{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:17:52Z","timestamp":1792192672901,"version":"4.4.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.eplepsyres.2014.04.008","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T04:49:55Z","timestamp":1400042995000},"page":"1046-1051","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["4217C&gt;A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy"],"prefix":"10.1016","volume":"108","author":[{"given":"Kazuyuki","family":"Inoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Yazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukitoshi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kou","family":"Miyakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiko","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0005","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jhep.2010.11.031","article-title":"New insights on the mechanisms of valproate-induced hyperammonemia: inhibition of hepatic N-acetylglutamate synthase activity by valproyl-CoA","volume":"55","author":"Aires","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0010","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1124\/dmd.108.022426","article-title":"Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10","volume":"37","author":"Argikar","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0015","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1213\/ANE.0b013e318228a001","article-title":"Perioperative exacerbation of valproic acid-associated hyperammonemia: a clinical and genetic analysis","volume":"113","author":"Bezinover","year":"2011","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0020","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0006-291X(02)02696-7","article-title":"Cloning and expression of the human N-acetylglutamate synthase gene","volume":"299","author":"Caldovic","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0025","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1042\/bj20020161","article-title":"Identification, cloning and expression of the mouse N-acetylglutamate synthase gene","volume":"364","author":"Caldovic","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0030","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s00439-003-0909-5","article-title":"Null mutations in the N-acetylglutamate synthase gene associated with acute neonatal disease and hyperammonemia","volume":"112","author":"Caldovic","year":"2003","journal-title":"Hum. Genet."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0035","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/humu.20518","article-title":"Mutations and polymorphisms in the human N-acetylglutamate synthase (NAGS) gene","volume":"28","author":"Caldovic","year":"2007","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0040","doi-asserted-by":"crossref","first-page":"1605S","DOI":"10.1093\/jn\/134.6.1605S","article-title":"Clinical manifestations of inborn errors of the urea cycle and related metabolic disorders during childhood","volume":"134","author":"Endo","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0045","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0050","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0021-9258(18)66077-6","article-title":"Catalytic role of glutamate derivatives in citrulline biosynthesis","volume":"204","author":"Grisolia","year":"1953","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0055","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1002\/humu.21553","article-title":"N-carbamylglutamate enhancement of ureagenesis leads to discovery of a novel deleterious mutation in a newly defined enhancer of the NAGS gene and to effective therapy","volume":"32","author":"Heibel","year":"2011","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0060","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1528-1157.1992.tb01708.x","article-title":"Is 2-propyl-4-pentenoic acid, a hepatotoxic metabolite of valproate, responsible for valproate-induced hyperammonemia?","volume":"33","author":"Kondo","year":"1992","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0065","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1001\/archneur.1982.00510210061016","article-title":"Asymptomatic hyperammonemia in patients receiving valproic acid","volume":"39","author":"Murphy","year":"1982","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0070","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1474-4422(03)00409-5","article-title":"Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs","volume":"2","author":"Patsalos","year":"2003","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0075","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3109\/02699050903302344","article-title":"Valproic acid-induced encephalopathy in very long course treated patients","volume":"23","author":"Rousseau","year":"2009","journal-title":"Brain Inj."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/0883073810377235","article-title":"Blood ammonia levels in epileptic children on 2 dose ranges of valproic acid monotherapy: a cross-sectional study","volume":"26","author":"Sharma","year":"2011","journal-title":"J. Child. Neurol."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0085","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1365-2710.1999.00201.x","article-title":"Clinically significant pharmacokinetic drug interactions between antiepileptic drugs","volume":"24","author":"Tanaka","year":"1999","journal-title":"J. Clin. Pharm. Ther."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0090","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/j.1442-200X.2010.03157.x","article-title":"Effect of CPS14217C>A genotype on valproic-acid-induced hyperammonemia","volume":"52","author":"Yagi","year":"2010","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0095","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1111\/epi.12125","article-title":"Risk factors for hyperammonemia in pediatric patients with epilepsy","volume":"54","author":"Yamamoto","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0100","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1023\/A:1021918104127","article-title":"Valproate-induced hyperammonemic encephalopathy","volume":"17","author":"Verrotti","year":"2002","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.eplepsyres.2014.04.008_bib0105","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00007691-198703000-00007","article-title":"Long-term treatment with sodium valproate: monitoring of venous ammonia concentrations and adverse effects","volume":"9","author":"Zaccara","year":"1987","journal-title":"Ther. Drug Monit."}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121114001247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121114001247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:31:13Z","timestamp":1760275873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121114001247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0920121114001247"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2014.04.008","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2014.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}