j.eplepsyres.2009.07.011_bib13","first-page":"191","article-title":"Homocysteine induces endothelial dysfunction via inhibition of arginine transport","volume":"58","author":"Jin","year":"2007","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib14","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1681\/ASN.V103594","article-title":"Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: relationship to treatment method and atherosclerotic disease","volume":"10","author":"Kielstein","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.eplepsyres.2009.07.011_bib15","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.atherosclerosis.2005.12.007","article-title":"Asymmetric dimethylarginine is associated with macrovascular disease and total homocysteine in patients with type 2 diabetes","volume":"189","author":"Krzyzanowska","year":"2006","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.eplepsyres.2009.07.011_bib16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1567-5688(03)00035-7","article-title":"Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA","volume":"4","author":"Lentz","year":"2003","journal-title":"Atheroscler. Suppl."},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib17","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1528-1157.1997.tb01219.x","article-title":"Vascular determinants of epilepsy: the Rotterdam study","volume":"38","author":"Li","year":"1997","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib18","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1212\/01.WNL.0000115653.82763.07","article-title":"Cognitive side effects of antiepileptic drugs in children","volume":"62","author":"Loring","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000115130","article-title":"Plasma high-density lipoprotein cholesterol inepileptics treated with anticonvulants","volume":"19","author":"Luoma","year":"1980","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib20","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1111\/j.1528-1157.1993.tb02139.x","article-title":"Hematologic manifestations of longterm valproate therapy","volume":"34","author":"May","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib21","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1161\/01.CIR.99.9.1141","article-title":"Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis","volume":"99","author":"Miyazaki","year":"1999","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.eplepsyres.2009.07.011_bib22","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1528-1157.1997.tb01194.x","article-title":"Cause-specific mortality in epilepsy: a cohort study of more than 9,000 patients once hospitalized for epilepsy","volume":"38","author":"Nilsson","year":"1997","journal-title":"Epilepsia"},{"issue":"8","key":"10.1016\/j.eplepsyres.2009.07.011_bib23","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0026-0495(97)90087-1","article-title":"Plasma total homocysteine concentrations in epileptic patients taking anticonvulsants","volume":"46","author":"Ono","year":"1997","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.eplepsyres.2009.07.011_bib24","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1528-1157.1999.tb00716.x","article-title":"Elevated plasma concentrations of homocysteine in antiepileptic drug treatment","volume":"40","author":"Schwaninger","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib25","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1056\/NEJM199502023320502","article-title":"Association between plasma homocysteine concentrations and extracranial carotid artery stenosis","volume":"332","author":"Selhub","year":"1995","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.eplepsyres.2009.07.011_bib26","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1001\/jama.1992.03490070059042","article-title":"A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians","volume":"268","author":"Stampfer","year":"1992","journal-title":"JAMA"},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1389200052997393","article-title":"Asymmetric dimethyl-l-arginine (ADMA): a possible link between homocyst(e)ine and endothelial dysfunction","volume":"6","author":"St\u00fchlinger","year":"2005","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0920-1211(00)00101-7","article-title":"Homocysteine, folate, vitamin B-12 and vitamin B-6 in patients receiving antiepileptic drug monotherapy","volume":"40","author":"Tamura","year":"2000","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib29","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/S0140-6736(01)07184-7","article-title":"Risk of acute coronary events and serum concentration of asymmetric dimethylarginine","volume":"358","author":"Valkonen","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib30","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/S0140-6736(01)07229-4","article-title":"Importance of asymmetric dimethylarginine in cardiovascular risk","volume":"358","author":"Vallance","year":"2001","journal-title":"Lancet"},{"issue":"Suppl. 12","key":"10.1016\/j.eplepsyres.2009.07.011_bib31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/00005344-199204002-00018","article-title":"Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis","volume":"20","author":"Vallance","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"March (3)","key":"10.1016\/j.eplepsyres.2009.07.011_bib32","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1365-2362.1995.tb01545.x","article-title":"Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease","volume":"25","author":"Van den Berg","year":"1995","journal-title":"Eur. J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.eplepsyres.2009.07.011_bib33","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0920-1211(00)00150-9","article-title":"Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine","volume":"41","author":"Verrotti","year":"2000","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2009.07.011_bib34","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0021-9150(01)00444-0","article-title":"Elevated levels of plasma homocysteine and asymmetric dimethylarginine in elderly patients with stroke","volume":"158","author":"Yoo","year":"2001","journal-title":"Atherosclerosis"},{"issue":"14\u201315","key":"10.1016\/j.eplepsyres.2009.07.011_bib35","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.clinbiochem.2008.07.011","article-title":"Determination of protein-incorporated methylated arginine reference values in healthy subjects whole blood and evaluation of factors affecting protein methylation","volume":"41","author":"Zinellu","year":"2008","journal-title":"Clin. Biochem."}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121109002009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121109002009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:21:35Z","timestamp":1760275295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121109002009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0920121109002009"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2009.07.011","relation":{},"ISSN":["0920-1211"],"issn-type":[{"type":"print","value":"0920-1211"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment?","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2009.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}