{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:32:13Z","timestamp":1761708733517,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.eplepsyres.2011.12.010","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T04:36:31Z","timestamp":1327898191000},"page":"306-311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of valproic acid treatment on penile structure in prepubertal rats"],"prefix":"10.1016","volume":"99","author":[{"given":"\u00d6mer","family":"Kutlu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Cansu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ersagun","family":"Karag\u00fczel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seren G\u00fcl\u015fen","family":"G\u00fcrgen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zg\u00fcr","family":"Ko\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Metin","family":"G\u00fcr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcner Kemal","family":"\u00d6zg\u00fcr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0005","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.seizure.2010.11.019","article-title":"Effects of chronic treatment with valproate and oxcarbazepine on testicular development in rats","volume":"20","author":"Cansu","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0010","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1528-1167.2009.02259.x","article-title":"Histologic and morphologic effects of valproic acid and oxcarbazepine on rat uterine and ovarian cells","volume":"51","author":"Cansu","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0015","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/j.1528-1167.2008.01576.x","article-title":"Effects of chronic treatment with valproate and oxcarbazepine on ovarian folliculogenesis in rats","volume":"49","author":"Cansu","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0020","first-page":"2010","article-title":"Molecular and therapeutic potential and toxicity of valproic acid","author":"Chateauvieux","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0025","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1476-4598-5-71","article-title":"Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt\/protein kinase B","volume":"5","author":"Chen","year":"2006","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0030","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/sj.onc.1205108","article-title":"Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling","volume":"21","author":"Deroanne","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0035","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/niox.2001.0421","article-title":"Antifibrotic role of inducible nitric oxide synthase","volume":"6","author":"Ferrini","year":"2002","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0040","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.bbrc.2006.12.204","article-title":"Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: involvement of Sp1","volume":"354","author":"Ghosh","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0045","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"Gottlicher","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0050","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1743-6109.2009.01624.x","article-title":"Anatomy, physiology, and pathophysiology of erectile dysfunction","volume":"7","author":"Gratzke","year":"2010","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0055","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.urology.2009.11.022","article-title":"The effect of epigenetic therapy on congenital neurogenic bladders\u2014a pilot study","volume":"75","author":"Hodges","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0060","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1001\/archneur.1990.00530060082023","article-title":"Serum hormones in male epileptic patients receiving anticonvulsant medication","volume":"47","author":"Isojarvi","year":"1990","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0065","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1528-1157.1988.tb03747.x","article-title":"Circulating hormones and pituitary responsiveness in young epileptic men receiving long-term antiepileptic medication","volume":"29","author":"Macphee","year":"1988","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0070","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1124\/mol.65.3.520","article-title":"Valproic acid inhibits angiogenesis in vitro and in vivo","volume":"65","author":"Michaelis","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0075","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1534\/genetics.107.070946","article-title":"Valproic acid affects membrane trafficking and cell-wall integrity in fission yeast","volume":"175","author":"Miyatake","year":"2007","journal-title":"Genetics"},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0080","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1743-6109.2008.00794.x","article-title":"The functional and structural consequences of cavernous nerve injury are ameliorated by sildenafil citrate","volume":"5","author":"Mulhall","year":"2008","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0085","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1600-0773.1991.tb01303.x","article-title":"Valproic acid-induced neural tube defects in mouse and human: aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms","volume":"69","author":"Nau","year":"1991","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0090","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.reprotox.2006.08.003","article-title":"Endometrial damage and apoptosis in rats induced by dichlorvos and ameliorating effect of antioxidant vitamins E and C","volume":"22","author":"Oral","year":"2006","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0095","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1124\/jpet.110.168385","article-title":"Histone deacetylase: a potential therapeutic target for fibrotic disorders","volume":"335","author":"Pang","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0100","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuint.2006.04.010","article-title":"Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms","volume":"49","author":"Pannu","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0105","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.eururo.2004.04.032","article-title":"Intracavernosal injection of vascular endothelial growth factor improves erectile function in aged rats","volume":"46","author":"Park","year":"2004","journal-title":"Eur. Urol."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0110","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/j.1939-4640.2002.tb02246.x","article-title":"Altered growth factor expression in the aging penis: the Brown-Norway rat model","volume":"23","author":"Rajasekaran","year":"2002","journal-title":"J. Androl."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0115","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1212\/WNL.56.1.31","article-title":"Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy","volume":"56","author":"Rattya","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0120","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1468-1331.2004.00899.x","article-title":"Antiepileptic drugs alter reproductive endocrine hormones in men with epilepsy","volume":"12","author":"Roste","year":"2005","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0125","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3109\/10428190109064584","article-title":"Searching for the magic bullet against cancer: the butyrate saga","volume":"42","author":"Santini","year":"2001","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0130","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/tera.1420480206","article-title":"Sodium valproate-induced cardiovascular abnormalities in the Jcl:ICR mouse fetus: peak sensitivity of gestational day and dose-dependent effect","volume":"48","author":"Sonoda","year":"1993","journal-title":"Teratology"},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0135","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1053\/seiz.2001.0545","article-title":"Morphological changes in the testis after long-term valproate treatment in male Wistar rats","volume":"10","author":"Sveberg Roste","year":"2001","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0140","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0890-6238(02)00054-0","article-title":"Effects of chronic valproate treatment on reproductive endocrine hormones in female and male Wistar rats","volume":"16","author":"Sveberg Roste","year":"2002","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0145","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s004310000590","article-title":"Serum sex hormone levels in young male patients with epilepsy receiving carbamazepine and valproic acid and after their withdrawal","volume":"159","author":"Verrotti","year":"2000","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0150","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1745-7262.2008.00372.x","article-title":"Growth factors for therapeutic angiogenesis in hypercholesterolemic erectile dysfunction","volume":"10","author":"Xie","year":"2008","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.eplepsyres.2011.12.010_bib0155","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.bbrc.2004.02.105","article-title":"Modulation of angiogenesis-related protein synthesis by valproic acid","volume":"316","author":"Zgouras","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121111004177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121111004177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:27:27Z","timestamp":1760275647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121111004177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0920121111004177"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2011.12.010","relation":{},"ISSN":["0920-1211"],"issn-type":[{"type":"print","value":"0920-1211"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of valproic acid treatment on penile structure in prepubertal rats","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2011.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}