{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:04:25Z","timestamp":1790553865984,"version":"4.1.0"},"reference-count":11,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.eplepsyres.2011.10.033","type":"journal-article","created":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T00:52:25Z","timestamp":1322787145000},"page":"183-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases"],"prefix":"10.1016","volume":"99","author":[{"given":"Junji","family":"Saruwatari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Deguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yoshimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madoka","family":"Noai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Ogusu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Oniki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Yasui-Furukori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunao","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takateru","family":"Ishitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2011.10.033_bib0005","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jhep.2010.11.006","article-title":"Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver","volume":"54","author":"Begriche","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.eplepsyres.2011.10.033_bib0010","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/479364","article-title":"Molecular and therapeutic potential and toxicity of valproic acid","author":"Chateauvieux","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.eplepsyres.2011.10.033_bib0015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/mas.20226","article-title":"The Sod2 mutant mouse as a model for oxidative stress: a functional proteomics perspective","volume":"29","author":"Lee","year":"2010","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.eplepsyres.2011.10.033_bib0020","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.eplepsyres.2009.04.004","article-title":"Non-alcoholic fatty liver disease (NAFLD), insulin resistance and lipid profile in antiepileptic drug treatment","volume":"86","author":"Luef","year":"2009","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2011.10.033_bib0025","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/ana.20074","article-title":"Valproate therapy and nonalcoholic fatty liver disease","volume":"55","author":"Luef","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.eplepsyres.2011.10.033_bib0030","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jhep.2004.01.028","article-title":"Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis","volume":"40","author":"Namikawa","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.eplepsyres.2011.10.033_bib0035","first-page":"833","article-title":"Non-alcoholic fatty liver disease in obese children evaluated by magnetic resonance imaging","volume":"95","author":"Radetti","year":"2006","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.eplepsyres.2011.10.033_bib0040","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10545-008-0841-x","article-title":"Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: a review","volume":"31","author":"Silva","year":"2008","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.eplepsyres.2011.10.033_bib0045","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/00008571-200303000-00004","article-title":"The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria","volume":"13","author":"Sutton","year":"2003","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.eplepsyres.2011.10.033_bib0050","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.yebeh.2010.12.012","article-title":"Nonalcoholic fatty liver disease in adolescents receiving valproic acid","volume":"20","author":"Verrotti","year":"2011","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2011.10.033_bib0055","series-title":"Interpretation of Diagnostic Tests","author":"Wallach","year":"1996"}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121111003603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121111003603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:27:12Z","timestamp":1760275632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121111003603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":11,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0920121111003603"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2011.10.033","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2011.10.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}