{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T14:11:52Z","timestamp":1760278312405,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.eplepsyres.2013.10.011","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T15:49:07Z","timestamp":1382975347000},"page":"11-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nitric oxide synthase inhibition reverts muscarinic receptor down-regulation induced by pilocarpine- and kainic acid-evoked seizures in rat fronto-parietal cortex"],"prefix":"10.1016","volume":"108","author":[{"given":"Marta","family":"Capannolo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Ciccarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Molteni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Fumagalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Rocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Romeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Fasciani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Aloisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca M.","family":"Zani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco A.","family":"Riva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Maggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0005","series-title":"Diversity of Interacting Receptors, vol. 757","first-page":"215","article-title":"S-nitrosylation of M2 muscarinic receptor thiols disrupts receptor-G protein coupling","author":"Aronstam","year":"1995"},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0010","doi-asserted-by":"crossref","first-page":"808","DOI":"10.2174\/187152711798072347","article-title":"Nitric oxide, epileptic seizures, and action of antiepileptic drugs","volume":"10","author":"Banach","year":"2011","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"9","key":"10.1016\/j.eplepsyres.2013.10.011_bib0015","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1111\/j.1460-9568.2012.08234.x","article-title":"N (\u03c9)-Propyl-l-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses","volume":"36","author":"Beamer","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0020","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1046\/j.0953-816x.2001.01680.x","article-title":"Exogenous nitric oxide causes potentiation of hippocampal synaptic transmission during low-frequency stimulation via the endogenous nitric oxide-cGMP pathway","volume":"14","author":"Bon","year":"2001","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.eplepsyres.2013.10.011_bib0025","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0165-3806(02)00549-7","article-title":"FGF-2 NGF and IGF-1, but not BDNF, utilize a nitric oxide pathway to signal neurotrophic and neuroprotective effects against alcohol toxicity in cerebellar granule cell cultures","volume":"140","author":"Bonthius","year":"2003","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0030","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1046\/j.1460-9568.2003.02588.x","article-title":"Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity","volume":"17","author":"Bymaster","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0035","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single step method of RNA isolation by guanidium thiocyanate-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0040","first-page":"57","article-title":"Soman- or kainic acid-induced convulsions decrease muscarinic receptors but not benzodiazepine receptors","volume":"11","author":"Churchill","year":"1990","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0045","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jneumeth.2008.04.019","article-title":"The pilocarpine model of temporal lobe epilepsy","volume":"172","author":"Curia","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0050","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.bbagen.2011.03.007","article-title":"S-nitrosylation-regulated GPCR signaling","volume":"1820","author":"Daaka","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0055","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0014-2999(93)90797-L","article-title":"l-Arginine potentiates excitatory amino acid-induced seizures elicited in the deep prepiriform cortex","volume":"230","author":"De Sarro","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0060","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.pbb.2006.02.011","article-title":"Expression of muscarinic and dopaminergic receptors and monoamine levels frontal cortex of epileptic rats","volume":"83","author":"Freitas","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0065","doi-asserted-by":"crossref","first-page":"11513","DOI":"10.1523\/JNEUROSCI.2259-06.2006","article-title":"Tonic and phasic nitric oxide signals in hippocampal long-term potentiation","volume":"26","author":"Hopper","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0070","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/j.1471-4159.1987.tb00985.x","article-title":"Acetylcholine content in rat brain is elevated by status epilepticus induced by lithium and pilocarpine","volume":"49","author":"Jope","year":"1987","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.eplepsyres.2013.10.011_bib0075","doi-asserted-by":"crossref","first-page":"e17361","DOI":"10.1371\/journal.pone.0017361","article-title":"Internalization dissociates \u03b22-adrenergic receptors","volume":"6","author":"Lan","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0080","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1523\/JNEUROSCI.11-10-03218.1991","article-title":"Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies","volume":"11","author":"Levey","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0085","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0090","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0006-8993(90)91661-Y","article-title":"Selective stimulation of kainate but not quisqualate or NMDA receptors in substantia nigra evokes limbic motor seizures","volume":"528","author":"Maggio","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0095","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1046\/j.1471-4159.1995.65020943.x","article-title":"Sodium nitroprusside induces internalization of muscarinic receptors stably expressed in Chinese hamster ovary cell lines","volume":"65","author":"Maggio","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0100","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0006-8993(95)00217-E","article-title":"Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats","volume":"679","author":"Maggio","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0105","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1111\/j.1471-4159.2007.04896.x","article-title":"G protein-coupled receptor oligomerization provides the framework for signal discrimination","volume":"103","author":"Maggio","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0110","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0197-0186(98)00028-X","article-title":"Effects of lithium, alone or associated with pilocarpine, on muscarinic and dopaminergic receptors and on phosphoinositide metabolism in rat hippocampus and striatum","volume":"33","author":"Marinho","year":"1998","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0115","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0006-8993(02)03669-7","article-title":"Involvement of nitric oxide in kainic acid-induced excitotoxicity in rat brain","volume":"957","author":"Milatovic","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0120","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.eplepsyres.2013.10.011_bib0125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1210\/endo.142.1.7866","article-title":"Fibroblast growth factor-2 stimulates endothelial nitric oxide synthase expression and inhibits apoptosis by a nitric oxide-dependent pathway in Nb2 lymphoma cells","volume":"142","author":"Murphy","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0130","doi-asserted-by":"crossref","first-page":"7476","DOI":"10.1074\/jbc.M306818200","article-title":"The paired activation of the two components of the muscarinic M3 receptor dimer is required for induction of ERK1\/2 phosphorylation","volume":"279","author":"Novi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0135","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/j.1471-4159.2007.04660.x","article-title":"Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D2L receptors are modified by co-transfection of D3 receptors: potential role of heterodimer formation","volume":"102","author":"Novi","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0140","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0006-8993(94)91283-1","article-title":"Antiepileptic effects of inhibitors of nitric oxide synthase examined in pentylenetetrazol-induced seizures in rats","volume":"663","author":"Osonoe","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0145","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.molcel.2008.05.024","article-title":"S-nitrosylation of \u03b2-arrestin regulates \u03b2-adrenergic receptor trafficking","volume":"31","author":"Ozawa","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0150","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1023\/A:1020936231662","article-title":"Regulation of M1 muscarinic receptor-mediated signaling in intact cells by exogenous, but not endogenously produced, nitric oxide","volume":"24","author":"Parsons","year":"1999","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0155","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0920-1211(94)90038-8","article-title":"Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents","volume":"18","author":"Penix","year":"1994","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0160","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation. 11. Motor seizures","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0165","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0169-328X(92)90123-S","article-title":"Basic fibroblast growth factor mRNA increases in specific brain regions following convulsive seizures","volume":"15","author":"Riva","year":"1992","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0170","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0306-4522(94)90098-1","article-title":"Short- and long-term induction of basic fibroblast growth factor gene expression in rat central nervous system following kainate injection","volume":"59","author":"Riva","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0175","first-page":"1187","article-title":"l-Nitroarginine, an inhibitor of NO synthase dramatically worsens limbic epilepsy in rats","volume":"4","author":"Rondouin","year":"1993","journal-title":"Neuroreport"},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0180","doi-asserted-by":"crossref","first-page":"16768","DOI":"10.1074\/jbc.M111.329912","article-title":"Cell type-specific \u03b22-adrenergic receptor clusters identified using photoactivated localization microscopy are not lipid raft related, but depend on actin cytoskeleton integrity","volume":"287","author":"Scarselli","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0185","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0091-3057(93)90246-P","article-title":"Paradoxical facilitation of pilocarpine-induced seizures in the mouse by MK-801 and the nitric oxide synthesis inhibitor l-NAME","volume":"45","author":"Starr","year":"1993","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.eplepsyres.2013.10.011_bib0190","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0006-8993(09)90026-9","article-title":"Nitric oxide (NO) is an endogenous anti-convulsant but not a mediator of the increase in cerebral blood flow accompanying bicuculline-induced seizure in rats","volume":"658","author":"Wang","year":"1994","journal-title":"Brain Res."}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121113002763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121113002763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:29:56Z","timestamp":1760275796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121113002763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0920121113002763"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2013.10.011","relation":{},"ISSN":["0920-1211"],"issn-type":[{"type":"print","value":"0920-1211"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide synthase inhibition reverts muscarinic receptor down-regulation induced by pilocarpine- and kainic acid-evoked seizures in rat fronto-parietal cortex","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2013.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}