{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:03:28Z","timestamp":1791266608789,"version":"4.1.0"},"reference-count":125,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.eplepsyres.2015.04.008","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T13:30:02Z","timestamp":1430141402000},"page":"2-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"special_numbering":"C","title":["Juvenile myoclonic epilepsy: A system disorder of the brain"],"prefix":"10.1016","volume":"114","author":[{"given":"Peter","family":"Wolf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elza M\u00e1rcia Targas","family":"Yacubian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Avanzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Sander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Wandschneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Koepp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0005","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/brain\/awh136","article-title":"fMRI activation during spike and wave discharges in idiopathic generalized epilepsy","volume":"127","author":"Aghakhani","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0010","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1528-1157.1994.tb02433.x","article-title":"Focal electroencephalographic abnormalities in juvenile myoclonic epilepsy","volume":"35","author":"Aliberti","year":"1994","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0015","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1053\/seiz.1999.0376","article-title":"Photosensitivity in juvenile myoclonic epilepsy","volume":"9","author":"Appleton","year":"2000","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0020","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S1053-8119(03)00294-5","article-title":"fMRI \u201cdeactivation\u201d of the posterior cingulate during generalized spike and wave","volume":"20","author":"Archer","year":"2003","journal-title":"Neuroimage"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0025","series-title":"Juvenile Myoclonic Epilepsy: The Janz Syndrome","first-page":"57","article-title":"Pathophysiology on myoclonus in Janz Syndrome","author":"Avanzini","year":"2000"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0030","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1528-1167.2012.03462.x","article-title":"The system epilepsies: a pathophysiological hypothesis","volume":"53","author":"Avanzini","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0035","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1212\/WNL.0b013e3181ae7ca6","article-title":"Why do seizures in generalized epilepsy often occur in the morning","volume":"73","author":"Badawy","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0040","doi-asserted-by":"crossref","first-page":"5884","DOI":"10.1523\/JNEUROSCI.5101-09.2010","article-title":"Dynamic time course of typical childhood absence seizures: EEG, behavior, and functional magnetic resonance imaging","volume":"30","author":"Bai","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0045","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1212\/01.wnl.0000313148.34629.1d","article-title":"Myoclonic seizures subside in the fourth decade in juvenile myoclonic epilepsy","volume":"70","author":"Baykan","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0050","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/j.1528-1167.2012.03454.x","article-title":"Modulation of epileptiform discharges in juvenile myoclonic epilepsy: an investigation of reflex epileptic traits","volume":"53","author":"Beniczky","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0055","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.neuroimage.2006.04.174","article-title":"Voxel-based morphometry in patients with idiopathic generalized epilepsies","volume":"32","author":"Betting","year":"2006","journal-title":"Neuroimage"},{"issue":"Suppl. 9","key":"10.1016\/j.eplepsyres.2015.04.008_bib0060","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1528-1167.2005.00311.x","article-title":"Cellular and network mechanisms of spike-wave seizures","volume":"46","author":"Blumenfeld","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0065","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.yebeh.2013.02.010","article-title":"Visual cortex hyperexcitability in idiopathic generalized epilepsies with photosensitivity: a TMS pilot study","volume":"27","author":"Brigo","year":"2013","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0070","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1212\/WNL.0b013e3181b9c86f","article-title":"JME 25 years after seizure onset. A population-based study","volume":"73","author":"Camfield","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0075","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.eplepsyres.2013.06.017","article-title":"Neurophysiology of juvenile myoclonic epilepsy: EEG-based network and graph analysis of the interictal and immediate preictal states","volume":"106","author":"Clemens","year":"2013","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0080","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1528-1157.1970.tb03871.x","article-title":"Clinical and electroencephalographical classification of epileptic seizures","volume":"11","author":"Commission for Classification and Terminology of the International League Against Epilepsy","year":"1970","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0085","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1528-1157.1985.tb05417.x","article-title":"Proposal for classification of epilepsies and epileptic syndromes","volume":"26","author":"Commission for Classification and Terminology of the International League Against Epilepsy","year":"1985","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0090","series-title":"Atlas of Epilepsies","first-page":"1080","article-title":"Jeavons syndrome","author":"Covanis","year":"2010"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0095","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.seizure.2014.10.011","article-title":"Blinking and eyelid myoclonia: characteristics and correlation of eylid movements","volume":"24","author":"da Concei\u00e7\u00e3o","year":"2015","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0105","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/j.1528-1167.2009.02021.x","article-title":"Are personality traits of juvenile myoclonic epilepsy related to frontal lobe dysfunctions? A proton MRS study","volume":"50","author":"de Araujo Filho","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0100","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.yebeh.2013.02.004","article-title":"Personality traits in juvenile myoclonic epilepsy: evidence of cortical abnormalities from a surface morphometry study","volume":"27","author":"de Araujo Filho","year":"2013","journal-title":"Epilepsy Behav."},{"issue":"Suppl. 1","key":"10.1016\/j.eplepsyres.2015.04.008_bib0110","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1016\/j.yebeh.2013.03.026","article-title":"Juvenile myoclonic epilepsy: psychiatric comorbidity and impact on outcome","volume":"28","author":"de Araujo Filho","year":"2013","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0115","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/brain\/awp262","article-title":"Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies","volume":"133","author":"de Kovel","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0120","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.nbd.2014.02.001","article-title":"Exonic microdeletions of the gephyrin gene impair GABAergic synaptic inhibition in patients with idiopathic generalized epilepsy","volume":"67","author":"Dejanovic","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0125","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1212\/WNL.34.3.285","article-title":"Juvenile myoclonic epilepsy of Janz","volume":"34","author":"Delgado-Escueta","year":"1984","journal-title":"Neurology"},{"issue":"July (Suppl. 1)","key":"10.1016\/j.eplepsyres.2015.04.008_bib0130","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/j.yebeh.2012.06.033","article-title":"The quest for juvenile myoclonic epilepsy genes","volume":"28","author":"Delgado-Escueta","year":"2013","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0135","first-page":"243","article-title":"Frontal functions in juvenile myoclonic epilepsy","volume":"10","author":"Devinsky","year":"1997","journal-title":"Neuropsychiatry Neuropsychol. Behav. Neurol."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0140","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1601-183X.2007.00333.x","article-title":"A polygenic heterogeneity model for common epilepsies with complex genetics","volume":"6","author":"Dibbens","year":"2007","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0145","series-title":"Adv. in Epileptology. XVIth Epilepsy International Symposium","first-page":"259","article-title":"Epileptic discharge after eye closure: relation to photosensitivity","author":"Fabian","year":"1987"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0150","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1111\/j.1528-1167.2012.03526.x","article-title":"Predictors for long-term seizure outcome in juvenile myoclonic epilepsy: 25\u201363 years of follow-up","volume":"53","author":"Geithner","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0155","first-page":"297","article-title":"Psychiatric disorders in juvenile myoclonic epilepsy","volume":"157","author":"G\u00e9lisse","year":"2001","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0160","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1034\/j.1600-0404.2001.00003.x","article-title":"Premature death in juvenile myoclonic epilepsy","volume":"104","author":"Genton","year":"2001","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0165","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1528-1157.1992.tb02184.x","article-title":"Sleep microstructure and EEG epileptiform activity in patients with juvenile myoclonic epilepsy","volume":"33","author":"Gigli","year":"1992","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0170","doi-asserted-by":"crossref","first-page":"15236","DOI":"10.1073\/pnas.0504935102","article-title":"Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain","volume":"102","author":"Gotman","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0175","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.seizure.2010.10.004","article-title":"Prognosis of juvenile myoclonic epilepsy is related to endophenotypes","volume":"20","author":"Guaranha","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0180","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1111\/j.1528-1167.2009.02126.x","article-title":"Provocative and inhibitory effects of a video-EEG neuropsychologic protocol in juvenile myoclonic epilepsy","volume":"50","author":"Guaranha","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0185","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.neuroimage.2006.02.016","article-title":"EEG-fMRI of idiopathic and secondarily generalized epilepsies","volume":"31","author":"Hamandi","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0190","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.clinph.2011.04.017","article-title":"Reduced movement-related \u03b2 desynchronisation in juvenile myoclonic epilepsy: a MEG study of task specific cortical modulation","volume":"122","author":"Hamandi","year":"2011","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0195","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ng.292","article-title":"15q13.3 microdeletions increase risk of idiopathic generalized epilepsy","volume":"41","author":"Helbig","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0200","series-title":"Des acc\u00e9s incomplets d\u2019\u00e9pilepsie","author":"Herpin","year":"1867"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0205","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.eplepsyres.2014.09.008","article-title":"Seizure outcome in 175 patients with juvenile myoclonic epilepsy \u2013 a long-term observational study","volume":"108","author":"H\u00f6fler","year":"2014","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0210","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neubiorev.2005.06.004","article-title":"Idiopathic epileptic syndromes and cognition","volume":"30","author":"Hommet","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0215","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.yebeh.2008.12.025","article-title":"Neuropsychological profiles of patients with juvenile myoclonic epilepsy and their siblings: a preliminary controlled experimental video-EEG case series","volume":"14","author":"Iqbal","year":"2009","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0230","series-title":"Die Epilepsien. Spezielle Pathologie und Therapie","author":"Janz","year":"1969"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0235","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1600-0404.1985.tb00900.x","article-title":"Epilepsy with impulsive petit mal (juvenile myoclonic epilepsy)","volume":"72","author":"Janz","year":"1985","journal-title":"Acta Neurol. Scand."},{"issue":"Suppl.","key":"10.1016\/j.eplepsyres.2015.04.008_bib0240","first-page":"S23","article-title":"Juvenile myoclonic epilepsy","volume":"56","author":"Janz","year":"1989","journal-title":"Cleve. Clin. J. Med."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0225","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/BF00242439","article-title":"Impulsiv \u2013 Petit mal","volume":"176","author":"Janz","year":"1957","journal-title":"J. Neurol."},{"issue":"Suppl. 5","key":"10.1016\/j.eplepsyres.2015.04.008_bib0220","first-page":"48","article-title":"Do idiopathic generalized epilepsies share a common susceptibility gene","volume":"42","author":"Janz","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0245","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.seizure.2014.03.017","article-title":"Factors associated with lack of response to valproic acid monotherapy in juvenile myoclonic epilepsy","volume":"23","author":"Jayalakshmi","year":"2014","journal-title":"Seizure"},{"issue":"July (Suppl. 1)","key":"10.1016\/j.eplepsyres.2015.04.008_bib0250","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1016\/j.yebeh.2012.11.051","article-title":"Consensus on diagnosis and management of JME: from founder's observations to current trends","volume":"28","author":"Kasteleijn-Nolst Trenit\u00e9","year":"2013","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0255","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.neuroimage.2007.06.025","article-title":"Regional grey matter abnormalities in juvenile myoclonic epilepsy: a voxel-based morphometry study","volume":"37","author":"Kim","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0260","series-title":"Juvenile Myoclonic Epilepsy: The Janz Syndrome","first-page":"91","article-title":"Positron emission tomography in idiopathic generalized epilepsy: imaging beyond structure","author":"Koepp","year":"2000"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0265","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1111\/j.1528-1157.1997.tb01198.x","article-title":"Central benzodiazepine\/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: an [11C]flumazenil positron emission tomography study","volume":"38","author":"Koepp","year":"1997","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0270","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.eplepsyres.2013.12.007","article-title":"Altered polysomnographic profile in juvenile myoclonic epilepsy","volume":"108","author":"Krishnan","year":"2014","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0275","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/epi.12084","article-title":"Rare exonic deletions of the RBFOX1 gene increase risk of idiopathic generalized epilepsy","volume":"54","author":"Lal","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005226","article-title":"Genome-wide burden analysis of rare deletions suggests a strong impact of neurodevelopmental genes in the aetiology of genetic generalised epilepsies","author":"Lal","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0285","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/hbm.20323","article-title":"Temporal lobe interictal epileptic discharges affect cerebral activity in \u201cdefault mode\u201d brain regions","volume":"28","author":"Laufs","year":"2007","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0290","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.eplepsyres.2013.11.005","article-title":"Causal influence of epileptic network during spike-and-wave discharge in juvenile myoclonic epilepsy","volume":"108","author":"Lee","year":"2014","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0295","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1076\/jcen.24.3.311.985","article-title":"Familial association of neuropsychological traits in patients with generalized and partial seizure disorders","volume":"24","author":"Levav","year":"2002","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0300","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/ana.24240","article-title":"Neurodevelopment in new-onset juvenile myoclonic epilepsy over the first 2 years","volume":"76","author":"Lin","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0305","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/j.1528-1167.2008.01948.x","article-title":"Magnetic resonance spectroscopy reveals an epileptic network in juvenile myoclonic epilepsy","volume":"50","author":"Lin","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0310","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yebeh.2013.06.034","article-title":"Hippocampal atrophy and memory dysfunction in patients with juvenile myoclonic epilepsy","volume":"29","author":"Lin","year":"2013","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0315","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.2004.041137","article-title":"Effects of sleep deprivation on cortical excitability in patients affected by juvenile myoclonic epilepsy: a combined transcranial magnetic stimulation and EEG study","volume":"77","author":"Manganotti","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0320","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/brain\/123.2.318","article-title":"Neuropsychological EEG activation in patients with epilepsy","volume":"123","author":"Matsuoka","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0325","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/j.1528-1167.2006.00575.x","article-title":"Perioral reflex myoclonias: a controlled study in patients with JME and focal epilepsies","volume":"47","author":"Mayer","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0330","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.yebeh.2003.10.020","article-title":"Focal network involvement in generalized seizures: new insights from electroconvulsive therapy","volume":"5","author":"McNally","year":"2004","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0335","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1528-1157.1984.tb04149.x","article-title":"Neuropathological findings in primary generalized epilepsy: a study of eight cases","volume":"25","author":"Meencke","year":"1984","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0340","doi-asserted-by":"crossref","first-page":"e1000962","DOI":"10.1371\/journal.pgen.1000962","article-title":"(2010) Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsies","volume":"6","author":"Mefford","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0345","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1111\/j.1528-1167.2010.02698.x","article-title":"Absence seizures: individual patterns revealed by EEG-fMRI","volume":"51","author":"Moeller","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0350","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.neuroimage.2009.07.019","article-title":"fMRI activation during spike and wave discharges evoked by photic stimulation","volume":"48","author":"Moeller","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0355","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/epi.12078","article-title":"Exon-disrupting deletions of NRXN1 in idiopathic generalized epilepsy","volume":"54","author":"M\u00f8ller","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0360","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/epi.12116","article-title":"Impulsivity and seizure frequency, but not cognitive deficits, impact social adjustment in patients with juvenile myoclonic epilepsy","volume":"54","author":"Moschetta","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0365","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1528-1157.1994.tb02435.x","article-title":"Video-polygraphic analysis of myoclonic seizures in juvenile myoclonic epilepsy","volume":"35","author":"Oguni","year":"1994","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0370","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1093\/brain\/aws296","article-title":"Abnormal thalamocortical structural and functional connectivity in juvenile myoclonic epilepsy","volume":"135","author":"O\u2019Muircheartaigh","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0375","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1212\/WNL.0b013e318203e93d","article-title":"Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy","volume":"76","author":"O\u2019Muircheartaigh","year":"2011","journal-title":"Neurology"},{"issue":"Suppl. 10","key":"10.1016\/j.eplepsyres.2015.04.008_bib0380","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1528-1167.2005.00350.x","article-title":"Analysis of genetically complex epilepsies","volume":"46","author":"Ottman","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0385","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/ana.410250411","article-title":"Absences in juvenile myoclonic epilepsy: a clinical and video-electroencephalographic study","volume":"25","author":"Panayiotopoulos","year":"1989","journal-title":"Ann. Neurol."},{"issue":"October (10)","key":"10.1016\/j.eplepsyres.2015.04.008_bib0390","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/S1388-2457(01)00634-4","article-title":"Cortical myoclonus in Janz syndrome","volume":"112","author":"Panzica","year":"2001","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0395","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1093\/brain\/awg109","article-title":"Gamma-band phase clustering and photosensitivity: is there an underlying mechanism common to photosensitive epilepsy and visual perception","volume":"126","author":"Parra","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0400","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.yebeh.2006.11.012","article-title":"Neuropsychological profile of patients with juvenile myoclonic epilepsy: a controlled study of 50 patients","volume":"10","author":"Pascalicchio","year":"2007","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0405","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/brain\/awt368","article-title":"Familial risk of epilepsy: a population-based study","volume":"137","author":"Peljto","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0410","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/jnnp.61.6.601","article-title":"Interictal mood and personality disorders in temporal lobe epilepsy and juvenile myoclonic epilepsy","volume":"6","author":"Perini","year":"1996","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0415","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1528-1167.2007.01482.x","article-title":"Frontal cognitive dysfunction in juvenile myoclonic epilepsy","volume":"49","author":"Piazzini","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0420","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/j.1528-1167.2008.01952.x","article-title":"Thalamofrontal circuitry and executive dysfunction in recent-onset juvenile myoclonic epilepsy","volume":"50","author":"Pulsipher","year":"2009","journal-title":"Epilepsia"},{"issue":"Suppl. 2","key":"10.1016\/j.eplepsyres.2015.04.008_bib0425","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1528-1167.2006.00707.x","article-title":"Circadian rhythm and personality profile in juvenile myoclonic epilepsy","volume":"47","author":"Pung","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0430","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1111\/j.1528-1167.2009.02127.x","article-title":"Evaluation of cognition, structural, and functional MRI in juvenile myoclonic epilepsy","volume":"50","author":"Roebling","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0435","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1528-1167.2008.01737.x","article-title":"Imaging seizure activity: a combined EEG\/EMG-fMRI study in reading epilepsy","volume":"50","author":"Salek-Haddadi","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0440","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nrneurol.2014.146","article-title":"Epilepsy beyond the single nucleotide variant in epilepsy genetics","volume":"10","author":"Scheffer","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0445","series-title":"Juvenile Myoclonic Epilepsy: The Janz Syndrome","first-page":"129","article-title":"Clinical genetics of idiopathic generalized epilepsies","author":"Schmitz","year":"2000"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0450","first-page":"1","article-title":"Prognosis of juvenile myoclonic epilepsy 45 years after onset","volume":"81","author":"Senf","year":"2013","journal-title":"Neurology"},{"issue":"July (Suppl. 1)","key":"10.1016\/j.eplepsyres.2015.04.008_bib0455","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.yebeh.2012.11.042","article-title":"Neurophysiology of juvenile myoclonic epilepsy","author":"Serafini","year":"2013","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0460","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.yebeh.2004.01.007","article-title":"Cognitive function in juvenile myoclonic epilepsy","volume":"5","author":"Sonmez","year":"2004","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0465","first-page":"825","article-title":"Ictal electroencephalogram","volume":"vol. 1","author":"Sperling","year":"2008"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0470","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.eplepsyres.2009.03.015","article-title":"Network characteristics of idiopathic generalized epilepsies in combined MEG\/EEG","volume":"85","author":"Stefan","year":"2009","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0475","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0896-6974(94)90034-5","article-title":"Primary memory in patients with frontal and primary generalized epilepsy","volume":"7","author":"Swartz","year":"1994","journal-title":"J. Epilepsy"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0480","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1212\/WNL.47.5.1203","article-title":"Visual working memory in primary generalized epilepsy: an 18FDG-PET study","volume":"47","author":"Swartz","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0485","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.seizure.2014.01.012","article-title":"Clinical heterogeneity of juvenile myoclonic epilepsy: follow-up after an interval of more than 20 yrs","author":"Syvertsen","year":"2014","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0490","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s00415-006-0491-6","article-title":"CBF changes in drug naive juvenile myoclonic epilepsy patients","volume":"254","author":"Tae","year":"2007","journal-title":"J. Neurol."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0495","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1093\/cercor\/bhp118","article-title":"Brain maturation in adolescence and young adulthood: regional age-related changes in cortical thickness and white matter volume and microstructure","volume":"20","author":"Tamnes","year":"2010","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0500","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.yebeh.2014.04.027","article-title":"A comprehensive neuropsychological description of cognition in drug-refractory juvenile myoclonic epilepsy","volume":"36","author":"Thomas","year":"2014","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0505","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1111\/j.1528-1167.2006.00828.x","article-title":"Psychiatric comorbidity in juvenile myoclonic epilepsy","volume":"47","author":"Trinka","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0510","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1212\/WNL.0000000000000790","article-title":"Genetics of epilepsy: the testimony of twins in the molecular era","volume":"83","author":"Vadlamudi","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0515","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1528-1167.2011.03352.x","article-title":"Enhanced frontocentral EEG connectivity in photosensitive generalized epilepsies: a partial directed coherence study","volume":"53","author":"Varotto","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0520","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/ana.24236","article-title":"The visual system in eyelid myoclonia with absences","volume":"76","author":"Vaudano","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0525","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1093\/brain\/awr098","article-title":"Motor system hyperconnectivity in juvenile myoclonic epilepsy: a cognitive functional magnetic resonance imaging study","volume":"134","author":"Vollmar","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0530","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1212\/WNL.0b013e3182563b44","article-title":"Altered microstructural connectivity in juvenile myoclonic epilepsy: the missing link","volume":"78","author":"Vollmar","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0540","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yebeh.2014.03.026","article-title":"Executive functions and psychiatric symptoms in drug-refractory juvenile myoclonic epilepsy","volume":"35","author":"Walsh","year":"2014","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0545","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1093\/brain\/awu175","article-title":"Motor co-activation in siblings of patients with juvenile myoclonic epilepsy: an imaging endophenotype?","volume":"137","author":"Wandschneider","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0550","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1111\/epi.12413","article-title":"Risk-taking behavior in juvenile myoclonic epilepsy","volume":"54","author":"Wandschneider","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0555","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1212\/WNL.0b013e318202010a","article-title":"Prospective memory in patients with juvenile myoclonic epilepsy and their healthy siblings","volume":"75","author":"Wandschneider","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0560","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1111\/epi.12003","article-title":"Frontal lobe function and structure in juvenile myoclonic epilepsy: a comprehensive review of neuropsychological and imaging data","volume":"53","author":"Wandschneider","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0565","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev-genom-091212-153408","article-title":"The genetics of microdeletion and microduplication syndromes: an update","volume":"15","author":"Watson","year":"2012","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0570","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neuroimage.2013.11.010","article-title":"Unique developmental trajectories of cortical thickness and surface area","volume":"87","author":"Wierenga","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0575","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1212\/01.wnl.0000172920.34994.63","article-title":"Familial clustering of seizure types within the idiopathic generalized epilepsies","volume":"65","author":"Winawer","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0580","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1212\/WNL.47.4.912","article-title":"Long-term prognosis of typical childhood absence epilepsy","volume":"47","author":"Wirrell","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0585","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1093\/brain\/122.11.2101","article-title":"Abnormal cerebral structure in juvenile myoclonic epilepsy demonstrated with voxel-based analysis of MRI","volume":"122","author":"Woermann","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0605","series-title":"Epileptic Syndromes in Infancy, Childhood and Adolescence","first-page":"281","article-title":"Reading epilepsy","author":"Wolf","year":"1992"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0615","series-title":"Epileptic Seizures and Syndromes, With Some of their Theoretical Implications","first-page":"3","article-title":"Epileptic seizures and syndromes: terms and concepts","author":"Wolf","year":"1994"},{"issue":"Suppl. 1","key":"10.1016\/j.eplepsyres.2015.04.008_bib0595","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.eplepsyres.2006.01.015","article-title":"Basic principles of the ILAE syndrome classification","volume":"70","author":"Wolf","year":"2006","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0600","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1528-1167.2010.02529.x","article-title":"Much ado about nothing?","volume":"51","author":"Wolf","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2015.08.033","article-title":"Reflex epileptic mechanisms in humans: lessons about natural ictogenesis","author":"Wolf","year":"2015","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0590","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1136\/jnnp.49.12.1386","article-title":"Relation of photosensitivity to epileptic syndromes","volume":"49","author":"Wolf","year":"1986","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0620","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.seizure.2014.01.011","article-title":"Praxis induction. Definition, relation to epilepsy syndromes, nosological and prognostic significance: a focused review","volume":"23","author":"Yacubian","year":"2014","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0625","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00415-012-6715-z","article-title":"Decision making in juvenile myoclonic epilepsy","volume":"260","author":"Zamarian","year":"2013","journal-title":"J. Neurol."},{"key":"10.1016\/j.eplepsyres.2015.04.008_bib0630","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/01.wco.0000162856.75391.b1","article-title":"Mechanisms, genetics, and pathogenesis of juvenile myoclonic epilepsy","volume":"18","author":"Zifkin","year":"2005","journal-title":"Curr. Opin. Neurol."}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121115000819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121115000819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:33:30Z","timestamp":1760276010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121115000819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":125,"alternative-id":["S0920121115000819"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2015.04.008","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Juvenile myoclonic epilepsy: A system disorder of the brain","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2015.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}