{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:34:04Z","timestamp":1772764444181,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Department Neurowissenschaften"},{"name":"Department Molecular Medicine"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.eplepsyres.2014.02.005","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T14:16:37Z","timestamp":1392732997000},"page":"623-633","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Valproic acid in normal therapeutic concentration has no neuroprotective or differentiation influencing effects on long term expanded murine neural stem cells"],"prefix":"10.1016","volume":"108","author":[{"given":"Judith","family":"Brunn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8236-3264","authenticated-orcid":false,"given":"Viktor","family":"Wiroth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kowalski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Runge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sabolek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.eplepsyres.2014.02.005_bib0005","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1055\/s-2008-1038218","article-title":"Neurogenesis in the adult brain: from bench to bedside?","volume":"76","author":"Brandt","year":"2008","journal-title":"Fortschr. Neurol. Psychiatr."},{"issue":"5","key":"10.1016\/j.eplepsyres.2014.02.005_bib0010","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1210\/endo.142.5.8148","article-title":"Minireview: tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology","volume":"142","author":"Butler","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.eplepsyres.2014.02.005_bib0015","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.brainres.2009.11.053","article-title":"Hippocampal-related memory deficits and histological damage induced by neonatal ionizing radiation exposure. Role of oxidative status","volume":"1312","author":"Caceres","year":"2010","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.eplepsyres.2014.02.005_bib0020","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ecoenv.2008.09.009","article-title":"Long-lasting effects of neonatal ionizing radiation exposure on spatial memory and anxiety-like behavior","volume":"72","author":"Caceres","year":"2009","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.eplepsyres.2014.02.005_bib0025","first-page":"2010","article-title":"Molecular and therapeutic potential and toxicity of valproic acid","author":"Chateauvieux","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.eplepsyres.2014.02.005_bib0030","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1476-4598-5-71","article-title":"Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt\/protein kinase B","volume":"5","author":"Chen","year":"2006","journal-title":"Mol. Cancer"},{"issue":"12","key":"10.1016\/j.eplepsyres.2014.02.005_bib0035","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/sj.mp.4001893","article-title":"Valproate protects dopaminergic neurons in midbrain neuron\/glia cultures by stimulating the release of neurotrophic factors from astrocytes","volume":"11","author":"Chen","year":"2006","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.eplepsyres.2014.02.005_bib0040","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuroscience.2007.06.053","article-title":"Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity","volume":"149","author":"Chen","year":"2007","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.eplepsyres.2014.02.005_bib0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1399-5618.2004.00164.x","article-title":"Comparative analysis of the effects of four mood stabilizers in SH-SY5Y cells and in primary neurons","volume":"7","author":"Di Daniel","year":"2005","journal-title":"Bipolar Disord."},{"issue":"3","key":"10.1016\/j.eplepsyres.2014.02.005_bib0050","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2174\/187152707780619353","article-title":"Adult hippocampal neurogenesis as target for the treatment of depression","volume":"6","author":"Drew","year":"2007","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"3","key":"10.1016\/j.eplepsyres.2014.02.005_bib0055","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2174\/138920107780906540","article-title":"Adult neurogenesis: can analysis of cell cycle proteins move us Beyond BrdU?","volume":"8","author":"Eisch","year":"2007","journal-title":"Curr. Pharm. Biotechnol."},{"issue":"4","key":"10.1016\/j.eplepsyres.2014.02.005_bib0060","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.4049\/jimmunol.133.4.1710","article-title":"Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67","volume":"133","author":"Gerdes","year":"1984","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.eplepsyres.2014.02.005_bib0065","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ijc.2910310104","article-title":"Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation","volume":"31","author":"Gerdes","year":"1983","journal-title":"Int. J. Cancer"},{"issue":"6","key":"10.1016\/j.eplepsyres.2014.02.005_bib0070","first-page":"717","article-title":"Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human","volume":"19","author":"Giustina","year":"1998","journal-title":"Endocr. Rev."},{"issue":"47","key":"10.1016\/j.eplepsyres.2014.02.005_bib0075","doi-asserted-by":"crossref","first-page":"16659","DOI":"10.1073\/pnas.0407643101","article-title":"Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells","volume":"101","author":"Hsieh","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.eplepsyres.2014.02.005_bib0080","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.neuropharm.2004.11.010","article-title":"Opposite effects of lithium and valproic acid on trophic factor deprivation-induced glycogen synthase kinase-3 activation, c-Jun expression and neuronal cell death","volume":"48","author":"Jin","year":"2005","journal-title":"Neuropharmacology"},{"issue":"2\u20133","key":"10.1016\/j.eplepsyres.2014.02.005_bib0085","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0197-0186(00)00013-9","article-title":"Mechanisms of action of valproate: a commentatory","volume":"37","author":"Johannessen","year":"2000","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.eplepsyres.2014.02.005_bib0090","first-page":"3","article-title":"Insulin-like growth factors and their binding proteins: biological actions","volume":"16","author":"Jones","year":"1995","journal-title":"Endocr. Rev."},{"issue":"3","key":"10.1016\/j.eplepsyres.2014.02.005_bib0095","doi-asserted-by":"crossref","first-page":"a001271","DOI":"10.1101\/cshperspect.a001271","article-title":"NF-kappaB in the nervous system","volume":"1","author":"Kaltschmidt","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"5","key":"10.1016\/j.eplepsyres.2014.02.005_bib0100","first-page":"782","article-title":"Pharmacokinetics of sodium valproate in dog and mouse","volume":"28","author":"Loscher","year":"1978","journal-title":"Arzneimittelforschung"},{"issue":"3","key":"10.1016\/j.eplepsyres.2014.02.005_bib0105","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1034\/j.1399-5618.2002.40301.x","article-title":"Different dependence of lithium and valproate on PI3K\/PKB pathway","volume":"4","author":"Mora","year":"2002","journal-title":"Bipolar Disord."},{"issue":"1","key":"10.1016\/j.eplepsyres.2014.02.005_bib0110","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1128\/MCB.17.1.427","article-title":"Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis","volume":"17","author":"O\u2019Connor","year":"1997","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.eplepsyres.2014.02.005_bib0115","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.molbrainres.2004.10.021","article-title":"Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia","volume":"134","author":"Peng","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"5","key":"10.1016\/j.eplepsyres.2014.02.005_bib0120","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-2710.2005.00671.x","article-title":"Valproate: a simple chemical with so much to offer","volume":"30","author":"Peterson","year":"2005","journal-title":"J. Clin. Pharm. Ther."},{"issue":"39","key":"10.1016\/j.eplepsyres.2014.02.005_bib0125","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.eplepsyres.2014.02.005_bib0130","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1002\/stem.122","article-title":"Initiation of dopaminergic differentiation of Nurr1(\u2212) mesencephalic precursor cells depends on activation of multiple mitogen-activated protein kinase pathways","volume":"27","author":"Sabolek","year":"2009","journal-title":"Stem Cells"},{"issue":"16","key":"10.1016\/j.eplepsyres.2014.02.005_bib0135","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1097\/01.wnr.0000236862.08834.50","article-title":"Dexamethasone blocks astroglial differentiation from neural precursor cells","volume":"17","author":"Sabolek","year":"2006","journal-title":"Neuroreport"},{"issue":"4","key":"10.1016\/j.eplepsyres.2014.02.005_bib0140","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.neuro.2008.04.007","article-title":"Stage-dependent vulnerability of fetal mesencephalic neuroprogenitors towards dopaminergic neurotoxins","volume":"29","author":"Sabolek","year":"2008","journal-title":"Neurotoxicology"},{"issue":"3","key":"10.1016\/j.eplepsyres.2014.02.005_bib0145","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1023\/A:1005955017615","article-title":"Structure and function of the insulin-like growth factor I receptor","volume":"47","author":"Sepp-Lorenzino","year":"1998","journal-title":"Breast Cancer Res. Treat."},{"issue":"6","key":"10.1016\/j.eplepsyres.2014.02.005_bib0150","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.surg.2005.09.019","article-title":"Valproic acid inhibits growth, induces apoptosis, and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cells","volume":"138","author":"Shen","year":"2005","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/j.eplepsyres.2014.02.005_bib0155","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0891-0618(03)00067-X","article-title":"Functional characterization of dopaminergic neurons derived from rodent mesencephalic progenitor cells","volume":"26","author":"Storch","year":"2003","journal-title":"J. Chem. Neuroanat."},{"issue":"5","key":"10.1016\/j.eplepsyres.2014.02.005_bib0160","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0197-0186(99)00083-2","article-title":"HEK-293 cells expressing the human dopamine transporter are susceptible to low concentrations of 1-methyl-4-phenylpyridine (MPP+) via impairment of energy metabolism","volume":"35","author":"Storch","year":"1999","journal-title":"Neurochem. Int."},{"issue":"3","key":"10.1016\/j.eplepsyres.2014.02.005_bib0165","first-page":"347","article-title":"Actions of sodium valproate on the central nervous system","volume":"50","author":"Tunnicliff","year":"1999","journal-title":"J. Physiol. Pharmacol."},{"issue":"11\u201312","key":"10.1016\/j.eplepsyres.2014.02.005_bib0170","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/j.yexcr.2008.03.019","article-title":"Neurofibromatosis 2 tumor suppressor, the gene induced by valproic acid, mediates neurite outgrowth through interaction with paxillin","volume":"314","author":"Yamauchi","year":"2008","journal-title":"Exp. Cell Res."},{"issue":"9","key":"10.1016\/j.eplepsyres.2014.02.005_bib0175","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1016\/j.yexcr.2007.02.019","article-title":"Gadd45a, the gene induced by the mood stabilizer valproic acid, regulates neurite outgrowth through JNK and the substrate paxillin in N1E-115 neuroblastoma cells","volume":"313","author":"Yamauchi","year":"2007","journal-title":"Exp. Cell Res."},{"issue":"12","key":"10.1016\/j.eplepsyres.2014.02.005_bib0180","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.yexcr.2009.03.012","article-title":"Valproic acid-inducible Arl4D and cytohesin-2\/ARNO, acting through the downstream Arf6, regulate neurite outgrowth in N1E-115 cells","volume":"315","author":"Yamauchi","year":"2009","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.eplepsyres.2014.02.005_bib0185","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1399-5618.2009.00675.x","article-title":"Valproate activates the Notch3\/c-FLIP signaling cascade: a strategy to attenuate white matter hyperintensities in bipolar disorder in late life?","volume":"11","author":"Yuan","year":"2009","journal-title":"Bipolar Disord."},{"issue":"1","key":"10.1016\/j.eplepsyres.2014.02.005_bib0190","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.neuroscience.2010.03.029","article-title":"Effects of neonatal flutamide treatment on hippocampal neurogenesis and synaptogenesis correlate with depression-like behaviors in preadolescent male rats","volume":"169","author":"Zhang","year":"2010","journal-title":"Neuroscience"}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092012111400045X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092012111400045X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:30:19Z","timestamp":1760275819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092012111400045X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S092012111400045X"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2014.02.005","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valproic acid in normal therapeutic concentration has no neuroprotective or differentiation influencing effects on long term expanded murine neural stem cells","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2014.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}