{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T18:42:11Z","timestamp":1793472131138,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.eplepsyres.2013.02.020","type":"journal-article","created":{"date-parts":[[2013,4,6]],"date-time":"2013-04-06T21:01:31Z","timestamp":1365282091000},"page":"368-376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Effect of eslicarbazepine acetate on the pharmacokinetics of a combined ethinylestradiol\/levonorgestrel oral contraceptive in healthy women"],"prefix":"10.1016","volume":"105","author":[{"given":"Amilcar","family":"Falc\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Vaz-da-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Gama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcio","family":"Soares-da-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0005","series-title":"The Treatment of Epilepsy","first-page":"485","article-title":"Eslicarbazepine Acetate","author":"Almeida","year":"2009"},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0010","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1177\/0091270005279364","article-title":"Single-dose and steady-state pharmacokinetics of eslicarbazepine acetate (BIA 2-093) in healthy elderly and young subjects","volume":"45","author":"Almeida","year":"2005","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0015","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1177\/0091270008319706","article-title":"Pharmacokinetics, efficacy, and tolerability of eslicarbazepine acetate in children and adolescents with epilepsy","volume":"48","author":"Almeida","year":"2008","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0020","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00228-007-0414-1","article-title":"Pharmacokinetics of eslicarbazepine acetate in patients with moderate hepatic impairment","volume":"64","author":"Almeida","year":"2008","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0025","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1177\/0091270004267591","article-title":"Safety, tolerability, and pharmacokinetic profile of BIA 2-093, a novel putative antiepileptic, in a rising multiple-dose study in young healthy humans","volume":"44","author":"Almeida","year":"2004","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0030","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2125.1982.tb01382.x","article-title":"The gut wall metabolism of ethinyloestradiol and its contribution to the pre-systemic metabolism of ethinyloestradiol in humans","volume":"13","author":"Back","year":"1982","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0035","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1021\/jm980627g","article-title":"Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives","volume":"42","author":"Benes","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0040","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1528-1167.2012.03519.x","article-title":"Pharmacokinetics and drug interactions of eslicarbazepine acetate","volume":"53","author":"Bialer","year":"2012","journal-title":"Epilepsia"},{"issue":"Suppl. (6)","key":"10.1016\/j.eplepsyres.2013.02.020_bib0045","first-page":"260","article-title":"The effects of eslicarbazepine, R-licarbazepine, oxcarbazepine and carbamazepine on ion transmission Cav3.2 channels","volume":"52","author":"Brady","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0050","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1023\/A:1011503032353","article-title":"On sample size calculation in bioequivalence trials","volume":"28","author":"Chow","year":"2001","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0055","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/j.1365-2125.1990.tb05457.x","article-title":"The interaction of phenytoin and carbamazepine with combined oral contraceptive steroids","volume":"30","author":"Crawford","year":"1990","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0060","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1528-1167.2010.02917.x","article-title":"Carbamazepine coadministration with an oral contraceptive: effects on steroid pharmacokinetics, ovulation, and bleeding","volume":"52","author":"Davis","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0065","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1528-1167.2007.00984.x","article-title":"Eslicarbazepine acetate: a double-blind, add-on, placebo-controlled exploratory trial in adult patients with partial-onset seizures","volume":"48","author":"Elger","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0070","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/bdd.549","article-title":"Effect of gender on the pharmacokinetics of eslicarbazepine acetate (BIA 2-093), a new voltage-gated sodium channel blocker","volume":"28","author":"Falcao","year":"2007","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0075","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1528-1157.1999.tb00779.x","article-title":"Induction of ethinylestradiol and levonorgestrel metabolism by oxcarbazepine in healthy women","volume":"40","author":"Fattore","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0080","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/0002-9378(90)90557-N","article-title":"Inhibition of oral contraceptive steroid-metabolizing enzymes by steroids and drugs","volume":"163","author":"Guengerich","year":"1990","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0085","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0920-1211(01)00231-5","article-title":"Metabolism of two new antiepileptic drugs and their principal metabolites S(+)- and R(\u2212)-10,11-dihydro-10-hydroxy carbamazepine","volume":"44","author":"Hainzl","year":"2001","journal-title":"Epilepsy Res."},{"issue":"Suppl. (6)","key":"10.1016\/j.eplepsyres.2013.02.020_bib0090","first-page":"257","article-title":"Inhibitory effects of eslicarbazepine acetate and its metabolites against neuronal voltage-gated sodium channels","volume":"52","author":"Hebeisen","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0095","doi-asserted-by":"crossref","first-page":"254","DOI":"10.2174\/157015910792246254","article-title":"Antiepileptic drug interactions \u2013 principles and clinical implications","volume":"8","author":"Johannessen","year":"2010","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0100","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.yebeh.2009.02.023","article-title":"Female issues in epilepsy: a critical review","volume":"15","author":"Luef","year":"2009","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0105","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5414\/CPP46119","article-title":"Effect of renal impairment on the pharmacokinetics of eslicarbazepine acetate","volume":"46","author":"Maia","year":"2008","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0110","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2165\/00126839-200506040-00002","article-title":"Effect of food on the pharmacokinetic profile of eslicarbazepine acetate (BIA 2-093)","volume":"6","author":"Maia","year":"2005","journal-title":"Drugs R. D."},{"issue":"Suppl. (6)","key":"10.1016\/j.eplepsyres.2013.02.020_bib0115","first-page":"257","article-title":"Effects of eslicarbazepine acetate and its metabolites in the corneal kindling model of epilepsy","volume":"52","author":"Pekcec","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0120","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.eplepsyres.2011.05.013","article-title":"Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures","volume":"96","author":"Perucca","year":"2011","journal-title":"Epilepsy Res."},{"issue":"Suppl. (6)","key":"10.1016\/j.eplepsyres.2013.02.020_bib0125","first-page":"118","article-title":"Effects of eslicarbazepine acetate, eslicarbazepine, carbamazepine and oxcarbazepine in the maximal electroconvulsive shock test in the mice","volume":"52","author":"Pires","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0130","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1046\/j.1528-1157.2002.57701.x","article-title":"Levetiracetam does not alter the pharmacokinetics of an oral contraceptive in healthy women","volume":"43","author":"Ragueneau-Majlessi","year":"2002","journal-title":"Epilepsia"},{"issue":"Suppl. (6)","key":"10.1016\/j.eplepsyres.2013.02.020_bib0135","first-page":"119","article-title":"Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus","volume":"52","author":"Sierra-Paredes","year":"2011","journal-title":"Epilepsia"},{"issue":"Suppl. (6)","key":"10.1016\/j.eplepsyres.2013.02.020_bib0140","first-page":"257","article-title":"The effects of eslicarbazepine acetate in the amygdala kindling model of temporal lobe epilepsy","volume":"52","author":"Soerensen","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0145","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0010-7824(90)90093-B","article-title":"Metabolism of levonorgestrel, norethindrone, and structurally related contraceptive steroids","volume":"42","author":"Stanczyk","year":"1990","journal-title":"Contraception"},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0150","first-page":"427","article-title":"Reference tables for the intrasubject coefficient of variation in bioequivalence studies","volume":"33","author":"Steinijans","year":"1995","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.eplepsyres.2013.02.020_bib0155","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.yebeh.2006.05.002","article-title":"The impact of antiepileptic drug therapy on steroidal contraceptive efficacy","volume":"9","author":"Thorneycroft","year":"2006","journal-title":"Epilepsy Behav."},{"issue":"Suppl. (6)","key":"10.1016\/j.eplepsyres.2013.02.020_bib0160","first-page":"118","article-title":"Effects of eslicarbazepine acetate, eslicarbazepine, carbamazepine and oxcarbazepine in the 6-Hz psychomotor seizure model in the mice","volume":"52","author":"Torrao","year":"2011","journal-title":"Epilepsia"}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121113000806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121113000806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:28:31Z","timestamp":1760275711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121113000806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0920121113000806"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2013.02.020","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of eslicarbazepine acetate on the pharmacokinetics of a combined ethinylestradiol\/levonorgestrel oral contraceptive in healthy women","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2013.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}