{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T23:42:34Z","timestamp":1783208554660,"version":"3.54.6"},"reference-count":32,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":165,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"Telethon Facility","award":["GGP09134A"],"award-info":[{"award-number":["GGP09134A"]}]},{"name":"the Italian Ministry of University and Research"},{"DOI":"10.13039\/100007388","name":"the Compagnia di San Paolo, Torino","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.eplepsyres.2012.07.012","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T11:46:55Z","timestamp":1343476015000},"page":"153-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Temporal evolution of neurophysiological and behavioral features of synapsin I\/II\/III triple knock-out mice"],"prefix":"10.1016","volume":"103","author":[{"given":"Marco","family":"Cambiaghi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cursi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Monzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Benfenati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Comi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Minicucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Valtorta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Leocani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"49","key":"10.1016\/j.eplepsyres.2012.07.012_bib0005","doi-asserted-by":"crossref","first-page":"13520","DOI":"10.1523\/JNEUROSCI.3151-07.2007","article-title":"Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses","volume":"27","author":"Baldelli","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0010","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/sleep\/29.10.1339","article-title":"Sleep EEG changes after middle cerebral artery infarcts in mice: different effects of striatal and cortical lesions","volume":"29","author":"Baumann","year":"2006","journal-title":"Sleep"},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0015","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.neuroscience.2010.08.046","article-title":"Cortico-hippocampal hyperexcitability in synapsin I\/II\/III knockout mice: age-dependency and response to the antiepileptic drug levetiracetam","volume":"171","author":"Boido","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0020","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/S1474-4422(07)70247-8","article-title":"Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case\u2013control study","volume":"6","author":"Cavalleri","year":"2007","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0025","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.pneurobio.2010.04.006","article-title":"The synapsins: key actors of synapse function and plasticity","volume":"91","author":"Cesca","year":"2010","journal-title":"Prog. Neurobiol."},{"issue":"6","key":"10.1016\/j.eplepsyres.2012.07.012_bib0030","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1093\/cercor\/bhn182","article-title":"Opposite changes in glutamatergic and GABAergic transmission underlie the diffuse hyperexcitability of synapsin I-deficient cortical networks","volume":"9","author":"Chiappalone","year":"2009","journal-title":"Cereb. Cortex."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0035","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1242\/jcs.035063","article-title":"Synapsin-I- and synapsin-II-null mice display an increased age-dependent cognitive impairment","volume":"121","author":"Corradi","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0040","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S1474-4422(04)00906-8","article-title":"Chronic epilepsy and cognition","volume":"3","author":"Elger","year":"2004","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0045","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.yebeh.2009.02.021","article-title":"Seizure elements and seizure element transitions during tonic\u2013clonic seizure activity in the synapsin I\/II double knockout mouse: a neuroethological description","volume":"14","author":"Etholm","year":"2009","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0050","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.brainres.2011.01.070","article-title":"Electroencephalographic characterization of seizure activity in the synapsin I\/II double knockout mouse","volume":"1383","author":"Etholm","year":"2011","journal-title":"Brain Res."},{"issue":"January","key":"10.1016\/j.eplepsyres.2012.07.012_bib0055","article-title":"Neuroethologically delineated differences in the seizure behavior of synapsin 1 and synapsin 2 knock-out mice","author":"Etholm","year":"2012","journal-title":"Epil. Res."},{"issue":"12","key":"10.1016\/j.eplepsyres.2012.07.012_bib0060","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1093\/hmg\/ddr122","article-title":"SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function","volume":"20","author":"Fassio","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0065","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.semcdb.2011.07.005","article-title":"Synapsins: from synapse to network hyperexcitability and epilepsy","volume":"22","author":"Fassio","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0070","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/BF03401726","article-title":"Distinct roles of synapsin I and synapsin II during neuronal development","volume":"4","author":"Ferreira","year":"1998","journal-title":"Mol. Med."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0075","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1523\/JNEUROSCI.20-10-03736.2000","article-title":"Synapsin III: developmental expression, subcellular localization, and role in axon formation","volume":"20","author":"Ferreira","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0080","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1089\/neu.2010.1370","article-title":"Hippocampal (dysfunction after lateral fluid percussion injury","volume":"27","author":"Fedor","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0085","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1136\/jmg.2003.013680","article-title":"Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsy","volume":"41","author":"Garcia","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0090","doi-asserted-by":"crossref","first-page":"11368","DOI":"10.1523\/JNEUROSCI.3795-04.2004","article-title":"Different presynaptic roles of synapsins at excitatory and inhibitory synapses","volume":"24","author":"Gitler","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0095","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1126\/science.8430330","article-title":"Synaptic vesicle phosphoproteins and regulation of synaptic function","volume":"259","author":"Greengard","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0100","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neuroscience.2011.05.030","article-title":"Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice","volume":"189","author":"Ketzef","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0105","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/syn.20740","article-title":"Association of intronic polymorphism rs3773364 A>G in synapsin-2 gene with idiopathic epilepsy","volume":"64","author":"Lakhan","year":"2010","journal-title":"Synapse"},{"issue":"5","key":"10.1016\/j.eplepsyres.2012.07.012_bib0110","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.stem.2011.09.008","article-title":"Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions","volume":"9","author":"Magri","year":"2011","journal-title":"Cell Stem Cell."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0115","first-page":"1185","article-title":"Diffusion-weighted MR in experimental sustained seizures elicited with kainic acid","volume":"16","author":"Nakasu","year":"1995","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0120","doi-asserted-by":"crossref","first-page":"13157","DOI":"10.1523\/JNEUROSCI.1359-10.2010","article-title":"Manipulation of adenosine kinase affects sleep regulation in mice","volume":"30","author":"Palchykova","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0125","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1136\/bmj.316.7139.1236","article-title":"What's wrong with Bonferroni adjustments","volume":"316","author":"Perneger","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0130","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1007\/BF01950020","article-title":"Arousal deficit shown in aged rat's quantitative EEG and ameliorative action of pramiracetam compared to piracetam","volume":"41","author":"Poschel","year":"1985","journal-title":"Experientia"},{"issue":"6","key":"10.1016\/j.eplepsyres.2012.07.012_bib0135","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/ana.20658","article-title":"In vivo imaging of dendritic spines during electrographic seizures","volume":"58","author":"Rensing","year":"2005","journal-title":"Ann. Neurol."},{"issue":"375","key":"10.1016\/j.eplepsyres.2012.07.012_bib0140","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/375488a0","article-title":"Essential functions of synapsins I and II in synaptic vesicle regulation","volume":"8","author":"Rosahl","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0145","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev.neuro.26.041002.131412","article-title":"The synaptic vesicle cycle","volume":"27","author":"S\u00fcdhof","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.eplepsyres.2012.07.012_bib0150","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.semcdb.2011.07.008","article-title":"The synapsins: multitask modulators of neuronal development","volume":"22","author":"Valtorta","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0155","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0166-4328(05)80027-0","article-title":"Anti-muscarinic drug effects in a swim-to-platform test: dose\u2013response relations","volume":"44","author":"Vanderwolf","year":"1991","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.eplepsyres.2012.07.012_bib0160","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1109\/TAU.1967.1161901","article-title":"The use of fast fourier transform for the estimation of power spectra: a method based on time averaging over short, modified periodograms","volume":"AU\u201315","author":"Welch","year":"1967","journal-title":"IEEE Trans. Audio Electroacoustics"}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121112002045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121112002045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:29:04Z","timestamp":1760275744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121112002045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":32,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0920121112002045"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2012.07.012","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Temporal evolution of neurophysiological and behavioral features of synapsin I\/II\/III triple knock-out mice","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2012.07.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}